Nano/Microfluidics for diagnosis of infectious diseases in developing countries

Advanced Drug Delivery Reviews

Volumn 62, Issue 4-5, 2010, Pages 449-457

  Lee, Won Gu ^a,b   Kim, Yun Gon ^a,b   Chung, Bong Geun ^a,b   Demirci, Utkan ^a,b   Khademhosseini, Ali ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Diagnostics; Global health; HIV AIDS; Infectious diseases; Nano Microfluidics; Point of care

Indexed keywords

DIAGNOSTIC TECHNOLOGIES; ENABLING TOOLS; FLUID VOLUMES; GLOBAL HEALTH; HIV/AIDS; INFECTIOUS DISEASE; MEDICAL DIAGNOSIS; POINT OF CARE;

DEVELOPING COUNTRIES; HEALTH;

DIAGNOSIS;

PHENYTOIN; POLYMETHACRYLIC ACID; QUANTUM DOT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ATOMIC FORCE MICROSCOPY; CAUSE OF DEATH; CD4+ T LYMPHOCYTE; DEVELOPING COUNTRY; ELECTRONICS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE IMAGING; GENE AMPLIFICATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMAGE ANALYSIS; IMMUNOASSAY; INFECTION; LIGHT EMITTING DIODE; MALARIA; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; NANOSENSOR; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POINT OF CARE TESTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; TUBERCULOSIS; VIRUS LOAD;

DEVELOPING COUNTRIES; FLOW CYTOMETRY; HIV INFECTIONS; HUMANS; IMMUNOASSAY; INFECTION; MALARIA; MICROCOMPUTERS; MICROFLUIDICS; NANOTECHNOLOGY; TUBERCULOSIS;

EID: 76849096270     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2009.11.016     Document Type: Review

References (97)

1. Yager P., Edwards T., Fu E., Helton K., Nelson K., Tam M.R., and Weigl B.H. Microfluidic diagnostic technologies for global public health. Nature 442 (2006) 412-418
2. Urdea M., Penny L.A., Olmsted S.S., Giovanni M.Y., Kaspar P., Shepherd A., Wilson P., Dahl C.A., Buchsbaum S., Moeller G., and Hay Burgess D.C. Requirements for high impact diagnostics in the developing world. Nature 444 Suppl 1 (2006) 73-79
3. Yager P., Domingo G.J., and Gerdes J. Point-of-care diagnostics for global health. Annu. Rev. Biomed. Eng. 10 (2008) 107-144
4. Mabey D., Peeling R.W., Ustianowski A., and Perkins M.D. Diagnostics for the developing world. Nat. Rev. Microbiol. 2 (2004) 231-240
5. Hay Burgess D.C., Wasserman J., and Dahl C.A. Global health diagnostics. Nature 444 Suppl 1 (2006) 1-2
6. Houpt E.R., and Guerrant R.L. Technology in global health: the need for essential diagnostics. Lancet 372 (2008) 873-874
7. Girosi F., Olmsted S.S., Keeler E., Hay Burgess D.C., Lim Y.W., Aledort J.E., Rafael M.E., Ricci K.A., Boer R., Hilborne L., Derose K.P., Shea M.V., Beighley C.M., Dahl C.A., and Wasserman J. Developing and interpreting models to improve diagnostics in developing countries. Nature 444 Suppl 1 (2006) 3-8
8. Huckle D. Point-of-care diagnostics: an advancing sector with nontechnical issues. Expert Rev. Mol. Diagn. 8 (2008) 679-688
9. Huckle D. Point-of-care diagnostics: will the hurdles be overcome this time?. Expert Rev. Med. Devic. 3 (2006) 421-426
10. Petti C.A., Polage C.R., Quinn T.C., Ronald A.R., and Sande M.A. Laboratory medicine in Africa: a barrier to effective health care. Clin. Infect. Dis. 42 (2006) 377-382
11. Chin C.D., Linder V., and Sia S.K. Lab-on-a-chip devices for global health: past studies and future opportunities. Lab Chip 7 (2007) 41-57
12. Myers F.B., and Lee L.P. Innovations in optical microfluidic technologies for point-of-care diagnostics. Lab Chip 8 (2008) 2015-2031
13. El-Ali J., Sorger P.K., and Jensen K.F. Cells on chips. Nature 442 (2006) 403-411
14. Dittrich P.S., and Manz A. Lab-on-a-chip: microfluidics in drug discovery. Nat. Rev. Drug. Discov. 5 (2006) 210-218
15. West J., Becker M., Tombrink S., and Manz A. Micro total analysis systems: latest achievements. Anal. Chem. 80 (2008) 4403-4419
16. Song Y.S., Moon S., Hulli L., Hasan S.K., Kayaalp E., and Demirci U. Microfluidics for cryopreservation. Lab Chip 9 (2009) 1874-1881
17. Lagally E.T., Scherer J.R., Blazej R.G., Toriello N.M., Diep B.A., Ramchandani M., Sensabaugh G.F., Riley L.W., and Mathies R.A. Integrated portable genetic analysis microsystem for pathogen/infectious disease detection. Anal. Chem. 76 (2004) 3162-3170
18. Whitesides G.M. The origins and the future of microfluidics. Nature 442 (2006) 368-373
19. Dittrich P.S., Tachikawa K., and Manz A. Micro total analysis systems. Latest advancements and trends. Anal. Chem. 78 (2006) 3887-3908
20. Schulte T.H., Bardell R.L., and Weigl B.H. Microfluidic technologies in clinical diagnostics. Clin. Chim. Acta 321 (2002) 1-10
21. Kang L., Chung B.G., Langer R., and Khademhosseini A. Microfluidics for drug discovery and development: from target selection to product lifecycle management. Drug Discov. Today 13 (2008) 1-13
22. Moon S.J., Keles H.O., Ozcan A., Khademhosseini A., Hæggstrom E., Kuritzkes D., and Demirci U. Integrating microfluidics and lensless imaging for point-of-care testing. Biosens. Bioelectron. 24 (2009) 3208-3214
23. Alyassin M.A., Moon S.J., Keles H.O., Manzur F., Lin R.L., Hæggstrom E., Kuritzkes D.R., and Demirci U. Rapid automated cell quantification on HIV microfluidic devices. Lab. Chip 9 (2009) 3364-3369
24. Bhattacharyya A., and Klapperich C.M. Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples. Biomed. Microdevices 9 (2007) 245-251
25. Eijkel J.C.T., and van den Berg A. Nanofluidics: what is it and what can we expect from it?. Microfluid. Nanofluid. 1 (2005) 249-267
26. van den Berg A., and Wessling M. Nanofluidics: silicon for the perfect membrane. Nature 445 (2007) 726
27. Holtzel A., and Tallarek U. Ionic conductance of nanopores in microscale analysis systems: where microfluidics meets nanofluidics. J. Sep. Sci. 30 (2007) 1398-1419
28. Jain K.K. Applications of nanobiotechnology in clinical diagnostics. Clin. Chem. 53 (2007) 2002-2009
29. Toner M., and Irimia D. Blood-on-a-chip. Annu. Rev. Biomed. Eng. 7 (2005) 77-103
30. Cheng X., Irimia D., Dixon M., Sekine K., Demirci U., Zamir L., Tompkins R.G., Rodriguez W., and Toner M. A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects. Lab Chip 7 (2007) 170-178
31. Cheng X., Irimia D., Dixon M., Ziperstein J.C., Demirci U., Zamir L., Tompkins R.G., Toner M., and Rodriguez W.R. A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. J. Acquir. Immune Defic. Syndr. 45 (2007) 257-261
32. VanDelinder V., and Groisman A. Perfusion in microfluidic cross-flow: separation of white blood cells from whole blood and exchange of medium in a continuous flow. Anal. Chem. 79 (2007) 2023-2030
33. Kokoris M., Nabavi M., Lancaster C., Clemmens J., Maloney P., Capadanno J., Gerdes J., and Battrell C.F. Rare cancer cell analyzer for whole blood applications: automated nucleic acid purification in a microfluidic disposable card. Methods 37 (2005) 114-119
34. Helton K.L., and Yager P. Interfacial instabilities affect microfluidic extraction of small molecules from non-Newtonian fluids. Lab Chip 7 (2007) 1581-1588
35. Chung S., Yun H., and Kamm R.D. Nanointerstice-driven microflow. Small 5 (2009) 609-613
36. Martinez A.W., Phillips S.T., Wiley B.J., Gupta M., and Whitesides G.M. FLASH: a rapid method for prototyping paper-based microfluidic devices. Lab Chip 8 (2008) 2146-2150
37. Shelby J.P., White J., Ganesan K., Rathod P.K., and Chiu D.T. A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 14618-14622
38. Lee W.G., Bang H., Yun H., Lee J., Park J., Kim J.K., Chung S., Cho K., Chung C., Han D.C., and Chang J.K. On-chip erythrocyte deformability test under optical pressure. Lab Chip 7 (2007) 516-519
39. Psaltis D., Quake S.R., and Yang C. Developing optofluidic technology through the fusion of microfluidics and optics. Nature 442 (2006) 381-386
40. Ozcan A, Demirci U. Ultra wide-field lens-free monitoring of cells on-chip. Lab Chip- Miniaturisation for Chemistry and Biology (2007), 8(1), 98-106, DOI: 10.1039/b713695a
41. Granot Y., Ivorra A., and Rubinsky B. A new concept for medical imaging centered on cellular phone technology. PLoS ONE 3 (2008) e2075
42. Breslauer D.N., Maamari R.N., Switz N.A., Lam W.A., and Fletcher D.A. Mobile phone based clinical microscopy for global health applications. PLoS ONE 4 (2009) e6320
43. Mandy F.F. Twenty-five years of clinical flow cytometry: AIDS accelerated global instrument distribution. Cytom. A 58 (2004) 55-56
44. Fu A.Y., Spence C., Scherer A., Arnold F.H., and Quake S.R. A microfabricated fluorescence-activated cell sorter. Nat. Biotechnol. 17 (1999) 1109-1111
45. Goddard G.R., Sanders C.K., Martin J.C., Kaduchak G., and Graves S.W. Analytical performance of an ultrasonic particle focusing flow cytometer. Anal. Chem. 79 (2007) 8740-8746
46. Rodriguez W.R., Christodoulides N., Floriano P.N., Graham S., Mohanty S., Dixon M., Hsiang M., Peter T., Zavahir S., Thior I., Romanovicz D., Bernard B., Goodey A.P., Walker B.D., and McDevitt J.T. A microchip CD4 counting method for HIV monitoring in resource-poor settings. PLoS Med 2 (2005) e182
47. Bang H., Yun H., Lee W.G., Park J., Lee J., Chung S., Cho K., Chung C., Han D.C., and Chang J.K. Expansion channel for microchip flow cytometers. Lab Chip 6 (2006) 1381-1383
48. Yun H., Min J., Lee W.G., Bang H., Park J., Chung C., Chang J.K., and Han D.-C. Microchip flowcytometer using fluorescent silica nanoparticles for HIV screening. 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2007) (2007) 1258-1260
49. Ohashi T., Mawatari K., Sato K., Tokeshi M., and Kitamori T. A micro-ELISA system for the rapid and sensitive measurement of total and specific immunoglobulin E and clinical application to allergy diagnosis. Lab Chip 9 (2009) 991-995
50. Herr A.E., Hatch A.V., Throckmorton D.J., Tran H.M., Brennan J.S., Giannobile W.V., and Singh A.K. Microfluidic immunoassays as rapid saliva-based clinical diagnostics. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 5268-5273
51. Sia S.K., Linder V., Parviz B.A., Siegel A., and Whitesides G.M. An integrated approach to a portable and low-cost immunoassay for resource-poor settings. Angew. Chem. Int. Ed. Engl. 43 (2004) 498-502
52. Morozov V.N., Groves S., Turell M.J., and Bailey C. Three minutes-long electrophoretically assisted zeptomolar microfluidic immunoassay with magnetic-beads detection. J. Am. Chem. Soc. 129 (2007) 12628-12629
53. Yacoub-George E., Hell W., Meixner L., Wenninger F., Bock K., Lindner P., Wolf H., Kloth T., and Feller K.A. Automated 10-channel capillary chip immunodetector for biological agents detection. Biosens. Bioelectron. 22 (2007) 1368-1375
54. Stevens D.Y., Petri C.R., Osborn J.L., Spicar-Mihalic P., McKenzie K.G., and Yager P. Enabling a microfluidic immunoassay for the developing world by integration of on-card dry reagent storage. Lab Chip 8 (2008) 2038-2045
55. Zimmermann M., Delamarche E., Wolf M., and Hunziker P. Modeling and optimization of high-sensitivity, low-volume microfluidic-based surface immunoassays. Biomed. Microdevices 7 (2005) 99-110
56. Cho J.H., Han S.M., Paek E.H., Cho I.H., and Paek S.H. Plastic ELISA-on-a-chip based on sequential cross-flow chromatography. Anal. Chem. 78 (2006) 793-800
57. Parsa H., Chin C.D., Mongkolwisetwara P., Lee B.W., Wang J.J., and Sia S.K. Effect of volume- and time-based constraints on capture of analytes in microfluidic heterogeneous immunoassays. Lab Chip 8 (2008) 2062-2070
58. Hatch A., Kamholz A.E., Hawkins K.R., Munson M.S., Schilling E.A., Weigl B.H., and Yager P. A rapid diffusion immunoassay in a T-sensor. Nat. Biotechnol. 19 (2001) 461-465
59. Burg T.P., Godin M., Knudsen S.M., Shen W., Carlson G., Foster J.S., Babcock K., and Manalis S.R. Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 446 (2007) 1066-1069
60. Carter D.J., and Cary R.B. Lateral flow microarrays: a novel platform for rapid nucleic acid detection based on miniaturized lateral flow chromatography. Nucleic Acids Res. 35 (2007) e74
61. Nelson K.E., Foley J.O., and Yager P. Concentration gradient immunoassay. 1. An immunoassay based on interdiffusion and surface binding in a microchannel. Anal. Chem. 79 (2007) 3542-3548
62. Fu E., Chinowsky T., Nelson K., Johnston K., Edwards T., Helton K., Grow M., Miller J.W., and Yager P. SPR imaging-based salivary diagnostics system for the detection of small molecule analytes. Ann. N. Y. Acad. Sci. 1098 (2007) 335-344
63. Tabak L.A. Point-of-care diagnostics enter the mouth. Ann. N. Y. Acad. Sci. 1098 (2007) 7-14
64. Ly N., Foley K., and Tao N. Integrated label-free protein detection and separation in real time using confined surface plasmon resonance imaging. Anal. Chem. 79 (2007) 2546-2551
65. Star A., Han T.-R., Joshi V., GabrieL J.-C.P., and Grüner G. Nanoelectronic carbon dioxide sensors. Adv. Mater. 16 (2004) 2049-2052
66. Star A., Tu E., Niemann J., Gabriel J.C., Joiner C.S., and Valcke C. Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 921-926
67. Nettikadan S.R., Johnson J.C., Vengasandra S.G., Muys J., and Henderson E. ViriChip: a solid phase assay for detection and identification of viruses by atomic force microscopy. Nanotechnology 15 (2004) 383-389
68. Nettikadan S.R., Johnson J.C., Mosher C., and Henderson E. Virus particle detection by solid phase immunocapture and atomic force microscopy. Biochem. Biophys. Res. Commun. 311 (2003) 540-545
69. Kim Y.G., Moon S., Kuritzkes D.R., and Demirci U. Quantum dot-based HIV capture and imaging in a microfluidic channel. Biosens. Bioelectron. 25 (2009) 253-258
70. Willyard C. Simpler tests for immune cells could transform AIDS care in Africa. Nat. Med. 13 (2007) 1131
71. Cohen J. Monitoring treatment: at what cost?. Science 304 (2004) 1936
72. Linder V., Sia S.K., and Whitesides G.M. Reagent-loaded cartridges for valveless and automated fluid delivery in microfluidic devices. Anal. Chem. 77 (2005) 64-71
73. Butte M.J., Wong A.P., Sharpe A.H., and Whitesides G.M. Microfluidic device for low-cost screening of newborns for severe combined immune deficiency. Clin. Immunol. 116 (2005) 282
74. WHO. Patient Monitoring Guidelines for HIV Care and ART (2005). http://www.who.int/hiv/pub/guidelines/patientmonitoring.pdf http://www.who.int/hiv/pub/guidelines/patientmonitoring.pdf
75. Simon V., and Ho D.D. HIV-1 dynamics in vivo: implications for therapy. Nat. Rev. Microbiol. 1 (2003) 181-190
76. Hammer S.M., Eron Jr. J.J., Reiss P., Schooley R.T., Thompson M.A., Walmsley S., Cahn P., Fischl M.A., Gatell J.M., Hirsch M.S., Jacobsen D.M., Montaner J.S., Richman D.D., Yeni P.G., and Volberding P.A. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA 300 (2008) 555-570
77. Fiscus S.A., Cheng B., Crowe S.M., Demeter L., Jennings C., Miller V., Respess R., and Stevens W. HIV-1 viral load assays for resource-limited settings. PLoS Med 3 (2006) e417
78. Dalgleish A.G., Beverley P.C., Clapham P.R., Crawford D.H., Greaves M.F., and Weiss R.A. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312 (1984) 763-767
79. WHO. Patient Monitoring Guidelines for HIV Care and Antiretroviral Therapy (2008) http://www.who.int/hiv/
80. Spacek L.A., Shihab H.M., Lutwama F., Summerton J., Mayanja H., Ronald A., Margolick J.B., Nilles T.L., and Quinn T.C. Evaluation of a low-cost method, the guava easyCD4 assay, to enumerate CD4-positive lymphocyte counts in HIV-infected patients in the United States and Uganda. JAIDS (J. Acquir. Immune Defic. Syndr.) 41 (2006) 607-610
81. Lee S.H., Kim S.W., Kang J.Y., and Ahn C.H. A polymer lab-on-a-chip for reverse transcription (RT)-PCR based point-of-care clinical diagnostics. Lab Chip 8 (2008) 2121-2127
82. Evans J.A., Adusei A., Timmann C., May J., Mack D., Agbenyega T., Horstmann R.D., and Frimpong E. High mortality of infant bacteraemia clinically indistinguishable from severe malaria. QJM 97 (2004) 591-597
83. Moody A. Rapid diagnostic tests for malaria parasites. Clin. Microbiol. Rev. 15 (2002) 66-78
84. Rafael M.E., Taylor T., Magill A., Lim Y.W., Girosi F., and Allan R. Reducing the burden of childhood malaria in Africa: the role of improved. Nature 444 Suppl 1 (2006) 39-48
85. Laveran C.L. Classics in infectious diseases: a newly discovered parasite in the blood of patients suffering from malaria. Parasitic etiology of attacks of malaria: Charles Louis Alphonse Laveran (1845-1922). Rev Infect Dis 4 (1982) 908-911
86. Jorgensen P., Chanthap L., Rebueno A., Tsuyuoka R., and Bell D. Malaria rapid diagnostic tests in tropical climates: the need for a cool chain. Am. J. Trop. Med. Hyg. 74 (2006) 750-754
87. Bell D., Wongsrichanalai C., and Barnwell J.W. Ensuring quality and access for malaria diagnosis: how can it be achieved?. Nat. Rev. Microbiol. 4 (2006) 682-695
88. Antia M., Herricks T., and Rathod P.K. Microfluidic modeling of cell-cell interactions in malaria pathogenesis. PLoS Pathog 3 (2007) e99
89. Padayatchi N., and Friedland G. Decentralised management of drug-resistant tuberculosis (MDR- and XDR-TB) in South Africa: an alternative model of care. Int. J. Tuberc. Lung Dis. 12 (2008) 978-980
90. Singh J.A., Upshur R., and Padayatchi N. XDR-TB in South Africa: no time for denial or complacency. PLoS Med 4 (2007) e50
91. Ridderhof J.C., van Deun A., Kam K.M., Narayanan P.R., and Aziz M.A. Roles of laboratories and laboratory systems in effective tuberculosis programmes. Bull. World Health Organ. 85 (2007) 354-359
92. Steingart K.R., Ng V., Henry M., Hopewell P.C., Ramsay A., Cunningham J., Urbanczik R., Perkins M.D., Aziz M.A., and Pai M. Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis 6 (2006) 664-674
93. Ke C., Berney H., Mathewson A., and Sheehan M.M. Rapid amplification for the detection of Mycobacterium tuberculosis using a non-contact heating method in a silicon microreactor based thermal cycler. Sens. Actuators B 102 (2004) 308-314
94. Lee H., Sun E., Ham D., and Weissleder R. Chip-NMR biosensor for detection and molecular analysis of cells. Nat. Med. 14 (2008) 869-874
95. Peeling R.W., Smith P.G., and Bossuyt P.M. A guide for diagnostic evaluations. Nat. Rev. Microbiol. 4 (2006) S2-S6
96. WHO. Regulation of in vitro diagnostics: a global perspective,http://www.who.int/tdrold/publications/publications/pdf/tbdi/tbdi_annex.pdf.
97. Weigl B., Domingo G., Labarre P., and Gerlach J. Towards non- and minimally instrumented, microfluidics-based diagnostic devices. Lab Chip 8 (2008) 1999-2014