Peptide and small molecule inhibitors of HECT-type ubiquitin ligases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 47, 2014, Pages 16736-16741

  Mund, Thomas ^a   Lewis, Michael J ^a   Maslen, Sarah ^a   Pelham, Hugh R ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

HECT ligase; Inhibitor; Phage display; Ubiquitin

Indexed keywords

CYSTEINE; ENZYME INHIBITOR; HECLIN; HECT LIGASE; HECT LIGASE INHIBITOR; LIGASE INHIBITOR; PEPTIDE; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE HUWE1; UBIQUITIN PROTEIN LIGASE MULE; UBIQUITIN PROTEIN LIGASE NEDD4; UBIQUITIN PROTEIN LIGASE SMURF2; UBIQUITIN PROTEIN LIGASE WWP1; UNCLASSIFIED DRUG; BICYCLO COMPOUND;

ARTICLE; BINDING SITE; CELL GROWTH; CELL KILLING; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVE SITE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MAMMAL CELL; OXIDATION; PEPTIDE LIBRARY; PHAGE DISPLAY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; TISSUE CULTURE CELL; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; METABOLISM;

MAMMALIA;

BICYCLO COMPOUNDS; BINDING SITES; ENZYME INHIBITORS; HUMANS; PEPTIDES; UBIQUITIN-PROTEIN LIGASES;

EID: 84912567137     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412152111     Document Type: Article

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