Distinct patterns of Wnt3a and Wnt5a signaling pathway in the lung from rats with endotoxic shock

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Hii, Hiong Ping ^a   Liao, Mei Hui ^b   Chen, Shiu Jen ^b,c   Wu, Chin Chen ^b   Shih, Chih Chin ^b  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c Kang Ning Junior College of Medical Care and Management   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; BETA CATENIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CREATININE; DISHEVELLED 1; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; LACTATE DEHYDROGENASE; NITROGEN; NORADRENALIN; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETED FRIZZLED RELATED PROTEIN 5; SUPEROXIDE; UREA; WNT3A PROTEIN; WNT5A PROTEIN; ENDOTOXIN; WNT PROTEIN; WNT5A PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HEART RATE; HYPERVENTILATION; IN VIVO STUDY; ISCHEMIA; LUNG EDEMA; LYMPHOCYTIC INFILTRATION; MALE; MEAN ARTERIAL PRESSURE; METABOLIC ACIDOSIS; MORTALITY; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; PRESSOR RESPONSE; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK; SURVIVAL RATE; SURVIVAL TIME; UPREGULATION; WNT SIGNALING PATHWAY; ACUTE LUNG INJURY; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; ENDOTOXEMIA; HEMODYNAMICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WISTAR RAT;

ACUTE LUNG INJURY; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ENDOTOXINS; HEMODYNAMICS; MALE; RATS; RATS, WISTAR; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; SUPEROXIDES; WNT PROTEINS; WNT-5A PROTEIN; WNT3A PROTEIN;

EID: 84941902038     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134492     Document Type: Article

References (34)

1. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. (2013) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41: 580-637. doi:10.1097/CCM.0b013e31827e83af PMID: 23353941.
2. Van Amersfoort ES, Van Berkel TJC, Kuiper J (2003) Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev 16: 379-414. PMID: 12857774.
3. Triantafilou M, Triantafilou K (2004) Sepsis: molecular mechanisms underlying lipopolysaccharide recognition. Expert Rev Mol Med 6: 1-18.
4. van Amerongen R, Nusse R (2009) Towards an integrated view of Wnt signaling in development. Development 136: 3205-3214. doi:10.1242/dev.033910 PMID: 19736321.
5. MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26. doi:10.1016/j.devcel.2009.06.016 PMID: 19619488.
6. Gordon MD, Nusse R (2006) Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281: 22429-22433. PMID: 16793760.
7. Angers S, Moon RT (2009) Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol 10: 468- 477. doi:10.1038/nrm2717 PMID: 19536106.
8. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480. PMID: 17081971.
9. Veeman MT, Axelrod JD, Moon RT (2003) A second canon. Functions and mechanisms of beta-catenin- independent Wnt signaling. Dev Cell 5: 367-377. PMID: 12967557.
10. Kohn AD, Moon RT (2005) Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium 38: 439-446. PMID: 16099039.
11. Neumann J, Schaale K, Farhat K, Endermann T, Ulmer AJ, Ehlers S, et al. (2010) Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB J 24: 4599-4612. doi:10.1096/fj.10-160994 PMID: 20667980.
12. Malhotra S, Kincade PW (2009) Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells. Exp Hematol 37: 19-30. doi:10.1016/j.exphem.2008.08.008 PMID: 18951693.
13. Tickenbrock L, Schwäble J, Strey A, Sargin B, Hehn S, Baas M, et al. (2006) Wnt signaling regulates transendothelial migration of monocytes. J Leukoc Biol 79: 1306-1313. PMID: 16565323.
14. Guo Y, Mishra A, Weng T, Chintagari NR, Wang Y, Zhao C, et al. (2014) Wnt3a mitigates acute lung injury by reducing P2X7 receptor-mediated alveolar epithelial type I cell death. Cell Death Dis 5: e1286. doi:10.1038/cddis.2014.254 PMID: 24922070.
15. Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, et al. (2013) β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. Am J Respir Crit Care Med 187: 630-639. doi:10.1164/rccm.201205-0972OC PMID: 23306543.
16. Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez RM, Wang YC, et al. (2010) Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329: 849-853. doi:10.1126/science.1188510 PMID: 20705860.
17. Bhatt PM, Malgor R (2014) Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders. Atherosclerosis 237: 155-162. doi:10.1016/j.atherosclerosis.2014.08.027 PMID: 25240110.
18. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson DA (2000) Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Nati Acad Sci USA 97: 2791-2796.
19. Reischl J, Schwenke S, Beekman JM, Mrowietz U, Stürzebecher S, Heubach JF (2007) Increased expression of Wnt5a in psoriatic plaques. J Invest Dermatol 127: 163-169. PMID: 16858420.
20. Christman MA, Goetz DJ, Dickerson E, McCall KD, Lewis CJ, Benencia F, et al. (2008) Wnt5a is expressed in murine and human atherosclerotic lesions. Am J Physiol Heart Circ Physiol 294: H2864- 870. doi:10.1152/ajpheart.00982.2007 PMID: 18456733.
21. Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108: 965-973. PMID: 16601243.
22. Pereira C, Schaer DJ, Bachli EB, Kurrer MO, Schoedon G (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol 28: 504-510. doi:10.1161/ATVBAHA.107.157438 PMID: 18174455.
23. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, et al. (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353: 1685-1693. PMID: 16236739.
24. Sheu CC, Gong MN, Zhai R, Chen F, Bajwa EK, Clardy PF, et al. (2010) Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS. Chest 138: 559-567. doi:10.1378/chest.09-2933 PMID: 20507948.
25. Niehrs C (2012) The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol 13: 767-779. doi10.1038/nrm3470 PMID: 23151663.
26. Boutros M, Mlodzik M (1999) Dishevelled: At the crossroads of divergent intracellular signaling pathways. Mech Dev 83: 27-37. PMID: 10507837.
27. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406: 86-90. PMID: 10894547.
28. Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810. PMID: 15473860.
29. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789. PMID: 8524413.
30. Martin M, Rehani K, Jope RS, Michalek SM (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6: 777-784. PMID: 16007092.
31. Dugo L, Collin M, Allen DA, Patel NS, Bauer I, Mervaala EM, et al. (2005) GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. Crit Care Med 33: 1903-1912. PMID: 16148458.
32. Schaale K, Neumann J, Schneider D, Ehlers S, Reiling N (2011) Wnt signaling in macrophages: Augmenting and inhibiting mycobacteria-induced inflammatory responses. Eur J Cell Biol 90: 553-559. doi:10.1016/j.ejcb.2010.11.004 PMID: 21185106.
33. Villar J, Cabrera-Benítez NE, Ramos-Nuez A, Flores C, García-Hernández S, Valladares F, et al. (2014) Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury. Crit Care 18: 568. doi:10.1186/s13054-014-0568-z PMID: 25331176.
34. Miller SG, Kennedy MB (1986) Regulation of brain type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch. Cell 44: 861-870. PMID: 3006921.