A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency

Molecular Biology of the Cell

Volumn 23, Issue 21, 2012, Pages 4175-4187

  Cline, Abigail ^a   Gao, Ningguo ^b   Flanagan Steet, Heather ^a   Sharma, Vandana ^c   Rosa, Sabrina ^d   Sonon, Roberto ^a   Azadi, Parastoo ^a   Sadler, Kirsten C ^d   Freeze, Hudson H ^c   Lehrman, Mark A ^b   Steet, Richard ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c BURNHAM INSTITUTE   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE DIPHOSPHATE MANNOSE; LIPOOLIGOSACCHARIDE; MANNOSE 1 PHOSPHATE; MANNOSE 6 PHOSPHATE; MANNOSE PHOSPHATE; MANNOSE PHOSPHATE ISOMERASE; PHOSPHOMANNOMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONGENITAL DISORDER OF GLYCOSYLATION; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; EMBRYO; MOTOR NERVE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN GLYCOSYLATION; SPINAL CORD; ZEBRA FISH;

ANIMALS; CARTILAGE; CELL SHAPE; CHONDROCYTES; CONGENITAL DISORDERS OF GLYCOSYLATION; CRANIOFACIAL ABNORMALITIES; DISEASE MODELS, ANIMAL; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOSYLATION; LIPOPOLYSACCHARIDES; MANNOSE-6-PHOSPHATE ISOMERASE; MANNOSEPHOSPHATES; MORPHOLINOS; MOTOR NEURONS; MOVEMENT; NEUROGENESIS; PHOSPHOTRANSFERASES (PHOSPHOMUTASES); SKULL; SPINAL CORD; SUBSTRATE SPECIFICITY; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO;

EID: 84868248946     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-05-0411     Document Type: Article

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