Poncirin induces apoptosis in AGS human gastric cancer cells through extrinsic apoptotic pathway by up-regulation of fas ligand

International Journal of Molecular Sciences

Volumn 16, Issue 9, 2015, Pages 22676-22691

  Gowda Saralamma, Venu Venkatarame ^a   Nagappan, Arulkumar ^b   Hong, Gyeong Eun ^a   Lee, Ho Jeong ^a   Yumnam, Silvia ^a   Raha, Suchismita ^a   Heo, Jeong Doo ^c   Lee, Sang Joon ^c   Lee, Won Sup ^b   Kim, Eun Hee ^d   Kim, Gon Sup ^a  

^a Gyeongsang National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c Korea Institute of Toxicology   (South Korea)

^d International University of Korea   (South Korea)

Author keywords

AGS cells; Apoptosis; Caspases; FasL; Gastric adenocarcinoma; Poncirin

Indexed keywords

BETA ACTIN; CASPASE 3; CASPASE 8; CASPASE 9; FAS LIGAND; FLAVONOID; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PONCIRIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL XL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASPASE; FASLG PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PROTEIN EXPRESSION; STOMACH CANCER; UPREGULATION; WESTERN BLOTTING; ADENOCARCINOMA; CHEMISTRY; CITRUS; DNA FRAGMENTATION; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; STOMACH; STOMACH NEOPLASMS; TUMOR CELL LINE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CITRUS; DNA FRAGMENTATION; FAS LIGAND PROTEIN; FLAVONOIDS; HUMANS; SIGNAL TRANSDUCTION; STOMACH; STOMACH NEOPLASMS; UP-REGULATION;

EID: 84942163058     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160922676     Document Type: Article

References (37)

1. Crew, K.D.; Neugut, A.I. Epidemiology of gastric cancer. World J. Gastroenterol. 2006, 12, 354–362.
2. Green, D.; Ponce de Leon, S.; Leon-Rodriguez, E.; Sosa-Sanchez, R. Adenocarcinoma of the stomach: Univariate and multivariate analysis of factors associated with survival. Am. J. Clin. Oncol. 2002, 25, 84–89.
3. Harrison, L.E.; Karpeh, M.S.; Brennan, M.F. Extended lymphadenectomy is associated with a survival benefit for node-negative gastric cancer. J. Gastrointest. Surg. 1998, 2, 126–131.
4. Jung, K.W.; Won, Y.J.; Kong, H.J.; Oh, C.M.; Lee, D.H.; Lee, J.S. Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2011. Cancer Res. Treat. 2014, 46, 109–123.
5. Lee, J.E.; Mannisto, S.; Spiegelman, D.; Hunter, D.J.; Bernstein, L.; van den Brandt, P.A.; Buring, J.E.; Cho, E.; English, D.R.; Flood, A. et al.Intakes of fruit, vegetables, and carotenoids and renal cell cancer risk: A pooled analysis of 13 prospective studies. Cancer Epidemiol. Biomark. Prev. 2009, 18, 1730–1739.
6. Gandini, S.; Merzenich, H.; Robertson, C.; Boyle, P. Meta-analysis of studies on breast cancer risk and diet: The role of fruit and vegetable consumption and the intake of associated micronutrients. Eur. J. Cancer 2000, 36, 636–646.
7. Theodoratou, E.; Kyle, J.; Cetnarskyj, R.; Farrington, S.M.; Tenesa, A.; Barnetson, R.; Porteous, M.; Dunlop, M.; Campbell, H. Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol. Biomark. Prev. 2007, 16, 684–693.
8. Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646–674.
9. Kim, D.I.; Lee, S.J.; Lee, S.B.; Park, K.; Kim, W.J.; Moon, S.K. Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis 2008, 29, 1701–1709.
10. Luo, G.; Guan, X.; Zhou, L. Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line a549 in vitro and in vivo. Cancer Biol. Ther. 2008, 7, 966–973.
11. Kim, J.B.; Han, A.R.; Park, E.Y.; Kim, J.Y.; Cho, W.; Lee, J.; Seo, E.K.; Lee, K.T. Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by Poncirin through the NF-κB inactivation in raw 264.7 macrophage cells. Biol. Pharm. Bull. 2007, 30, 2345–2351.
12. Yoon, H.Y.; Won, Y.Y.; Chung, Y.S. Poncirin prevents bone loss in glucocorticoid-induced osteoporosis in vivo and in vitro. J. Bone Miner. Metab. 2012, 30, 509–516.
13. Zhu, X.; Luo, F.; Zheng, Y.; Zhang, J.; Huang, J.; Sun, C.; Li, X.; Chen, K. Characterization, purification of Poncirin from edible Citrus ougan (Citrus reticulate cv. Suavissima) and its growth inhibitory effect on human gastric cancer cells SGC-7901. Int. J. Mol. Sci.2013, 14, 8684–8697.
14. Buendia, B.; Santa-Maria, A.; Courvalin, J.C. Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis. J. Cell Sci. 1999, 112, 1743–1753.
15. Kerr, J.F.; Wyllie, A.H.; Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26, 239–257.
16. Li, P.; Nijhawan, D.; Budihardjo, I.; Srinivasula, S.M.; Ahmad, M.; Alnemri, E.S.; Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997, 91, 479–489.
17. Walczak, H.; Krammer, P.H. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp. Cell Res. 2000, 256, 58–66.
18. Yang, J.; Zhou, Y.; Cheng, X.; Fan, Y.; He, S.; Li, S.; Ye, H.; Xie, C.; Wu, W.; Li, C. et al.Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells. Sci. Rep. 2015, 5, 7697.
19. Chen, Y.F.; Yang, J.S.; Chang, W.S.; Tsai, S.C.; Peng, S.F.; Zhou, Y.R. Houttuynia cordata thunb extract modulates G0/G1 arrest and Fas/CD95-mediated death receptor apoptotic cell death in human lung cancer A549 cells. J. Biomed. Sci.2013, 20, 18.
20. Agarwal, A.; Mahfouz, R.Z.; Sharma, R.K.; Sarkar, O.; Mangrola, D.; Mathur, P.P. Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes. Reprod. Biol. Endocrinol. 2009, 7, 143.
21. Raha, S.; Yumnam, S.; Hong, G.E.; Lee, H.J.; Saralamma, V.V.; Park, H.S.; Heo, J.D.; Lee, S.J.; Kim, E.H.; Kim, J.A. et al.Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of mapk pathways in ags cancer cells. Int. J. Oncol.2015, 47, 1061–1069.
22. Yumnam, S.; Park, H.S.; Kim, M.K.; Nagappan, A.; Hong, G.E.; Lee, H.J.; Lee, W.S.; Kim, E.H.; Cho, J.H.; Shin, S.C. et al. Hesperidin induces paraptosis like cell death in hepatoblatoma, HepG2 cells: Involvement of ERK1/2 MAPK. PLoS ONE 2014, 9, e101321.
23. Hsiao, P.C.; Lee, W.J.; Yang, S.F.; Tan, P.; Chen, H.Y.; Lee, L.M.; Chang, J.L.; Lai, G.M.; Chow, J.M.; Chien, M.H. Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells. Tumour Biol. 2014, 35, 11903–11911.
24. Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495–516.
25. Zhang, W.; Ha, M.; Gong, Y.; Xu, Y.; Dong, N.; Yuan, Y. Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. Oncol. Rep. 2010, 24, 1585–1592.
26. Li, X.; Lao, Y.; Zhang, H.; Wang, X.; Tan, H.; Lin, Z.; Xu, H. The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation. BMC Cancer 2015, 15, 254.
27. Zhou, Y.; Wang, X.; Huang, Y.; Chen, Y.; Zhao, G.; Yao, Q.; Jin, C.; Liu, X.; Li, G. Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in xuanwei female lung cancer patients. J. Cell. Biochem. 2015, 116, 1007–1018.
28. Majno, G.; Joris, I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol.1995, 146, 3–15.
29. Hyun, H.B.; Lee, W.S.; Go, S.I.; Nagappan, A.; Park, C.; Han, M.H.; Hong, S.H.; Kim, G.; Kim, G.Y.; Cheong, J. et al.The flavonoid morin from moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. Int J. Oncol.2015, 46, 2670–2678.
30. Park, H.S.; Park, K.I.; Lee, D.H.; Kang, S.R.; Nagappan, A.; Kim, J.A.; Kim, E.H.; Lee, W.S.; Shin, S.C.; Hah, Y.S. et al.Polyphenolic extract isolated from korean Lonicera japonica Thunb. Induce G2/M cell cycle arrest and apoptosis in HepG2 cells: Involvements of PI3K/AKT and MAPKs. Food Chem. Toxicol. 2012, 50, 2407–2416.
31. Lazebnik, Y.A.; Kaufmann, S.H.; Desnoyers, S.; Poirier, G.G.; Earnshaw, W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371, 346–347.
32. Choi, H.S.; Seo, H.S.; Kim, J.H.; Um, J.Y.; Shin, Y.C.; Ko, S.G. Ethanol extract of Paeonia suffruticosa andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways. J. Biomed. Sci.2012, 19, 82.
33. Saxena, N.; Yadav, P.; Kumar, O. The Fas/Fas ligand apoptotic pathway is involved in abrin-induced apoptosis. Toxicol. Sci.2013, 135, 103–118.
34. Yang, J.; Liu, X.; Bhalla, K.; Kim, C.N.; Ibrado, A.M.; Cai, J.; Peng, T.I.; Jones, D.P.; Wang, X. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 1997, 275, 1129–1132.
35. Mouria, M.; Gukovskaya, A.S.; Jung, Y.; Buechler, P.; Hines, O.J.; Reber, H.A.; Pandol, S.J. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome c release and apoptosis. Int. J. Cancer 2002, 98, 761–769.
36. Han, M.H.; Lee, W.S.; Jung, J.H.; Jeong, J.H.; Park, C.; Kim, H.J.; Kim, G.; Jung, J.M.; Kwon, T.K.; Kim, G.Y. et al.Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells. Food Chem. Toxicol. 2013, 62, 382–389.
37. Sinha, K.; Das, J.; Pal, P.B.; Sil, P.C. Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch. Toxicol.2013, 87, 1157–1180.