Markers of dengue disease severity

Current Topics in Microbiology and Immunology

Volumn 338, Issue 1, 2009, Pages 67-82

  Srikiatkhachorn, Anon ^a   Green, Sharone ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CYTOKINE; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LIVER ENZYME; NONSTRUCTURAL PROTEIN 1; RANTES; SOLUBLE INTERLEUKIN 2 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; CYTOKINE RECEPTOR;

ADAPTIVE IMMUNITY; CELL ACTIVATION; CLINICAL FEATURE; CYTOKINE PRODUCTION; DENGUE; DENGUE VIRUS; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; ENDOTHELIUM CELL; FEVER; HUMAN; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; THROMBOCYTE COUNT; THROMBOCYTOPENIA; VIRUS LOAD; BLOOD; CAPILLARY PERMEABILITY; EARLY DIAGNOSIS; HOSPITALIZATION; IMMUNOLOGY; ISOLATION AND PURIFICATION;

ANIMALIA; DENGUE VIRUS;

BIOLOGICAL MARKERS; CAPILLARY PERMEABILITY; CYTOKINES; DENGUE; DENGUE VIRUS; DISEASE PROGRESSION; EARLY DIAGNOSIS; HUMANS; PLATELET COUNT; RECEPTORS, CYTOKINE; SEVERITY OF ILLNESS INDEX; VIRAL LOAD;

EID: 74049103755     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-02215-9-6     Document Type: Review

References (61)

1. Ajariyakhajorn C, Mammen MP Jr, Endy TP, Gettayacamin M, Nisalak A, Nimmannitya S, Libraty DH (2005) Randomized, placebo-controlled trial of nonpegylated and pegylated forms of recombinant human alpha interferon 2a for suppression of dengue virus viremia in rhesus monkeys. Antimicrob Agents Chemother 49:4508-4514 (Pubitemid 41552579)
2. Anderson R, Wang S, Osiowy C, Issekutz AC (1997) Activation of endothelial cells via antibodyenhanced dengue virus infection of peripheral blood monocytes. J Virol 71:4226-4232 (Pubitemid 27204108)
3. Avila-Aguero ML, Avila-Aguero CR, Um SL, Soriano-Fallas A, Canas-Coto A, Yan SB (2004) Systemic host inflammatory and coagulation response in the Dengue virus primo-infection. Cytokine 27:173-179 (Pubitemid 39078524)
4. Avirutnan P, Malasit P, Seliger B, Bhakdi S, Husmann M (1998) Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis. J Immunol 161:6338-6346 (Pubitemid 28536010)
5. Avirutnan P, Punyadee N, Noisakran S, Komoltri C, Thiemmeca S, Auethavornanan K, Jairungsri A, Kanlaya R, Tangthawornchaikul N, Puttikhunt C, et al. (2006) Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement. J Infect Dis 193:1078-1088
6. Azeredo EL, Zagne SM, Santiago MA, Gouvea AS, Santana AA, Neves-Souza PC, Nogueira RM, Miagostovich MP, Kubelka CF (2001) Characterisation of lymphocyte response and cytokine patterns in patients with dengue fever. Immunobiology 204:494-507
7. Azeredo EL, De Oliveira-Pinto LM, Zagne SM, Cerqueira DI, Nogueira RM, Kubelka CF (2006) NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. Clin Exp Immunol 143:345-356
8. Becerra A, Warke RV, de Bosch N, Rothman AL, Bosch I (2008) Elevated levels of soluble ST2 protein in dengue virus infected patients. Cytokine 41:114-120
9. Bethell DB, Flobbe K, Cao XT, Day NP, Pham TP, Buurman WA, Cardosa MJ, White NJ, Kwiatkowski D (1998) Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever. J Infect Dis 177:778-782 (Pubitemid 28099898)
10. Bhamarapravati N, Tuchinda P, Boonyapaknavik V (1967) Pathology of Thailand haemorrhagic fever: a study of 100 autopsy cases. Ann Trop Med Parasitol 61:500-510
11. Bosch I, Xhaja K, Estevez L, Raines G, Melichar H, Warke RV, Fournier MV, Ennis FA, Rothman AL (2002) Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge. J Virol 76:5588-5597 (Pubitemid 34517909)
12. Bozza FA, Cruz OG, Zagne SM, Azeredo EL, Nogueira RM, Assis EF, Bozza PT, Kubelka CF (2008) Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infect Dis 8:86
13. Braga EL, Moura P, Pinto LM, Ignacio SR, Oliveira MJ, Cordeiro MT, Kubelka CF (2001) Detection of circulant tumor necrosis factor-alpha, soluble tumor necrosis factor p75 and interferon-gamma in Brazilian patients with dengue fever and dengue hemorrhagic fever. Mem Inst Oswaldo Cruz 96:229-232 (Pubitemid 33640932)
14. Butthep P, Chunhakan S, Tangnararatchakit K, Yoksan S, Pattanapanyasat K, Chuansumrit A (2006) Elevated soluble thrombomodulin in the febrile stage related to patients at risk for dengue shock syndrome. Pediatr Infect Dis J 25:894-897 (Pubitemid 44510582)
15. Cam BV, Fonsmark L, Hue NB, Phuong NT, Poulsen A, Heegaard ED (2001) Prospective casecontrol study of encephalopathy in children with dengue hemorrhagic fever. Am J Trop Med Hyg 65:848-851 (Pubitemid 34049483)
16. Cardier JE, Rivas B, Romano E, Rothman AL, Perez-Perez C, Ochoa M, Caceres AM, Cardier M, Guevara N, Giovannetti R (2006) Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells. Endothelium 13:335-340 (Pubitemid 44712323)
17. Chen HC, Lai SY, Sung JM, Lee SH, Lin YC, Wang WK, Chen YC, Kao CL, King CC, Wu-Hsieh BA (2004) Lymphocyte activation and hepatic cellular infiltration in immunocompetent mice infected by dengue virus. J Med Virol 73:419-431
18. Chen LC, Lei HY, Liu CC, Shiesh SC, Chen SH, Liu HS, Lin YS, Wang ST, Shyu HW, Yeh TM (2006) Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am J Trop Med Hyg 74:142-147
19. Dejnirattisai W, Duangchinda T, Lin CL, Vasanawathana S, Jones M, Jacobs M, Malasit P, Xu XN, Screaton G, Mongkolsapaya J (2008) A complex interplay among virus, dendritic cells, T cells, and cytokines in dengue virus infections. J Immunol 181:5865-5874
20. Gagnon SJ, Ennis FA, Rothman AL (1999) Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones. J Virol 73:3623-3629
21. Green S, Pichyangkul S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Nisalak A, Kurane I, Rothman AL, Ennis FA (1999a) Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis 180:1429-1435 (Pubitemid 29506442)
22. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Rothman AL, Ennis FA (1999b) Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity. J Med Virol 59:329-334 (Pubitemid 29468075)
23. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Lew R, Innis BL, Kurane I, Rothman AL, et al. (1999c) Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J Infect Dis 179:755-762 (Pubitemid 29159319)
24. Ho LJ, Wang JJ, Shaio MF, Kao CL, Chang DM, Han SW, Lai JH (2001) Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production. J Immunol 166:1499-1506
25. Hober D, Poli L, Roblin B, Gestas P, Chungue E, Granic G, Imbert P, Pecarere JL, Vergez-Pascal R, Wattre P, et al. (1993) Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients. Am J Trop Med Hyg 48:324-331 (Pubitemid 23115317)
26. Homchampa P, Sarasombath S, Suvatte V, Vongskul M (1988) Natural killer cells in dengue hemorrhagic fever/dengue shock syndrome. Asian Pac J Allergy Immunol 6:95-102 (Pubitemid 19018846)
27. Huang YH, Lei HY, Liu HS, Lin YS, Liu CC, Yeh TM (2000) Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production. Am J Trop Med Hyg 63:71-75
28. Huerre MR, Lan NT, Marianneau P, Hue NB, Khun H, Hung NT, Khen NT, Drouet MT, Huong VT, Ha DQ, et al. (2001) Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch 438:107-115 (Pubitemid 32186577)
29. Jessie K, Fong MY, Devi S, Lam SK, Wong KT (2004) Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. J Infect Dis 189:1411-1418 (Pubitemid 38543590)
30. Kalayanarooj S, Nimmannitya S (2003) Clinical presentations of dengue hemorrhagic fever in infants compared to children. J Med Assoc Thai 86(Suppl 3):S673-680 (Pubitemid 38009759)
31. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis BL, et al. (1997) Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176:313-321 (Pubitemid 27328752)
32. Koraka P, Murgue B, Deparis X, Van Gorp EC, Setiati TE, Osterhaus AD, Groen J (2004) Elevation of soluble VCAM-1 plasma levels in children with acute dengue virus infection of varying severity. J Med Virol 72:445-450 (Pubitemid 38133985)
33. Kurane I, Ennis FA (1988) Production of interferon alpha by dengue virus-infected human monocytes. J Gen Virol 69(Pt 2):445-449 (Pubitemid 18064171)
34. Kurane I, Innis BL, Nimmannitya S, Nisalak A, Meager A, Janus J, Ennis FA (1991) Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue. J Clin Invest 88:1473-1480
35. Kurane I, Janus J, Ennis FA (1992) Dengue virus infection of human skin fibroblasts in vitro production of IFN-beta, IL-6 and GM-CSF. Arch Virol 124:21-30
36. Kurane I, Innis BL, Nimmannitya S, Nisalak A, Meager A, Ennis FA (1993) High levels of interferon alpha in the sera of children with dengue virus infection. Am J Trop Med Hyg 48:222-229 (Pubitemid 23083739)
37. Laur F, Murgue B, Deparis X, Roche C, Cassar O, Chungue E (1998) Plasma levels of tumour necrosis factor alpha and transforming growth factor beta-1 in children with dengue 2 virus infection in French Polynesia. Trans R Soc Trop Med Hyg 92:654-656 (Pubitemid 29015221)
38. Libraty DH, Pichyangkul S, Ajariyakhajorn C, Endy TP, Ennis FA (2001) Human dendritic cells are activated by dengue virus infection: enhancement by gamma interferon and implications for disease pathogenesis. J Virol 75:3501-3508 (Pubitemid 32246359)
39. Libraty DH, Endy TP, Houng HS, Green S, Kalayanarooj S, Suntayakorn S, Chansiriwongs W, Vaughn DW, Nisalak A, Ennis FA, et al. (2002a) Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections. J Infect Dis 185:1213-1221 (Pubitemid 34439127)
40. Libraty DH, Young PR, Pickering D, Endy TP, Kalayanarooj S, Green S, Vaughn DW, Nisalak A, Ennis FA, Rothman AL (2002b) High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J Infect Dis 186:1165-1168 (Pubitemid 35177121)
41. Limonta D, Capo V, Torres G, Perez AB, Guzman MG (2007) Apoptosis in tissues from fatal dengue shock syndrome. J Clin Virol 40:50-54 (Pubitemid 47302858)
42. Mitrakul C, Poshyachinda M, Futrakul P, Sangkawibha N, Ahandrik S (1977) Hemostatic and platelet kinetic studies in dengue hemorrhagic fever. Am J Trop Med Hyg 26:975-984 (Pubitemid 8191538)
43. Mustafa AS, Elbishbishi EA, Agarwal R, Chaturvedi UC (2001) Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever. FEMS Immunol Med Microbiol 30:229-233 (Pubitemid 32373298)
44. Navarro-Sanchez E, Despres P, Cedillo-Barron L (2005) Innate immune responses to dengue virus. Arch Med Res 36:425-435 (Pubitemid 41140044)
45. Nimmannitya S (1993) Clinical manifestations of Dengue/Dengue haemorrhagic fever. In: Thongcharoen P (ed) Monograph on Dengue/Dengue haemorrhagic fever. World Health Organization, India, pp 48-57
46. Pancharoen C, Rungsarannont A, Thisyakorn U (2002) Hepatic dysfunction in dengue patients with various severity. J Med Assoc Thai 85(Suppl 1):S298-301
47. Phanichyakarn P, Israngkura PB, Krisarin C, Pongpanich B, Dhanamitta S, Valyasevi A (1977) Studies on dengue hemorrhagic feverIV. Fluorescence staining of the immune complexes on platelets. J Med Assoc Thai 60:307-311
48. Pichyangkul S, Endy TP, Kalayanarooj S, Nisalak A, Yongvanitchit K, Green S, Rothman AL, Ennis FA, Libraty DH (2003) A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity. J Immunol 171:5571-5578 (Pubitemid 37432848)
49. Raghupathy R, Chaturvedi UC, Al-Sayer H, Elbishbishi EA, Agarwal R, Nagar R, Kapoor S, Misra A, Mathur A, Nusrat H, et al. (1998) Elevated levels of IL-8 in dengue hemorrhagic fever. J Med Virol 56:280-285 (Pubitemid 28458099)
50. Saito M, Oishi K, Inoue S, Dimaano EM, Alera MT, Robles AM, Estrella BD Jr, Kumatori A, Moji K, Alonzo MT, et al. (2004) Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections. Clin Exp Immunol 138:299-303 (Pubitemid 39472447)
51. Shen BQ, Lee DY, Cortopassi KM, Damico LA, Zioncheck TF (2001) Vascular endothelial growth factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells. J Biol Chem 276:5281-5286 (Pubitemid 37371427)
52. Sosothikul D, Seksarn P, Pongsewalak S, Thisyakorn U, Lusher J (2007) Activation of endothelial cells, coagulation and fibrinolysis in children with Dengue virus infection. Thromb Haemost 97:627-634 (Pubitemid 46592941)
53. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, Ennis FA, Rothman AL (2007) Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic fever. J Virol 81:1592-1600 (Pubitemid 46214434)
54. Suharti C, van Gorp EC, Dolmans WM, Setiati TE, Hack CE, Djokomoeljanto R, van der Meer JW (2003) Cytokine patterns during dengue shock syndrome. Eur Cytokine Netw 14:172-177 (Pubitemid 37249238)
55. Sun DS, King CC, Huang HS, Shih YL, Lee CC, Tsai WJ, Yu CC, Chang HH (2007) Antiplatelet autoantibodies elicited by dengue virus non-structural protein 1 cause thrombocytopenia and mortality in mice. J Thromb Haemost 5:2291-2299
56. Tseng CS, Lo HW, Teng HC, Lo WC, Ker CG (2005) Elevated levels of plasma VEGF in patients with dengue hemorrhagic fever. FEMS Immunol Med Microbiol 43:99-102 (Pubitemid 40029433)
57. Valero N, Larreal Y, Espina LM, Reyes I, Maldonado M, Mosquera J (2008) Elevated levels of interleukin-2 receptor and intercellular adhesion molecule 1 in sera from a venezuelan cohort of patients with dengue. Arch Virol 153:199-203
58. Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, Endy TP, Raengsakulrach B, Rothman AL, Ennis FA, et al. (2000) Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis 181:2-9 (Pubitemid 30049026)
59. Wang S, He R, Patarapotikul J, Innis BL, Anderson R (1995) Antibody-enhanced binding of dengue-2 virus to human platelets. Virology 213:254-257
60. Wang L, Chen RF, Liu JW, Yu HR, Kuo HC, Yang KD (2007) Implications of dynamic changes among tumor necrosis factor-alpha (TNF-alpha), membrane TNF receptor, and soluble TNF receptor levels in regard to the severity of dengue infection. Am J Trop Med Hyg 77:297-302 (Pubitemid 351859279)
61. Zarco RM, Espiritu-Campos L, Chan V (1957) Preliminary report on laboratory studies on Philippine hemorrhagic fever. J Philipp Med Assoc 33:676-683