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Volumn 75, Issue 8, 2015, Pages 1645-1656

High-mobility group box 1 promotes hepatocellular carcinoma progression through MIR-21-mediated matrix metalloproteinase activity

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MICRORNA 21; RECK PROTEIN; STAT3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HMGB1 PROTEIN, HUMAN; MICRORNA; MIRN21 MICRORNA, HUMAN; RECK PROTEIN, HUMAN; TIMP3 PROTEIN, HUMAN;

EID: 84941920442     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-2147     Document Type: Article
Times cited : (86)

References (49)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology 2007;132: 2557-76.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 3
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140: 883-99.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 4
    • 84863601838 scopus 로고    scopus 로고
    • Chronic inflammation in cancer development
    • Multhoff G, Molls M, Radons J. Chronic inflammation in cancer development. Front Immunol 2011;2: 98.
    • (2011) Front Immunol , vol.2 , pp. 98
    • Multhoff, G.1    Molls, M.2    Radons, J.3
  • 6
    • 84861536618 scopus 로고    scopus 로고
    • Highmobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases
    • Yan W, Chang Y, Liang X, Cardinal JS, Huang H, Thorne SH, et al. Highmobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases. Hepatology 2012;55: 1863-75.
    • (2012) Hepatology , vol.55 , pp. 1863-1875
    • Yan, W.1    Chang, Y.2    Liang, X.3    Cardinal, J.S.4    Huang, H.5    Thorne, S.H.6
  • 7
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1) : Nuclear weapon in the immune arsenal
    • Lotze MT, Tracey KJ.High-mobility group box 1 protein (HMGB1) : Nuclear weapon in the immune arsenal. Nat Rev Immunol 2005;5: 331-42.
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 8
    • 36548999695 scopus 로고    scopus 로고
    • HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling
    • Tsung A, Klune JR, Zhang X, Jeyabalan G, Cao Z, Peng X, et al. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 2007;204: 2913-23.
    • (2007) J Exp Med , vol.204 , pp. 2913-2923
    • Tsung, A.1    Klune, J.R.2    Zhang, X.3    Jeyabalan, G.4    Cao, Z.5    Peng, X.6
  • 10
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418: 191-5.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 11
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian J, Avalos AM,MaoS-Y, Chen B, Senthil K,WuH, et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007;8: 487-96.
    • (2007) Nat Immunol , vol.8 , pp. 487-496
    • Tian, J.1    Avalos, A.M.2    Mao, S.-Y.3    Chen, B.4    Senthil, K.5    Wu, H.6
  • 13
    • 84883856321 scopus 로고    scopus 로고
    • MicroRNA: Function, detection, and bioanalysis
    • Dong H, Lei J, Ding L, Wen Y, Ju H, Zhang X. MicroRNA: Function, Detection, and Bioanalysis. Chem Rev 2013;113: 6207-33.
    • (2013) Chem Rev , vol.113 , pp. 6207-6233
    • Dong, H.1    Lei, J.2    Ding, L.3    Wen, Y.4    Ju, H.5    Zhang, X.6
  • 14
    • 77953286512 scopus 로고    scopus 로고
    • Roles of small RNAs in tumor formation
    • Di Leva G, Croce CM. Roles of small RNAs in tumor formation. TrendsMol Med 2010;16: 257-67.
    • (2010) TrendsMol Med , vol.16 , pp. 257-267
    • Di Leva, G.1    Croce, C.M.2
  • 15
  • 16
    • 77952918274 scopus 로고    scopus 로고
    • Genetic variation in microRNA networks: The implications for cancer research
    • Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: The implications for cancer research. Nat Rev Cancer 2010;10: 389-402.
    • (2010) Nat Rev Cancer , vol.10 , pp. 389-402
    • Ryan, B.M.1    Robles, A.I.2    Harris, C.C.3
  • 17
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan JA, Krichevsky AM, Kosik KS.MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65: 6029-33.
    • (2005) Cancer Res , vol.65 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 19
    • 38749089854 scopus 로고    scopus 로고
    • MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    • Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 2008;299: 425-36.
    • (2008) JAMA , vol.299 , pp. 425-436
    • Schetter, A.J.1    Leung, S.Y.2    Sohn, J.J.3    Zanetti, K.A.4    Bowman, E.D.5    Yanaihara, N.6
  • 20
    • 77953585000 scopus 로고    scopus 로고
    • MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma
    • Liu C, Yu J, Yu S, Lavker RM, Cai L, Liu W, et al. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. J Hepatol 2010;53: 98-107.
    • (2010) J Hepatol , vol.53 , pp. 98-107
    • Liu, C.1    Yu, J.2    Yu, S.3    Lavker, R.M.4    Cai, L.5    Liu, W.6
  • 21
    • 80052482248 scopus 로고    scopus 로고
    • TLR4 knockout protects mice from radiation-induced thymic lymphoma by downregulation of IL6 and MIR-21
    • Liu C, Gao F, Li B, Mitchel REJ, Liu X, Lin J, et al. TLR4 knockout protects mice from radiation-induced thymic lymphoma by downregulation of IL6 and miR-21. Leukemia 2011;25: 1516-9.
    • (2011) Leukemia , vol.25 , pp. 1516-1519
    • Liu, C.1    Gao, F.2    Li, B.3    Mitchel, R.E.J.4    Liu, X.5    Lin, J.6
  • 22
    • 33746864818 scopus 로고    scopus 로고
    • Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling
    • Du Q, Park KS, Guo Z, He P, Nagashima M, Shao L, et al. Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. Cancer Res 2006;66: 7024-31.
    • (2006) Cancer Res , vol.66 , pp. 7024-7031
    • Du, Q.1    Park, K.S.2    Guo, Z.3    He, P.4    Nagashima, M.5    Shao, L.6
  • 23
    • 84862750365 scopus 로고    scopus 로고
    • MIR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions
    • Chang Y, Yan W, He X, Zhang L, Li C, Huang H, et al. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology 2012;143: 177-87.e8.
    • (2012) Gastroenterology , vol.143 , pp. 177-87e8
    • Chang, Y.1    Yan, W.2    He, X.3    Zhang, L.4    Li, C.5    Huang, H.6
  • 24
    • 84863804699 scopus 로고    scopus 로고
    • MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo
    • He X-X, Chang Y, Meng F-Y, Wang M-Y, Xie Q-H, Tang F, et al. MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. Oncogene 2012;31: 3357-69.
    • (2012) Oncogene , vol.31 , pp. 3357-3369
    • He, X.-X.1    Chang, Y.2    Meng, F.-Y.3    Wang, M.-Y.4    Xie, Q.-H.5    Tang, F.6
  • 25
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    • Tsung A, Sahai R, Tanaka H, Nakao A, Fink MP, LotzeMT, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005;201: 1135-43.
    • (2005) J Exp Med , vol.201 , pp. 1135-1143
    • Tsung, A.1    Sahai, R.2    Tanaka, H.3    Nakao, A.4    Fink, M.P.5    Lotze, M.T.6
  • 26
    • 78650859531 scopus 로고    scopus 로고
    • NF-κB and STAT3-key players in liver inflammation and cancer
    • He G, Karin M. NF-κB and STAT3-key players in liver inflammation and cancer. Cell Res 2011;21: 159-68.
    • (2011) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 27
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120: 15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 28
    • 0035192918 scopus 로고    scopus 로고
    • RECK gene expression in hepatocellular carcinoma: Correlation with invasionrelated clinicopathological factors and its clinical significance.Reverse-inducing-cysteine-rich protein with Kazal motifs
    • FurumotoK,AriiS,MoriA,FuruyamaH,GorrinRivasMJ,NakaoT,etal.RECK gene expression in hepatocellular carcinoma: Correlation with invasionrelated clinicopathological factors and its clinical significance.Reverse-inducing-cysteine-rich protein with Kazal motifs. Hepatology 2001;33: 189-95.
    • (2001) Hepatology , vol.33 , pp. 189-195
    • Furumoto, K.1    Arii, S.2    Mori, A.3    Furuyama, H.4    Gorrin Rivas, M.J.5    Nakao, T.6
  • 29
    • 59149105815 scopus 로고    scopus 로고
    • Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
    • Chen J-S, Wang Q, Fu X-H, Huang X-H, Chen X-L, Cao L-Q, et al. Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9. Hepatol Res 2009;39: 177-86.
    • (2009) Hepatol Res , vol.39 , pp. 177-186
    • Chen, J.-S.1    Wang, Q.2    Fu, X.-H.3    Huang, X.-H.4    Chen, X.-L.5    Cao, L.-Q.6
  • 30
    • 58149376548 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocellular carcinoma
    • Aravalli RN, Steer CJ, Cressman ENK. Molecular mechanisms of hepatocellular carcinoma. Hepatology 2008;48: 2047-63.
    • (2008) Hepatology , vol.48 , pp. 2047-2063
    • Aravalli, R.N.1    Steer, C.J.2    Cressman, E.N.K.3
  • 31
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011;365: 1118-27.
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 33
    • 80051969149 scopus 로고    scopus 로고
    • Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice
    • Huang H, Evankovich J, Yan W, Nace G, Zhang L, Ross M, et al. Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology 2011;54: 999-1008.
    • (2011) Hepatology , vol.54 , pp. 999-1008
    • Huang, H.1    Evankovich, J.2    Yan, W.3    Nace, G.4    Zhang, L.5    Ross, M.6
  • 34
    • 84875786973 scopus 로고    scopus 로고
    • MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer
    • Tili E, Michaille J-J, Croce CM. MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer. Immunol Rev 2013;253: 167-84.
    • (2013) Immunol Rev , vol.253 , pp. 167-184
    • Tili, E.1    Michaille, J.-J.2    Croce, C.M.3
  • 35
    • 79959906720 scopus 로고    scopus 로고
    • Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of MIR-21 upon oxygen deprivation
    • Polytarchou C, Iliopoulos D, HatziapostolouM, Kottakis F, Maroulakou I, Struhl K, et al. Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res 2011;71: 4720-31.
    • (2011) Cancer Res , vol.71 , pp. 4720-4731
    • Polytarchou, C.1    Iliopoulos, D.2    Hatziapostolou, M.3    Kottakis, F.4    Maroulakou, I.5    Struhl, K.6
  • 36
    • 84877263372 scopus 로고    scopus 로고
    • Expression of microRNAs, MIR-21, MIR-31, MIR-122, MIR-145, MIR-146a, MIR-200c, MIR-221, MIR-222, and MIR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
    • Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G, Voros D. Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog 2013;52: 297-303.
    • (2013) Mol Carcinog , vol.52 , pp. 297-303
    • Karakatsanis, A.1    Papaconstantinou, I.2    Gazouli, M.3    Lyberopoulou, A.4    Polymeneas, G.5    Voros, D.6
  • 37
    • 34547524771 scopus 로고    scopus 로고
    • Micro-RNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. Micro-RNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133: 647-58.
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 38
    • 84880259289 scopus 로고    scopus 로고
    • HBx-mediated MIR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma
    • Qiu X, Dong S, Qiao F, Lu S, Song Y, Lao Y, et al. HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma. Oncogene 2013;32: 3296-305.
    • (2013) Oncogene , vol.32 , pp. 3296-3305
    • Qiu, X.1    Dong, S.2    Qiao, F.3    Lu, S.4    Song, Y.5    Lao, Y.6
  • 39
    • 79959464268 scopus 로고    scopus 로고
    • HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and MIR-206-mediated inhibition of TIMP-3
    • Limana F, Esposito G, D'Arcangelo D, Di Carlo A, Romani S, Melillo G, et al. HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3. PLoS ONE 2011;6: E19845.
    • (2011) PLoS ONE , vol.6 , pp. e19845
    • Limana, F.1    Esposito, G.2    D'Arcangelo, D.3    Di Carlo, A.4    Romani, S.5    Melillo, G.6
  • 40
    • 84868126751 scopus 로고    scopus 로고
    • HMGB1 induces the overexpression of MIR-222 and MIR-221 and increases growth and motility in papillary thyroid cancer cells
    • Mardente S, Mari E, Consorti F, Di Gioia C, Negri R, Etna M, et al. HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells. Oncol Rep 2012;28: 2285-9.
    • (2012) Oncol Rep , vol.28 , pp. 2285-2289
    • Mardente, S.1    Mari, E.2    Consorti, F.3    Di Gioia, C.4    Negri, R.5    Etna, M.6
  • 41
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, Kim J-Y, Strassheim D, Ishizaka A, et al. Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004;279: 7370-7.
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.-Y.4    Strassheim, D.5    Ishizaka, A.6
  • 42
    • 0037376222 scopus 로고    scopus 로고
    • Activation of gene expression in human neutrophils by high mobility group box 1 protein
    • Park JS, Arcaroli J, YumH-K, Yang H, Wang H, Yang K-Y, et al. Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol 2003;284: C870-9.
    • (2003) Am J Physiol Cell Physiol , vol.284 , pp. C870-C879
    • Park, J.S.1    Arcaroli, J.2    YumH-K Yang, H.3    Wang, H.4    Yang, K.-Y.5
  • 43
    • 77956409919 scopus 로고    scopus 로고
    • IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-Induced STAT3 phosphorylation in human hepatocellular cancer cells
    • Liu Y, Fuchs J, Li C, Lin J. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-Induced STAT3 phosphorylation in human hepatocellular cancer cells. Cell Cycle 2010;9: 3423-7.
    • (2010) Cell Cycle , vol.9 , pp. 3423-3427
    • Liu, Y.1    Fuchs, J.2    Li, C.3    Lin, J.4
  • 44
    • 84875440552 scopus 로고    scopus 로고
    • HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes
    • Lepiller Q, Abbas W, Kumar A, Tripathy MK, Herbein G. HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes. PLoS ONE 2013;8: E59591.
    • (2013) PLoS ONE , vol.8 , pp. e59591
    • Lepiller, Q.1    Abbas, W.2    Kumar, A.3    Tripathy, M.K.4    Herbein, G.5
  • 45
    • 84883435027 scopus 로고    scopus 로고
    • Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors
    • Li L, Li H. Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors. Cancer Biol Ther 2013;14: 796-805.
    • (2013) Cancer Biol Ther , vol.14 , pp. 796-805
    • Li, L.1    Li, H.2
  • 46
  • 47
    • 84879071318 scopus 로고    scopus 로고
    • Hepatocellular carcinoma-Associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis
    • Yan X-L, Jia Y-L, Chen L, Zeng Q, Zhou J-N, Fu C-J, et al. Hepatocellular carcinoma-Associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis. Hepatology 2013;57: 2274-86.
    • (2013) Hepatology , vol.57 , pp. 2274-2286
    • Yan, X.-L.1    Jia, Y.-L.2    Chen, L.3    Zeng, Q.4    Zhou, J.-N.5    Fu, C.-J.6
  • 48
    • 56649120601 scopus 로고    scopus 로고
    • MIR-21 plays a pivotal role in gastric cancer pathogenesis and progression
    • Zhang Z, Li Z, Gao C, Chen P, Chen J, Liu W, et al. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest 2008;88: 1358-66.
    • (2008) Lab Invest , vol.88 , pp. 1358-1366
    • Zhang, Z.1    Li, Z.2    Gao, C.3    Chen, P.4    Chen, J.5    Liu, W.6
  • 49
    • 77950905590 scopus 로고    scopus 로고
    • MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression
    • Song B, Wang C, Liu J, Wang X, Lv L, Wei L, et al. MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J Exp Clin Cancer Res 2010;29: 29.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 29
    • Song, B.1    Wang, C.2    Liu, J.3    Wang, X.4    Lv, L.5    Wei, L.6


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