Hesperidin induces paraptosis like cell death in hepatoblatoma, Hepg2 cells: Involvement of ERK1/2 MAPK

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Yumnam, Silvia ^a   Park, Hyeon Soo ^a   Kim, Mun Ki ^a   Nagappan, Arulkumar ^a   Hong, Gyeong Eun ^a   Lee, Ho Jeong ^a   Lee, Won Sup ^b   Kim, Eun Hee ^c   Cho, Jae Hyeon ^a   Shin, Sung Chul ^a   Kim, Gon Sup ^a  

^a Gyeongsang National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c International University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR; CASPASE; CATHEPSIN D; CYTOKINE; HESPERIDIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL SWELLING; CELL VACUOLE; CELL VIABILITY; CHROMATIN; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFECT; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEPATOBLASTOMA; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; PARAPTOSIS LIKE CELL DEATH; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; DRUG EFFECTS; HEPG2 CELL LINE; METABOLISM; MITOCHONDRION;

ANTINEOPLASTIC AGENTS; CELL DEATH; ENDOPLASMIC RETICULUM; HEP G2 CELLS; HESPERIDIN; HUMANS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3;

EID: 84903592219     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101321     Document Type: Article

References (43)

1. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Tsatsakis AM, Spandidos DA (2010) Dietary flavonoids in cancer therapy and prevention: Substrates and inhibitors of cytochrome P450 CYP1 enzymes. Pharmacol Ther 126: 9-20.
2. Broker LE, Kruyt FA, Giaccone G (2005) Cell death independent of caspases: A review. Clin Cancer Res 11: 3155-3162.
3. Chen TS, Wang XP, Sun L, Wang LX, Xing D, et al. (2008) Taxol induces caspase-independent cytoplasmic vacuolization and cell death through endoplasmic reticulum (ER) swelling in ASTC-a-1 cells. Cancer Lett 270: 164-172.
4. Constantinou C, Papas KA, Constantinou AI (2009) Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy? Curr Cancer Drug Targets 9: 717-728.
5. Cragg GM, Grothaus PG, Newman DJ (2009) Impact of natural products on developing new anti-cancer agents. Chem Rev 109: 3012-3043.
6. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917.
7. Galati EM, Monforte MT, Kirjavainen S, Forestieri AM, Trovato A, et al. (1994) Biological effects of hesperidin, a citrus flavonoid. (note I): Anti-inflammatory and analgesic activity. Farmaco 40: 709-712.
8. Jambrina E, Alonso R, Alcalde M, del Carmen Rodriguez M, Serrano A, et al. (2003) Calcium influx through receptor-operated channel induces mitochondria-triggered paraptotic cell death. J Biol Chem 278: 14134-14145.
9. Justesen U, Knuthsen P, Leth T (1998) Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection. J Chromatogr A 799: 101-110.
10. Kamaraj S, Ramakrishnan G, Anandakumar P, Jagan S, Devaki T (2009) Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs 27: 214-222.
11. Kar R, Singha PK, Venkatachalam MA, Saikumar P (2009) A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. Oncogene 28: 2556-2568.
12. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257.
13. Kim SO, Han J (2001) Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages. J Endotoxin Res 7: 292-296.
14. Korsnes MS, Espenes A, Hetland DL, Hermansen LC (2011) Paraptosis-like cell death induced by yessotoxin. Toxicol In Vitro 25: 1764-1770.
15. Lee CJ, Wilson L, Jordan MA, Nguyen V, Tang J, et al. (2010) Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells. Phytother Res 24 Suppl 1: S15-9.
16. Lee DH, Park KI, Park HS, Kang SR, Nagappan A, et al. (2012) Flavonoids isolated from korea citrus aurantium L. induce G2/M phase arrest and apoptosis in human gastric cancer AGS cells. Evid Based Complement Alternat Med 2012: 515901.
17. Lee KA, Lee SH, Lee YJ, Baeg SM, Shim JH (2012) Hesperidin induces apoptosis by inhibiting Sp1 and its regulatory protein in MSTO-211H cells. Biomol Ther (Seoul) 20: 273-279.
18. Lee KH (2010) Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod 73: 500-516.
19. Lee KH, Yeh MH, Kao ST, Hung CM, Liu CJ, et al. (2010) The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells. Toxicol Lett 194: 42-49.
20. Li B, Zhao J, Wang CZ, Searle J, He TC, et al. (2011) Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett 301: 185-192.
21. Liaudet-Coopman E, Beaujouin M, Derocq D, Garcia M, Glondu-Lassis M, et al. (2006) Cathepsin D: Newly discovered functions of a long-standing aspartic protease in cancer and apoptosis. Cancer Lett 237: 167-179.
22. Liu HL, Jang WB, Xie MX (2010) Flavanoids: Recent advances as anticancer drugs. Recent Pat Anticancer Drug Discov 5: 152-164.
23. Natarajan N, Thamaraiselvan R, Lingaiah H, Srinivasan P, Periyasamy BM (2011). Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomedicine & Preventive Nutrition, 1(3), 207-215.
24. Palmeri CM, Petiti JP, Sosa Ldel V, Gutierrez S, De Paul AL, et al. (2009) Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage. Toxicol Appl Pharmacol 240: 55-65.
25. Park HJ, Kim MJ, Ha E, Chung JH (2008) Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4. Phytomedicine 15: 147-151.
26. Park HS, Park KI, Lee DH, Kang SR, Nagappan A, et al. (2012) Polyphenolic extract isolated from korean lonicera japonica thunb. induce G2/M cell cycle arrest and apoptosis in HepG2 cells: Involvements of PI3K/Akt and MAPKs. Food Chem Toxicol 50: 2407-2416.
27. Park KI, Park HS, Kang SR, Nagappan A, Lee DH, et al. (2011) Korean scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells. J Ethnopharmacol 133: 634-641.
28. Ren W, Qiao Z, Wang H, Zhu L, Zhang L (2003) Flavonoids: Promising anticancer agents. Med Res Rev 23: 519-534.
29. Souza LC, de Gomes MG, Goes AT, Del Fabbro L, Filho CB, et al. (2013) Evidence for the involvement of the serotonergic 5-HT(1A) receptors in the antidepressant-like effect caused by hesperidin in mice. Prog Neuropsychopharmacol Biol Psychiatry 40: 103-109.
30. Sperandio S, de Belle I, Bredesen DE (2000) An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci U S A 97: 14376-14381.
31. Sperandio S, Poksay K, de Belle I, Lafuente MJ, Liu B, et al. (2004) Paraptosis: Mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ 11: 1066-1075.
32. Sun Q, Chen T, Wang X, Wei X (2010) Taxol induces paraptosis independent of both protein synthesis and MAPK pathway. J Cell Physiol 222: 421-432.
33. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, et al. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446.
34. Thornberry NA, Lazebnik Y (1998) Caspases: Enemies within. Science 281: 1312-1316.
35. Wang Y, Li X, Wang L, Ding P, Zhang Y, et al. (2004) An alternative form of paraptosis- like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression. J Cell Sci 117: 1525-1532.
36. Wang Y, Zhu X, Yang Z, Zhao X (2013) Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells. Biochem Biophys Res Commun 430: 876-882.
37. Wyllie AH, Golstein P (2001) More than one way to go. Proc Natl Acad Sci U S A 98: 11-13.
38. Yang M, Tanaka T, Hirose Y, Deguchi T, Mori H, et al. (1997) Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice. Int J Cancer 73: 719-724.
39. Yeh MH, Kao ST, Hung CM, Liu CJ, Lee KH, et al. (2009) Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells. Toxicol Lett 184: 204-210.
40. 2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells. Cancer Lett 324: 197-209.
41. Zhang FJ, Yang JY, Mou YH, Sun BS, Wang JM, et al. (2010) Oligomer procyanidins from grape seeds induce a paraptosis-like programmed cell death in human glioblastoma U-87 cells. Pharm Biol 48: 883-890.
42. Zhang JS, Li DM, Ma Y, He N, Gu Q, et al. (2013) Gamma-tocotrienol induces paraptosis-like cell death in human colon carcinoma SW620 cells. PLoS One 8: e57779.
43. Zhang Y, Zhang WL, Huang DS, Hong L, Wang YZ, et al. (2014) Clinical effectiveness of multimodality treatment on advanced pediatric hepatoblastoma. Eur Rev Med & Pharmacol Sci 18:1018-1026.