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Journal of General Physiology
Volumn 138, Issue 4, 2011, Pages 467-471
To be, or not to be two sites: That is the question about LeuT substrate binding
Author keywords

[No Author keywords available]
Indexed keywords

LEUT PROTEIN, HUMAN; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORTER;
EID: 80054016203     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.201110652     Document Type: Note
Times cited : (15)
References (16)
  • 1
    • 78650949718 scopus 로고    scopus 로고
    • Measurement and analysis of equilibrium binding titrations: A beginner's guide
    • Beckett, D. 2011. Measurement and analysis of equilibrium binding titrations: A beginner's guide. Methods Enzymol. 488:1-16. http://dx.doi.org/10.1016/B978-0-12-381268-1.00001-X
    • (2011) Methods Enzymol , vol.488 , pp. 1-16
    • Beckett, D.1
  • 2
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254. http://dx.doi.org/10.1016/0003-2697(76)90527-3
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 3
    • 73949083478 scopus 로고    scopus 로고
    • The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters
    • Forrest, L.R., and G. Rudnick. 2009. The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters. Physiology (Bethesda). 24:377-386.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 377-386
    • Forrest, L.R.1    Rudnick, G.2
  • 4
    • 33745555489 scopus 로고    scopus 로고
    • Neurotransmitter transporters: molecular function of important drug targets
    • Gether, U., P.H. Andersen, O.M. Larsson, and A. Schousboe. 2006. Neurotransmitter transporters: molecular function of important drug targets. Trends Pharmacol. Sci. 27:375-383. http://dx.doi.org/10.1016/j.tips.2006.05.003
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 375-383
    • Gether, U.1    Andersen, P.H.2    Larsson, O.M.3    Schousboe, A.4
  • 5
    • 0014029736 scopus 로고
    • Simple allosteric model for membrane pumps
    • Jardetzky, O. 1966. Simple allosteric model for membrane pumps. Nature. 211:969-970. http://dx.doi.org/10.1038/211969a0
    • (1966) Nature , vol.211 , pp. 969-970
    • Jardetzky, O.1
  • 6
    • 27844506567 scopus 로고    scopus 로고
    • Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1
    • Krause, S., and W. Schwarz. 2005. Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1. Mol. Pharmacol. 68:1728-1735.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1728-1735
    • Krause, S.1    Schwarz, W.2
  • 7
    • 66249098083 scopus 로고    scopus 로고
    • Unlocking the molecular secrets of sodium-coupled transporters
    • Krishnamurthy, H., C.L. Piscitelli, and E. Gouaux. 2009. Unlocking the molecular secrets of sodium-coupled transporters. Nature. 459:347-355. http://dx.doi.org/10.1038/nature08143
    • (2009) Nature , vol.459 , pp. 347-355
    • Krishnamurthy, H.1    Piscitelli, C.L.2    Gouaux, E.3
  • 8
    • 2342629856 scopus 로고    scopus 로고
    • Serotonin transporter: gene, genetic disorders, and pharmacogenetics
    • Murphy, D.L., A. Lerner, G. Rudnick, and K.P. Lesch. 2004. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol. Interv. 4:109-123. http://dx.doi.org/10.1124/mi.4.2.8
    • (2004) Mol. Interv. , vol.4 , pp. 109-123
    • Murphy, D.L.1    Lerner, A.2    Rudnick, G.3    Lesch, K.P.4
  • 9
    • 78650817193 scopus 로고    scopus 로고
    • Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site
    • Piscitelli, C.L., H. Krishnamurthy, and E. Gouaux. 2010. Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site. Nature. 468:1129-1132. http://dx.doi.org/10.1038/nature09581
    • (2010) Nature , vol.468 , pp. 1129-1132
    • Piscitelli, C.L.1    Krishnamurthy, H.2    Gouaux, E.3
  • 10
    • 33847675341 scopus 로고    scopus 로고
    • Monitoring the function of membrane transport proteins in detergent-solubilized form
    • Quick, M., and J.A. Javitch. 2007. Monitoring the function of membrane transport proteins in detergent-solubilized form. Proc. Natl. Acad. Sci. USA. 104:3603-3608. http://dx.doi.org/10.1073/pnas.0609573104
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 3603-3608
    • Quick, M.1    Javitch, J.A.2
  • 11
    • 65249169367 scopus 로고    scopus 로고
    • Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitorbound conformation
    • Quick, M., A.M. Winther, L. Shi, P. Nissen, H. Weinstein, and J.A. Javitch. 2009. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitorbound conformation. Proc. Natl. Acad. Sci. USA. 106:5563-5568. http://dx.doi.org/10.1073/pnas.0811322106
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 5563-5568
    • Quick, M.1    Winther, A.M.2    Shi, L.3    Nissen, P.4    Weinstein, H.5    Javitch, J.A.6
  • 12
    • 44949086583 scopus 로고    scopus 로고
    • The mechanism of a neurotransmitter:sodium symporter- inward release of Na+ and substrate is triggered by substrate in a second binding site
    • Shi, L., M. Quick, Y. Zhao, H. Weinstein, and J.A. Javitch. 2008. The mechanism of a neurotransmitter:sodium symporter-inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol. Cell. 30:667-677. http://dx.doi.org/10.1016/j.molcel.2008.05.008
    • (2008) Mol. Cell , vol.30 , pp. 667-677
    • Shi, L.1    Quick, M.2    Zhao, Y.3    Weinstein, H.4    Javitch, J.A.5
  • 13
    • 34548178234 scopus 로고    scopus 로고
    • Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
    • Singh, S.K., A. Yamashita, and E. Gouaux. 2007. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature. 448:952-956. http://dx.doi.org/10.1038/nature06038
    • (2007) Nature , vol.448 , pp. 952-956
    • Singh, S.K.1    Yamashita, A.2    Gouaux, E.3
  • 14
    • 58149233796 scopus 로고    scopus 로고
    • A competitive inhibitor traps LeuT in an open-to-out conformation
    • Singh, S.K., C.L. Piscitelli, A. Yamashita, and E. Gouaux. 2008. A competitive inhibitor traps LeuT in an open-to-out conformation. Science. 322:1655-1661. http://dx.doi.org/10.1126/science.1166777
    • (2008) Science , vol.322 , pp. 1655-1661
    • Singh, S.K.1    Piscitelli, C.L.2    Yamashita, A.3    Gouaux, E.4
  • 15
    • 24644470065 scopus 로고    scopus 로고
    • Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
    • Yamashita, A., S.K. Singh, T. Kawate, Y. Jin, and E. Gouaux. 2005. Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature. 437:215-223. http://dx.doi.org/10.1038/nature03978
    • (2005) Nature , vol.437 , pp. 215-223
    • Yamashita, A.1    Singh, S.K.2    Kawate, T.3    Jin, Y.4    Gouaux, E.5
  • 16
    • 34548684744 scopus 로고    scopus 로고
    • LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
    • Zhou, Z., J. Zhen, N.K. Karpowich, R.M. Goetz, C.J. Law, M.E. Reith, and D.N. Wang. 2007. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science. 317:1390-1393. http://dx.doi.org/10.1126/science.1147614
    • (2007) Science , vol.317 , pp. 1390-1393
    • Zhou, Z.1    Zhen, J.2    Karpowich, N.K.3    Goetz, R.M.4    Law, C.J.5    Reith, M.E.6    Wang, D.N.7

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.