Botulinum neurotoxins can enter cultured neurons independent of synaptic vesicle recycling

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Pellett, Sabine ^a   Tepp, William H ^a   Scherf, Jacob M ^a   Johnson, Eric A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN D; BOTULINUM TOXIN E; BOTULINUM TOXIN F; LACTATE DEHYDROGENASE; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; UNCLASSIFIED DRUG; SNAP25 PROTEIN, HUMAN; SYNAPTOBREVIN 2; VAMP2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BOTULISM; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; ENZYME RELEASE; EXOCYTOSIS; FLACCID PARALYSIS; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MOUSE; NERVE CELL CULTURE; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROTRANSMITTER RELEASE; NONHUMAN; PROTEIN CLEAVAGE; SYNAPSE VESICLE; ANIMAL; BIOASSAY; CELL CULTURE; CHEMICALLY INDUCED; CLASSIFICATION; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; INDUCED PLURIPOTENT STEM CELL; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRAPERITONEAL DRUG ADMINISTRATION; LD50; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; SEROTYPING; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT; BOTULINUM TOXINS; BOTULISM; CELLS, CULTURED; ENDOCYTOSIS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INJECTIONS, INTRAPERITONEAL; LETHAL DOSE 50; MICE; MICE, INBRED ICR; NEUROGENESIS; NEURONS; SEROTYPING; SYNAPTIC VESICLES; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

EID: 84941695742     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133737     Document Type: Article

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