Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity

Journal of Hepatology

Volumn 63, Issue 4, 2015, Pages 813-821

  Koutsoudakis, George ^a,i   Romero Brey, Inés ^b   Berger, Carola ^b   Pérez Vilaró, Gemma ^a   Monteiro Perin, Paula ^c,d   Vondran, Florian Wolfgang Rudolf ^d,e   Kalesse, Markus ^d   Harmrolfs, Kirsten ^f   Müller, Rolf ^f   Martinez, Javier P ^a   Pietschmann, Thomas ^c,d   Bartenschlager, Ralf ^b,g   Brönstrup, Mark ^d   Meyerhans, Andreas ^a,h   Díez, Juana ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f SAARLAND UNIVERSITY   (Germany)

^g Partner Site Heidelberg   (Germany)

^h INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

ⁱ HOSPITAL CLÍNIC   (Spain)

Author keywords

Broad spectrum antiviral; HCV replication inhibitor; HCV HIV co infection; Lipid metabolism; Natural product

Indexed keywords

ANTIVIRUS AGENT; DASATINIB; NATURAL PRODUCT; SORAPHEN A; TELAPREVIR; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS RNA; MACROLIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXIC CONCENTRATION; DEMETHYLATION; DRUG CYTOTOXICITY; EC50; ELECTRON MICROSCOPY; FERMENTATION; HEPATITIS C; HEPATITIS C VIRUS; HEPATITIS C VIRUS SUBTYPE 1B; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HYDROXYLATION; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTERNAL RIBOSOME ENTRY SITE; INTRACELLULAR MEMBRANE; LIPID METABOLISM; LIVER CELL; MEMBRANE VESICLE; PRIORITY JOURNAL; REPLICON CELL; RNA REPLICATION; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; SUPERNATANT; VIRUS ENTRY; VIRUS REPLICATION; WESTERN BLOTTING; WILD TYPE; CELL LINE; DRUG EFFECTS; GENETICS; HEPACIVIRUS; PATHOLOGY; ULTRASTRUCTURE; VIROLOGY;

ANTIVIRAL AGENTS; CELL LINE; HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; MACROLIDES; MICROSCOPY, ELECTRON; RNA, VIRAL; VIRUS REPLICATION;

EID: 84941944590     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.06.002     Document Type: Article

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