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Volumn 5, Issue 5, 2014, Pages 326-335

The evolution of colorectal cancer genetics-Part 1: From discovery to practice

Author keywords

Colorectal cancer (CRC); CRC syndromes; Genetics; Lynch syndrome (LS); Prevention

Indexed keywords

ACETYLSALICYLIC ACID; B RAF KINASE; DNA GLYCOSYLASE MUTY; EPITHELIAL CELL ADHESION MOLECULE; MISMATCH REPAIR PROTEIN PMS2; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

EID: 84995783181     PISSN: 20786891     EISSN: 2219679X     Source Type: Journal    
DOI: 10.3978/j.issn.2078-6891.2014.069     Document Type: Review
Times cited : (16)

References (64)
  • 1
    • 84870548246 scopus 로고    scopus 로고
    • Familial colon cancer syndromes: An update of a rapidly evolving field
    • Patel SG, Ahnen DJ. Familial colon cancer syndromes: An update of a rapidly evolving field. Curr Gastroenterol Rep 2012;14:428-38.
    • (2012) Curr Gastroenterol Rep , vol.14 , pp. 428-438
    • Patel, S.G.1    Ahnen, D.J.2
  • 2
    • 0022151745 scopus 로고
    • Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the university of michigan, 1895-1913., By aldred scott, warthin., 1913
    • Classics in oncology
    • Classics in oncology. Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the university of michigan, 1895-1913. By aldred scott warthin. 1913. CA Cancer J Clin 1985;35:348-59.
    • (1985) CA Cancer J Clin , vol.35 , pp. 348-359
  • 3
    • 0015077284 scopus 로고
    • Cancer family "G"
    • revisited: 1895-1970
    • Lynch HT, Krush AJ. Cancer family "G" revisited: 1895-1970. Cancer 1971;27:1505-11.
    • (1971) Cancer , vol.27 , pp. 1505-1511
    • Lynch, H.T.1    Krush, A.J.2
  • 4
    • 0017716034 scopus 로고
    • Role of heredity in multiple primary cancer
    • Lynch HT, Harris RE, Lynch PM, et al. Role of heredity in multiple primary cancer. Cancer 1977;40:1849-54.
    • (1977) Cancer , vol.40 , pp. 1849-1854
    • Lynch, H.T.1    Harris, R.E.2    Lynch, P.M.3
  • 5
    • 0029781416 scopus 로고    scopus 로고
    • Muir-torre syndrome and defective DNA mismatch repair genes
    • Fusaro RM, Lemon SJ, Lynch HT. Muir-torre syndrome and defective DNA mismatch repair genes. J Am Acad Dermatol 1996;35:493-4.
    • (1996) J Am Acad Dermatol , vol.35 , pp. 493-494
    • Fusaro, R.M.1    Lemon, S.J.2    Lynch, H.T.3
  • 6
    • 0034677493 scopus 로고    scopus 로고
    • Conversion of diploidy to haploidy
    • Yan H, Papadopoulos N, Marra G, et al. Conversion of diploidy to haploidy. Nature 2000;403:723-4.
    • (2000) Nature , vol.403 , pp. 723-724
    • Yan, H.1    Papadopoulos, N.2    Marra, G.3
  • 7
    • 0015295131 scopus 로고
    • Mutation and cancer: A model for Wilms' tumor of the kidney
    • Knudson AG Jr, Strong LC. Mutation and cancer: A model for Wilms' tumor of the kidney. J Natl Cancer Inst 1972;48:313-24.
    • (1972) J Natl Cancer Inst , vol.48 , pp. 313-324
    • Knudson, A.G.1    Strong, L.C.2
  • 8
    • 0016134997 scopus 로고
    • Heredity and human cancer
    • Knudson AG Jr. Heredity and human cancer. Am J Pathol 1974;77:77-84.
    • (1974) Am J Pathol , vol.77 , pp. 77-84
    • Knudson, A.G.1
  • 9
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 10
    • 0001301088 scopus 로고
    • The hereditary factor in polyposis intestini, or multiple adenomata
    • Dukes C. The hereditary factor in polyposis intestini, or multiple adenomata. Cancer Rev 1930;5:241-55.
    • (1930) Cancer Rev , vol.5 , pp. 241-255
    • Dukes, C.1
  • 11
    • 16344363431 scopus 로고
    • Intestinal polyposis and carcinoma originating from a mutation in a family group
    • Gardner EJ, Woolf CM. Intestinal polyposis and carcinoma originating from a mutation in a family group. Cancer 1952;5:695-9.
    • (1952) Cancer , vol.5 , pp. 695-699
    • Gardner, E.J.1    Woolf, C.M.2
  • 12
    • 0023223410 scopus 로고
    • Localization of the gene for familial adenomatous polyposis on chromosome 5
    • Bodmer WF, Bailey CJ, Bodmer J, et al. Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 1987;328:614-6.
    • (1987) Nature , vol.328 , pp. 614-616
    • Bodmer, W.F.1    Bailey, C.J.2    Bodmer, J.3
  • 13
    • 15144342709 scopus 로고    scopus 로고
    • Phenotypic expression of disease in families that have mutations in the 5' region of the adenomatous polyposis coli gene
    • Giardiello FM, Brensinger JD, Luce MC, et al. Phenotypic expression of disease in families that have mutations in the 5' region of the adenomatous polyposis coli gene. Ann Intern Med 1997;126:514-9.
    • (1997) Ann Intern Med , vol.126 , pp. 514-519
    • Giardiello, F.M.1    Brensinger, J.D.2    Luce, M.C.3
  • 14
    • 0022619767 scopus 로고
    • Cancer family syndrome. Genetic analysis of 22 finnish kindreds.
    • Mecklin JP, Jarvinen HJ, Peltokallio P. Cancer family syndrome. Genetic analysis of 22 finnish kindreds. Gastroenterology 1986;90:328-33.
    • (1986) Gastroenterology , vol.90 , pp. 328-333
    • Mecklin, J.P.1    Jarvinen, H.J.2    Peltokallio, P.3
  • 15
    • 0023917556 scopus 로고
    • Differential diagnosis of hereditary nonpolyposis colorectal cancer (lynch syndrome I and lynch syndrome II)
    • Lynch HT, Watson P, Kriegler M, et al. Differential diagnosis of hereditary nonpolyposis colorectal cancer (lynch syndrome I and lynch syndrome II). Dis Colon Rectum 1988;31:372-7.
    • (1988) Dis Colon Rectum , vol.31 , pp. 372-377
    • Lynch, H.T.1    Watson, P.2    Kriegler, M.3
  • 16
    • 0025326851 scopus 로고
    • The tumour spectrum in hereditary non-polyposis colorectal cancer: A study of 24 kindreds in the netherlands
    • Vasen HF, Offerhaus GJ, den Hartog Jager FC, et al. The tumour spectrum in hereditary non-polyposis colorectal cancer: A study of 24 kindreds in the netherlands. Int J Cancer 1990;46:31-4.
    • (1990) Int J Cancer , vol.46 , pp. 31-34
    • Vasen, H.F.1    Offerhaus, G.J.2    den Hartog Jager, F.C.3
  • 17
    • 74849117329 scopus 로고    scopus 로고
    • Surgical management of hereditary colorectal cancer: Surgery based on molecular analysis and family history
    • Perea J, Justo I, Alvaro E, et al. Surgical management of hereditary colorectal cancer: Surgery based on molecular analysis and family history. Rev Esp Enferm Dig 2009;101:536-40.
    • (2009) Rev Esp Enferm Dig , vol.101 , pp. 536-540
    • Perea, J.1    Justo, I.2    Alvaro, E.3
  • 18
    • 84874638950 scopus 로고    scopus 로고
    • Genetic testing in gastrointestinal cancers: A case-based approach
    • 444-6 passim
    • Schrader K, Offit K, Stadler ZK. Genetic testing in gastrointestinal cancers: A case-based approach. Oncology 2012;26:433-6, 438, 444-6 passim.
    • (2012) Oncology , vol.26
    • Schrader, K.1    Offit, K.2    Stadler, Z.K.3
  • 19
    • 0006171447 scopus 로고    scopus 로고
    • Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum
    • Jass JR, Iino H, Ruszkiewicz A, et al. Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut 2000;47:43-9.
    • (2000) Gut , vol.47 , pp. 43-49
    • Jass, J.R.1    Iino, H.2    Ruszkiewicz, A.3
  • 20
    • 33845608798 scopus 로고    scopus 로고
    • Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
    • Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 2007;50:113-30.
    • (2007) Histopathology , vol.50 , pp. 113-130
    • Jass, J.R.1
  • 21
    • 84995792646 scopus 로고    scopus 로고
    • Updated 20052014
    • National society of genetic counselors. Available online: www.nsgc.org. Updated 20052014.
  • 22
    • 61949256316 scopus 로고    scopus 로고
    • American college of gastroenterology guidelines for colorectal cancer screening 2009 [corrected]
    • Rex DK, Johnson DA, Anderson JC, et al. American college of gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol 2009;104:739-50.
    • (2009) Am J Gastroenterol , vol.104 , pp. 739-750
    • Rex, D.K.1    Johnson, D.A.2    Anderson, J.C.3
  • 23
    • 84863609627 scopus 로고    scopus 로고
    • Identification of individuals at risk for lynch syndrome using targeted evaluations and genetic testing: National society of genetic counselors and the collaborative group of the americas on inherited colorectal cancer joint practice guideline
    • Weissman SM, Burt R, Church J, et al. Identification of individuals at risk for lynch syndrome using targeted evaluations and genetic testing: National society of genetic counselors and the collaborative group of the americas on inherited colorectal cancer joint practice guideline. J Genet Couns 2012;21:484-93.
    • (2012) J Genet Couns , vol.21 , pp. 484-493
    • Weissman, S.M.1    Burt, R.2    Church, J.3
  • 24
    • 84907275948 scopus 로고    scopus 로고
    • Genetic/familial high-risk assessment: Colorectal
    • (version 1.2014). National Comprehensive Cancer Network Web site.Updated 2014. Accessed 03/27
    • National Comprehensive Cancer Network. Genetic/familial high-risk assessment: Colorectal (version 1.2014). National Comprehensive Cancer Network Web site. Available online: http://www.nccn.org. Updated 2014. Accessed 03/27, 2014.
    • (2014)
  • 25
    • 68749111581 scopus 로고    scopus 로고
    • The current state of cancer family history collection tools in primary care: A systematic review
    • Qureshi N, Carroll JC, Wilson B, et al. The current state of cancer family history collection tools in primary care: A systematic review. Genet Med 2009;11:495-506.
    • (2009) Genet Med , vol.11 , pp. 495-506
    • Qureshi, N.1    Carroll, J.C.2    Wilson, B.3
  • 26
    • 1242292336 scopus 로고    scopus 로고
    • Referral for cancer genetics consultation: A review and compilation of risk assessment criteria
    • Hampel H, Sweet K, Westman JA, et al. Referral for cancer genetics consultation: A review and compilation of risk assessment criteria. J Med Genet 2004;41:81-91.
    • (2004) J Med Genet , vol.41 , pp. 81-91
    • Hampel, H.1    Sweet, K.2    Westman, J.A.3
  • 27
    • 70350247878 scopus 로고    scopus 로고
    • Do colorectal cancer patients understand that their family is at risk?
    • Rubin DT, Gandhi RK, Hetzel JT, et al. Do colorectal cancer patients understand that their family is at risk? Dig Dis Sci 2009;54:2473-83.
    • (2009) Dig Dis Sci , vol.54 , pp. 2473-2483
    • Rubin, D.T.1    Gandhi, R.K.2    Hetzel, J.T.3
  • 28
    • 65349177304 scopus 로고    scopus 로고
    • Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels
    • Domanska K, Carlsson C, Bendahl PO, et al. Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels. BMC Med Genet 2009;10:30.
    • (2009) BMC Med Genet , vol.10 , Issue.30
    • Domanska, K.1    Carlsson, C.2    Bendahl, P.O.3
  • 29
    • 42049113883 scopus 로고    scopus 로고
    • Value of database linkage: Are patients at risk of familial colorectal cancer being referred for genetic counselling and testing?
    • Wong C, Gibbs P, Johns J, et al. Value of database linkage: Are patients at risk of familial colorectal cancer being referred for genetic counselling and testing? Intern Med J 2008;38:328-33.
    • (2008) Intern Med J , vol.38 , pp. 328-333
    • Wong, C.1    Gibbs, P.2    Johns, J.3
  • 30
    • 0037080326 scopus 로고    scopus 로고
    • Identification and referral of families at high risk for cancer susceptibility
    • Sweet KM, Bradley TL, Westman JA. Identification and referral of families at high risk for cancer susceptibility. J Clin Oncol 2002;20:528-37.
    • (2002) J Clin Oncol , vol.20 , pp. 528-537
    • Sweet, K.M.1    Bradley, T.L.2    Westman, J.A.3
  • 31
    • 33750049649 scopus 로고    scopus 로고
    • Cancer risk assessment: Examining the family physician's role
    • Tyler CV Jr, Snyder CW. Cancer risk assessment: Examining the family physician's role. J Am Board Fam Med 2006;19:468-77.
    • (2006) J Am Board Fam Med , vol.19 , pp. 468-477
    • Tyler, C.V.1    Snyder, C.W.2
  • 32
    • 84857661146 scopus 로고    scopus 로고
    • Screening practices of unaffected people at familial risk of colorectal cancer
    • Ait Ouakrim D, Boussioutas A, Lockett T, et al. Screening practices of unaffected people at familial risk of colorectal cancer. Cancer Prev Res (Phila) 2012;5:240-7.
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 240-247
    • Ait Ouakrim, D.1    Boussioutas, A.2    Lockett, T.3
  • 33
    • 78549281822 scopus 로고    scopus 로고
    • Cost-effectiveness of colorectal cancer screening in high-risk spanish patients: Use of a validated model to inform public policy
    • Ladabaum U, Ferrandez A, Lanas A. Cost-effectiveness of colorectal cancer screening in high-risk spanish patients: Use of a validated model to inform public policy. Cancer Epidemiol Biomarkers Prev 2010;19:2765-76.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 2765-2776
    • Ladabaum, U.1    Ferrandez, A.2    Lanas, A.3
  • 34
    • 77951758579 scopus 로고    scopus 로고
    • Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
    • Cairns SR, Scholefield JH, Steele RJ, et al. Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut 2010;59:666-89.
    • (2010) Gut , vol.59 , pp. 666-689
    • Cairns, S.R.1    Scholefield, J.H.2    Steele, R.J.3
  • 35
    • 42449156005 scopus 로고    scopus 로고
    • Screening participation in individuals with a family history of colorectal cancer: A review.
    • Rees G, Martin PR, Macrae FA. Screening participation in individuals with a family history of colorectal cancer: A review. Eur J Cancer Care (Engl) 2008;17:221-32.
    • (2008) Eur J Cancer Care (Engl) , vol.17 , pp. 221-232
    • Rees, G.1    Martin, P.R.2    Macrae, F.A.3
  • 36
    • 27744477699 scopus 로고    scopus 로고
    • Prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study
    • Dove-Edwin I, Sasieni P, Adams J, et al. Prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study. BMJ 2005;331:1047.
    • (2005) BMJ , vol.331 , pp. 1047
    • Dove-Edwin, I.1    Sasieni, P.2    Adams, J.3
  • 37
    • 77958041420 scopus 로고    scopus 로고
    • Cancer --Australian cancer statistics
    • update May 2010. AIHW
    • Australian institute of health and welfare. Cancer --Australian cancer statistics update May 2010. AIHW. 2010.
    • (2010)
  • 38
    • 84855609553 scopus 로고    scopus 로고
    • GLOBOCAN 2008, cancer incidence and mortality worldwide: IARC
    • CancerBase no. 10. Lyon, France: International Agency for Research on Cancer Web site. Updated 20102012
    • Ferlay J, Bray F, Forman D, et al. GLOBOCAN 2008, cancer incidence and mortality worldwide: IARC CancerBase no. 10. Lyon, France: International Agency for Research on Cancer Web site. Available online: http://wwwdep. iarc.fr. Updated 20102012.
    • Ferlay, J.1    Bray, F.2    Forman, D.3
  • 39
    • 0036433067 scopus 로고    scopus 로고
    • Primary care physicians' awareness and implementation of screening guidelines for colorectal cancer
    • Schattner A, Gilad A. Primary care physicians' awareness and implementation of screening guidelines for colorectal cancer. Prev Med 2002;35:447-52.
    • (2002) Prev Med , vol.35 , pp. 447-452
    • Schattner, A.1    Gilad, A.2
  • 40
    • 0033955686 scopus 로고    scopus 로고
    • Patient adherence to family practitioners' recommendations for breast cancer screening: A historical cohort study
    • Giveon S, Kahan E. Patient adherence to family practitioners' recommendations for breast cancer screening: A historical cohort study. Fam Pract 2000;17:42-5.
    • (2000) Fam Pract , vol.17 , pp. 42-45
    • Giveon, S.1    Kahan, E.2
  • 41
    • 0030296568 scopus 로고    scopus 로고
    • Increasing cancer screening: A meta analysis
    • Snell JL, Buck EL. Increasing cancer screening: A meta analysis. Prev Med 1996;25:702-7.
    • (1996) Prev Med , vol.25 , pp. 702-707
    • Snell, J.L.1    Buck, E.L.2
  • 42
    • 0025899162 scopus 로고
    • Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    • Nishisho I, Nakamura Y, Miyoshi Y, et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991;253:665-9.
    • (1991) Science , vol.253 , pp. 665-669
    • Nishisho, I.1    Nakamura, Y.2    Miyoshi, Y.3
  • 43
    • 84863750173 scopus 로고    scopus 로고
    • Molecular testing in colorectal cancer: diagnosis of lynch syndrome and personalized cancer medicine
    • Shi C, Washington K. Molecular testing in colorectal cancer: diagnosis of lynch syndrome and personalized cancer medicine. Am J Clin Pathol 2012;137:847-59.
    • (2012) Am J Clin Pathol , vol.137 , pp. 847-859
    • Shi, C.1    Washington, K.2
  • 44
    • 0032730774 scopus 로고    scopus 로고
    • Genetic susceptibility to nonpolyposis colorectal cancer
    • Lynch HT, de la Chapelle A. Genetic susceptibility to nonpolyposis colorectal cancer. J Med Genet 1999;36:801-18.
    • (1999) J Med Genet , vol.36 , pp. 801-818
    • Lynch, H.T.1    de la Chapelle, A.2
  • 46
    • 33644626371 scopus 로고    scopus 로고
    • DNA mismatch repair: Functions and mechanisms
    • Iyer RR, Pluciennik A, Burdett V, et al. DNA mismatch repair: Functions and mechanisms. Chem Rev 2006;106:302-23.
    • (2006) Chem Rev , vol.106 , pp. 302-323
    • Iyer, R.R.1    Pluciennik, A.2    Burdett, V.3
  • 47
    • 77952474986 scopus 로고    scopus 로고
    • SnapShot: DNA mismatch repair
    • Larrea AA, Lujan SA, Kunkel TA. SnapShot: DNA mismatch repair. Cell 2010;141:730.e1
    • (2010) Cell , vol.141 , Issue.730 , pp. e1
    • Larrea, A.A.1    Lujan, S.A.2    Kunkel, T.A.3
  • 48
    • 77951030494 scopus 로고    scopus 로고
    • Modulation of mismatch repair and genomic stability by miR-155
    • Valeri N, Gasparini P, Fabbri M, et al. Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A 2010;107:6982-7.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6982-6987
    • Valeri, N.1    Gasparini, P.2    Fabbri, M.3
  • 49
    • 84893653548 scopus 로고    scopus 로고
    • Working Group of the American College of Medical Genetics and Genomics (ACMG) Laboratory Quality Assurance Committee. ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis)
    • Hegde M, Ferber M, Mao R, et al. Working Group of the American College of Medical Genetics and Genomics (ACMG) Laboratory Quality Assurance Committee. ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). Genet Med 2014;16:101-16.
    • (2014) Genet Med , vol.16 , pp. 101-116
    • Hegde, M.1    Ferber, M.2    Mao, R.3
  • 50
    • 79952754996 scopus 로고    scopus 로고
    • Recurrence and variability of germline EPCAM deletions in lynch syndrome
    • Kuiper RP, Vissers LE, Venkatachalam R, et al. Recurrence and variability of germline EPCAM deletions in lynch syndrome. Hum Mutat 2011;32:407-14.
    • (2011) Hum Mutat , vol.32 , pp. 407-414
    • Kuiper, R.P.1    Vissers, L.E.2    Venkatachalam, R.3
  • 51
    • 1042290354 scopus 로고    scopus 로고
    • Testing guidelines for hereditary non-polyposis colorectal cancer
    • Umar A, Risinger JI, Hawk ET, et al. Testing guidelines for hereditary non-polyposis colorectal cancer. Nat Rev Cancer 2004;4:153-8.
    • (2004) Nat Rev Cancer , vol.4 , pp. 153-158
    • Umar, A.1    Risinger, J.I.2    Hawk, E.T.3
  • 52
    • 78650692633 scopus 로고    scopus 로고
    • Risk of colorectal and endometrial cancers in EPCAM deletionpositive lynch syndrome: A cohort study
    • Kempers MJ, Kuiper RP, Ockeloen CW, et al. Risk of colorectal and endometrial cancers in EPCAM deletionpositive lynch syndrome: A cohort study. Lancet Oncol 2011;12:49-55.
    • (2011) Lancet Oncol , vol.12 , pp. 49-55
    • Kempers, M.J.1    Kuiper, R.P.2    Ockeloen, C.W.3
  • 53
    • 84880920383 scopus 로고    scopus 로고
    • Gene variants of unknown clinical significance in lynch syndrome. An introduction for clinicians.
    • Sijmons RH, Greenblatt MS, Genuardi M. Gene variants of unknown clinical significance in lynch syndrome. An introduction for clinicians. Fam Cancer 2013;12:181-7.
    • (2013) Fam Cancer , vol.12 , pp. 181-187
    • Sijmons, R.H.1    Greenblatt, M.S.2    Genuardi, M.3
  • 55
    • 84897400369 scopus 로고    scopus 로고
    • Epigenetic mechanisms in the pathogenesis of lynch syndrome
    • Peltomäki P. Epigenetic mechanisms in the pathogenesis of lynch syndrome. Clin Genet 2014;85:403-12.
    • (2014) Clin Genet , vol.85 , pp. 403-412
    • Peltomäki, P.1
  • 56
    • 84880922857 scopus 로고    scopus 로고
    • The role of epigenetics in lynch syndrome
    • Hitchins MP. The role of epigenetics in lynch syndrome. Fam Cancer 2013;12:189-205.
    • (2013) Fam Cancer , vol.12 , pp. 189-205
    • Hitchins, M.P.1
  • 57
    • 77952965113 scopus 로고    scopus 로고
    • Point: Justification for lynch syndrome screening among all patients with newly diagnosed colorectal cancer
    • Hampel H. Point: Justification for lynch syndrome screening among all patients with newly diagnosed colorectal cancer. J Natl Compr Canc Netw 2010;8:597-601.
    • (2010) J Natl Compr Canc Netw , vol.8 , pp. 597-601
    • Hampel, H.1
  • 58
    • 0034098691 scopus 로고    scopus 로고
    • Biology of the adenomatous polyposis coli tumor suppressor
    • Goss KH, Groden J. Biology of the adenomatous polyposis coli tumor suppressor. J Clin Oncol 2000;18:1967-79.
    • (2000) J Clin Oncol , vol.18 , pp. 1967-1979
    • Goss, K.H.1    Groden, J.2
  • 60
    • 33748180713 scopus 로고    scopus 로고
    • Celecoxib for the prevention of colorectal adenomatous polyps
    • Arber N, Eagle CJ, Spicak J, et al. Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med 2006;355:885-95.
    • (2006) N Engl J Med , vol.355 , pp. 885-895
    • Arber, N.1    Eagle, C.J.2    Spicak, J.3
  • 61
    • 0037018508 scopus 로고    scopus 로고
    • Primary chemoprevention of familial adenomatous polyposis with sulindac
    • Giardiello FM, Yang VW, Hylind LM, et al. Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med 2002;346:1054-9.
    • (2002) N Engl J Med , vol.346 , pp. 1054-1059
    • Giardiello, F.M.1    Yang, V.W.2    Hylind, L.M.3
  • 64
    • 84867817838 scopus 로고    scopus 로고
    • Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    • Liao X, Lochhead P, Nishihara R, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012;367:1596-606.
    • (2012) N Engl J Med , vol.367 , pp. 1596-1606
    • Liao, X.1    Lochhead, P.2    Nishihara, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.