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Volumn 147, Issue 5, 2009, Pages 653-661

FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations

Author keywords

Acute myeloid leukaemia; Bcl xl; FLT3; NPM; Signal transducer and activator of transcription 5

Indexed keywords

CD135 ANTIGEN; NUCLEOPHOSMIN; PROTEIN BCL XL; STAT5 PROTEIN;

EID: 70449362059     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07901.x     Document Type: Article
Times cited : (10)

References (43)
  • 1
    • 41949087055 scopus 로고    scopus 로고
    • Prognostic relevance of FLT3-TKD mutations in AML: The combination matters - An analysis of 3082 patients
    • Bacher, U., Haferlach, C., Kern, W., Haferlach, T. Schnittger, S. (2008) Prognostic relevance of FLT3-TKD mutations in AML: the combination matters - an analysis of 3082 patients. Blood, 111, 2527 2537.
    • (2008) Blood , vol.111 , pp. 2527-2537
    • Bacher, U.1    Haferlach, C.2    Kern, W.3    Haferlach, T.4    Schnittger, S.5
  • 2
    • 0035203382 scopus 로고    scopus 로고
    • Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts
    • Birkenkamp, K.U., Geugien, M., Lemmink, H.H., Kruijer, W. Vellenga, E. (2001) Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts. Leukemia, 15, 1923 1931.
    • (2001) Leukemia , vol.15 , pp. 1923-1931
    • Birkenkamp, K.U.1    Geugien, M.2    Lemmink, H.H.3    Kruijer, W.4    Vellenga, E.5
  • 3
    • 34948903802 scopus 로고    scopus 로고
    • Cytoplasmic localization of phosphorylated STAT5 in human acute myeloid leukemia is inversely correlated with Flt3-ITD
    • Bunting, K.D., Xie, X.Y., Warshawsky, I. Hsi, E.D. (2007) Cytoplasmic localization of phosphorylated STAT5 in human acute myeloid leukemia is inversely correlated with Flt3-ITD. Blood, 110, 2775 2776.
    • (2007) Blood , vol.110 , pp. 2775-2776
    • Bunting, K.D.1    Xie, X.Y.2    Warshawsky, I.3    Hsi, E.D.4
  • 5
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Dohner, K., Schlenk, R.F., Habdank, M., Scholl, C., Rucker, F.G., Corbacioglu, A., Bullinger, L., Frohling, S. Dohner, H. (2005) Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood, 106, 3740 3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3    Scholl, C.4    Rucker, F.G.5    Corbacioglu, A.6    Bullinger, L.7    Frohling, S.8    Dohner, H.9
  • 8
    • 33846876123 scopus 로고    scopus 로고
    • Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): Biologic and clinical features
    • Falini, B., Nicoletti, I., Martelli, M.F. Mecucci, C. (2007) Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood, 109, 874 885.
    • (2007) Blood , vol.109 , pp. 874-885
    • Falini, B.1    Nicoletti, I.2    Martelli, M.F.3    Mecucci, C.4
  • 9
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale, R.E., Green, C., Allen, C., Mead, A.J., Burnett, A.K., Hills, R.K. Linch, D.C. (2008) The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood, 111, 2776 2784.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3    Mead, A.J.4    Burnett, A.K.5    Hills, R.K.6    Linch, D.C.7
  • 10
    • 0034665780 scopus 로고    scopus 로고
    • Bcr/Abl activates transcription of the Bcl-X gene through STAT5
    • Gesbert, F. Griffin, J.D. (2000) Bcr/Abl activates transcription of the Bcl-X gene through STAT5. Blood, 96, 2269 2276.
    • (2000) Blood , vol.96 , pp. 2269-2276
    • Gesbert, F.1    Griffin, J.D.2
  • 15
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa, F., Towatari, M., Kiyoi, H., Tanimoto, M., Kitamura, T., Saito, H. Naoe, T. (2000) Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene, 19, 624 631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6    Naoe, T.7
  • 18
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis, P.D., Gale, R.E., Frew, M.E., Harrison, G., Langabeer, S.E., Belton, A.A., Walker, H., Wheatley, K., Bowen, D.T., Burnett, A.K., Goldstone, A.H. Linch, D.C. (2001) The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood, 98, 1752 1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3    Harrison, G.4    Langabeer, S.E.5    Belton, A.A.6    Walker, H.7    Wheatley, K.8    Bowen, D.T.9    Burnett, A.K.10    Goldstone, A.H.11    Linch, D.C.12
  • 20
    • 33745628343 scopus 로고    scopus 로고
    • More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML)
    • author reply 406.
    • Kusec, R., Jaksic, O., Ostojic, S., Kardum-Skelin, I., Vrhovac, R. Jaksic, B. (2006) More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML). Blood, 108, 405 406 author reply 406.
    • (2006) Blood , vol.108 , pp. 405-406
    • Kusec, R.1    Jaksic, O.2    Ostojic, S.3    Kardum-Skelin, I.4    Vrhovac, R.5    Jaksic, B.6
  • 21
    • 0141836914 scopus 로고    scopus 로고
    • FLT3: ITDoes matter in leukemia
    • Levis, M. Small, D. (2003) FLT3: ITDoes matter in leukemia. Leukemia, 17, 1738 1752.
    • (2003) Leukemia , vol.17 , pp. 1738-1752
    • Levis, M.1    Small, D.2
  • 23
    • 0141958305 scopus 로고    scopus 로고
    • Different antiapoptotic pathways between wild-type and mutated FLT3: Insights into therapeutic targets in leukemia
    • Minami, Y., Yamamoto, K., Kiyoi, H., Ueda, R., Saito, H. Naoe, T. (2003) Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. Blood, 102, 2969 2975.
    • (2003) Blood , vol.102 , pp. 2969-2975
    • Minami, Y.1    Yamamoto, K.2    Kiyoi, H.3    Ueda, R.4    Saito, H.5    Naoe, T.6
  • 26
    • 23844546308 scopus 로고    scopus 로고
    • Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia
    • DOI 10.1038/sj.leu.2403846
    • Noguera, N.I., Ammatuna, E., Zangrilli, D., Lavorgna, S., Divona, M., Buccisano, F., Amadori, S., Mecucci, C., Falini, B. Lo-Coco, F. (2005) Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia. Leukemia, 19, 1479 1482. (Pubitemid 41148948)
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1479-1482
    • Noguera, N.I.1    Ammatuna, E.2    Zangrilli, D.3    Lavorgna, S.4    Divona, M.5    Buccisano, F.6    Amadori, S.7    Mecucci, C.8    Falini, B.9    Lo-Coco, F.10
  • 29
    • 0037865499 scopus 로고    scopus 로고
    • Flow cytometric measurement of phosphorylated STAT5 in AML: Lack of specific association with FLT3 internal tandem duplications
    • Pallis, M., Seedhouse, C., Grundy, M. Russell, N. (2003) Flow cytometric measurement of phosphorylated STAT5 in AML: lack of specific association with FLT3 internal tandem duplications. Leukemia Research, 27, 803 805.
    • (2003) Leukemia Research , vol.27 , pp. 803-805
    • Pallis, M.1    Seedhouse, C.2    Grundy, M.3    Russell, N.4
  • 30
    • 0032724360 scopus 로고    scopus 로고
    • Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript
    • Pallisgaard, N., Clausen, N., Schroder, H. Hokland, P. (1999) Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript. Genes, Chromosomes and Cancer, 26, 355 365.
    • (1999) Genes, Chromosomes and Cancer , vol.26 , pp. 355-365
    • Pallisgaard, N.1    Clausen, N.2    Schroder, H.3    Hokland, P.4
  • 33
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger, S., Schoch, C., Dugas, M., Kern, W., Staib, P., Wuchter, C., Loffler, H., Sauerland, C.M., Serve, H., Buchner, T., Haferlach, T. Hiddemann, W. (2002) Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood, 100, 59 66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3    Kern, W.4    Staib, P.5    Wuchter, C.6    Loffler, H.7    Sauerland, C.M.8    Serve, H.9    Buchner, T.10    Haferlach, T.11    Hiddemann, W.12
  • 34
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger, S., Schoch, C., Kern, W., Mecucci, C., Tschulik, C., Martelli, M.F., Haferlach, T., Hiddemann, W. Falini, B. (2005) Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood, 106, 3733 3739.
    • (2005) Blood , vol.106 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3    Mecucci, C.4    Tschulik, C.5    Martelli, M.F.6    Haferlach, T.7    Hiddemann, W.8    Falini, B.9
  • 35
    • 33751242335 scopus 로고    scopus 로고
    • DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412
    • Seedhouse, C.H., Hunter, H.M., Lloyd-Lewis, B., Massip, A.M., Pallis, M., Carter, G.I., Grundy, M., Shang, S. Russell, N.H. (2006) DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412. Leukemia, 20, 2130 2136.
    • (2006) Leukemia , vol.20 , pp. 2130-2136
    • Seedhouse, C.H.1    Hunter, H.M.2    Lloyd-Lewis, B.3    Massip, A.M.4    Pallis, M.5    Carter, G.I.6    Grundy, M.7    Shang, S.8    Russell, N.H.9
  • 36
    • 0037441745 scopus 로고    scopus 로고
    • The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3
    • Spiekermann, K., Dirschinger, R.J., Schwab, R., Bagrintseva, K., Faber, F., Buske, C., Schnittger, S., Kelly, L.M., Gilliland, D.G. Hiddemann, W. (2003a) The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood, 101, 1494 1504.
    • (2003) Blood , vol.101 , pp. 1494-1504
    • Spiekermann, K.1    Dirschinger, R.J.2    Schwab, R.3    Bagrintseva, K.4    Faber, F.5    Buske, C.6    Schnittger, S.7    Kelly, L.M.8    Gilliland, D.G.9    Hiddemann, W.10
  • 37
    • 0037838661 scopus 로고    scopus 로고
    • Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
    • Spiekermann, K., Bagrintseva, K., Schwab, R., Schmieja, K. Hiddemann, W. (2003b) Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clinical Cancer Research, 9, 2140 2150.
    • (2003) Clinical Cancer Research , vol.9 , pp. 2140-2150
    • Spiekermann, K.1    Bagrintseva, K.2    Schwab, R.3    Schmieja, K.4    Hiddemann, W.5
  • 39
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede, C., Steudel, C., Mohr, B., Schaich, M., Schakel, U., Platzbecker, U., Wermke, M., Bornhauser, M., Ritter, M., Neubauer, A., Ehninger, G. Illmer, T. (2002) Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood, 99, 4326 4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schakel, U.5    Platzbecker, U.6    Wermke, M.7    Bornhauser, M.8    Ritter, M.9    Neubauer, A.10    Ehninger, G.11    Illmer, T.12
  • 40
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede, C., Koch, S., Creutzig, E., Steudel, C., Illmer, T., Schaich, M. Ehninger, G. (2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood, 107, 4011 4020.
    • (2006) Blood , vol.107 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3    Steudel, C.4    Illmer, T.5    Schaich, M.6    Ehninger, G.7
  • 41
    • 28444446313 scopus 로고    scopus 로고
    • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    • Verhaak, R.G., Goudswaard, C.S., van Putten, W., Bijl, M.A., Sanders, M.A., Hugens, W., Uitterlinden, A.G., Erpelinck, C.A., Delwel, R., Lowenberg, B. Valk, P.J. (2005) Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood, 106, 3747 3754.
    • (2005) Blood , vol.106 , pp. 3747-3754
    • Verhaak, R.G.1    Goudswaard, C.S.2    Van Putten, W.3    Bijl, M.A.4    Sanders, M.A.5    Hugens, W.6    Uitterlinden, A.G.7    Erpelinck, C.A.8    Delwel, R.9    Lowenberg, B.10    Valk, P.J.11


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