Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes

Journal of the American Chemical Society

Volumn 137, Issue 36, 2015, Pages 11846-11853

  Ye, Ying ^a   Minami, Atsushi ^a   Mandi, Attila ^a   Liu, Chengwei ^a   Taniguchi, Tohru ^a   Kuzuyama, Tomohisa ^b   Monde, Kenji ^a   Gomi, Katsuya ^c   Oikawa, Hideaki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERGILLUS; GENE EXPRESSION; GENES; METABOLITES; OLEFINS; POSITIVE IONS; TERPENES;

AMINO ACID SEQUENCE; CATION INTERMEDIATES; ENZYMATIC REACTION; HETEROLOGOUS EXPRESSION; ISOTOPICALLY LABELED; NEOSARTORYA FISCHERI; PHYLOGENETIC ANALYSIS; SECONDARY METABOLITES;

CYCLIZATION;

BIFUNCTIONAL TERPENE SYNTHASE; CYTOCHROME P450; DITERPENE; SESTERTERPENE; SYNTHETASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; SESQUITERPENE; TERPENE SYNTHASE; TRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS ORYZAE; BIOGENESIS; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CLADISTICS; CONFORMATIONAL TRANSITION; CYCLIZATION; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME MECHANISM; FUNGAL GENOME; GENE CLUSTER; GENE PRODUCT; GENOME ANALYSIS; GENOME MINING; HETEROLOGOUS EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEMBRANE BINDING; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PHYLOGENY; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; GENETICS; METABOLISM;

ALKYL AND ARYL TRANSFERASES; ASPERGILLUS ORYZAE; GENOME, FUNGAL; SESQUITERPENES;

EID: 84941768267     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b08319     Document Type: Article

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