-
1
-
-
41949087055
-
Prognostic relevance of FLT3-TKD mutations in AML: The combination matters - An analysis of 3082 patients
-
Bacher, U., Haferlach, C., Kern, W., Haferlach, T. Schnittger, S. (2008) Prognostic relevance of FLT3-TKD mutations in AML: the combination matters - an analysis of 3082 patients. Blood, 111, 2527 2537.
-
(2008)
Blood
, vol.111
, pp. 2527-2537
-
-
Bacher, U.1
Haferlach, C.2
Kern, W.3
Haferlach, T.4
Schnittger, S.5
-
2
-
-
0035203382
-
Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts
-
Birkenkamp, K.U., Geugien, M., Lemmink, H.H., Kruijer, W. Vellenga, E. (2001) Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts. Leukemia, 15, 1923 1931.
-
(2001)
Leukemia
, vol.15
, pp. 1923-1931
-
-
Birkenkamp, K.U.1
Geugien, M.2
Lemmink, H.H.3
Kruijer, W.4
Vellenga, E.5
-
3
-
-
34948903802
-
Cytoplasmic localization of phosphorylated STAT5 in human acute myeloid leukemia is inversely correlated with Flt3-ITD
-
Bunting, K.D., Xie, X.Y., Warshawsky, I. Hsi, E.D. (2007) Cytoplasmic localization of phosphorylated STAT5 in human acute myeloid leukemia is inversely correlated with Flt3-ITD. Blood, 110, 2775 2776.
-
(2007)
Blood
, vol.110
, pp. 2775-2776
-
-
Bunting, K.D.1
Xie, X.Y.2
Warshawsky, I.3
Hsi, E.D.4
-
4
-
-
22044448746
-
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
-
Choudhary, C., Schwable, J., Brandts, C., Tickenbrock, L., Sargin, B., Kindler, T., Fischer, T., Berdel, W.E., Muller-Tidow, C. Serve, H. (2005) AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood, 106, 265 273.
-
(2005)
Blood
, vol.106
, pp. 265-273
-
-
Choudhary, C.1
Schwable, J.2
Brandts, C.3
Tickenbrock, L.4
Sargin, B.5
Kindler, T.6
Fischer, T.7
Berdel, W.E.8
Muller-Tidow, C.9
Serve, H.10
-
5
-
-
28444473100
-
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
-
Dohner, K., Schlenk, R.F., Habdank, M., Scholl, C., Rucker, F.G., Corbacioglu, A., Bullinger, L., Frohling, S. Dohner, H. (2005) Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood, 106, 3740 3746.
-
(2005)
Blood
, vol.106
, pp. 3740-3746
-
-
Dohner, K.1
Schlenk, R.F.2
Habdank, M.3
Scholl, C.4
Rucker, F.G.5
Corbacioglu, A.6
Bullinger, L.7
Frohling, S.8
Dohner, H.9
-
6
-
-
0033595087
-
IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line
-
Dumon, S., Santos, S.C., Debierre-Grockiego, F., Gouilleux-Gruart, V., Cocault, L., Boucheron, C., Mollat, P., Gisselbrecht, S. Gouilleux, F. (1999) IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line. Oncogene, 18, 4191 4199.
-
(1999)
Oncogene
, vol.18
, pp. 4191-4199
-
-
Dumon, S.1
Santos, S.C.2
Debierre-Grockiego, F.3
Gouilleux-Gruart, V.4
Cocault, L.5
Boucheron, C.6
Mollat, P.7
Gisselbrecht, S.8
Gouilleux, F.9
-
7
-
-
19944427850
-
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
-
DOI 10.1056/NEJMoa041974
-
Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Diverio, D., Colombo, E., Santucci, A., Bigerna, B., Pacini, R., Pucciarini, A., Liso, A., Vignetti, M., Fazi, P., Meani, N., Pettirossi, V., Saglio, G., Mandelli, F., Lo-Coco, F., Pelicci, P.G. Martelli, M.F. (2005) Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. New England Journal of Medicine, 352, 254 266. (Pubitemid 40110814)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.3
, pp. 254-266
-
-
Falini, B.1
Mecucci, C.2
Tiacci, E.3
Alcalay, M.4
Rosati, R.5
Pasqualucci, L.6
La Starza, R.7
Diverio, D.8
Colombo, E.9
Santucci, A.10
Bigerna, B.11
Pacini, R.12
Pucciarini, A.13
Liso, A.14
Vignetti, M.15
Fazi, P.16
Meani, N.17
Pettirossi, V.18
Saglio, G.19
Mandelli, F.20
Lo-Coco, F.21
Pelicci, P.-G.22
Martelli, M.F.23
more..
-
8
-
-
33846876123
-
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): Biologic and clinical features
-
Falini, B., Nicoletti, I., Martelli, M.F. Mecucci, C. (2007) Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood, 109, 874 885.
-
(2007)
Blood
, vol.109
, pp. 874-885
-
-
Falini, B.1
Nicoletti, I.2
Martelli, M.F.3
Mecucci, C.4
-
9
-
-
41949090673
-
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
-
Gale, R.E., Green, C., Allen, C., Mead, A.J., Burnett, A.K., Hills, R.K. Linch, D.C. (2008) The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood, 111, 2776 2784.
-
(2008)
Blood
, vol.111
, pp. 2776-2784
-
-
Gale, R.E.1
Green, C.2
Allen, C.3
Mead, A.J.4
Burnett, A.K.5
Hills, R.K.6
Linch, D.C.7
-
10
-
-
0034665780
-
Bcr/Abl activates transcription of the Bcl-X gene through STAT5
-
Gesbert, F. Griffin, J.D. (2000) Bcr/Abl activates transcription of the Bcl-X gene through STAT5. Blood, 96, 2269 2276.
-
(2000)
Blood
, vol.96
, pp. 2269-2276
-
-
Gesbert, F.1
Griffin, J.D.2
-
11
-
-
28544446584
-
Acquired isodisomy for chromosome 13 is common in AML, and associated with FLT3-itd mutations
-
Griffiths, M., Mason, J., Rindl, M., Akiki, S., McMullan, D., Stinton, V., Powell, H., Curtis, A., Bown, N. Craddock, C. (2005) Acquired isodisomy for chromosome 13 is common in AML, and associated with FLT3-itd mutations. Leukemia, 19, 2355 2358.
-
(2005)
Leukemia
, vol.19
, pp. 2355-2358
-
-
Griffiths, M.1
Mason, J.2
Rindl, M.3
Akiki, S.4
McMullan, D.5
Stinton, V.6
Powell, H.7
Curtis, A.8
Bown, N.9
Craddock, C.10
-
12
-
-
33745534443
-
Nucleophosmin and cancer
-
Grisendi, S., Mecucci, C., Falini, B. Pandolfi, P.P. (2006) Nucleophosmin and cancer. Nature Reviews Cancer, 6, 493 505.
-
(2006)
Nature Reviews Cancer
, vol.6
, pp. 493-505
-
-
Grisendi, S.1
Mecucci, C.2
Falini, B.3
Pandolfi, P.P.4
-
13
-
-
44449151696
-
Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia
-
Gupta, M., Raghavan, M., Gale, R.E., Chelala, C., Allen, C., Molloy, G., Chaplin, T., Linch, D.C., Cazier, J.B. Young, B.D. (2008) Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes, Chromosomes and Cancer, 47, 729 739.
-
(2008)
Genes, Chromosomes and Cancer
, vol.47
, pp. 729-739
-
-
Gupta, M.1
Raghavan, M.2
Gale, R.E.3
Chelala, C.4
Allen, C.5
Molloy, G.6
Chaplin, T.7
Linch, D.C.8
Cazier, J.B.9
Young, B.D.10
-
14
-
-
33846927933
-
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
-
Harir, N., Pecquet, C., Kerenyi, M., Sonneck, K., Kovacic, B., Nyga, R., Brevet, M., Dhennin, I., Gouilleux-Gruart, V., Beug, H., Valent, P., Lassoued, K., Moriggl, R. Gouilleux, F. (2007) Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood, 109, 1678 1686.
-
(2007)
Blood
, vol.109
, pp. 1678-1686
-
-
Harir, N.1
Pecquet, C.2
Kerenyi, M.3
Sonneck, K.4
Kovacic, B.5
Nyga, R.6
Brevet, M.7
Dhennin, I.8
Gouilleux-Gruart, V.9
Beug, H.10
Valent, P.11
Lassoued, K.12
Moriggl, R.13
Gouilleux, F.14
-
15
-
-
0034598830
-
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
-
Hayakawa, F., Towatari, M., Kiyoi, H., Tanimoto, M., Kitamura, T., Saito, H. Naoe, T. (2000) Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene, 19, 624 631.
-
(2000)
Oncogene
, vol.19
, pp. 624-631
-
-
Hayakawa, F.1
Towatari, M.2
Kiyoi, H.3
Tanimoto, M.4
Kitamura, T.5
Saito, H.6
Naoe, T.7
-
16
-
-
3242683662
-
Single cell profiling of potentiated phospho-protein networks in cancer cells
-
Irish, J.M., Hovland, R., Krutzik, P.O., Perez, O.D., Bruserud, O., Gjertsen, B.T. Nolan, G.P. (2004) Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell, 118, 217 228.
-
(2004)
Cell
, vol.118
, pp. 217-228
-
-
Irish, J.M.1
Hovland, R.2
Krutzik, P.O.3
Perez, O.D.4
Bruserud, O.5
Gjertsen, B.T.6
Nolan, G.P.7
-
17
-
-
0033134792
-
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
-
Kiyoi, H., Naoe, T., Nakano, Y., Yokota, S., Minami, S., Miyawaki, S., Asou, N., Kuriyama, K., Jinnai, I., Shimazaki, C., Akiyama, H., Saito, K., Oh, H., Motoji, T., Omoto, E., Saito, H., Ohno, R. Ueda, R. (1999) Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood, 93, 3074 3080.
-
(1999)
Blood
, vol.93
, pp. 3074-3080
-
-
Kiyoi, H.1
Naoe, T.2
Nakano, Y.3
Yokota, S.4
Minami, S.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Jinnai, I.9
Shimazaki, C.10
Akiyama, H.11
Saito, K.12
Oh, H.13
Motoji, T.14
Omoto, E.15
Saito, H.16
Ohno, R.17
Ueda, R.18
-
18
-
-
0035885955
-
The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
-
Kottaridis, P.D., Gale, R.E., Frew, M.E., Harrison, G., Langabeer, S.E., Belton, A.A., Walker, H., Wheatley, K., Bowen, D.T., Burnett, A.K., Goldstone, A.H. Linch, D.C. (2001) The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood, 98, 1752 1759.
-
(2001)
Blood
, vol.98
, pp. 1752-1759
-
-
Kottaridis, P.D.1
Gale, R.E.2
Frew, M.E.3
Harrison, G.4
Langabeer, S.E.5
Belton, A.A.6
Walker, H.7
Wheatley, K.8
Bowen, D.T.9
Burnett, A.K.10
Goldstone, A.H.11
Linch, D.C.12
-
19
-
-
29144497917
-
Detailed analysis of FLT3 expression levels in acute myeloid leukemia
-
Kuchenbauer, F., Kern, W., Schoch, C., Kohlmann, A., Hiddemann, W., Haferlach, T. Schnittger, S. (2005) Detailed analysis of FLT3 expression levels in acute myeloid leukemia. Haematologica, 90, 1617 1625.
-
(2005)
Haematologica
, vol.90
, pp. 1617-1625
-
-
Kuchenbauer, F.1
Kern, W.2
Schoch, C.3
Kohlmann, A.4
Hiddemann, W.5
Haferlach, T.6
Schnittger, S.7
-
20
-
-
33745628343
-
More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML)
-
author reply 406.
-
Kusec, R., Jaksic, O., Ostojic, S., Kardum-Skelin, I., Vrhovac, R. Jaksic, B. (2006) More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML). Blood, 108, 405 406 author reply 406.
-
(2006)
Blood
, vol.108
, pp. 405-406
-
-
Kusec, R.1
Jaksic, O.2
Ostojic, S.3
Kardum-Skelin, I.4
Vrhovac, R.5
Jaksic, B.6
-
21
-
-
0141836914
-
FLT3: ITDoes matter in leukemia
-
Levis, M. Small, D. (2003) FLT3: ITDoes matter in leukemia. Leukemia, 17, 1738 1752.
-
(2003)
Leukemia
, vol.17
, pp. 1738-1752
-
-
Levis, M.1
Small, D.2
-
22
-
-
0141455981
-
FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress
-
Libura, M., Asnafi, V., Tu, A., Delabesse, E., Tigaud, I., Cymbalista, F., Bennaceur-Griscelli, A., Villarese, P., Solbu, G., Hagemeijer, A., Beldjord, K., Hermine, O. Macintyre, E. (2003) FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress. Blood, 102, 2198 2204.
-
(2003)
Blood
, vol.102
, pp. 2198-2204
-
-
Libura, M.1
Asnafi, V.2
Tu, A.3
Delabesse, E.4
Tigaud, I.5
Cymbalista, F.6
Bennaceur-Griscelli, A.7
Villarese, P.8
Solbu, G.9
Hagemeijer, A.10
Beldjord, K.11
Hermine, O.12
MacIntyre, E.13
-
23
-
-
0141958305
-
Different antiapoptotic pathways between wild-type and mutated FLT3: Insights into therapeutic targets in leukemia
-
Minami, Y., Yamamoto, K., Kiyoi, H., Ueda, R., Saito, H. Naoe, T. (2003) Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. Blood, 102, 2969 2975.
-
(2003)
Blood
, vol.102
, pp. 2969-2975
-
-
Minami, Y.1
Yamamoto, K.2
Kiyoi, H.3
Ueda, R.4
Saito, H.5
Naoe, T.6
-
24
-
-
0034554796
-
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
-
Mizuki, M., Fenski, R., Halfter, H., Matsumura, I., Schmidt, R., Muller, C., Gruning, W., Kratz-Albers, K., Serve, S., Steur, C., Buchner, T., Kienast, J., Kanakura, Y., Berdel, W.E. Serve, H. (2000) Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood, 96, 3907 3914.
-
(2000)
Blood
, vol.96
, pp. 3907-3914
-
-
Mizuki, M.1
Fenski, R.2
Halfter, H.3
Matsumura, I.4
Schmidt, R.5
Muller, C.6
Gruning, W.7
Kratz-Albers, K.8
Serve, S.9
Steur, C.10
Buchner, T.11
Kienast, J.12
Kanakura, Y.13
Berdel, W.E.14
Serve, H.15
-
25
-
-
0030451722
-
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
-
Nakao, M., Yokota, S., Iwai, T., Kaneko, H., Horiike, S., Kashima, K., Sonoda, Y., Fujimoto, T. Misawa, S. (1996) Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia, 10, 1911 1918.
-
(1996)
Leukemia
, vol.10
, pp. 1911-1918
-
-
Nakao, M.1
Yokota, S.2
Iwai, T.3
Kaneko, H.4
Horiike, S.5
Kashima, K.6
Sonoda, Y.7
Fujimoto, T.8
Misawa, S.9
-
26
-
-
23844546308
-
Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia
-
DOI 10.1038/sj.leu.2403846
-
Noguera, N.I., Ammatuna, E., Zangrilli, D., Lavorgna, S., Divona, M., Buccisano, F., Amadori, S., Mecucci, C., Falini, B. Lo-Coco, F. (2005) Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia. Leukemia, 19, 1479 1482. (Pubitemid 41148948)
-
(2005)
Leukemia
, vol.19
, Issue.8
, pp. 1479-1482
-
-
Noguera, N.I.1
Ammatuna, E.2
Zangrilli, D.3
Lavorgna, S.4
Divona, M.5
Buccisano, F.6
Amadori, S.7
Mecucci, C.8
Falini, B.9
Lo-Coco, F.10
-
27
-
-
0036121142
-
Bcl-2 and bcl-xL antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages
-
Olie, R.A., Hafner, C., Kuttel, R., Sigrist, B., Willers, J., Dummer, R., Hall, J., Stahel, R.A. Zangemeister-Wittke, U. (2002) Bcl-2 and bcl-xL antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages. Journal of Investigative Dermatology, 118, 505 512.
-
(2002)
Journal of Investigative Dermatology
, vol.118
, pp. 505-512
-
-
Olie, R.A.1
Hafner, C.2
Kuttel, R.3
Sigrist, B.4
Willers, J.5
Dummer, R.6
Hall, J.7
Stahel, R.A.8
Zangemeister-Wittke, U.9
-
28
-
-
10744230464
-
Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia
-
Ozeki, K., Kiyoi, H., Hirose, Y., Iwai, M., Ninomiya, M., Kodera, Y., Miyawaki, S., Kuriyama, K., Shimazaki, C., Akiyama, H., Nishimura, M., Motoji, T., Shinagawa, K., Takeshita, A., Ueda, R., Ohno, R., Emi, N. Naoe, T. (2004) Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Blood, 103, 1901 1908.
-
(2004)
Blood
, vol.103
, pp. 1901-1908
-
-
Ozeki, K.1
Kiyoi, H.2
Hirose, Y.3
Iwai, M.4
Ninomiya, M.5
Kodera, Y.6
Miyawaki, S.7
Kuriyama, K.8
Shimazaki, C.9
Akiyama, H.10
Nishimura, M.11
Motoji, T.12
Shinagawa, K.13
Takeshita, A.14
Ueda, R.15
Ohno, R.16
Emi, N.17
Naoe, T.18
-
29
-
-
0037865499
-
Flow cytometric measurement of phosphorylated STAT5 in AML: Lack of specific association with FLT3 internal tandem duplications
-
Pallis, M., Seedhouse, C., Grundy, M. Russell, N. (2003) Flow cytometric measurement of phosphorylated STAT5 in AML: lack of specific association with FLT3 internal tandem duplications. Leukemia Research, 27, 803 805.
-
(2003)
Leukemia Research
, vol.27
, pp. 803-805
-
-
Pallis, M.1
Seedhouse, C.2
Grundy, M.3
Russell, N.4
-
30
-
-
0032724360
-
Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript
-
Pallisgaard, N., Clausen, N., Schroder, H. Hokland, P. (1999) Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript. Genes, Chromosomes and Cancer, 26, 355 365.
-
(1999)
Genes, Chromosomes and Cancer
, vol.26
, pp. 355-365
-
-
Pallisgaard, N.1
Clausen, N.2
Schroder, H.3
Hokland, P.4
-
31
-
-
33750369309
-
The size of duplication does not add to the prognostic significance of FLT3 internal tandem duplication in acute myeloid leukemia patients
-
Ponziani, V., Gianfaldoni, G., Mannelli, F., Leoni, F., Ciolli, S., Guglielmelli, P., Antonioli, E., Longo, G., Bosi, A. Vannucchi, A.M. (2006) The size of duplication does not add to the prognostic significance of FLT3 internal tandem duplication in acute myeloid leukemia patients. Leukemia, 20, 2074 2076.
-
(2006)
Leukemia
, vol.20
, pp. 2074-2076
-
-
Ponziani, V.1
Gianfaldoni, G.2
Mannelli, F.3
Leoni, F.4
Ciolli, S.5
Guglielmelli, P.6
Antonioli, E.7
Longo, G.8
Bosi, A.9
Vannucchi, A.M.10
-
32
-
-
0037069425
-
Expression profiling of CD34+ hematopoietic stem/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia
-
Qian, Z., Fernald, A.A., Godley, L.A., Larson, R.A. Le Beau, M.M. (2002) Expression profiling of CD34+ hematopoietic stem/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 99, 14925 14930.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 14925-14930
-
-
Qian, Z.1
Fernald, A.A.2
Godley, L.A.3
Larson, R.A.4
Le Beau, M.M.5
-
33
-
-
0036659931
-
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
-
Schnittger, S., Schoch, C., Dugas, M., Kern, W., Staib, P., Wuchter, C., Loffler, H., Sauerland, C.M., Serve, H., Buchner, T., Haferlach, T. Hiddemann, W. (2002) Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood, 100, 59 66.
-
(2002)
Blood
, vol.100
, pp. 59-66
-
-
Schnittger, S.1
Schoch, C.2
Dugas, M.3
Kern, W.4
Staib, P.5
Wuchter, C.6
Loffler, H.7
Sauerland, C.M.8
Serve, H.9
Buchner, T.10
Haferlach, T.11
Hiddemann, W.12
-
34
-
-
28444449081
-
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
-
Schnittger, S., Schoch, C., Kern, W., Mecucci, C., Tschulik, C., Martelli, M.F., Haferlach, T., Hiddemann, W. Falini, B. (2005) Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood, 106, 3733 3739.
-
(2005)
Blood
, vol.106
, pp. 3733-3739
-
-
Schnittger, S.1
Schoch, C.2
Kern, W.3
Mecucci, C.4
Tschulik, C.5
Martelli, M.F.6
Haferlach, T.7
Hiddemann, W.8
Falini, B.9
-
35
-
-
33751242335
-
DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412
-
Seedhouse, C.H., Hunter, H.M., Lloyd-Lewis, B., Massip, A.M., Pallis, M., Carter, G.I., Grundy, M., Shang, S. Russell, N.H. (2006) DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412. Leukemia, 20, 2130 2136.
-
(2006)
Leukemia
, vol.20
, pp. 2130-2136
-
-
Seedhouse, C.H.1
Hunter, H.M.2
Lloyd-Lewis, B.3
Massip, A.M.4
Pallis, M.5
Carter, G.I.6
Grundy, M.7
Shang, S.8
Russell, N.H.9
-
36
-
-
0037441745
-
The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3
-
Spiekermann, K., Dirschinger, R.J., Schwab, R., Bagrintseva, K., Faber, F., Buske, C., Schnittger, S., Kelly, L.M., Gilliland, D.G. Hiddemann, W. (2003a) The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood, 101, 1494 1504.
-
(2003)
Blood
, vol.101
, pp. 1494-1504
-
-
Spiekermann, K.1
Dirschinger, R.J.2
Schwab, R.3
Bagrintseva, K.4
Faber, F.5
Buske, C.6
Schnittger, S.7
Kelly, L.M.8
Gilliland, D.G.9
Hiddemann, W.10
-
37
-
-
0037838661
-
Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
-
Spiekermann, K., Bagrintseva, K., Schwab, R., Schmieja, K. Hiddemann, W. (2003b) Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clinical Cancer Research, 9, 2140 2150.
-
(2003)
Clinical Cancer Research
, vol.9
, pp. 2140-2150
-
-
Spiekermann, K.1
Bagrintseva, K.2
Schwab, R.3
Schmieja, K.4
Hiddemann, W.5
-
38
-
-
33646431111
-
Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
-
Stirewalt, D.L., Kopecky, K.J., Meshinchi, S., Engel, J.H., Pogosova-Agadjanyan, E.L., Linsley, J., Slovak, M.L., Willman, C.L. Radich, J.P. (2006) Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia. Blood, 107, 3724 3726.
-
(2006)
Blood
, vol.107
, pp. 3724-3726
-
-
Stirewalt, D.L.1
Kopecky, K.J.2
Meshinchi, S.3
Engel, J.H.4
Pogosova-Agadjanyan, E.L.5
Linsley, J.6
Slovak, M.L.7
Willman, C.L.8
Radich, J.P.9
-
39
-
-
0037097716
-
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
Thiede, C., Steudel, C., Mohr, B., Schaich, M., Schakel, U., Platzbecker, U., Wermke, M., Bornhauser, M., Ritter, M., Neubauer, A., Ehninger, G. Illmer, T. (2002) Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood, 99, 4326 4335.
-
(2002)
Blood
, vol.99
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
Schaich, M.4
Schakel, U.5
Platzbecker, U.6
Wermke, M.7
Bornhauser, M.8
Ritter, M.9
Neubauer, A.10
Ehninger, G.11
Illmer, T.12
-
40
-
-
33646557337
-
Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
-
Thiede, C., Koch, S., Creutzig, E., Steudel, C., Illmer, T., Schaich, M. Ehninger, G. (2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood, 107, 4011 4020.
-
(2006)
Blood
, vol.107
, pp. 4011-4020
-
-
Thiede, C.1
Koch, S.2
Creutzig, E.3
Steudel, C.4
Illmer, T.5
Schaich, M.6
Ehninger, G.7
-
41
-
-
28444446313
-
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
-
Verhaak, R.G., Goudswaard, C.S., van Putten, W., Bijl, M.A., Sanders, M.A., Hugens, W., Uitterlinden, A.G., Erpelinck, C.A., Delwel, R., Lowenberg, B. Valk, P.J. (2005) Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood, 106, 3747 3754.
-
(2005)
Blood
, vol.106
, pp. 3747-3754
-
-
Verhaak, R.G.1
Goudswaard, C.S.2
Van Putten, W.3
Bijl, M.A.4
Sanders, M.A.5
Hugens, W.6
Uitterlinden, A.G.7
Erpelinck, C.A.8
Delwel, R.9
Lowenberg, B.10
Valk, P.J.11
-
42
-
-
0035476264
-
Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
-
Whitman, S.P., Archer, K.J., Feng, L., Baldus, C., Becknell, B., Carlson, B.D., Carroll, A.J., Mrozek, K., Vardiman, J.W., George, S.L., Kolitz, J.E., Larson, R.A., Bloomfield, C.D. Caligiuri, M.A. (2001) Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Research, 61, 7233 7239.
-
(2001)
Cancer Research
, vol.61
, pp. 7233-7239
-
-
Whitman, S.P.1
Archer, K.J.2
Feng, L.3
Baldus, C.4
Becknell, B.5
Carlson, B.D.6
Carroll, A.J.7
Mrozek, K.8
Vardiman, J.W.9
George, S.L.10
Kolitz, J.E.11
Larson, R.A.12
Bloomfield, C.D.13
Caligiuri, M.A.14
-
43
-
-
0035871889
-
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
-
Yamamoto, Y., Kiyoi, H., Nakano, Y., Suzuki, R., Kodera, Y., Miyawaki, S., Asou, N., Kuriyama, K., Yagasaki, F., Shimazaki, C., Akiyama, H., Saito, K., Nishimura, M., Motoji, T., Shinagawa, K., Takeshita, A., Saito, H., Ueda, R., Ohno, R. Naoe, T. (2001) Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood, 97, 2434 2439.
-
(2001)
Blood
, vol.97
, pp. 2434-2439
-
-
Yamamoto, Y.1
Kiyoi, H.2
Nakano, Y.3
Suzuki, R.4
Kodera, Y.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Yagasaki, F.9
Shimazaki, C.10
Akiyama, H.11
Saito, K.12
Nishimura, M.13
Motoji, T.14
Shinagawa, K.15
Takeshita, A.16
Saito, H.17
Ueda, R.18
Ohno, R.19
Naoe, T.20
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