-
1
-
-
0021326738
-
The preclinical new drug research program of the National Cancer Institute.
-
Driscoll JS. The preclinical new drug research program of the National Cancer Institute. Cancer Treat Rep 1984, 68:63-76.
-
(1984)
Cancer Treat Rep
, vol.68
, pp. 63-76
-
-
Driscoll, J.S.1
-
2
-
-
77957075885
-
Some effects of barbituric and diethylbarbituric acid on the development of the zebra fish, Brachydanio rerio.
-
Hisaoka K, Hopper A. Some effects of barbituric and diethylbarbituric acid on the development of the zebra fish, Brachydanio rerio. Anat Rec 1957, 129:297-307.
-
(1957)
Anat Rec
, vol.129
, pp. 297-307
-
-
Hisaoka, K.1
Hopper, A.2
-
3
-
-
77957061971
-
Factors influencing mitotic activity and morphogenesis in embryonic development. I. The effects of thyroxine and thiouracil on the development of Brachydanio rerio (zebrafish).
-
Jones R, Gibson W, Nickolls C. Factors influencing mitotic activity and morphogenesis in embryonic development. I. The effects of thyroxine and thiouracil on the development of Brachydanio rerio (zebrafish). Anat Rec 1951, 111:440-586.
-
(1951)
Anat Rec
, vol.111
, pp. 440-586
-
-
Jones, R.1
Gibson, W.2
Nickolls, C.3
-
4
-
-
0000647552
-
Fish embryos as bio-assay material in testing chemicals for effects on cell division and differentiation.
-
Jones R, Huffman M. Fish embryos as bio-assay material in testing chemicals for effects on cell division and differentiation. Trans Am Microsc Soc 1957, 76:177-183.
-
(1957)
Trans Am Microsc Soc
, vol.76
, pp. 177-183
-
-
Jones, R.1
Huffman, M.2
-
5
-
-
0034700166
-
Small molecule developmental screens reveal the logic and timing of vertebrate development.
-
Peterson RT, Link BA, Dowling JE, Schreiber SL. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci U S A 2000, 97:12965-12969.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12965-12969
-
-
Peterson, R.T.1
Link, B.A.2
Dowling, J.E.3
Schreiber, S.L.4
-
6
-
-
2342454415
-
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.
-
Peterson RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, Schreiber SL, Macrae CA, Fishman MC. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol 2004, 22:595-599.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 595-599
-
-
Peterson, R.T.1
Shaw, S.Y.2
Peterson, T.A.3
Milan, D.J.4
Zhong, T.P.5
Schreiber, S.L.6
Macrae, C.A.7
Fishman, M.C.8
-
7
-
-
33644788489
-
Small molecules that delay S phase suppress a zebrafish bmyb mutant.
-
Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub CT, Pfaff KL, Weber G, Tallarico JA, King RW, Zon LI. Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol 2005, 1:366-370.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 366-370
-
-
Stern, H.M.1
Murphey, R.D.2
Shepard, J.L.3
Amatruda, J.F.4
Straub, C.T.5
Pfaff, K.L.6
Weber, G.7
Tallarico, J.A.8
King, R.W.9
Zon, L.I.10
-
8
-
-
33751032262
-
A chemical genetic screen for cell cycle inhibitors in zebrafish embryos.
-
Murphey RD, Stern HM, Straub CT, Zon LI. A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Design 2006, 68:213-219.
-
(2006)
Chem Biol Drug Design
, vol.68
, pp. 213-219
-
-
Murphey, R.D.1
Stern, H.M.2
Straub, C.T.3
Zon, L.I.4
-
9
-
-
76049128716
-
Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models.
-
Cao Y, Semanchik N, Lee SH, Somlo S, Barbano PE, Coifman R, Sun Z. Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proc Natl Acad Sci U S A 2009, 106:21819-21824.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 21819-21824
-
-
Cao, Y.1
Semanchik, N.2
Lee, S.H.3
Somlo, S.4
Barbano, P.E.5
Coifman, R.6
Sun, Z.7
-
10
-
-
38949180229
-
AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression.
-
Yeh JR, Munson KM, Chao YL, Peterson QP, Macrae CA, Peterson RT. AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development 2008, 135:401-410.
-
(2008)
Development
, vol.135
, pp. 401-410
-
-
Yeh, J.R.1
Munson, K.M.2
Chao, Y.L.3
Peterson, Q.P.4
Macrae, C.A.5
Peterson, R.T.6
-
11
-
-
34250883337
-
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
-
North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang I-H, Grosser T, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 2007, 447:1007-1011.
-
(2007)
Nature
, vol.447
, pp. 1007-1011
-
-
North, T.E.1
Goessling, W.2
Walkley, C.R.3
Lengerke, C.4
Kopani, K.R.5
Lord, A.M.6
Weber, G.J.7
Bowman, T.V.8
Jang, I.-H.9
Grosser, T.10
-
12
-
-
79751468871
-
Zebrafish models for cancer.
-
Liu S, Leach SD. Zebrafish models for cancer. Annu Rev Pathol 2011, 6:71-93.
-
(2011)
Annu Rev Pathol
, vol.6
, pp. 71-93
-
-
Liu, S.1
Leach, S.D.2
-
13
-
-
19944426854
-
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
-
Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Fletcher CD, Morris JP, Liu TX, Schulte-Merker S, Kanki JP, et al. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A 2005, 102:407-412.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 407-412
-
-
Berghmans, S.1
Murphey, R.D.2
Wienholds, E.3
Neuberg, D.4
Kutok, J.L.5
Fletcher, C.D.6
Morris, J.P.7
Liu, T.X.8
Schulte-Merker, S.9
Kanki, J.P.10
-
14
-
-
13444258032
-
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
-
Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 2005, 15:249-254.
-
(2005)
Curr Biol
, vol.15
, pp. 249-254
-
-
Patton, E.E.1
Widlund, H.R.2
Kutok, J.L.3
Kopani, K.R.4
Amatruda, J.F.5
Murphey, R.D.6
Berghmans, S.7
Mayhall, E.A.8
Traver, D.9
Fletcher, C.D.10
-
15
-
-
74049101047
-
Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.
-
Dovey M, White RM, Zon LI. Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish 2009, 6:397-404.
-
(2009)
Zebrafish
, vol.6
, pp. 397-404
-
-
Dovey, M.1
White, R.M.2
Zon, L.I.3
-
16
-
-
74049135297
-
Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation.
-
Anelli V, Santoriello C, Distel M, Koster RW, Ciccarelli FD, Mione M. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Zebrafish 2009, 6:417-424.
-
(2009)
Zebrafish
, vol.6
, pp. 417-424
-
-
Anelli, V.1
Santoriello, C.2
Distel, M.3
Koster, R.W.4
Ciccarelli, F.D.5
Mione, M.6
-
17
-
-
0036337052
-
Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis.
-
Kalev-Zylinska ML, Horsfield JA, Flores MVC, Postlethwait JH, Vitas MR, Baas AM, Crosier PS, Crosier KE. Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development 2002, 129:2015-2030.
-
(2002)
Development
, vol.129
, pp. 2015-2030
-
-
Kalev-Zylinska, M.L.1
Horsfield, J.A.2
Flores, M.V.C.3
Postlethwait, J.H.4
Vitas, M.R.5
Baas, A.M.6
Crosier, P.S.7
Crosier, K.E.8
-
18
-
-
12844253743
-
Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion.
-
Onnebo SM, Condron MM, McPhee DO, Lieschke GJ, Ward AC. Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion. Exp Hematol 2005, 33:182-188.
-
(2005)
Exp Hematol
, vol.33
, pp. 182-188
-
-
Onnebo, S.M.1
Condron, M.M.2
McPhee, D.O.3
Lieschke, G.J.4
Ward, A.C.5
-
19
-
-
33847211457
-
NOTCH1-induced T-cell leukemia in transgenic zebrafish.
-
Chen J, Jette C, Kanki JP, Aster JC, Look AT, Griffin JD. NOTCH1-induced T-cell leukemia in transgenic zebrafish. Leukemia 2007, 21:462-471.
-
(2007)
Leukemia
, vol.21
, pp. 462-471
-
-
Chen, J.1
Jette, C.2
Kanki, J.P.3
Aster, J.C.4
Look, A.T.5
Griffin, J.D.6
-
20
-
-
0347785481
-
Myc-induced T cell leukemia in transgenic zebrafish.
-
Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, et al. Myc-induced T cell leukemia in transgenic zebrafish. Science 2003, 299:887-890.
-
(2003)
Science
, vol.299
, pp. 887-890
-
-
Langenau, D.M.1
Traver, D.2
Ferrando, A.A.3
Kutok, J.L.4
Aster, J.C.5
Kanki, J.P.6
Lin, S.7
Prochownik, E.8
Trede, N.S.9
Zon, L.I.10
-
21
-
-
33750044055
-
TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia.
-
Sabaawy HE, Azuma M, Embree LJ, Tsai HJ, Starost MF, Hickstein DD. TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 2006, 103:15166-15171.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 15166-15171
-
-
Sabaawy, H.E.1
Azuma, M.2
Embree, L.J.3
Tsai, H.J.4
Starost, M.F.5
Hickstein, D.D.6
-
22
-
-
44649114063
-
Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.
-
Park SW, Davison JM, Rhee J, Hruban RH, Maitra A, Leach SD. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology 2008, 134:2080-2090.
-
(2008)
Gastroenterology
, vol.134
, pp. 2080-2090
-
-
Park, S.W.1
Davison, J.M.2
Rhee, J.3
Hruban, R.H.4
Maitra, A.5
Leach, S.D.6
-
23
-
-
34547179422
-
Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.
-
Le X, Langenau DM, Keefe MD, Kutok JL, Neuberg DS, Zon LI. Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish. Proc Natl Acad Sci U S A 2007, 104:9410-9415.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 9410-9415
-
-
Le, X.1
Langenau, D.M.2
Keefe, M.D.3
Kutok, J.L.4
Neuberg, D.S.5
Zon, L.I.6
-
24
-
-
34249905448
-
Effects of RAS on the genesis of embryonal rhabdomyosarcoma.
-
Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le X, Goessling W, Neuberg DS, Kunkel LM, Zon LI. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev 2007, 21:1382-1395.
-
(2007)
Genes Dev
, vol.21
, pp. 1382-1395
-
-
Langenau, D.M.1
Keefe, M.D.2
Storer, N.Y.3
Guyon, J.R.4
Kutok, J.L.5
Le, X.6
Goessling, W.7
Neuberg, D.S.8
Kunkel, L.M.9
Zon, L.I.10
-
25
-
-
79953064886
-
DHODH modulates transcriptional elongation in the neural crest and melanoma.
-
White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, et al. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature 2011, 471:518-522.
-
(2011)
Nature
, vol.471
, pp. 518-522
-
-
White, R.M.1
Cech, J.2
Ratanasirintrawoot, S.3
Lin, C.Y.4
Rahl, P.B.5
Burke, C.J.6
Langdon, E.7
Tomlinson, M.L.8
Mosher, J.9
Kaufman, C.10
-
26
-
-
77249135113
-
Rapid behavior-based identification of neuroactive small molecules in the zebrafish.
-
Kokel D, Bryan J, Laggner C, White R, Cheung CYJ, Mateus R, Healey D, Kim S, Werdich AA, Haggarty SJ, et al. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol 2010, 6:231-237.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 231-237
-
-
Kokel, D.1
Bryan, J.2
Laggner, C.3
White, R.4
Cheung, C.Y.J.5
Mateus, R.6
Healey, D.7
Kim, S.8
Werdich, A.A.9
Haggarty, S.J.10
-
27
-
-
74549126594
-
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.
-
Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, et al. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 2010, 327:348-351.
-
(2010)
Science
, vol.327
, pp. 348-351
-
-
Rihel, J.1
Prober, D.A.2
Arvanites, A.3
Lam, K.4
Zimmerman, S.5
Jang, S.6
Haggarty, S.J.7
Kokel, D.8
Rubin, L.L.9
Peterson, R.T.10
-
28
-
-
37249010753
-
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.
-
Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 2008, 4:33-41.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 33-41
-
-
Yu, P.B.1
Hong, C.C.2
Sachidanandan, C.3
Babitt, J.L.4
Deng, D.Y.5
Hoyng, S.A.6
Lin, H.Y.7
Bloch, K.D.8
Peterson, R.T.9
-
29
-
-
69249210903
-
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.
-
Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, Znosko W, Smithgall TE, Bahar I, Lazo JS, Day BW, et al. Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol 2009, 5:680-687.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 680-687
-
-
Molina, G.1
Vogt, A.2
Bakan, A.3
Dai, W.4
Queiroz de Oliveira, P.5
Znosko, W.6
Smithgall, T.E.7
Bahar, I.8
Lazo, J.S.9
Day, B.W.10
-
30
-
-
77953112505
-
Small molecule screen in zebrafish and HSC expansion.
-
Trompouki E, Zon LI. Small molecule screen in zebrafish and HSC expansion. Methods Mol Biol 2010, 636:301-316.
-
(2010)
Methods Mol Biol
, vol.636
, pp. 301-316
-
-
Trompouki, E.1
Zon, L.I.2
-
31
-
-
70349126280
-
Chemical genetic screening in the zebrafish embryo.
-
Kaufman CK, White RM, Zon L. Chemical genetic screening in the zebrafish embryo. Nat Protocols 2009, 4:1422-1432.
-
(2009)
Nat Protocols
, vol.4
, pp. 1422-1432
-
-
Kaufman, C.K.1
White, R.M.2
Zon, L.3
-
32
-
-
79959641354
-
A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos.
-
Adatto I, Lawrence C, Thompson M, Zon LI. A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos. PLoS One 2011, 6:e21715.
-
(2011)
PLoS One
, vol.6
-
-
Adatto, I.1
Lawrence, C.2
Thompson, M.3
Zon, L.I.4
-
33
-
-
77955169046
-
High-throughput in vivo vertebrate screening.
-
Pardo-Martin C, Chang TY, Koo BK, Gilleland CL, Wasserman SC, Yanik MF. High-throughput in vivo vertebrate screening. Nat Methods 2010, 7:634-636.
-
(2010)
Nat Methods
, vol.7
, pp. 634-636
-
-
Pardo-Martin, C.1
Chang, T.Y.2
Koo, B.K.3
Gilleland, C.L.4
Wasserman, S.C.5
Yanik, M.F.6
-
34
-
-
80355140624
-
Development of automated imaging and analysis for zebrafish chemical screens.
-
Vogt A, Codore H, Day BW, Hukriede NA, Tsang M. Development of automated imaging and analysis for zebrafish chemical screens. J Vis Exp 2010, 40:e1900.
-
(2010)
J Vis Exp
, vol.40
-
-
Vogt, A.1
Codore, H.2
Day, B.W.3
Hukriede, N.A.4
Tsang, M.5
-
35
-
-
61649105020
-
Automated image-based phenotypic analysis in zebrafish embryos.
-
Vogt A, Cholewinski A, Shen X, Nelson SG, Lazo JS, Tsang M, Hukriede NA. Automated image-based phenotypic analysis in zebrafish embryos. Dev Dyn 2009, 238:656-663.
-
(2009)
Dev Dyn
, vol.238
, pp. 656-663
-
-
Vogt, A.1
Cholewinski, A.2
Shen, X.3
Nelson, S.G.4
Lazo, J.S.5
Tsang, M.6
Hukriede, N.A.7
-
36
-
-
37049028158
-
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.
-
Tran TC, Sneed B, Haider J, Blavo D, White A, Aiyejorun T, Baranowski TC, Rubinstein AL, Doan TN, Dingledine R, et al. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res 2007, 67:11386-11392.
-
(2007)
Cancer Res
, vol.67
, pp. 11386-11392
-
-
Tran, T.C.1
Sneed, B.2
Haider, J.3
Blavo, D.4
White, A.5
Aiyejorun, T.6
Baranowski, T.C.7
Rubinstein, A.L.8
Doan, T.N.9
Dingledine, R.10
-
37
-
-
77149143194
-
Fish proteome analysis: model organisms and non-sequenced species.
-
Forné I, Abián J, Cerdà J. Fish proteome analysis: model organisms and non-sequenced species. Proteomics 2010, 10:858-872.
-
(2010)
Proteomics
, vol.10
, pp. 858-872
-
-
Forné, I.1
Abián, J.2
Cerdà, J.3
-
38
-
-
35949000935
-
Tagged small molecule library approach for facilitated chemical genetics.
-
Ahn Y-H, Chang Y-T. Tagged small molecule library approach for facilitated chemical genetics. Acc Chem Res 2007, 40:1025-1033.
-
(2007)
Acc Chem Res
, vol.40
, pp. 1025-1033
-
-
Ahn, Y.-H.1
Chang, Y.-T.2
-
39
-
-
84886249451
-
-
HHMI's BioInteractive-What is chemical genetics
-
HHMI's BioInteractive-What is chemical genetics? (http://www.hhmi.org/biointeractive/genomics/poster_a2.html)
-
-
-
-
40
-
-
84886245219
-
-
Harvard Medical School Screening Facility-Chemical Libraries
-
Harvard Medical School Screening Facility-Chemical Libraries http://iccb.med.harvard.edu/screening/compound_libraries/index.htm
-
-
-
|