Two Peptides from Soy β-Conglycinin Induce a Hypocholesterolemic Effect in HepG2 Cells by a Statin-Like Mechanism: Comparative in Vitro and in Silico Modeling Studies

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 36, 2015, Pages 7945-7951

  Lammi, Carmen ^a   Zanoni, Chiara ^b   Arnoldi, Anna ^a   Vistoli, Giulio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b OSPEDALE NIGUARDA CA GRANDA   (Italy)

Author keywords

cholesterol regulation; HepG2 cell line; HMGCoA reductase; plant protein; conglycinin

Indexed keywords

CELL CULTURE; CHOLESTEROL; PEPTIDES;

CHOLESTEROL METABOLISM; CONGLYCININ; HEPG2 CELL LINE; HMG-COA REDUCTASE; HYPOCHOLESTEROLEMIC EFFECT; LOW DENSITY LIPOPROTEINS; PLANT PROTEINS; PROTEIN PRODUCTION;

PROTEINS;

BETA-CONGLYCININ PROTEIN, GLYCINE MAX; CHOLESTEROL; GLOBULIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; PEPTIDE; PLANT ANTIGEN; SEED STORAGE PROTEIN; SOYBEAN PROTEIN;

CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEPG2 CELL LINE; HUMAN; LIVER CELL; METABOLISM;

ANTICHOLESTEREMIC AGENTS; ANTIGENS, PLANT; CHOLESTEROL; COMPUTER SIMULATION; GLOBULINS; HEP G2 CELLS; HEPATOCYTES; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MODELS, MOLECULAR; PEPTIDES; SEED STORAGE PROTEINS; SOYBEAN PROTEINS;

EID: 84941767791     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b03497     Document Type: Article

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