Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis

Journal of Molecular and Cellular Cardiology

Volumn 88, Issue , 2015, Pages 1-13

  Basheer, Wassim A ^a   Harris, Brett S ^b   Mentrup, Heather L ^a   Abreha, Measho ^a   Thames, Elizabeth L ^a   Lea, Jessica B ^a   Swing, Deborah A ^c   Copeland, Neal G ^c,e   Jenkins, Nancy A ^c,e   Price, Robert L ^d   Matesic, Lydia E ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

Arrhythmogenesis; Connexin; Gap junction; Ubiquitin; Wwp1

Indexed keywords

CONNEXIN 43; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; WW DOMAIN CONTAINING PROTEIN 1; ACTIN; GJA1 PROTEIN, MOUSE; PROTEASOME; WWP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GAP JUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE ARRHYTHMIA; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STEADY STATE; UBIQUITINATION; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HEART ARRHYTHMIA; HEART VENTRICLE; METABOLISM; PATHOLOGY; PROMOTER REGION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ACTINS; ANIMALS; ARRHYTHMIAS, CARDIAC; CONNEXIN 43; DISEASE MODELS, ANIMAL; FEMALE; GAP JUNCTIONS; GENE EXPRESSION REGULATION; HEART VENTRICLES; HYPERTROPHY, LEFT VENTRICULAR; MALE; MICE; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; PHENOTYPE; PROMOTER REGIONS, GENETIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84941947513     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.09.004     Document Type: Article

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