Pharmacologic inhibition of the CK2-mediated phosphorylation of B23/NPM in cancer cells selectively modulates genes related to protein synthesis, energetic metabolism, and ribosomal biogenesis

Molecular and Cellular Biochemistry

Volumn 404, Issue 1-2, 2015, Pages 103-112

  Perera, Yasser ^a   Pedroso, Seidy ^a   Borras Hidalgo, Orlando ^a   Vázquez, Dania M ^a   Miranda, Jamilet ^a   Villareal, Adelaida ^a   Falcón, Viviana ^a   Cruz, Luis D ^b   Farinas, Hernán G ^c   Perea, Silvio E ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b Center of Advanced Studies   (Cuba)

^c UNIVERSIDAD NACIONAL DE QUILMES   (Argentina)

Author keywords

B23 NPM; CIGB 300; CK2 inhibitor; Nucleophosmin phosphorylation

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CASEIN KINASE II; CIGB 300; EVEROLIMUS; INITIATION FACTOR 4E BINDING PROTEIN 1; NSC 348884; NUCLEOPHOSMIN; PEPTIDE DERIVATIVE; PROTEIN S6; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SILMITASERTIB; UNCLASSIFIED DRUG; CIGB-300; CYCLOPEPTIDE; NUCLEAR PROTEIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOGENESIS; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; ENERGY METABOLISM; ENZYME INHIBITION; FUNCTIONAL ANNOTATION CLUSTERING; GENE CLUSTER; GENE CONTROL; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR BIOLOGY; NUCLEOLUS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RIBOSOME; SEQUENCE ANALYSIS; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; GENETICS; METABOLISM; NEOPLASMS; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

APOPTOSIS; CASEIN KINASE II; CELL LINE, TUMOR; CELL PROLIFERATION; ENERGY METABOLISM; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; PEPTIDES, CYCLIC; PHOSPHORYLATION; RIBOSOMES;

EID: 84941730819     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-015-2370-x     Document Type: Article

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