Changes in lipid metabolism by soy β-conglycinin-derived peptides in hepg2 cells

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 4, 2009, Pages 1473-1480

  Mochizuki, Yuko ^a   Maebuchi, Motohiro ^b   Kohno, Mitsutaka ^b   Hirotsuka, Motohiko ^b   Wadahama, Hiroyuki ^a   Moriyama, Tatsuya ^a,c   Kawada, Teruo ^a   Urade, Reiko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b FUJI OIL CO LTD   (Japan)

^c KINKI UNIVERSITY   (Japan)

Author keywords

conglycinin; Apolipoprotein B 100; HepG2 cells; Peptides; Soy protein; Triacylglycerol

Indexed keywords

APOLIPOPROTEIN B100; BETA CONGLYCININ PROTEIN, GLYCINE MAX; BETA-CONGLYCININ PROTEIN, GLYCINE MAX; GLOBULIN; LIPOPROTEIN; PEPTIDE; PEPTIDE HYDROLASE; SEED STORAGE PROTEIN; SOYBEAN PROTEIN; TRIACYLGLYCEROL;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; HUMAN; LIPID METABOLISM; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; SOYBEAN; TUMOR CELL LINE;

APOLIPOPROTEIN B-100; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GLOBULINS; HUMANS; LIPID METABOLISM; LIPOPROTEINS; LIVER NEOPLASMS; PEPTIDE HYDROLASES; PEPTIDES; SEED STORAGE PROTEINS; SOYBEAN PROTEINS; SOYBEANS; TRIGLYCERIDES;

GLYCINE MAX;

EID: 64549096895     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf8031793     Document Type: Article

References (28)

1. Teixeira, S. R.; Potter, S. M.; Weigel, R.; Hannum, S.; Erdman, J. W., Jr.; Hasler, M. E. Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am. J. Clin. Nutr. 2000, 71, 1077-1084.
2. Potter, S. M. Soy protein and cardiovascular disease: The impact of bioactive components in soy. Nutr. Rev. 1998, 56, 231-235.
3. Fukui, K.; Kojima, M.; Tachibana, N.; Kohno, M.; Takamatsu, K.; Hirotsuka, M.; Kito, M. Effects of soybean beta-conglycinin on hepatic lipid metabolism and fecal lipid excretion in normal adult rats. Biosci.. Biotechnol. Biochem. 2004, 68, 1153-1155.
4. Lovati, M. R.; Manzoni, C.; Gianazza, E.; Arnoldi, A.; Kurowska, E.; Carroll, K. K.; Sirtori, C. R. Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells. J. Nutr. 2000, 130, 2543-2549.
5. Samoto, M.; Maebuchi, M.; Miyazaki, C.; Kugitani, H.; Kohno, M.; Hirotsuka, M.; Kito, M. Abundant proteins associated with lecithin in soy protein isolate. Food Chem. 2007, 102, 317-322.
6. Kanamoto, R.; Kimura, S.; Okamura, G. Cholesterol lowering effect of soybean lipophilic proteins associated with phospholipids in rat. Sov Protein Res. 2007, 10, 83-87.
7. Kohno, M.; Hirotsuka, M.; Kito, M.; Matsuzawa, Y. Decreases in serum triacylglycerol and visceral fat mediated by dietary soybean beta-conglycinin. J. Atheroscler. Thromb. 2006, 13, 247-255.
8. Davis, R. A. Cell and molecular biology of the assembly and secretion of apolipoprotein B-containing lipoproteins by the liver. Biochim. Biophys. Acta 1999, 1440, 1-31.
9. Mead, J. R.; Irvine, S. A.; Ramji, D. P. Lipoprotein lipase: structure, function, regulation, and role in disease. J. Mol. Med. 2002, 80, 753-769.
10. Kudou, S.; Fleury, Y.; Welti, D.; Magnolato, D.; Uchida, T.; Kitamura, K.; Okubo, K. Malonyl isoflavone glycosides in soybean seeds (Glycine max MERRILL). Agric.Biol.Chem. 1991, 55, 2227-2233.
11. Maebuchi, M.; Samoto, M.; Kohno, M.; Ito, R.; Koikeda, T.; Hirotsuka, M.; Nakabou, Y. Improvement in the intestinal absorption of soy protein by enzymatic digestion to oligopeptide in healthy adult men. Food Sci. Technol. Res. 2007, 13, 45-53.
12. Bligh, E. G.; Dyer, W. J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37, 911-917.
13. Ganji, S. H.; Tavintharan, S.; Zhu, D.; Xing, Y.; Vaijinath, S.; Kamanna, V. S.; Kashyap, M. L. Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. J. Lipid Res. 2004, 45, 1835-1845.
14. Swinnen, J. V.; Esquenet, M.; Goossens, K.; Heyns, W.; Verhoeven, G. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res. 1997, 57, 1086-1090.
15. Hsu, R. Y.; Lardy, H. A. Pigeon liver malic enzyme: II. Isolation, crystallization, and some properties. J. Biol. Chem. 1967, 242, 520-526.
16. Markwell, M. A. K.; McGroarty, E. J.; Bieber, L. L.; Tolbert, N. E. The subcellular distribution of carnitine acyltransferase in mammalian liver and kidney. J. Biol. Chem. 1973, 248, 3426-3432.
17. Davidson, N. O.; Shelness, G. S. Apolipoprotein B: mRNA editing, lipoprotein assembly, and presecretory degradation. Annu. Rev. Nutr. 2000, 20, 169-193.
18. Minokoshi, Y.; Kim, Y. B.; Peroni, O. D.; Fryer, L. G.; Muller, C.; Carling, D.; Kahn, B. B. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002, 415, 339-343.
19. Zhang, Y.; Yu, C.; Liu, J.; Spencer, T. A.; Chang, C. C.; Chang, T. Y. Cholesterol is superior to 7-ketocholesterol or 7 alphahydroxycholesterol as an allosteric activator for acyl-coenzyme Axholesterol acyltransferase 1. J. Biol. Chem. 2003, 278, 11642-11647.
20. Hampton, R. Y. Proteolysis and sterol regulation. Annu. Rev. Cell Dev. Biol. 2002, 18, 345-378.
21. Larsson, S. L.; Skogsberg, J.; Björkegren, J. The low density lipoprotein receptor prevents secretion of dense apoB-100-containing lipoproteins from the liver. J. Biol. Chem. 2004, 279, 831-836.
22. Shimizugawa, T.; Ono, M.; Shimamura, M.; Yoshida, K.; Ando, Y.; Koishi, R.; Ueda, K.; Inaba, T.; Minekura, H.; Kohama, T.; Furukawa, H. ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. J. Biol. Chem. 2002, 277, 33742-33748.
23. Shimamura, M.; Matsuda, M.; Kobayashi, S.; Ando, Y.; Ono, M.; Koishi, R.; Furukawa, H.; Makishima, M.; Shimomura, I. Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. Biochem.Biophys.Res.Commun. 2003, 301, 604-609.
24. Koishi, R.; Ando, Y.; Ono, M.; Shimamura, M.; Yasumo, H.; Fujiwara, T.; Horikoshi, H.; Furukawa, H. Angptl3 regulates lipid metabolism in mice. Nat. Genet. 2002, 30, 151-157.
25. Kaplan, R.; Zhang, T.; Hernandez, M.; Gan, F. X.; Wright, S. D.; Waters, M. G.; Cai, T. Q. Regulation of the angiopoietin-like protein 3 gene by LXR. J. Lipid Res. 2003, 44, 136-143.
26. Inaba, T. Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor. J.Biol.Chem. 2003, 278, 21344-21351.
27. Sheena, V.; Hertz, R.; Nousbeck, J.; Berman, I.; Magenheim, J.; Bar-Tana, J. Transcriptional regulation of human microsomal triglyceride transfer protein by hepatocyte nuclear factor-4 alpha. J. Lipid Res. 2005, 46, 328-341.
28. Sladek, F. M.; Zhong, W. M.; Lai, E.; Darnell, J. E. Liverenriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 1990, 4, 2353-2365.