Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 382-389

  Han, Min Ho ^a   Lee, Won Sup ^b   Jung, Ji Hyun ^b   Jeong, Jae Hun ^c   Park, Cheol ^d   Kim, Hye Jung ^b   Kim, GonSup ^e   Jung, Jin Myung ^b   Kwon, Taeg Kyu ^f   Kim, Gi Young ^g   Ryu, Chung Ho ^e   Shin, Sung Chul ^e   Hong, Soon Chan ^b   Choi, Yung Hyun ^a  

^a Dong Eui University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c Pusan National University   (South Korea)

^d Dong Eui University   (South Korea)

^e Gyeongsang National University   (South Korea)

^f Keimyung University   (South Korea)

^g Jeju National University   (South Korea)

Author keywords

Akt; Allium cepa; Apoptosis; Polyphenols; TRAIL; U937

Indexed keywords

CASPASE; CASPASE 8 INHIBITOR; CASPASE 9 INHIBITOR; DEATH RECEPTOR 5; INHIBITOR OF APOPTOSIS PROTEIN 1; ONION EXTRACT; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPHENOL DERIVATIVE; PROTEIN KINASE B; ANTINEOPLASTIC AGENT; BIRC2 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; POLYPHENOL; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DRUG ISOLATION; ENZYME INHIBITION; ENZYME REPRESSION; FREEZE DRYING; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; ONION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; K562 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL LINE, TUMOR; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; K562 CELLS; LEUKEMIA; ONIONS; PHOSPHATIDYLINOSITOL 3-KINASES; POLYPHENOLS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84884565599     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.085     Document Type: Article

References (26)

1. Block E. The chemistry of garlic and onions. Sci Am. 1985, 252:114-119.
2. Challier B., Perarnau J.M., Viel J.F. Garlic, onion and cereal fibre as protective factors for breast cancer: a French case-control study. Eur. J. Epidemiol. 1998, 14:737-747.
3. Chawla-Sarkar M., Bae S.I., Reu F.J., Jacobs B.S., Lindner D.J., Borden E.C. Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ. 2004, 11:915-923.
4. Chen X., Thakkar H., Tyan F., Gim S., Robinson H., Lee C., Pandey S.K., Nwokorie C., Onwudiwe N., Srivastava R.K. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer. Oncogene 2001, 20:6073-6083.
5. Cui Z.G., Hong N.Y., Guan J., Kang H.K., Lee D.H., Lee Y.K., Park D.B. cAMP antagonizes ERK-dependent antiapoptotic action of insulin. BMB Rep. 2011, 44:205-210.
6. Gibellini L., Pinti M., Nasi M., Montagna J.P., De Biasi S., Roat E., Bertoncelli L., Cooper E.L., Cossarizza A. Quercetin and cancer chemoprevention. Evid. Based Complement Alternat. Med. 2011, 2011:591356.
7. Jang Y.J., Park K.S., Chung H.Y., Kim H.I. Analysis of the phenotypes of Jurkat clones with different TRAIL-sensitivities. Cancer Lett. 2003, 194:107-117.
8. Kim Y.H., Lee Y.J. TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation. J. Cell. Biochem. 2007, 100:998-1009.
9. Kim J.Y., Kim E.H., Park S.S., Lim J.H., Kwon T.K., Choi K.S. Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. J. Cell. Biochem. 2008, 105:1386-1398.
10. Kim Y.H., Lee D.H., Jeong J.H., Guo Z.S., Lee Y.J. Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem. Pharmacol. 2008, 75:1946-1958.
11. Le Bon A.M., Siess M.H. Organosulfur compounds from Allium and the chemoprevention of cancer. Drug Metabol. Drug Interact. 2000, 17:51-79.
12. Lee J., Mitchell A.E. Quercetin and isorhamnetin glycosides in onion (Allium cepa L.): varietal comparison, physical distribution, coproduct evaluation, and long-term storage stability. J. Agric. Food Chem. 2011, 59:857-863.
13. Lee H.J., Lee E.O., Ko S.G., Bae H.S., Kim C.H., Ahn K.S., Lu J., Kim S.H. Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. Cancer Lett. 2008, 270:342-353.
14. Ma G., Yang C., Qu Y., Wei H., Zhang T., Zhang N. The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. Chem. Biol. Interact. 2007, 167:153-160.
15. Manach C., Williamson G., Morand C., Scalbert A., Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005, 81:230S-242S.
16. Mitsiades N., Poulaki V., Mitsiades C., Tsokos M. Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. Cancer Res. 2001, 61:2704-2712.
17. Mouria M., Gukovskaya A.S., Jung Y., Buechler P., Hines O.J., Reber H.A., Pandol S.J. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer 2002, 98:761-769.
18. O'Leary K.A., Day A.J., Needs P.W., Mellon F.A., O'Brien N.M., Williamson G. Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem. Pharmacol. 2003, 65:479-491.
19. Plastaras J.P., Dorsey J.F., Carroll K., Kim S.H., Birnbaum M.J., El-Deiry W.S. Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer Biol. Ther. 2008, 7:2047-2053.
20. Psahoulia F.H., Drosopoulos K.G., Doubravska L., Andera L., Pintzas A. Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol. Cancer Ther. 2007, 6:2591-2599.
21. Shin D.Y., Ryu C.H., Lee W.S., Kim D.C., Kim S.H., Hah Y.S., Lee S.J., Shin S.C., Kang H.S., Choi Y.H. Induction of apoptosis and inhibition of invasion in human hepatoma cells by anthocyanins from meoru. Ann. NY Acad. Sci. 2009, 1171:137-148.
22. Singh T.R., Shankar S., Srivastava R.K. HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma. Oncogene 2005, 24:4609-4623.
23. Sonnemann J., Gange J., Kumar K.S., Muller C., Bader P., Beck J.F. Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. Invest New Drugs 2005, 23:99-109.
24. Surh Y.J. Transcription factors in the cellular signaling network as prime targets of chemopreventive phytochemicals. Cancer Res. Treat. 2004, 36:275-286.
25. Walker P.R., Sikorska M. New aspects of the mechanism of DNA fragmentation in apoptosis. Biochem. Cell Biol. 1997, 75:287-299.
26. Wiczkowski W., Romaszko J., Bucinski A., Szawara-Nowak D., Honke J., Zielinski H., Piskula M.K. Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides. J. Nutr. 2008, 138:885-888.