Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease

Human Molecular Genetics

Volumn 24, Issue 17, 2015, Pages 4829-4847

  Peng, Min ^a   Ostrovsky, Julian ^a   Kwon, Young Joon ^a   Polyak, Erzsebet ^a   Licata, Joseph ^a   Tsukikawa, Mai ^a   Marty, Eric ^a   Thomas, Jeffrey ^b   Felix, Carolyn A ^a   Xiao, Rui ^a   Zhang, Zhe ^c   Gasser, David L ^a   Argon, Yair ^b   Falk, Marni J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; LITHIUM CHLORIDE; MAMMALIAN TARGET OF RAPAMYCIN; PROBUCOL; PROTEIN S6; RAPAMYCIN; TRANSCRIPTOME; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BIOGENESIS; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MOUSE; NEMATODE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECTS; ELECTRON TRANSPORT; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; PROTEIN SYNTHESIS;

ANIMALS; AUTOPHAGY; CELL SURVIVAL; CYCLOHEXIMIDE; CYTOSOL; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; HUMANS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROBUCOL; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEIN S6 KINASES; SIROLIMUS; TOR SERINE-THREONINE KINASES; TRANSCRIPTOME;

EID: 84941907491     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv207     Document Type: Article

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