Gardenamide a protects RGC-5 cells from H2O2-induced oxidative stress insults by activating PI3K/Akt/eNOS signaling pathway

International Journal of Molecular Sciences

Volumn 16, Issue 9, 2015, Pages 22350-22367

  Wang, Rikang ^a   Peng, Lizhi ^b   Zhao, Jiaqiang ^b   Zhang, Laitao ^b   Guo, Cuiping ^b   Zheng, Wenhua ^c   Chen, Heru ^b,d  

^a JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b JINAN UNIVERSITY   (China)

^c UNIVERSITY OF MACAU   (Macao)

^d Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research   (China)

Author keywords

Cell apoptosis; Gardenamide A; Neuroprotection; Neurotoxicity; Oxidative stress

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GARDENAMIDE A; GENIPIN; HYDROGEN PEROXIDE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTIOXIDANT; IRIDOID; NEUROPROTECTIVE AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL STRUCTURE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG EFFECTS; METABOLISM; RAT; SECOND MESSENGER;

ANIMALS; ANTIOXIDANTS; CELL LINE; HYDROGEN PEROXIDE; IRIDOIDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RETINAL GANGLION CELLS; SECOND MESSENGER SYSTEMS;

EID: 84941695614     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160922350     Document Type: Article

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