Diagnosing dengue virus infection: Rapid tests and the role of micro/nanotechnologies

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 11, Issue 7, 2015, Pages 1745-1761

  Zhang, Bei ^a   Salieb Beugelaar, Georgette B ^a,c   Nigo, Maurice Mutro ^a,d   Weidmann, Manfred ^b   Hunziker, Patrick ^a,c  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF STIRLING   (United Kingdom)

^c The European Foundation for Clinical Nanomedicine   (Switzerland)

^d Institut Supérieur des Techniques Médicales NYANKUNDE   (Congo)

Author keywords

Dengue virus; Label free biosensor; Microfluidic platform; Point of care; Rapid diagnosis

Indexed keywords

BIOSENSORS; DEVELOPING COUNTRIES; KNOWLEDGE BASED SYSTEMS; MICROFLUIDICS; NANOTECHNOLOGY; VIRUSES;

ANALYTICAL STRATEGY; CLINICAL SETTINGS; DENGUE VIRUS; KEY DETERMINANTS; LABEL-FREE BIOSENSOR; MICROFLUIDIC PLATFORMS; POINT OF CARE; TEMPERATE CLIMATE;

DIAGNOSIS;

ASSAY; BIOSENSOR; CLINICAL EVALUATION; DENGUE; DENGUE VIRUS; DIAGNOSTIC PROCEDURE; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; EPIDEMIOLOGICAL DATA; FEVER; HUMAN; KNOWLEDGE BASE; LABORATORY DIAGNOSIS; LABORATORY TEST; MICROARRAY ANALYSIS; MICROBIOLOGY; MICROFLUIDIC ANALYSIS; MICROTECHNOLOGY; NANOFABRICATION; NANOTECHNOLOGY; RAPID TEST; REVIEW; SCIENTIST; SURFACE PLASMON RESONANCE; GENETIC PROCEDURES; ISOLATION AND PURIFICATION; MICROFLUIDICS; PATHOGENICITY; PATHOLOGY; VIROLOGY;

BIOSENSING TECHNIQUES; DENGUE; DENGUE VIRUS; HUMANS; MICROFLUIDICS; NANOTECHNOLOGY;

EID: 84942099399     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2015.05.009     Document Type: Review

References (158)

1. Guzman M.G., Halstead S.B., Artsob H., Buchy P., Farrar J., Gubler D.J., et al. Dengue: a continuing global threat. Nat Rev Microbiol 2010, 8:S7-S16.
2. WHO Global strategy for dengue prevention and control, 2012-2020 2012, [online]http://www.who.int/denguecontrol/9789241504034/en/, WHO, Geneva, Switzerland.
3. Gubler D.J. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998, 11:480-496.
4. TDR/WHO Dengue: guidelines for diagnosis, treatment, prevention and control 2009, [online]http://www.who.int/denguecontrol/en/, TDR/WHO, Geneva, Switzerland.
5. Guzman M.G., Kouri G. Dengue: an update. Lancet Infect Dis 2002, 2:33-42.
6. Halstead S.B. Dengue. Lancet 2007, 370:1644-1652.
7. Bhatt S., Gething P.W., Brady O.J., Messina J.P., Farlow A.W., Moyes C.L., et al. The global distribution and burden of dengue. Nature 2013, 496:504-507.
8. Chawla P., Yadav A., Chawla V. Clinical implications and treatment of dengue. Asian Pac J Trop Med 2014, 7:169-178.
9. Laughlin C.A., Morens D.M., Cassetti M.C., Costero-Saint Denis A., San Martin J.L., Whitehead S.S., et al. Dengue research opportunities in the Americas. J Infect Dis 2012, 206:1121-1127.
10. Shu P.Y., Huang J.H. Current advances in dengue diagnosis. Clin Diagn Lab Immunol 2004, 11:642-650.
11. Peeling R.W., Artsob H., Pelegrino J.L., Buchy P., Cardosa M.J., Devi S., et al. Evaluation of diagnostic tests: dengue. Nat Rev Microbiol 2010, 8:S30-S38.
12. Holmes E.C. The evolutionary biology of dengue virus. Novartis Found Symp 2006, 277:177-187. [discussion 87-92, 251-3].
13. Khan A.M., Miotto O., Nascimento E.J., Srinivasan K.N., Heiny A.T., Zhang G.L., et al. Conservation and variability of dengue virus proteins: implications for vaccine design. PLoS Negl Trop Dis 2008, 2:e272.
14. TDR/WHO Dengue diagnostics: proceedings of an international workshop 4-6 October 2004 2005, [online]http://www.who.int/tdr/publications/tdr-research-publications/dengue-diagnostics-proceedings/en/, TDR/WHO, Geneva, Switzerland.
15. Kyle J.L., Harris E. Global spread and persistence of dengue. Annu Rev Microbiol 2008, 62:71-92.
16. Medlock J.M., Hansford K.M., Schaffner F., Versteirt V., Hendrickx G., Zeller H., et al. A review of the invasive mosquitoes in Europe: ecology, public health risks, and control options. Vector Borne Zoonotic Dis 2012, 12:435-447.
17. Neteler M., Metz M., Rocchini D., Rizzoli A., Flacio E., Engeler L., et al. Is Switzerland suitable for the invasion of Aedes albopictus [corrected]?. PLoS One 2013, 8:e82090.
18. Wymann M.N., Flacio E., Radczuweit S., Patocchi N., Lüthy P. Asian tiger mosquito (Aedes albopictus)-a threat for Switzerland?. Euro Surveill 2008, 13(10):1-2. [http://www.ncbi.nlm.nih.gov/pubmed/18445441 (accessed Mar 6), pii=8058].
19. Becker N., Geier M., Balczun C., Bradersen U., Huber K., Kiel E., et al. Repeated introduction of Aedes albopictus into Germany, July to October 2012. Parasitol Res 2013, 112:1787-1790.
20. Bockova E., Kocisova A., Letkova V. First record of Aedes albopictus in Slovakia. Acta Parasitol 2013, 58:603-606.
21. Scholte E.J., Den Hartog W., Dik M., Schoelitsz B., Brooks M., Schaffner F., et al. Introduction and control of three invasive mosquito species in the Netherlands, July-October 2010. Euro Surveill 2010, 15(45):1-4. [http://www.ncbi.nlm.nih.gov/pubmed/21087591 (accessed Nov 11), pii=19710].
22. Boukraa S., Raharimalala F.N., Zimmer J.Y., Schaffner F., Bawin T., Haubruge E., et al. Reintroduction of the invasive mosquito species Aedes albopictus in Belgium in July 2013. Parasite 2013, 20:1-3. [54] http://dx.doi.org/10.1051/parasite/2013054.
23. Jensenius M., Han P.V., Schlagenhauf P., Schwartz E., Parola P., Castelli F., et al. Acute and potentially life-threatening tropical diseases in western travelers-a GeoSentinel multicenter study, 1996-2011. Am J Trop Med Hyg 2013, 88:397-404.
24. Guzman M.G., Harris E. Dengue. Lancet 2015, 385:453-465.
25. Mairuhu A.T., Wagenaar J., Brandjes D.P., van Gorp E.C. Dengue: an arthropod-borne disease of global importance. Eur J Clin Microbiol Infect Dis 2004, 23:425-433.
26. Guzman M.G., Alvarez A., Vazquez S., Alvarez M., Rosario D., Pelaez O., et al. Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001-2002. Int J Infect Dis 2012, 16:e198-e203.
27. Montoya M., Gresh L., Mercado J.C., Williams K.L., Vargas M.J., Gutierrez G., et al. Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year. PLoS Negl Trop Dis 2013, 7:e2357.
28. Whitehorn J., Farrar J. Dengue. Br Med Bull 2010, 95:161-173.
29. Reiter P. Yellow fever and dengue: a threat to Europe?. Euro Surveill 2010, 15(10):1-7. [pii=19509].
30. Wahala W.M., Silva A.M. The human antibody response to dengue virus infection. Viruses 2011, 3:2374-2395.
31. Sam S.S., Omar S.F., Teoh B.T., Abd-Jamil J., AbuBakar S. Review of dengue hemorrhagic fever fatal cases seen among adults: a retrospective study. PLoS Negl Trop Dis 2013, 7:e2194.
32. Guzman M.G., Alvarez M., Halstead S.B. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol 2013, 158:1445-1459.
33. Zompi S., Harris E. Original antigenic sin in dengue revisited. Proc Natl Acad Sci U S A 2013, 110:8761-8762.
34. Rothman A.L. Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nat Rev Immunol 2011, 11:532-543.
35. Mongkolsapaya J., Dejnirattisai W., Xu X.N., Vasanawathana S., Tangthawornchaikul N., Chairunsri A., et al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med 2003, 9:921-927.
36. Pang T., Cardosa M.J., Guzman M.G. Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS). Immunol Cell Biol 2007, 85:43-45.
37. Lin C.F., Wan S.W., Cheng H.J., Lei H.Y., Lin Y.S. Autoimmune pathogenesis in dengue virus infection. Viral Immunol 2006, 19:127-132.
38. Wan S.W., Lin C.F., Yeh T.M., Liu C.C., Liu H.S., Wang S., et al. Autoimmunity in dengue pathogenesis. J Formos Med Assoc 2013, 112:3-11.
39. Thomas S.J., Endy T.P. Critical issues in dengue vaccine development. Curr Opin Infect Dis 2011, 24:442-450.
40. Thisyakorn U., Thisyakorn C. Latest developments and future directions in dengue vaccines. Ther Adv Vaccines 2014, 2:3-9.
41. Thomas S.J. Preventing dengue-is the possibility now a reality?. N Engl J Med 2015, 372:172-173.
42. FIND Acute febrile syndrome strategy [online]. http://www.finddiagnostics.org/resource-centre/reports_brochures/afs-nmfi-strategy.html.
43. Acestor N., Cooksey R., Newton P.N., Menard D., Guerin P.J., Nakagawa J., et al. Mapping the aetiology of non-malarial febrile illness in Southeast Asia through a systematic review-terra incognita impairing treatment policies. PLoS One 2012, 7:e44269.
44. Crump J.A., Gove S., Parry C.M. Management of adolescents and adults with febrile illness in resource limited areas. BMJ 2011, 343:d4847.
45. Joshi R., Colford J.M., Reingold A.L., Kalantri S. Nonmalarial acute undifferentiated fever in a rural hospital in central India: diagnostic uncertainty and overtreatment with antimalarial agents. Am J Trop Med Hyg 2008, 78:393-399.
46. Teles F.S. Biosensors and rapid diagnostic tests on the frontier between analytical and clinical chemistry for biomolecular diagnosis of dengue disease: a review. Anal Chim Acta 2011, 687:28-42.
47. Hauck T.S., Giri S., Gao Y., Chan W.C. Nanotechnology diagnostics for infectious diseases prevalent in developing countries. Adv Drug Deliv Rev 2010, 62:438-448.
48. Spoorthi Ravi Banavar and Vidya G.S. Diagnostic efficacy of saliva for dengue-a reality in near future? A piloting initiative. J Clin Diagn Res 2014, 8:229-232.
49. Teles F.R., Prazeres D.M., Lima-Filho J.L. Trends in dengue diagnosis. Rev Med Virol 2005, 15:287-302.
50. Patel P., Landt O., Kaiser M., Faye O., Koppe T., Lass U., et al. Development of one-step quantitative reverse transcription PCR for the rapid detection of flaviviruses. Virol J 2013, 10:1-11. [58].
51. Shu P.Y., Chang S.F., Kuo Y.C., Yueh Y.Y., Chien L.J., Sue C.L., et al. Development of group- and serotype-specific one-step SYBR green I-based real-time reverse transcription-PCR assay for dengue virus. J Clin Microbiol 2003, 41:2408-2416.
52. Gurukumar K.R., Priyadarshini D., Patil J.A., Bhagat A., Singh A., Shah P.S., et al. Development of real time PCR for detection and quantitation of dengue viruses. Virol J 2009, 6:1-8. [10].
53. Chien L.J., Liao T.L., Shu P.Y., Huang J.H., Gubler D.J., Chang G.J. Development of real-time reverse transcriptase PCR assays to detect and serotype dengue viruses. J Clin Microbiol 2006, 44:1295-1304.
54. Callahan J.D., Wu S.J., Dion-Schultz A., Mangold B.E., Peruski L.F., Watts D.M., et al. Development and evaluation of serotype- and group-specific fluorogenic reverse transcriptase PCR (TaqMan) assays for dengue virus. J Clin Microbiol 2001, 39:4119-4124.
55. Santiago G.A., Vergne E., Quiles Y., Cosme J., Vazquez J., Medina J.F., et al. Analytical and clinical performance of the CDC real time RT-PCR assay for detection and typing of dengue virus. PLoS Negl Trop Dis 2013, 7:e2311.
56. Wu S.J., Lee E.M., Putvatana R., Shurtliff R.N., Porter K.R., Suharyono W., et al. Detection of dengue viral RNA using a nucleic acid sequence-based amplification assay. J Clin Microbiol 2001, 39:2794-2798.
57. Teoh B.T., Sam S.S., Tan K.K., Johari J., Danlami M.B., Hooi P.S., et al. Detection of dengue viruses using reverse transcription-loop-mediated isothermal amplification. BMC Infect Dis 2013, 13:1-9. [387].
58. Lu X., Li X., Mo Z., Jin F., Wang B., Zhao H., et al. Rapid identification of Chikungunya and dengue virus by a real-time reverse transcription-loop-mediated isothermal amplification method. Am J Trop Med Hyg 2012, 87:947-953.
59. Li S., Fang M., Zhou B., Ni H., Shen Q., Zhang H., et al. Simultaneous detection and differentiation of dengue virus serotypes 1-4, Japanese encephalitis virus, and West Nile virus by a combined reverse-transcription loop-mediated isothermal amplification assay. Virol J 2011, 8:1-9. [360].
60. Sahni A.K., Grover N., Sharma A., Khan I.D., Kishore J. Reverse transcription loop-mediated isothermal amplification (RT-LAMP) for diagnosis of dengue. Med J Armed Forces India 2013, 69:246-253.
61. Guzman M.G., Jaenisch T., Gaczkowski R., Ty Hang V.T., Sekaran S.D., Kroeger A., et al. Multi-country evaluation of the sensitivity and specificity of two commercially-available NS1 ELISA assays for dengue diagnosis. PLoS Negl Trop Dis 2010, 4:e811.
62. Hunsperger E.A., Yoksan S., Buchy P., Nguyen V.C., Sekaran S.D., Enria D.A., et al. Evaluation of commercially available anti-dengue virus immunoglobulin M tests. Emerg Infect Dis 2009, 15:436-440.
63. Anandarao R., Swaminathan S., Fernando S., Jana A.M., Khanna N. Recombinant multiepitope protein for early detection of dengue infections. Clin Vaccine Immunol 2006, 13:59-67.
64. AnandaRao R., Swaminathan S., Fernando S., Jana A.M., Khanna N. A custom-designed recombinant multiepitope protein as a dengue diagnostic reagent. Protein Expr Purif 2005, 41:136-147.
65. Rainwater-Lovett K., Rodriguez-Barraquer I., Cummings D.A., Lessler J. Variation in dengue virus plaque reduction neutralization testing: systematic review and pooled analysis. BMC Infect Dis 2012, 12:1-15. [233].
66. CDC/USA Dengue Homepage: Laboratory Guidance and Diagnostic Testing [online]. http://www.cdc.gov/dengue/clinicalLab/laboratory.html.
67. Blacksell S.D. Commercial dengue rapid diagnostic tests for point-of-care application: recent evaluations and future needs?. J Biomed Biotechnol 2012, 2012:151967.
68. Martina B.E., Koraka P., Osterhaus A.D. Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 2009, 22:564-581.
69. Vazquez S., Cabezas S., Perez A.B., Pupo M., Ruiz D., Calzada N., et al. Kinetics of antibodies in sera, saliva, and urine samples from adult patients with primary or secondary dengue 3 virus infections. Int J Infect Dis 2007, 11:256-262.
70. Rathakrishnan A., Sekaran S.D. New development in the diagnosis of dengue infections. Expert Opin Med Diagn 2013, 7:99-112.
71. Mabey D., Peeling R.W., Ustianowski A., Perkins M.D. Diagnostics for the developing world. Nat Rev Microbiol 2004, 2:231-240.
72. Yager P., Edwards T., Fu E., Helton K., Nelson K., Tam M.R., et al. Microfluidic diagnostic technologies for global public health. Nature 2006, 442:412-418.
73. Syed M.A. Advances in nanodiagnostic techniques for microbial agents. Biosens Bioelectron 2014, 51:391-400.
74. Blacksell S.D., Newton P.N., Bell D., Kelley J., Mammen M.P., Vaughn D.W., et al. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 2006, 42:1127-1134.
75. WHO Evaluation of commercially available anti-dengue virus immunoglobulin M tests 2009, [online]http://www.who.int/tdr/publications/tdr-research-publications/diagnostics-evaluation-3/en/, WHO, Geneva, Switzerland.
76. Peeling R.W., Smith P.G., Bossuyt P.M. A guide for diagnostic evaluations. Nat Rev Microbiol 2006, 4:S2-S6.
77. Blacksell S.D., Doust J.A., Newton P.N., Peacock S.J., Day N.P., Dondorp A.M. A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. Trans R Soc Trop Med Hyg 2006, 100:775-784.
78. Rodrigues Ribeiro Teles F.S., Pires de Tavora Tavira L.A., Pina da Fonseca L.J. Biosensors as rapid diagnostic tests for tropical diseases. Crit Rev Clin Lab Sci 2010, 47:139-169.
79. Peh A.E., Leo Y.S., Toh C.S. Current and nano-diagnostic tools for dengue infection. Front Biosci (Schol Ed) 2011, 3:806-821.
80. Fee C.J. Label-free, real-time interaction and adsorption analysis 2: quartz crystal microbalance. Methods Mol Biol 2013, 996:313-322.
81. Prakrankamanant P. Quartz crystal microbalance biosensors: prospects for point-of-care diagnostics. J Med Assoc Thai 2014, 97(Suppl. 4):S56-S64.
82. Su C.C., Wu T.Z., Chen L.K., Yang H.H., Tai D.F. Development of immunochips for the detection of dengue viral antigens. Anal Chim Acta 2003, 479:117-123.
83. Wu T.Z., Su C.C., Chen L.K., Yang H.H., Tai D.F., Peng K.C. Piezoelectric immunochip for the detection of dengue fever in viremia phase. Biosens Bioelectron 2005, 21:689-695.
84. Tai D.F., Lin C.Y., Wu T.Z., Huang J.H., Shu P.Y. Artificial receptors in serologic tests for the early diagnosis of dengue virus infection. Clin Chem 2006, 52:1486-1491.
85. Chen S.H., Chuang Y.C., Lu Y.C., Lin H.C., Yang Y.L., Lin C.S. A method of layer-by-layer gold nanoparticle hybridization in a quartz crystal microbalance DNA sensing system used to detect dengue virus. Nanotechnology 2009, 20:215501.
86. Janshoff A., Galla H.J., Steinem C. Piezoelectric mass-sensing devices as biosensors-an alternative to optical biosensors?. Angew Chem Int Ed Engl 2000, 39:4004-4032.
87. Fee C.J. Label-free, real-time interaction and adsorption analysis 1: surface plasmon resonance. Methods Mol Biol 2013, 996:287-312.
88. Kumbhat S., Sharma K., Gehlot R., Solanki A., Joshi V. Surface plasmon resonance based immunosensor for serological diagnosis of dengue virus infection. J Pharm Biomed Anal 2010, 52:255-259.
89. Yau Y.H., Shochat S.G. Analysis of affinity of dengue virus protein interaction using Biacore. Methods Mol Biol 2014, 1138:271-284.
90. Jahanshahi P., Zalnezhad E., Sekaran S.D., Adikan F.R.M. Rapid immunoglobulin M-based dengue diagnostic test using surface plasmon resonance biosensor. Sci Rep 2014, 4:1-7. [3851]. http://dx.doi.org/10.1038/srep03851.
91. Camara A.R., Gouvea P.M., Dias A.C., Braga A.M., Dutra R.F., de Araujo R.E., et al. Dengue immunoassay with an LSPR fiber optic sensor. Opt Express 2013, 21:27023-27031.
92. Helmerhorst E., Chandler D.J., Nussio M., Mamotte C.D. Real-time and label-free bio-sensing of molecular interactions by surface plasmon resonance: a laboratory medicine perspective. Clin Biochem Rev 2012, 33:161-173.
93. Daniels J.S., Pourmand N. Label-free impedance biosensors: opportunities and challenges. Electroanalysis 2007, 19:1239-1257.
94. Yu X., Xu D., Cheng Q. Label-free detection methods for protein microarrays. Proteomics 2006, 6:5493-5503.
95. Kim G., Mun J.H., Om A.S. Nano-particle enhanced impedimetric biosensor for detedtion of foodborne pathogens. J Phys 2007, 61:555-559.
96. Ray S., Mehta G., Srivastava S. Label-free detection techniques for protein microarrays: prospects, merits and challenges. Proteomics 2010, 10:731-748.
97. Xu D., Xu D., Yu X., Liu Z., He W., Ma Z. Label-free electrochemical detection for aptamer-based array electrodes. Anal Chem 2005, 77:5107-5113.
98. Peh A.E., Li S.F. Dengue virus detection using impedance measured across nanoporous alumina membrane. Biosens Bioelectron 2013, 42:391-396.
99. Oliveira M.D., Correia M.T., Diniz F.B. Concanavalin A and polyvinyl butyral use as a potential dengue electrochemical biosensor. Biosens Bioelectron 2009, 25:728-732.
100. Nguyen B.T., Peh A.E., Chee C.Y., Fink K., Chow V.T., Ng M.M., et al. Electrochemical impedance spectroscopy characterization of nanoporous alumina dengue virus biosensor. Bioelectrochemistry 2012, 88:15-21.
101. Deng J., Toh C.S. Impedimetric DNA biosensor based on a nanoporous alumina membrane for the detection of the specific oligonucleotide sequence of dengue virus. Sensors (Basel) 2013, 13:7774-7785.
102. Zaytseva N.V., Goral V.N., Montagna R.A., Baeumner A.J. Development of a microfluidic biosensor module for pathogen detection. Lab Chip 2005, 5:805-811.
103. Huyghe A., Francois P., Schrenzel J. Characterization of microbial pathogens by DNA microarrays. Infect Genet Evol 2009, 9:987-995.
104. Nordstrom H., Falk K.I., Lindegren G., Mouzavi-Jazi M., Walden A., Elgh F., et al. DNA microarray technique for detection and identification of seven flaviviruses pathogenic for man. J Med Virol 2005, 77:528-540.
105. Berthet N., Paulous S., Coffey L.L., Frenkiel M.P., Moltini I., Tran C., et al. Resequencing microarray method for molecular diagnosis of human arboviral diseases. J Clin Virol 2013, 56:238-243.
106. Nascimento E.J., Braga-Neto U., Calzavara-Silva C.E., Gomes A.L., Abath F.G., Brito C.A., et al. Gene expression profiling during early acute febrile stage of dengue infection can predict the disease outcome. PLoS One 2009, 4:e7892.
107. Loke P., Hammond S.N., Leung J.M., Kim C.C., Batra S., Rocha C., et al. Gene expression patterns of dengue virus-infected children from Nicaragua reveal a distinct signature of increased metabolism. PLoS Negl Trop Dis 2010, 4:e710.
108. Simmons C.P., Popper S., Dolocek C., Chau T.N., Griffiths M., Dung N.T., et al. Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. J Infect Dis 2007, 195:1097-1107.
109. Arora A., Simone G., Salieb-Beugelaar G.B., Kim J.T., Manz A. Latest developments in micro total analysis systems. Anal Chem 2010, 82:4830-4847.
110. Salieb-Beugelaar G.B., Simone G., Arora A., Philippi A., Manz A. Latest developments in microfluidic cell biology and analysis systems. Anal Chem 2010, 82:4848-4864.
111. Salieb-Beugelaar G.B., Hunziker P.H. Towards nano-diagnostics for rapid diagnosis of infectious diseases-current technological state. Eur J Nanomed 2014, 6:11-28.
112. Wolf M., Juncker D., Michel B., Hunziker P., Delamarche E. Simultaneous detection of C-reactive protein and other cardiac markers in human plasma using micromosaic immunoassays and self-regulating microfluidic networks. Biosens Bioelectron 2004, 19:1193-1202.
113. Zimmermann M., Delamarche E., Wolf M., Hunziker P. Modeling and optimization of high-sensitivity, low-volume microfluidic-based surface immunoassays. Biomed Microdevices 2005, 7:99-110.
114. Zimmermann M., Hunziker P., Delamarche E. Autonomous capillary system for one-step immunoassays. Biomed Microdevices 2009, 11:1-8.
115. Lien K.Y., Lee W.C., Lei H.Y., Lee G.B. Integrated reverse transcription polymerase chain reaction systems for virus detection. Biosens Bioelectron 2007, 22:1739-1748.
116. Lee W.C., Lien K.Y., Lee G.B., Lei H.Y. An integrated microfluidic system using magnetic beads for virus detection. Diagn Microbiol Infect Dis 2008, 60:51-58.
117. Lee Y.F., Lien K.Y., Lei H.Y., Lee G.B. An integrated microfluidic system for rapid diagnosis of dengue virus infection. Biosens Bioelectron 2009, 25:745-752.
118. Li C., Dong X., Qin J., Lin B. Rapid nanoliter DNA hybridization based on reciprocating flow on a compact disk microfluidic device. Anal Chim Acta 2009, 640:93-99.
119. Mitsakakis K. Disc-shaped point-of-care platform for infectious disease diagnosis (EU FP7-ICT project "DiscoGnosis"). MicroTAS pre-conference workshop on Point-of-Care Platforms for Clinical Diagnostics 2013, HSG-IMIT & IMTEK, Freiburg, Germany.
120. Mitsakakis K. Multi-pathogen identification on a centrifugal microfluidic platform-EU FP7 DiscoGnosis. The 7th European Summit for Clinical Nanomedicine and Targeted Medicine 2014, CLINAM, Basel, Switzerland.
121. Kulinsky L., Noroozi Z., Madou M. Present technology and future trends in point-of-care microfluidic diagnostics. Methods Mol Biol 2013, 949:3-23.
122. Hattersley S.M., Greenman J., Haswell S.J. The application of microfluidic devices for viral diagnosis in developing countries. Methods Mol Biol 2013, 949:285-303.
123. Martinez A.W., Phillips S.T., Whitesides G.M., Carrilho E. Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal Chem 2010, 82:3-10.
124. Martinez A.W., Phillips S.T., Wiley B.J., Gupta M., Whitesides G.M. FLASH: a rapid method for prototyping paper-based microfluidic devices. Lab Chip 2008, 8:2146-2150.
125. Lo S.J., Yang S.C., Yao D.J., Chen J.H., Tu W.C., Cheng C.M. Molecular-level dengue fever diagnostic devices made out of paper. Lab Chip 2013, 13:2686-2692.
126. Zhao W., van der Berg A. Lab on paper. Lab Chip 2008, 8:1988-1991.
127. Lee W.G., Kim Y.G., Chung B.G., Demirci U., Khademhosseini A. Nano/microfluidics for diagnosis of infectious diseases in developing countries. Adv Drug Deliv Rev 2010, 62:449-457.
128. Mishra B., Gupta P.K., Dhiman V., Pujhari S.K., Sharma M., Ratho R.K. Clinical applicability of various dengue diagnostic tests in resource-limited endemic settings. J Global Infect Dis 2014, 6:109-113.
129. Duyen H.T., Ngoc T.V., Ha do T., Hang V.T., Kieu N.T., Young P.R., et al. Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status. J Infect Dis 2011, 203:1292-1300.
130. Chaterji S., Allen J.C., Chow A., Leo Y.S., Ooi E.E. Evaluation of the NS1 rapid test and the WHO dengue classification schemes for use as bedside diagnosis of acute dengue fever in adults. Am J Trop Med Hyg 2011, 84:224-228.
131. Tricou V., Vu H.T., Quynh N.V., Nguyen C.V., Tran H.T., Farrar J., et al. Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses. BMC Infect Dis 2010, 10:1-8. [142].
132. Hang V.T., Nguyet N.M., Trung D.T., Tricou V., Yoksan S., Dung N.M., et al. Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses. PLoS Negl Trop Dis 2009, 3:e360.
133. Wilder-Smith A. Dengue infections in travellers. Paediatr Int Child Health 2012, 32(Suppl. 1):28-32.
134. Ratnam I., Leder K., Black J., Torresi J. Dengue fever and international travel. J Travel Med 2013, 20:384-393.
135. Moi M.L., Omatsu T., Tajima S., Lim C.K., Kotaki A., Ikeda M., et al. Detection of dengue virus nonstructural protein 1 (NS1) by using ELISA as a useful laboratory diagnostic method for dengue virus infection of international travelers. J Travel Med 2013, 20:185-193.
136. Shu P.Y., Yang C.F., Kao J.F., Su C.L., Chang S.F., Lin C.C., et al. Application of the dengue virus NS1 antigen rapid test for on-site detection of imported dengue cases at airports. Clin Vaccine Immunol 2009, 16:589-591.
137. Hunsperger E.A., Yoksan S., Buchy P., Nguyen V.C., Sekaran S.D., Enria D.A., et al. Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody. PLoS Negl Trop Dis 2014, 8:e3171.
138. CDC/USA Dengue Homepage: Clinical Guidance [online]. http://www.cdc.gov/dengue/clinicalLab/clinical.html.
139. Suaya J.A., Shepard D.S., Beatty M.E., Farrar J. Disease burden of dengue fever and dengue hemorrhagic fever. Handbook of Disease Burdens and Quality of Life Measures 2010, 1263-1279. Springer, New York. V.R. Preedy, R.R. Watson (Eds.).
140. Levett P.N., Branch S.L., Edwards C.N. Detection of dengue infection in patients investigated for leptospirosis in Barbados. Am J Trop Med Hyg 2000, 62:112-114.
141. Brown M.G., Vickers I.E., Salas R.A., Smikle M.F. Leptospirosis in suspected cases of dengue in Jamaica, 2002-2007. Trop Doct 2010, 40:92-94.
142. LaRocque R.C., Breiman R.F., Ari M.D., Morey R.E., Janan F.A., Hayes J.M., et al. Leptospirosis during dengue outbreak, Bangladesh. Emerg Infect Dis 2005, 11:766-769.
143. Perez Rodriguez N.M., Galloway R., Blau D.M., Traxler R., Bhatnagar J., Zaki S.R., et al. Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012. Am J Trop Med Hyg 2014, 91:760-765.
144. Epelboin L., Hanf M., Dussart P., Ouar-Epelboin S., Djossou F., Nacher M., et al. Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana. Malar J 2012, 11:1-8. [142].
145. Assir M.Z., Masood M.A., Ahmad H.I. Concurrent dengue and malaria infection in Lahore, Pakistan during the 2012 dengue outbreak. Int J Infect Dis 2014, 18:41-46.
146. Bansal R., Bansal P., Tomar L.R. Typhoid and dengue coinfection: case reports. Trop Doct 2015, 45(1):52-53. [http://www.ncbi.nlm.nih.gov/pubmed/25315238 (accessed Oct 14)]. 10.1177/0049475514552835.
147. Parreira R., Centeno-Lima S., Lopes A., Portugal-Calisto D., Constantino A., Nina J. Dengue virus serotype 4 and chikungunya virus coinfection in a traveller returning from Luanda, Angola, January 2014. Euro Surveill 2014, 19(10):1-4. [http://www.ncbi.nlm.nih.gov/pubmed/24650864 (accessed Mar 13), pii=20730].
148. Capeding M.R., Chua M.N., Hadinegoro S.R., Hussain I.I., Nallusamy R., Pitisuttithum P., et al. Dengue and other common causes of acute febrile illness in Asia: an active surveillance study in children. PLoS Negl Trop Dis 2013, 7:e2331.
149. Srikiatkhachorn A., Green S. Markers of dengue disease severity. Curr Top Microbiol Immunol 2010, 338:67-82.
150. Reid A. Bringing the lab to the patient: developing point-of-care diagnostics for resource limited settings 2012, [online]http://academy.asm.org/index.php/clinical-medical-public-health-microbiology/526-bringing-the-lab-to-the-patient-developing-point-of-care-diagnostics-for-resource-limited-settings-2012, American Academy of Microbiology, Washington, DC.
151. Reddington K., Tuite N., Barry T., O'Grady J., Zumla A. Advances in multiparametric molecular diagnostics technologies for respiratory tract infections. Curr Opin Pulm Med 2013, 19:298-304.
152. Ellington A.A., Kullo I.J., Bailey K.R., Klee G.G. Antibody-based protein multiplex platforms: technical and operational challenges. Clin Chem 2010, 56:186-193.
153. Maitland K. New diagnostics for common childhood infections. N Engl J Med 2014, 370:875-877.
154. D'Acremont V., Kilowoko M., Kyungu E., Philipina S., Sangu W., Kahama-Maro J., et al. Beyond malaria-causes of fever in outpatient Tanzanian children. N Engl J Med 2014, 370:809-817.
155. Yager P., Domingo G.J., Gerdes J. Point-of-care diagnostics for global health. Annu Rev Biomed Eng 2008, 10:107-144.
156. Project-DiscoGnosis Disc-shaped Point-of-Care platform for infectious disease diagnosis [online], [funded by EC FP7 ICT-2011.3.2]. http://www.discognosis.eu/index.php.
157. Chappuis F., Alirol E., d'Acremont V., Bottieau E., Yansouni C.P. Rapid diagnostic tests for non-malarial febrile illness in the tropics. Clin Microbiol Infect 2013, 19:422-431.
158. Yansouni C.P., Bottieau E., Chappuis F., Phoba M.F., Lunguya O., Ifeka B.B., et al. Rapid diagnostic tests for a coordinated approach to fever syndromes in low-resource settings. Clin Infect Dis 2012, 55:610-611. [author reply 1-2].