Pancreatic neuroendocrine tumors in mice deficient in proglucagon-derived peptides

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Takano, Yuko ^a,b   Kasai, Kenji ^c   Takagishi, Yoshiko ^a   Kikumori, Toyone ^b   Imai, Tsuneo ^b,c   Murata, Yoshiharu ^a   Hayashi, Yoshitaka ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGRANIN A; GREEN FLUORESCENT PROTEIN; PROGLUCAGON; SYNAPTOPHYSIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRAFT; CELL HYPERPLASIA; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; LIVER METASTASIS; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; PANCREATIC NEUROENDOCRINE TUMOR; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR GROWTH; ANIMAL; CONFOCAL MICROSCOPY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIVER TUMOR; METABOLISM; NEUROENDOCRINE TUMOR; PANCREAS ISLET; PANCREAS TUMOR; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECONDARY; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; PROGLUCAGON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84941800935     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133812     Document Type: Article

References (33)

1. Kieffer TJ, Habener JF. The glucagon-like peptides. Endocr Rev. 1999; 20(6):876-913. Epub 1999/12/22. PMID: 10605628.
2. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007; 132(6):2131-57. Epub 2007/05/15. doi: S0016-5085(07)00580-X [pii] doi: 10.1053/j.gastro.2007.03.054 PMID: 17498508.
3. Habener JF, Stanojevic V. Alpha cells come of age. Trends Endocrinol Metab. 2012. Epub 2012/12/25. doi: S1043-2760(12)00200-7 [pii] doi: 10.1016/j.tem.2012.10.009 PMID: 23260869.
4. Unger RH, Cherrington AD. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Invest. 2012; 122(1):4-12. Epub 2012/01/05. doi: 10.1172/JCI6001660016 [pii]. PMID: 22214853; PubMed Central PMCID: PMC3248306.
5. Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev. 2007; 28(1):84-116. Epub 2007/01/31. doi: er.2006-0007 [pii] doi: 10.1210/er.2006-0007 PMID: 17261637.
6. Hayashi Y. Metabolic impact of glucagon deficiency. Diabetes Obes Metab. 2011; 13 Suppl 1:151-7. Epub 2011/08/17. doi: 10.1111/j.1463-1326.2011.01456.x PMID: 21824269.
7. Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, et al. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A. 2003; 100(3):1438-43. Epub 2003/01/29. doi: 10.1073/pnas.02371061000237106100 [pii]. PMID: 12552113; PubMed Central PMCID: PMC298791.
8. Furuta M, Yano H, Zhou A, Rouille Y, Holst JJ, Carroll R, et al. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci U S A. 1997; 94 (13):6646-51. Epub 1997/06/24. PMID: 9192619; PubMed Central PMCID: PMC21212.
9. Longuet C, Robledo AM, Dean ED, Dai C, Ali S, McGuinness I, et al. Liver-specific disruption of the murine glucagon receptor produces alpha-cell hyperplasia: evidence for a circulating alpha-cell growth factor. Diabetes. 2013; 62(4):1196-205. Epub 2012/11/20. doi: 10.2337/db11-1605db11-1605 [pii]. PMID: 23160527; PubMed Central PMCID: PMC3609565.
10. Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, et al. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. J Clin Invest. 2005; 115(11):3217-27. Epub 2005/10/22. doi: 10.1172/JCI24196 PMID: 16239968; PubMed Central PMCID: PMC1257533.
11. Chen M, Mema E, Kelleher J, Nemechek N, Berger A, Wang J, et al. Absence of the Glucagon-Like Peptide-1 Receptor Does Not Affect the Metabolic Phenotype of Mice with Liver-Specific G(s)alpha Deficiency. Endocrinology. 2011; 152(9):3343-50. doi: 10.1210/en.2011-0012 PMID: WOS:000294161000007.
12. Hayashi Y, Yamamoto M, Mizoguchi H, Watanabe C, Ito R, Yamamoto S, et al. Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells. Mol Endocrinol. 2009; 23(12):1990-9. Epub 2009/10/13. doi: 10.1210/me.2009-0296me. 2009-0296 [pii]. PMID: 19819987.
13. Yu R, Dhall D, Nissen NN, Zhou CQ, Ren SG. Pancreatic Neuroendocrine Tumors in Glucagon Receptor- Deficient Mice. Plos One. 2011; 6(8):10. doi: 10.1371/journal.pone.0023397 PMID: WOS:000295454200080.
14. Yu R. Pancreatic alpha-cell hyperplasia: facts and myths. J Clin Endocrinol Metab. 2014; 99(3):748-56. Epub 2013/11/29. doi: 10.1210/jc.2013-2952jc.2013-2952 [pii]. PMID: 24285676.
15. Klimstra D, Arnold R, Capella C, Hruban R, Kloppel G, Komminoth P, et al. Neuroendocrine neoplasms of the pancreas. WHO Classification of Tumours of the Digestive System. 2010:322-6.
16. Klöppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocrine- Related Cancer. 2011; 18(S1):S1-S16. doi: 10.1530/erc-11-0013
17. Yu R, Nissen NN, Dhall D, Heaney AP. Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature. Pancreas. 2008; 36 (4):428-31. Epub 2008/04/26. doi: 10.1097/MPA.0b013e31815ceb2300006676-200805000-00015 [pii]. PMID: 18437091.
18. Henopp T, Anlauf M, Schmitt A, Schlenger R, Zalatnai A, Couvelard A, et al. Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas. J Clin Endocrinol Metab. 2009; 94(1):213-7. Epub 2008/10/30. doi: jc.2008-1300 [pii] doi: 10.1210/jc.2008-1300 PMID: 18957496.
19. Zhou C, Dhall D, Nissen NN, Chen CR, Yu R. Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor. Pancreas. 2009; 38(8):941-6. Epub 2009/08/07. doi: 10.1097/MPA.0b013e3181b2bb03 PMID: 19657311; PubMed Central PMCID: PMC2767399.
20. Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, et al. Ectopic Expression of GIP in Pancreatic beta-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides. Diabetes. 2013; 62(2):510-8. Epub 2012/10/27. doi: 10.2337/db12- 0294db12-0294 [pii]. PMID: 23099862.
21. Futaki S, Hayashi Y, Yamashita M, Yagi K, Bono H, Hayashizaki Y, et al. Molecular basis of constitutive production of basement membrane components. Gene expression profiles of Engelbreth-Holm-Swarm tumor and F9 embryonal carcinoma cells. J Biol Chem. 2003; 278(50):50691-701. Epub 2003/09/12. doi: 10.1074/jbc.M304985200M304985200 [pii]. PMID: 12968032.
22. Habener JF, Kemp DM, Thomas MK.Minireview: transcriptional regulation in pancreatic development. Endocrinology. 2005; 146(3):1025-34. Epub 2004/12/18. doi: 10.1210/en.2004-1576 PMID: 15604203.
23. Hang Y, Stein R. MafA and MafB activity in pancreatic β cells. Trends in Endocrinology & Metabolism. 2011; 22(9):364-73. doi: http://dx.doi.org/10.1016/j.tem.2011.05.003.
24. Bramswig NC, Kaestner KH. Transcriptional regulation of alpha-cell differentiation. Diabetes Obes Metab. 2011; 13 Suppl 1:13-20. Epub 2011/08/17. doi: 10.1111/j.1463-1326.2011.01440.x PMID: 21824252.
25. Campbell JE, Drucker DJ. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 2013; 17(6):819-37. Epub 2013/05/21. doi: 10.1016/j.cmet.2013.04.008S1550-4131(13) 00150-2 [pii]. PMID: 23684623.
26. Xie T, Chen M, Weinstein LS. Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation. J Endocrinol. 2010; 206(3):261-9. Epub 2010/06/15. doi: 10. 1677/JOE-10-0030JOE-10-0030 [pii]. PMID: 20543009; PubMed Central PMCID: PMC2929693.
27. Ali S, Lamont BJ, Charron MJ, Drucker DJ. Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis. J Clin Invest. 2011; 121(5):1917-29. Epub 2011/05/05. doi: 10.1172/JCI4361543615 [pii]. PMID: 21540554; PubMed Central PMCID: PMC3083792.
28. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, et al. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep. 2013; 3(2):401-10. Epub 2013/02/05. doi: 10.1016/j.celrep.2013.01.007S2211-1247(13)00014-4 [pii]. PMID: 23375376; PubMed Central PMCID: PMC3655439.
29. Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, et al. Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science. 2008; 322(5905):1250-4. Epub 2008/11/22. doi: 10. 1126/science.1163971322/5905/1250 [pii]. PMID: 19023081.
30. Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell. 2013; 153(4):747-58. Epub 2013/04/30. doi: 10.1016/j.cell.2013.04.008S0092-8674(13)00449-2 [pii]. PMID: 23623304.
31. Quagliarini F, Wang Y, Kozlitina J, Grishin NV, Hyde R, Boerwinkle E, et al. Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A. 2012; 109(48):19751-6. Epub 2012/11/15. doi: 10.1073/pnas.12175521091217552109 [pii]. PMID: 23150577; PubMed Central PMCID: PMC3511699.
32. Fu Z, Yao F, Abou-Samra AB, Zhang R. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem Biophys Res Commun. 2013; 430(3):1126-31. Epub 2012/12/25. doi: 10.1016/j.bbrc.2012.12.025S0006-291X(12)02354-6 [pii]. PMID: 23261442.
33. Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab. 2012; 303(3):E334-51. Epub 2012/05/10. doi: 10.1152/ajpendo.00084.2012ajpendo.00084.2012 [pii]. PMID: 22569073; PubMed Central PMCID: PMC3423120.