메뉴 건너뛰기




Volumn 255, Issue , 2015, Pages 66-74

A novel 3D method of locomotor analysis in adult zebrafish: Implications for automated detection of CNS drug-evoked phenotypes

Author keywords

Drug discovery; High throughput screening; Neurophenotype; Video tracking; Zebrafish

Indexed keywords

LYSERGIDE; NICOTINE; PHENCYCLIDINE; NICOTINE VACCINE; PSYCHOTROPIC AGENT; VACCINE;

EID: 84941768968     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2015.07.023     Document Type: Article
Times cited : (76)

References (81)
  • 2
    • 77955845842 scopus 로고    scopus 로고
    • Genetic zebrafish models of neurodegenerative diseases
    • Bandmann O., Burton E.A. Genetic zebrafish models of neurodegenerative diseases. Neurobiol Dis 2010, 40:58-65.
    • (2010) Neurobiol Dis , vol.40 , pp. 58-65
    • Bandmann, O.1    Burton, E.A.2
  • 3
    • 84856957047 scopus 로고    scopus 로고
    • Zebrafish as a genomics model for human neurological and polygenic disorders
    • Becker T.S., Rinkwitz S. Zebrafish as a genomics model for human neurological and polygenic disorders. Dev Neurobiol 2012, 72:415-428.
    • (2012) Dev Neurobiol , vol.72 , pp. 415-428
    • Becker, T.S.1    Rinkwitz, S.2
  • 4
    • 84861218612 scopus 로고    scopus 로고
    • Measures of anxiety in Zebrafish (Danio rerio): dissociation of Black/White Preference and Novel Tank Test
    • Blaser R.E., Rosemberg D.B. Measures of anxiety in Zebrafish (Danio rerio): dissociation of Black/White Preference and Novel Tank Test. PLoS ONE 2012, 7:e36931.
    • (2012) PLoS ONE , vol.7 , pp. e36931
    • Blaser, R.E.1    Rosemberg, D.B.2
  • 5
    • 84904765812 scopus 로고    scopus 로고
    • Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish
    • Bruni G., Lakhani P., Kokel D. Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish. Front Pharmacol 2014, 5:153.
    • (2014) Front Pharmacol , vol.5 , pp. 153
    • Bruni, G.1    Lakhani, P.2    Kokel, D.3
  • 7
    • 84866512577 scopus 로고    scopus 로고
    • Unique and potent effects of acute ibogaine on zebrafish: the developing utility of novel aquatic models for hallucinogenic drug research
    • Cachat J., Kyzar E.J., Collins C., Gaikwad S., Green J., Roth A., et al. Unique and potent effects of acute ibogaine on zebrafish: the developing utility of novel aquatic models for hallucinogenic drug research. Behav Brain Res 2013, 236:258-269.
    • (2013) Behav Brain Res , vol.236 , pp. 258-269
    • Cachat, J.1    Kyzar, E.J.2    Collins, C.3    Gaikwad, S.4    Green, J.5    Roth, A.6
  • 11
    • 78049356810 scopus 로고    scopus 로고
    • Measuring behavioral and endocrine responses to novelty stress in adult zebrafish
    • Cachat J.M., Stewart A., Grossman L., Gaikwad S., Kadri F., Chung K.M., et al. Measuring behavioral and endocrine responses to novelty stress in adult zebrafish. Nat Protoc 2010, 5:1786-1799.
    • (2010) Nat Protoc , vol.5 , pp. 1786-1799
    • Cachat, J.M.1    Stewart, A.2    Grossman, L.3    Gaikwad, S.4    Kadri, F.5    Chung, K.M.6
  • 13
    • 77955269967 scopus 로고    scopus 로고
    • Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research
    • Champagne D.L., Hoefnagels C.C.M., de Kloet R.E., Richardson M.K. Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research. Behav Brain Res 2010, 214:332-342.
    • (2010) Behav Brain Res , vol.214 , pp. 332-342
    • Champagne, D.L.1    Hoefnagels, C.C.M.2    de Kloet, R.E.3    Richardson, M.K.4
  • 14
    • 84883185971 scopus 로고    scopus 로고
    • Psychopharmacology in crisis
    • Cressey D. Psychopharmacology in crisis. Nature 2011, 10.1038/news.2011.367.
    • (2011) Nature
    • Cressey, D.1
  • 17
    • 84941771447 scopus 로고    scopus 로고
    • Zebrafish in pharmaceutical industry research: finding the best fit
    • Fleming A., Alderton W.K. Zebrafish in pharmaceutical industry research: finding the best fit. Drug Discovery Today: Dis Models 2012, 1-8.
    • (2012) Drug Discovery Today: Dis Models , pp. 1-8
    • Fleming, A.1    Alderton, W.K.2
  • 18
    • 49549101116 scopus 로고    scopus 로고
    • Zebrafish as a new animal model for movement disorders
    • Flinn L., Bretaud S., Lo C., Ingham P.W., Bandmann O. Zebrafish as a new animal model for movement disorders. J Neurochem 2008, 106:1991-1997.
    • (2008) J Neurochem , vol.106 , pp. 1991-1997
    • Flinn, L.1    Bretaud, S.2    Lo, C.3    Ingham, P.W.4    Bandmann, O.5
  • 19
    • 79956330459 scopus 로고    scopus 로고
    • Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay
    • Gaikwad S., Stewart A., Hart P., Wong K., Piet V., Cachat J.M., et al. Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay. Behav Process 2011, 87:224-230.
    • (2011) Behav Process , vol.87 , pp. 224-230
    • Gaikwad, S.1    Stewart, A.2    Hart, P.3    Wong, K.4    Piet, V.5    Cachat, J.M.6
  • 20
    • 84860859564 scopus 로고    scopus 로고
    • Modeling human neurodegenerative diseases in transgenic systems
    • Gama Sosa M.A., De Gasperi R., Elder G.A. Modeling human neurodegenerative diseases in transgenic systems. Human Genet 2012, 131:535-563.
    • (2012) Human Genet , vol.131 , pp. 535-563
    • Gama Sosa, M.A.1    De Gasperi, R.2    Elder, G.A.3
  • 21
    • 84861458112 scopus 로고    scopus 로고
    • Using zebrafish to unravel the genetics of complex brain disorders
    • Gerlai R. Using zebrafish to unravel the genetics of complex brain disorders. Curr Top Behav Neurosci 2012, 12:3-24.
    • (2012) Curr Top Behav Neurosci , vol.12 , pp. 3-24
    • Gerlai, R.1
  • 22
    • 84941754313 scopus 로고    scopus 로고
    • Zebrafish, a potential novel research tool for the analysis and modeling of anxiety
    • 〈intechopen.com〉, S. Selek (Ed.)
    • Gerlai G.R. Zebrafish, a potential novel research tool for the analysis and modeling of anxiety. Different views on anxiety disorders 2011, 〈intechopen.com〉. S. Selek (Ed.).
    • (2011) Different views on anxiety disorders
    • Gerlai, G.R.1
  • 23
    • 0034486729 scopus 로고    scopus 로고
    • Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects
    • Gerlai R., Lahav M., Guo S., Rosenthal A. Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav 2000, 67:773-782.
    • (2000) Pharmacol Biochem Behav , vol.67 , pp. 773-782
    • Gerlai, R.1    Lahav, M.2    Guo, S.3    Rosenthal, A.4
  • 24
    • 77249094974 scopus 로고    scopus 로고
    • Latent learning in zebrafish (Danio rerio)
    • Gómez-Laplaza L.M., Gerlai R. Latent learning in zebrafish (Danio rerio). Behav Brain Res 2010, 208:509-515.
    • (2010) Behav Brain Res , vol.208 , pp. 509-515
    • Gómez-Laplaza, L.M.1    Gerlai, R.2
  • 25
    • 78149337549 scopus 로고    scopus 로고
    • Modified associative learning T-maze test for zebrafish (Danio rerio) and other small teleost fish
    • A.V. Kalueff, J. Cachat (Eds.)
    • Gould G.G. Modified associative learning T-maze test for zebrafish (Danio rerio) and other small teleost fish. Zebrafish neurobehavioral protocols, neuromethods 2011, 61-74. A.V. Kalueff, J. Cachat (Eds.).
    • (2011) Zebrafish neurobehavioral protocols, neuromethods , pp. 61-74
    • Gould, G.G.1
  • 26
  • 28
    • 80054783440 scopus 로고    scopus 로고
    • Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors
    • Guo S., Wagle M., Mathur P. Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors. Dev Neurobiol 2011.
    • (2011) Dev Neurobiol
    • Guo, S.1    Wagle, M.2    Mathur, P.3
  • 29
    • 63149158008 scopus 로고    scopus 로고
    • The power of the zebrafish for disease analysis
    • Ingham P.W. The power of the zebrafish for disease analysis. Hum Mol Gen 2009, 18:R107-R112.
    • (2009) Hum Mol Gen , vol.18 , pp. R107-R112
    • Ingham, P.W.1
  • 30
    • 84856977139 scopus 로고    scopus 로고
    • Fear anxiety, and control in the zebrafish
    • Jesuthasan S. Fear anxiety, and control in the zebrafish. Dev Neurobiol 2012, 72:395-403.
    • (2012) Dev Neurobiol , vol.72 , pp. 395-403
    • Jesuthasan, S.1
  • 31
    • 78751704366 scopus 로고    scopus 로고
    • Zebrafish models for the functional genomics of neurogenetic disorders
    • Kabashi E., Brustein E., Champagne N., Drapeau P. Zebrafish models for the functional genomics of neurogenetic disorders. BBA-Mol Basis Dis 2011, 1812:335-345.
    • (2011) BBA-Mol Basis Dis , vol.1812 , pp. 335-345
    • Kabashi, E.1    Brustein, E.2    Champagne, N.3    Drapeau, P.4
  • 32
    • 77955089579 scopus 로고    scopus 로고
    • In the swim of things: recent insights to neurogenetic disorders from zebrafish
    • Kabashi E., Champagne N., Brustein E., Drapeau P. In the swim of things: recent insights to neurogenetic disorders from zebrafish. Trends Genet 2010, 26:373-381.
    • (2010) Trends Genet , vol.26 , pp. 373-381
    • Kabashi, E.1    Champagne, N.2    Brustein, E.3    Drapeau, P.4
  • 34
    • 77249135113 scopus 로고    scopus 로고
    • Rapid behavior-based identification of neuroactive small molecules in the zebrafish
    • Kokel D., Bryan J., Laggner C., White R., Cheung C.Y.J., Mateus R., et al. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol 2010, 6:231-237.
    • (2010) Nat Chem Biol , vol.6 , pp. 231-237
    • Kokel, D.1    Bryan, J.2    Laggner, C.3    White, R.4    Cheung, C.Y.J.5    Mateus, R.6
  • 35
    • 58149380087 scopus 로고    scopus 로고
    • Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish
    • Kokel D., Peterson R.T. Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Brief Funct Genomics Proteomics 2008, 7:483-490.
    • (2008) Brief Funct Genomics Proteomics , vol.7 , pp. 483-490
    • Kokel, D.1    Peterson, R.T.2
  • 36
    • 80053189736 scopus 로고    scopus 로고
    • Using the zebrafish photomotor response for psychotropic drug screening
    • Kokel D., Peterson R.T. Using the zebrafish photomotor response for psychotropic drug screening. Methods Cell Biol 2011, 105:517-524.
    • (2011) Methods Cell Biol , vol.105 , pp. 517-524
    • Kokel, D.1    Peterson, R.T.2
  • 37
    • 84863867756 scopus 로고    scopus 로고
    • Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology
    • Kokel D., Rennekamp A.J., Shah A.H., Liebel U., Peterson R.T. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology. Trends Biotechnol 2012, 1-5.
    • (2012) Trends Biotechnol , pp. 1-5
    • Kokel, D.1    Rennekamp, A.J.2    Shah, A.H.3    Liebel, U.4    Peterson, R.T.5
  • 38
    • 84863867756 scopus 로고    scopus 로고
    • Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology
    • Kokel D., Rennekamp A.J., Shah A.H., Liebel U., Peterson R.T. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology. Trends Biotechnol 2012, 30:421-425.
    • (2012) Trends Biotechnol , vol.30 , pp. 421-425
    • Kokel, D.1    Rennekamp, A.J.2    Shah, A.H.3    Liebel, U.4    Peterson, R.T.5
  • 40
    • 80052972631 scopus 로고    scopus 로고
    • The developing zebrafish (Danio rerio): a vertebrate model for high-throughput screening of chemical libraries
    • Lessman C.A. The developing zebrafish (Danio rerio): a vertebrate model for high-throughput screening of chemical libraries. Birth Defects Res, C: Embryo Today: Rev 2011, 93:268-280.
    • (2011) Birth Defects Res, C: Embryo Today: Rev , vol.93 , pp. 268-280
    • Lessman, C.A.1
  • 41
    • 79960085088 scopus 로고    scopus 로고
    • The serotonergic system in fish
    • Lillesaar C. The serotonergic system in fish. J Chem Neuroanat 2011, 41:294-308.
    • (2011) J Chem Neuroanat , vol.41 , pp. 294-308
    • Lillesaar, C.1
  • 42
    • 79959354143 scopus 로고    scopus 로고
    • Analysis of behavioral changes of zebrafish (Danio rerio) in response to formaldehyde using Self-organizing map and a hidden Markov model
    • Liu Y., Lee S.-H., Chon T.-S. Analysis of behavioral changes of zebrafish (Danio rerio) in response to formaldehyde using Self-organizing map and a hidden Markov model. Ecol Modell 2011, 222:2191-2201.
    • (2011) Ecol Modell , vol.222 , pp. 2191-2201
    • Liu, Y.1    Lee, S.-H.2    Chon, T.-S.3
  • 43
    • 80053175310 scopus 로고    scopus 로고
    • In search of optimal fear inducing stimuli: differential behavioral responses to computer animated images in zebrafish
    • Luca R.M., Gerlai R. In search of optimal fear inducing stimuli: differential behavioral responses to computer animated images in zebrafish. Behav Brain Res 2012, 226:66-76.
    • (2012) Behav Brain Res , vol.226 , pp. 66-76
    • Luca, R.M.1    Gerlai, R.2
  • 44
    • 84889592996 scopus 로고    scopus 로고
    • Using an automated 3D-tracking system to record individual shoals of adult zebrafish
    • Maaswinkel H., Zhu L., Weng W. Using an automated 3D-tracking system to record individual shoals of adult zebrafish. J Visual Exp: JoVE 2013, 50681.
    • (2013) J Visual Exp: JoVE , pp. 50681
    • Maaswinkel, H.1    Zhu, L.2    Weng, W.3
  • 46
    • 57649140590 scopus 로고    scopus 로고
    • Removing obstacles in neuroscience drug discovery: the future path for animal models
    • official publication of the American College of Neuropsychopharmacology
    • Markou A., Chiamulera C., Geyer M.A., Tricklebank M., Steckler T. Removing obstacles in neuroscience drug discovery: the future path for animal models. Neuropsychopharmacology 2008, 34:74-89. official publication of the American College of Neuropsychopharmacology.
    • (2008) Neuropsychopharmacology , vol.34 , pp. 74-89
    • Markou, A.1    Chiamulera, C.2    Geyer, M.A.3    Tricklebank, M.4    Steckler, T.5
  • 47
    • 79952699351 scopus 로고    scopus 로고
    • Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish
    • Mathur P., Guo S. Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. Behav Brain Res 2011, 219:234-239.
    • (2011) Behav Brain Res , vol.219 , pp. 234-239
    • Mathur, P.1    Guo, S.2
  • 48
    • 77955847027 scopus 로고    scopus 로고
    • Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes
    • Mathur P., Guo S. Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiol Dis 2010, 40:66-72.
    • (2010) Neurobiol Dis , vol.40 , pp. 66-72
    • Mathur, P.1    Guo, S.2
  • 49
    • 79952389543 scopus 로고    scopus 로고
    • Conditioned place preference behavior in zebrafish
    • Mathur P., Lau B., Guo S. Conditioned place preference behavior in zebrafish. Nat Protoc 2011, 6:338-345.
    • (2011) Nat Protoc , vol.6 , pp. 338-345
    • Mathur, P.1    Lau, B.2    Guo, S.3
  • 50
    • 84905102303 scopus 로고    scopus 로고
    • Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors
    • Maximino C., da Silva A.W., Araujo J., Lima M.G., Miranda V., Puty B., et al. Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors. PLoS ONE 2014, 9:e431039.
    • (2014) PLoS ONE , vol.9 , pp. e431039
    • Maximino, C.1    da Silva, A.W.2    Araujo, J.3    Lima, M.G.4    Miranda, V.5    Puty, B.6
  • 52
    • 84859914613 scopus 로고    scopus 로고
    • Stages in the development of a model organism as a platform for mechanistic models in developmental biology: Zebrafish, 1970â€"2000
    • Meunier R. Stages in the development of a model organism as a platform for mechanistic models in developmental biology: Zebrafish, 1970â€"2000. Stud Hist Philos Biol Biomed Sci 2012, 43:522-531.
    • (2012) Stud Hist Philos Biol Biomed Sci , vol.43 , pp. 522-531
    • Meunier, R.1
  • 56
    • 77955059514 scopus 로고    scopus 로고
    • Adult zebrafish as a model organism for behavioural genetics
    • Norton W., Bally-Cuif L. Adult zebrafish as a model organism for behavioural genetics. BMC Neurosci 2010, 11:90.
    • (2010) BMC Neurosci , vol.11 , pp. 90
    • Norton, W.1    Bally-Cuif, L.2
  • 57
    • 77955844066 scopus 로고    scopus 로고
    • The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases
    • Panula P., Chen Y.C., Priyadarshini M., Kudo H., Semenova S., Sundvik M., et al. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiol Dis 2010, 40:46-57.
    • (2010) Neurobiol Dis , vol.40 , pp. 46-57
    • Panula, P.1    Chen, Y.C.2    Priyadarshini, M.3    Kudo, H.4    Semenova, S.5    Sundvik, M.6
  • 58
    • 33745540146 scopus 로고    scopus 로고
    • Modulatory neurotransmitter systems and behavior: towards zebrafish models of neurodegenerative diseases
    • Panula P., Sallinen V., Sundvik M., Kolehmainen J., Torkko V., Tiittula A., et al. Modulatory neurotransmitter systems and behavior: towards zebrafish models of neurodegenerative diseases. Zebrafish 2006, 3:235-247.
    • (2006) Zebrafish , vol.3 , pp. 235-247
    • Panula, P.1    Sallinen, V.2    Sundvik, M.3    Kolehmainen, J.4    Torkko, V.5    Tiittula, A.6
  • 62
    • 84855955477 scopus 로고    scopus 로고
    • Behavioral and physiological effects of acute ketamine exposure in adult zebrafish
    • Riehl R., Kyzar E., Allain A., Green J., Hook M., Monnig L., et al. Behavioral and physiological effects of acute ketamine exposure in adult zebrafish. Neurotoxicol Teratol 2011, 33:658-667.
    • (2011) Neurotoxicol Teratol , vol.33 , pp. 658-667
    • Riehl, R.1    Kyzar, E.2    Allain, A.3    Green, J.4    Hook, M.5    Monnig, L.6
  • 63
    • 74549126594 scopus 로고    scopus 로고
    • Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    • Rihel J., Prober D.A., Arvanites A., Lam K., Zimmerman S., Jang S., et al. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (New York N.Y.) 2010, 327:348-351.
    • (2010) Science (New York N.Y.) , vol.327 , pp. 348-351
    • Rihel, J.1    Prober, D.A.2    Arvanites, A.3    Lam, K.4    Zimmerman, S.5    Jang, S.6
  • 64
    • 78650607495 scopus 로고    scopus 로고
    • An integrative system for neurogenomics and neurosciences
    • Rinkwitz S., Mourrain P., Becker T.S., Zebrafish: An integrative system for neurogenomics and neurosciences. Prog Neurobiol 2011, 93:231-243.
    • (2011) Prog Neurobiol , vol.93 , pp. 231-243
    • Rinkwitz, S.1    Mourrain, P.2    Becker, T.S.3
  • 65
    • 79955828938 scopus 로고    scopus 로고
    • Differences in spatio-temporal behavior of zebrafish in the open tank paradigm after a short-period confinement into dark and bright environments
    • Rosemberg D.B., Rico E.P., Mussulini B.H., Piato A.L., Calcagnotto M.E., Bonan C.D., et al. Differences in spatio-temporal behavior of zebrafish in the open tank paradigm after a short-period confinement into dark and bright environments. PLoS ONE 2011, 6:e71939.
    • (2011) PLoS ONE , vol.6 , pp. e71939
    • Rosemberg, D.B.1    Rico, E.P.2    Mussulini, B.H.3    Piato, A.L.4    Calcagnotto, M.E.5    Bonan, C.D.6
  • 68
    • 84906849253 scopus 로고    scopus 로고
    • Integrating cross-scale analysis in the spatial and temporal domains for classification of behavioral movement
    • Soleymani A., Cachat J.M., Robinson K., Dodge S., Kalueff A., Wurbel R. Integrating cross-scale analysis in the spatial and temporal domains for classification of behavioral movement. J Spatial Inform Sci 2014, 8:1-25.
    • (2014) J Spatial Inform Sci , vol.8 , pp. 1-25
    • Soleymani, A.1    Cachat, J.M.2    Robinson, K.3    Dodge, S.4    Kalueff, A.5    Wurbel, R.6
  • 69
    • 55949136342 scopus 로고    scopus 로고
    • Track3D: visualization and flight track analysis of Anopheles gambiae ss mosquitoes
    • Spitzen J., Spoor C., Kranenbarg S. Track3D: visualization and flight track analysis of Anopheles gambiae ss mosquitoes. Proc Measur Behav 2008.
    • (2008) Proc Measur Behav
    • Spitzen, J.1    Spoor, C.2    Kranenbarg, S.3
  • 76
    • 84923253301 scopus 로고    scopus 로고
    • Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery
    • Stewart A.M., Gerlai R., Kalueff A.V. Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery. Front Behav Neurosci 2015, 9:14.
    • (2015) Front Behav Neurosci , vol.9 , pp. 14
    • Stewart, A.M.1    Gerlai, R.2    Kalueff, A.V.3
  • 77
    • 84890497787 scopus 로고    scopus 로고
    • Anxiolytic drug discovery: what are the novel approaches and how can we improve them?
    • Stewart A.M., Kalueff A.V. Anxiolytic drug discovery: what are the novel approaches and how can we improve them?. Expert Opin Drug Discovery 2014, 9:15-26.
    • (2014) Expert Opin Drug Discovery , vol.9 , pp. 15-26
    • Stewart, A.M.1    Kalueff, A.V.2
  • 78
    • 84899972497 scopus 로고    scopus 로고
    • Developing better and more valid animal models of brain disorders
    • Stewart A.M., Kalueff A.V. Developing better and more valid animal models of brain disorders. Behav Brain Res 2013.
    • (2013) Behav Brain Res
    • Stewart, A.M.1    Kalueff, A.V.2
  • 81
    • 79958756212 scopus 로고    scopus 로고
    • Vanishing clinical psychopharmacology
    • van Gerven J., Cohen A. Vanishing clinical psychopharmacology. Br J Clin Pharmacol 2011, 72:1-5.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 1-5
    • van Gerven, J.1    Cohen, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.