Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

Oncotarget

Volumn 5, Issue 18, 2014, Pages 8306-8316

  Corominas Faja, Bruna ^a,b   Cuyàs, Elisabet ^a,b   Gumuzio, Juan ^c   Bosch Barrera, Joaquim ^a   Leis, Olatz ^d   Martin, Ángel G ^d   Menendez, Javier A ^a,b  

^a CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^b GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^c Fundacion INBIOMED   (Spain)

^d StemTek Therapeutics   (Spain)

Author keywords

Acetyl CoA carboxylase; Breast cancer; Cancer stem cells; Lipogenesis; Metabolism; Soraphen A; Warburg effect

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ALDEHYDE DEHYDROGENASE; ISOENZYME; OLEIC ACID; POLYKETIDE; SORAPHEN A; UNCLASSIFIED DRUG; ACACA PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; MACROLIDE;

ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CELL POPULATION; CELL RENEWAL; CONTROLLED STUDY; CYTOSOLIC FRACTION; ENZYME INHIBITION; GENE OVEREXPRESSION; HER2 GENE; HUMAN; HUMAN CELL; LIPOGENESIS; MCF 7 CELL LINE; ONCOGENE; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MULTICELLULAR SPHEROID; PATHOLOGY; SIGNAL TRANSDUCTION;

ACETYL-COA CARBOXYLASE; ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HUMANS; LIPOGENESIS; MACROLIDES; MCF-7 CELLS; MOLECULAR TARGETED THERAPY; NEOPLASTIC STEM CELLS; OLEIC ACID; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TRANSFECTION;

EID: 84907980101     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2059     Document Type: Article

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