Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing

Thrombosis and Haemostasis

Volumn 112, Issue 5, 2014, Pages 992-1001

  Lopéz, Mercedes L ^a,b   Bruges, Gustavo ^a   Crespo, Gustavo ^a   Salazar, Victor ^a   Deglesne, Pierre Antoine ^a   Schneider, Heike ^c   Cabrera Fuentes, Hector ^b,d   Lienhard Schmitz, M ^b   Preissner, Klaus T ^b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d KAZAN FEDERAL UNIVERSITY   (Russian Federation)

Author keywords

Gene expression; Inflammation; Microarray technology; Mitogen activated protein kinases; Protease activated receptor; Thrombin; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; CD83 ANTIGEN; COMPLEMENTARY RNA; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; DIMETHYL SULFOXIDE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 2; PENTRAXIN 3; PROTEINASE ACTIVATED RECEPTOR 1; STRESS ACTIVATED PROTEIN KINASE; THROMBIN; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNINDEXED DRUG; WNT5A PROTEIN;

ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYBRIDIZATION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRACELLULAR SIGNALING; MICROARRAY ANALYSIS; MONOCYTE; MRNA EXPRESSION ASSAY; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PURIFICATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; WOUND HEALING; BIOSYNTHESIS; BLOOD CLOTTING; CELL CULTURE; DNA MICROARRAY; DRUG EFFECTS; FEEDBACK SYSTEM; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

BLOOD COAGULATION; CELLS, CULTURED; FACTOR XA; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, PAR-1; THROMBIN; THROMBOPLASTIN; TRANSCRIPTION, GENETIC; UP-REGULATION; WOUND HEALING;

EID: 84908537692     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-01-0034     Document Type: Article

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