A single bolus of docosahexaenoic acid promotes neuroplastic changes in the innervation of spinal cord interneurons and motor neurons and improves functional recovery after spinal cord injury

Journal of Neuroscience

Volumn 35, Issue 37, 2015, Pages 12733-12752

  Liu, Zhuo Hao ^a,b   Yip, Ping K ^a   Adams, Louise ^a   Davies, Meirion ^a   Lee, Jae Won ^a   Michael, Gregory J ^a   Priestley, John V ^a   Michael Titus, Adina T ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Docosahexaenoic acid; Neuroplasticity; Omega 3 polyunsaturated fatty acids; Spinal cord injury

Indexed keywords

DOCOSAHEXAENOIC ACID; IMMUNOGLOBULIN; MICRORNA 21; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SEROTONIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; AKT1 PROTEIN, RAT; MICRORNA; MIRN21 MICRORNA, RAT; NERVE PROTEIN; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE; PTEN PROTEIN, RAT;

ADULT; ANIMAL TISSUE; ARTICLE; BEHAVIOR ASSESSMENT; BRAIN CELL CULTURE; CERVICAL SPINE INJURY; CONTROLLED STUDY; FEMALE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; LAMINECTOMY; MOTONEURON; NERVE CELL PLASTICITY; NERVE FIBER REGENERATION; NEUROPROTECTION; NEUROSURGERY; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; PYRAMIDAL TRACT; PYRAMIDOTOMY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; SPINAL CORD NERVE CELL; STAIRCASE TEST; SYNAPTOGENESIS; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CERVICAL SPINE; COMPLICATION; DRUG EFFECTS; DRUG SCREENING; EXPLORATORY BEHAVIOR; GAIT DISORDERS, NEUROLOGIC; GENE EXPRESSION REGULATION; GENETICS; INJURIES; INTERNEURON; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MOUSE; NERVE REGENERATION; NEURITE; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SEROTONINERGIC NERVE CELL; SPINAL CORD; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; CELLS, CULTURED; CERVICAL VERTEBRAE; DOCOSAHEXAENOIC ACIDS; DRUG EVALUATION, PRECLINICAL; EXPLORATORY BEHAVIOR; FEMALE; GAIT DISORDERS, NEUROLOGIC; GENE EXPRESSION REGULATION; INJECTIONS, INTRAVENOUS; INTERNEURONS; MICE; MICRORNAS; MOTOR NEURONS; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURITES; NEURONAL PLASTICITY; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; PYRAMIDAL TRACTS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONERGIC NEURONS; SPINAL CORD; SPINAL CORD INJURIES;

EID: 84941771541     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0605-15.2015     Document Type: Article

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