-
1
-
-
23744458034
-
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
-
Huang J, Wu S, Barrera J, et al. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 2005;122:421-34.
-
(2005)
Cell
, vol.122
, pp. 421-434
-
-
Huang, J.1
Wu, S.2
Barrera, J.3
-
2
-
-
70549083563
-
Herding Hippos: regulating growth in flies and man
-
Badouel C, Garg A, McNeill H. Herding Hippos: regulating growth in flies and man. Curr Opin Cell Biol 2009;21:837-43.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 837-843
-
-
Badouel, C.1
Garg, A.2
McNeill, H.3
-
3
-
-
0037162714
-
Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
-
Tapon N, Harvey KF, Bell DW, et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002;110:467-78.
-
(2002)
Cell
, vol.110
, pp. 467-478
-
-
Tapon, N.1
Harvey, K.F.2
Bell, D.W.3
-
4
-
-
57049097531
-
The Hippo-YAP pathway: new connections between regulation of organ size and cancer
-
Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol 2008;20:638-46.
-
(2008)
Curr Opin Cell Biol
, vol.20
, pp. 638-646
-
-
Zhao, B.1
Lei, Q.Y.2
Guan, K.L.3
-
5
-
-
84884291548
-
Spatial organization of hippo signaling at the plasma membrane mediated by the tumor suppressor merlin/NF2
-
Yin F, Yu J, Zheng Y, et al. Spatial organization of hippo signaling at the plasma membrane mediated by the tumor suppressor merlin/NF2. Cell 2013;154:1342-55.
-
(2013)
Cell
, vol.154
, pp. 1342-1355
-
-
Yin, F.1
Yu, J.2
Zheng, Y.3
-
6
-
-
55849132186
-
The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP
-
Striedinger K, VandenBerg SR, Baia GS, et al. The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP. Neoplasia 2008;10:1204-12.
-
(2008)
Neoplasia
, vol.10
, pp. 1204-1212
-
-
Striedinger, K.1
VandenBerg, S.R.2
Baia, G.S.3
-
7
-
-
47549095853
-
TEAD mediates YAPdependent gene induction and growth control
-
Zhao B, Ye X, Yu J, et al. TEAD mediates YAPdependent gene induction and growth control. Genes Dev 2008;22:1962-71.
-
(2008)
Genes Dev
, vol.22
, pp. 1962-1971
-
-
Zhao, B.1
Ye, X.2
Yu, J.3
-
8
-
-
84877858820
-
Emerging roles of TEAD transcription factors and its coactivators in cancers
-
Pobbati AV, Hong W. Emerging roles of TEAD transcription factors and its coactivators in cancers. Cancer Biol Ther 2013;14:390-8.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 390-398
-
-
Pobbati, A.V.1
Hong, W.2
-
9
-
-
79952532529
-
AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
-
Xu MZ, Chan SW, Liu AM, et al. AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma. Oncogene 2011;30:1229-40.
-
(2011)
Oncogene
, vol.30
, pp. 1229-1240
-
-
Xu, M.Z.1
Chan, S.W.2
Liu, A.M.3
-
10
-
-
34548636132
-
Elucidation of a universal size-control mechanism in Drosophila and mammals
-
Dong J, Feldmann G, Huang J, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007;130:1120-33.
-
(2007)
Cell
, vol.130
, pp. 1120-1133
-
-
Dong, J.1
Feldmann, G.2
Huang, J.3
-
11
-
-
76549124517
-
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
-
Lu L, Li Y, Kim SM, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A 2010;107:1437-42.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 1437-1442
-
-
Lu, L.1
Li, Y.2
Kim, S.M.3
-
12
-
-
33745253109
-
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
-
Zender L, Spector MS, Xue W, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 2006;125:1253-67.
-
(2006)
Cell
, vol.125
, pp. 1253-1267
-
-
Zender, L.1
Spector, M.S.2
Xue, W.3
-
13
-
-
70349295967
-
Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma
-
Xu MZ, Yao TJ, Lee NP, et al. Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer 2009;115:4576-85.
-
(2009)
Cancer
, vol.115
, pp. 4576-4585
-
-
Xu, M.Z.1
Yao, T.J.2
Lee, N.P.3
-
14
-
-
79959658018
-
The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene
-
Zhang X, George J, Deb S, et al. The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene. Oncogene 2011;30:2810-22.
-
(2011)
Oncogene
, vol.30
, pp. 2810-2822
-
-
Zhang, X.1
George, J.2
Deb, S.3
-
15
-
-
79952304497
-
YAP is a candidate oncogene for esophageal squamous cell carcinoma
-
Muramatsu T, Imoto I, Matsui T, et al. YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis 2011;32:389-98.
-
(2011)
Carcinogenesis
, vol.32
, pp. 389-398
-
-
Muramatsu, T.1
Imoto, I.2
Matsui, T.3
-
16
-
-
77953197857
-
Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer
-
Wang Y, Dong Q, Zhang Q, et al. Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer Sci 2010;101:1279-85.
-
(2010)
Cancer Sci
, vol.101
, pp. 1279-1285
-
-
Wang, Y.1
Dong, Q.2
Zhang, Q.3
-
17
-
-
72549090299
-
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
-
Fernandez-L A, Northcott PA, Dalton J, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev 2009;23:2729-41.
-
(2009)
Genes Dev
, vol.23
, pp. 2729-2741
-
-
Fernandez-L, A.1
Northcott, P.A.2
Dalton, J.3
-
18
-
-
34247396134
-
Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics
-
Modena P, Lualdi E, Facchinetti F, et al. Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics. J Clin Oncol 2006;24:5223-33.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5223-5233
-
-
Modena, P.1
Lualdi, E.2
Facchinetti, F.3
-
19
-
-
20544465379
-
Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma
-
Snijders AM, Schmidt BL, Fridlyand J, et al. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene 2005;24:4232-42.
-
(2005)
Oncogene
, vol.24
, pp. 4232-4242
-
-
Snijders, A.M.1
Schmidt, B.L.2
Fridlyand, J.3
-
20
-
-
84858731473
-
YAP oncogene overexpression supercharges colon cancer proliferation
-
Avruch J, Zhou D, Bardeesy N. YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle 2012;11:1090-6.
-
(2012)
Cell Cycle
, vol.11
, pp. 1090-1096
-
-
Avruch, J.1
Zhou, D.2
Bardeesy, N.3
-
21
-
-
35148841871
-
Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
-
Seidel C, Schagdarsurengin U, Blumke K, et al. Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol Carcinog 2007;46:865-71.
-
(2007)
Mol Carcinog
, vol.46
, pp. 865-871
-
-
Seidel, C.1
Schagdarsurengin, U.2
Blumke, K.3
-
22
-
-
33751019980
-
Promoter hypermethylationmediated down-regulation of LATS1 and LATS2 in human astrocytoma
-
Jiang Z, Li X, Hu J, et al. Promoter hypermethylationmediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res 2006;56:450-8.
-
(2006)
Neurosci Res
, vol.56
, pp. 450-458
-
-
Jiang, Z.1
Li, X.2
Hu, J.3
-
23
-
-
14644420898
-
Downregulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
-
Takahashi Y, Miyoshi Y, Takahata C, et al. Downregulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin Cancer Res 2005;11:1380-5.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1380-1385
-
-
Takahashi, Y.1
Miyoshi, Y.2
Takahata, C.3
-
25
-
-
35948961118
-
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
-
Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007;21:2747-61.
-
(2007)
Genes Dev
, vol.21
, pp. 2747-2761
-
-
Zhao, B.1
Wei, X.2
Li, W.3
-
26
-
-
84865411430
-
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
-
Halder G, Dupont S, Piccolo S. Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol 2012;13:591-600.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 591-600
-
-
Halder, G.1
Dupont, S.2
Piccolo, S.3
-
27
-
-
84865260845
-
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
-
Yu FX, Zhao B, Panupinthu N, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 2012;150:780-91.
-
(2012)
Cell
, vol.150
, pp. 780-791
-
-
Yu, F.X.1
Zhao, B.2
Panupinthu, N.3
-
28
-
-
84878868616
-
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation
-
Yu FX, Zhang Y, Park HW, et al. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev 2013;27:1223-32.
-
(2013)
Genes Dev
, vol.27
, pp. 1223-1232
-
-
Yu, F.X.1
Zhang, Y.2
Park, H.W.3
-
29
-
-
84867182034
-
Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)
-
Mo JS, Yu FX, Gong R, et al. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev 2012;26:2138-43.
-
(2012)
Genes Dev
, vol.26
, pp. 2138-2143
-
-
Mo, J.S.1
Yu, F.X.2
Gong, R.3
-
30
-
-
84891940884
-
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
-
Wang Z, Wu Y, Wang H, et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A 2014;111:E89-98.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. E89-E98
-
-
Wang, Z.1
Wu, Y.2
Wang, H.3
-
31
-
-
84863012595
-
Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma
-
Carbone M, Yang H. Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma. Clin Cancer Res 2012;18:598-604.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 598-604
-
-
Carbone, M.1
Yang, H.2
-
34
-
-
80054885219
-
Malignant mesothelioma: facts, myths, and hypotheses
-
Carbone M, Ly BH, Dodson RF, et al. Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol 2012;227:44-58.
-
(2012)
J Cell Physiol
, vol.227
, pp. 44-58
-
-
Carbone, M.1
Ly, B.H.2
Dodson, R.F.3
-
35
-
-
26444458845
-
Advances in malignant mesothelioma
-
Robinson BW, Lake RA. Advances in malignant mesothelioma. N Engl J Med 2005;353:1591-603.
-
(2005)
N Engl J Med
, vol.353
, pp. 1591-1603
-
-
Robinson, B.W.1
Lake, R.A.2
-
36
-
-
0031217594
-
Mechanisms of fiber-induced genotoxicity
-
Jaurand MC. Mechanisms of fiber-induced genotoxicity. Environ Health Perspect 1997;105 Suppl 5:1073-84.
-
(1997)
Environ Health Perspect
, vol.105
, pp. 1073-1084
-
-
Jaurand, M.C.1
-
37
-
-
0020644968
-
Asbestos: mechanisms of toxicity and carcinogenicity in the respiratory tract
-
Mossman B, Light W, Wei E. Asbestos: mechanisms of toxicity and carcinogenicity in the respiratory tract. Annu Rev Pharmacol Toxicol 1983;23:595-615.
-
(1983)
Annu Rev Pharmacol Toxicol
, vol.23
, pp. 595-615
-
-
Mossman, B.1
Light, W.2
Wei, E.3
-
39
-
-
77952317021
-
Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
-
Donaldson K, Murphy FA, Duffin R, et al. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 2010;7:5.
-
(2010)
Part Fibre Toxicol
, vol.7
, pp. 5
-
-
Donaldson, K.1
Murphy, F.A.2
Duffin, R.3
-
40
-
-
62349106819
-
Asbestos-induced lung diseases: an update
-
Kamp DW. Asbestos-induced lung diseases: an update. Transl Res 2009;153:143-52.
-
(2009)
Transl Res
, vol.153
, pp. 143-152
-
-
Kamp, D.W.1
-
41
-
-
74549195498
-
Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways
-
Heintz NH, Janssen-Heininger YM, Mossman BT. Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol 2010;42:133-9.
-
(2010)
Am J Respir Cell Mol Biol
, vol.42
, pp. 133-139
-
-
Heintz, N.H.1
Janssen-Heininger, Y.M.2
Mossman, B.T.3
-
42
-
-
71849098457
-
Genomic abnormalities and signal transduction dysregulation in malignant mesothelioma cells
-
Sekido Y. Genomic abnormalities and signal transduction dysregulation in malignant mesothelioma cells. Cancer Sci 2010;101:1-6.
-
(2010)
Cancer Sci
, vol.101
, pp. 1-6
-
-
Sekido, Y.1
-
43
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324-31.
-
(2004)
Nature
, vol.432
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
44
-
-
79957593436
-
Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration
-
Carmona R, Cano E, Grueso E, et al. Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration. J Cell Mol Med 2011;15:1200-9.
-
(2011)
J Cell Mol Med
, vol.15
, pp. 1200-1209
-
-
Carmona, R.1
Cano, E.2
Grueso, E.3
-
45
-
-
80053266386
-
Mesothelial cell differention into osteoblast-and adipocyte-like cells
-
Lansley SM, Searles RG, Hoi A, et al. Mesothelial cell differention into osteoblast-and adipocyte-like cells. J Cell Mol Med 2011;15:2095-105.
-
(2011)
J Cell Mol Med
, vol.15
, pp. 2095-2105
-
-
Lansley, S.M.1
Searles, R.G.2
Hoi, A.3
-
46
-
-
20444457518
-
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
-
Glinsky GV, Berezovska O, Glinskii AB. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 2005;115:1503-21.
-
(2005)
J Clin Invest
, vol.115
, pp. 1503-1521
-
-
Glinsky, G.V.1
Berezovska, O.2
Glinskii, A.B.3
-
47
-
-
78049451932
-
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
-
Cai J, Zhang N, Zheng Y, et al. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev 2010;24:2383-8.
-
(2010)
Genes Dev
, vol.24
, pp. 2383-2388
-
-
Cai, J.1
Zhang, N.2
Zheng, Y.3
-
48
-
-
78651330430
-
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
-
Forbes SA, Bindal N, Bamford S, et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res 2011;39:D945-50.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D945-D950
-
-
Forbes, S.A.1
Bindal, N.2
Bamford, S.3
-
49
-
-
0028971496
-
Immunohistochemical analysis of the p16INK4 cyclindependent kinase inhibitor in malignant mesothelioma
-
Kratzke RA, Otterson GA, Lincoln CE, et al. Immunohistochemical analysis of the p16INK4 cyclindependent kinase inhibitor in malignant mesothelioma. J Natl Cancer Inst 1995;87:1870-5.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 1870-1875
-
-
Kratzke, R.A.1
Otterson, G.A.2
Lincoln, C.E.3
-
50
-
-
0034685531
-
Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells
-
Yang CT, You L, Yeh CC, et al. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. J Natl Cancer Inst 2000;92:636-41.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 636-641
-
-
Yang, C.T.1
You, L.2
Yeh, C.C.3
-
51
-
-
0027960580
-
p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma
-
Cheng JQ, Jhanwar SC, Klein WM, et al. p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. Cancer Res 1994;54:5547-51.
-
(1994)
Cancer Res
, vol.54
, pp. 5547-5551
-
-
Cheng, J.Q.1
Jhanwar, S.C.2
Klein, W.M.3
-
52
-
-
0029155471
-
Codeletion of p15 and p16 in primary malignant mesothelioma
-
Xio S, Li D, Vijg J, et al. Codeletion of p15 and p16 in primary malignant mesothelioma. Oncogene 1995;11:511-5.
-
(1995)
Oncogene
, vol.11
, pp. 511-515
-
-
Xio, S.1
Li, D.2
Vijg, J.3
-
53
-
-
0032498502
-
The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma
-
Prins JB, Williamson KA, Kamp MM, et al. The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma. Int J Cancer 1998;75:649-53.
-
(1998)
Int J Cancer
, vol.75
, pp. 649-653
-
-
Prins, J.B.1
Williamson, K.A.2
Kamp, M.M.3
-
54
-
-
0035423037
-
Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma
-
Toyooka S, Pass HI, Shivapurkar N, et al. Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma. Cancer Res 2001;61:5727-30.
-
(2001)
Cancer Res
, vol.61
, pp. 5727-5730
-
-
Toyooka, S.1
Pass, H.I.2
Shivapurkar, N.3
-
55
-
-
0036837992
-
Inactivation of p16INK4a expression in malignant mesothelioma by methylation
-
Wong L, Zhou J, Anderson D, et al. Inactivation of p16INK4a expression in malignant mesothelioma by methylation. Lung Cancer 2002;38:131-6.
-
(2002)
Lung Cancer
, vol.38
, pp. 131-136
-
-
Wong, L.1
Zhou, J.2
Anderson, D.3
-
56
-
-
40249088315
-
Gene methylation in pleural mesothelioma: Correlations with clinico-pathological features and patient's follow-up
-
Destro A, Ceresoli GL, Baryshnikova E, et al. Gene methylation in pleural mesothelioma: Correlations with clinico-pathological features and patient's follow-up. Lung Cancer 2008;59:369-76.
-
(2008)
Lung Cancer
, vol.59
, pp. 369-376
-
-
Destro, A.1
Ceresoli, G.L.2
Baryshnikova, E.3
-
57
-
-
0028818921
-
High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas
-
Bianchi AB, Mitsunaga SI, Cheng JQ, et al. High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci U S A 1995;92:10854-8.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10854-10858
-
-
Bianchi, A.B.1
Mitsunaga, S.I.2
Cheng, J.Q.3
-
58
-
-
0028907620
-
Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer
-
Sekido Y, Pass HI, Bader S, et al. Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. Cancer Res 1995;55:1227-31.
-
(1995)
Cancer Res
, vol.55
, pp. 1227-1231
-
-
Sekido, Y.1
Pass, H.I.2
Bader, S.3
-
59
-
-
0031874488
-
Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of the NF2 gene
-
Deguen B, Goutebroze L, Giovannini M, et al. Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of the NF2 gene. Int J Cancer 1998;77:554-60.
-
(1998)
Int J Cancer
, vol.77
, pp. 554-560
-
-
Deguen, B.1
Goutebroze, L.2
Giovannini, M.3
-
60
-
-
33746722720
-
Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
-
Jin H, Sperka T, Herrlich P, et al. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 2006;442:576-9.
-
(2006)
Nature
, vol.442
, pp. 576-579
-
-
Jin, H.1
Sperka, T.2
Herrlich, P.3
-
61
-
-
63049127084
-
Functional inactivation of NF2/merlin in human mesothelioma
-
Thurneysen C, Opitz I, Kurtz S, et al. Functional inactivation of NF2/merlin in human mesothelioma. Lung Cancer 2009;64:140-7.
-
(2009)
Lung Cancer
, vol.64
, pp. 140-147
-
-
Thurneysen, C.1
Opitz, I.2
Kurtz, S.3
-
62
-
-
34848921532
-
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation
-
Tang X, Jang SW, Wang X, et al. Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol 2007;9:1199-207.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1199-1207
-
-
Tang, X.1
Jang, S.W.2
Wang, X.3
-
63
-
-
0038548168
-
Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours
-
Fleury-Feith J, Lecomte C, Renier A, et al. Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours. Oncogene 2003;22:3799-805.
-
(2003)
Oncogene
, vol.22
, pp. 3799-3805
-
-
Fleury-Feith, J.1
Lecomte, C.2
Renier, A.3
-
64
-
-
29244440415
-
Similar tumor suppressor gene alteration profiles in asbestosinduced murine and human mesothelioma
-
Lecomte C, Andujar P, Renier A, et al. Similar tumor suppressor gene alteration profiles in asbestosinduced murine and human mesothelioma. Cell Cycle 2005;4:1862-9.
-
(2005)
Cell Cycle
, vol.4
, pp. 1862-1869
-
-
Lecomte, C.1
Andujar, P.2
Renier, A.3
-
65
-
-
39849089040
-
A conditional mouse model for malignant mesothelioma
-
Jongsma J, van Montfort E, Vooijs M, et al. A conditional mouse model for malignant mesothelioma. Cancer Cell 2008;13:261-71.
-
(2008)
Cancer Cell
, vol.13
, pp. 261-271
-
-
Jongsma, J.1
van Montfort, E.2
Vooijs, M.3
-
66
-
-
77954945373
-
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
-
Zhang N, Bai H, David KK, et al. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell 2010;19:27-38.
-
(2010)
Dev Cell
, vol.19
, pp. 27-38
-
-
Zhang, N.1
Bai, H.2
David, K.K.3
-
67
-
-
0030932869
-
Cancer-susceptibility genes. Gatekeepers and caretakers
-
Kinzler KW, Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997;386:761, 763.
-
(1997)
Nature
, vol.386
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
68
-
-
38549112079
-
Nf2/Merlin: a coordinator of receptor signalling and intercellular contact
-
Curto M, McClatchey AI. Nf2/Merlin: a coordinator of receptor signalling and intercellular contact. Br J Cancer 2008;98:256-62.
-
(2008)
Br J Cancer
, vol.98
, pp. 256-262
-
-
Curto, M.1
McClatchey, A.I.2
-
69
-
-
34249913434
-
Contactdependent inhibition of EGFR signaling by Nf2/Merlin
-
Curto M, Cole BK, Lallemand D, et al. Contactdependent inhibition of EGFR signaling by Nf2/Merlin. J Cell Biol 2007;177:893-903.
-
(2007)
J Cell Biol
, vol.177
, pp. 893-903
-
-
Curto, M.1
Cole, B.K.2
Lallemand, D.3
-
70
-
-
33847622035
-
The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion
-
McLaughlin ME, Kruger GM, Slocum KL, et al. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proc Natl Acad Sci U S A 2007;104:3261-6.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3261-3266
-
-
McLaughlin, M.E.1
Kruger, G.M.2
Slocum, K.L.3
-
71
-
-
76749108011
-
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
-
Li W, You L, Cooper J, et al. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 2010;140:477-90.
-
(2010)
Cell
, vol.140
, pp. 477-490
-
-
Li, W.1
You, L.2
Cooper, J.3
-
72
-
-
48649109725
-
Merlin is a potent inhibitor of glioma growth
-
Lau YK, Murray LB, Houshmandi SS, et al. Merlin is a potent inhibitor of glioma growth. Cancer Res 2008;68:5733-42.
-
(2008)
Cancer Res
, vol.68
, pp. 5733-5742
-
-
Lau, Y.K.1
Murray, L.B.2
Houshmandi, S.S.3
-
73
-
-
79551570342
-
LATS2 is a tumor suppressor gene of malignant mesothelioma
-
Murakami H, Mizuno T, Taniguchi T, et al. LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res 2011;71:873-83.
-
(2011)
Cancer Res
, vol.71
, pp. 873-883
-
-
Murakami, H.1
Mizuno, T.2
Taniguchi, T.3
-
74
-
-
79959694149
-
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
-
Bott M, Brevet M, Taylor BS, et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet 2011;43:668-72.
-
(2011)
Nat Genet
, vol.43
, pp. 668-672
-
-
Bott, M.1
Brevet, M.2
Taylor, B.S.3
-
75
-
-
79953303845
-
Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers
-
Ren YR, Patel K, Paun BC, et al. Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers. J Biol Chem 2011;286:11960-9.
-
(2011)
J Biol Chem
, vol.286
, pp. 11960-11969
-
-
Ren, Y.R.1
Patel, K.2
Paun, B.C.3
-
76
-
-
0026503664
-
Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium
-
Chang K, Pastan I, Willingham MC. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Int J Cancer 1992;50:373-81.
-
(1992)
Int J Cancer
, vol.50
, pp. 373-381
-
-
Chang, K.1
Pastan, I.2
Willingham, M.C.3
-
77
-
-
84870663404
-
Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: a review and update
-
Ordóñez NG. Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: a review and update. Hum Pathol 2013;44:1-19.
-
(2013)
Hum Pathol
, vol.44
, pp. 1-19
-
-
Ordóñez, N.G.1
-
78
-
-
84870807773
-
YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes
-
Mizuno T, Murakami H, Fujii M, et al. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene 2012;31:5117-22.
-
(2012)
Oncogene
, vol.31
, pp. 5117-5122
-
-
Mizuno, T.1
Murakami, H.2
Fujii, M.3
-
79
-
-
84885640667
-
Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry
-
Dixit R, Ai X, Fine A. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development 2013;140:4398-406.
-
(2013)
Development
, vol.140
, pp. 4398-4406
-
-
Dixit, R.1
Ai, X.2
Fine, A.3
-
80
-
-
84865708583
-
Role of hedgehog signaling in malignant pleural mesothelioma
-
Shi Y, Moura U, Opitz I, et al. Role of hedgehog signaling in malignant pleural mesothelioma. Clin Cancer Res 2012;18:4646-56.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4646-4656
-
-
Shi, Y.1
Moura, U.2
Opitz, I.3
-
81
-
-
41949138130
-
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
-
Hao Y, Chun A, Cheung K, et al. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 2008;283:5496-509.
-
(2008)
J Biol Chem
, vol.283
, pp. 5496-5509
-
-
Hao, Y.1
Chun, A.2
Cheung, K.3
-
82
-
-
4544285754
-
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
-
Romer JT, Kimura H, Magdaleno S, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 2004;6:229-40.
-
(2004)
Cancer Cell
, vol.6
, pp. 229-240
-
-
Romer, J.T.1
Kimura, H.2
Magdaleno, S.3
-
83
-
-
84925284726
-
LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade
-
[Epub ahead of print]
-
Tanaka I, Osada H, Fujii M, et al. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. Oncogene 2013. [Epub ahead of print].
-
(2013)
Oncogene
-
-
Tanaka, I.1
Osada, H.2
Fujii, M.3
-
84
-
-
0033045690
-
Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2-and Rasdependent manner
-
Goyal RK, Lin P, Kanungo J, et al. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2-and Rasdependent manner. Mol Cell Biol 1999;19:4379-89.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4379-4389
-
-
Goyal, R.K.1
Lin, P.2
Kanungo, J.3
-
85
-
-
77950474987
-
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway
-
Das Thakur M, Feng Y, Jagannathan R, et al. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol 2010;20:657-62.
-
(2010)
Curr Biol
, vol.20
, pp. 657-662
-
-
Das Thakur, M.1
Feng, Y.2
Jagannathan, R.3
-
86
-
-
84862605178
-
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
-
Liu-Chittenden Y, Huang B, Shim JS, et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev 2012;26:1300-5.
-
(2012)
Genes Dev
, vol.26
, pp. 1300-1305
-
-
Liu-Chittenden, Y.1
Huang, B.2
Shim, J.S.3
-
87
-
-
84880050914
-
Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor
-
Keshava S, Sahoo S, Tucker TA, et al. Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor. Cancer Res 2013;73:3963-73.
-
(2013)
Cancer Res
, vol.73
, pp. 3963-3973
-
-
Keshava, S.1
Sahoo, S.2
Tucker, T.A.3
-
88
-
-
84859760355
-
Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development
-
O'Callaghan K, Kuliopulos A, Covic L. Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development. J Biol Chem 2012;287:12787-96.
-
(2012)
J Biol Chem
, vol.287
, pp. 12787-12796
-
-
O'Callaghan, K.1
Kuliopulos, A.2
Covic, L.3
-
89
-
-
49749144775
-
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2
-
Yamada T, Yano S, Ogino H, et al. Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. Cancer Sci 2008;99:1603-10.
-
(2008)
Cancer Sci
, vol.99
, pp. 1603-1610
-
-
Yamada, T.1
Yano, S.2
Ogino, H.3
-
90
-
-
84866460606
-
Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy
-
Shi Y, Felley-Bosco E, Marti TM, et al. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS One 2012;7:e45354.
-
(2012)
PLoS One
, vol.7
-
-
Shi, Y.1
Felley-Bosco, E.2
Marti, T.M.3
-
91
-
-
84891748709
-
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
-
Johnson R, Halder G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov 2014;13:63-79.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 63-79
-
-
Johnson, R.1
Halder, G.2
-
92
-
-
84885182528
-
Regulation of the Hippo pathway and implications for anticancer drug development
-
Park HW, Guan KL. Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci 2013;34:581-9.
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 581-589
-
-
Park, H.W.1
Guan, K.L.2
|