Toward a refined definition of monocyte subsets

Frontiers in Immunology

Volumn 4, Issue FRB, 2013, Pages

  Ziegler Heitbrock, Loems ^a   Hofer, Thomas P J ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Classical monocytes; Intermediate monocytes; Monocyte classification; Monocyte subsets; Non classical monocytes

Indexed keywords

ANGIOPOIETIN RECEPTOR; CD14 ANTIGEN; CD16 ANTIGEN; CD163 ANTIGEN; CD64 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CX3CR1; COLONY STIMULATING FACTOR 1; INTERLEUKIN 10; MESSENGER RNA;

ANTIGEN EXPRESSION; CELL FUNCTION; CELL MIGRATION; CELL POPULATION; CELL PROLIFERATION; CEREBROVASCULAR ACCIDENT; CLASSIFICATION; FLOW CYTOMETRY; GENE EXPRESSION; HISTOCOMPATIBILITY GENE; HISTOGRAM; HUMAN; IMMUNE RESPONSE; INFECTION; MONOCYTE; NONHUMAN; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE;

EID: 84883719725     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00023     Document Type: Review

References (32)

1. Bajana, S., Herrera-Gonzalez, N., Narvaez, J., Torres-Aguilar, H., Rivas-Carvalho, A., Aguilar, S. R., et al. (2007). Differential CD4(+) T-cell memory responses induced by two subsets of human monocyte-derived dendritic cells. Immunology 122, 381-393.
2. Cooper, D. L., Martin, S. G., Robinson, J. I., Mackie, S. L., Charles, C. J., Nam, J., et al. (2012). FcgammaRIIIa expression on monocytes in rheumatoid arthritis: role in immune-complex stimulated TNF production and non-response to methotrexate therapy. PLoS ONE 7:e28918. doi:10.1371/journal.pone.0028918
3. De Palma, M., Venneri, M. A., Galli, R., Sergi Sergi, L., Politi, L. S., Sampaolesi, M., et al. (2005). Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8, 211-226.
4. Frankenberger, M., Hofer, T. P., Marei, A., Dayyani, F., Schewe, S., Strasser, C., et al. (2012). Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint. Eur. J. Immunol. 42, 957-974.
5. Grage-Griebenow, E., Zawatzky, R., Kahlert, H., Brade, L., Flad, H., and Ernst, M. (2001). Identification of a novel dendritic cell-like subset of CD64(+)/CD16(+) blood monocytes. Eur. J. Immunol. 31, 48-56.
6. Heine, G. H., Ortiz, A., Massy, Z. A., Lindholm, B., Wiecek, A., Martinez-Castelao, A., et al. (2012). Monocyte subpopulations and cardiovascular risk in chronic kidney disease. Nat. Rev. Nephrol. 8, 362-369.
7. Heine, G. H., Ulrich, C., Seibert, E., Seiler, S., Marell, J., Reichart, B., et al. (2008). CD14(++)CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients. Kidney Int. 73, 622-629.
8. Horelt, A., Belge, K. U., Steppich, B., Prinz, J., and Ziegler-Heitbrock, L. (2002). The CD14+ CD16+ monocytes in erysipelas are expanded and show reduced cytokine production. Eur. J. Immunol. 32, 1319-1327.
9. Ingersoll, M. A., Spanbroek, R., Lottaz, C., Gautier, E. L., Frankenberger, M., Hoffmann, R., et al. (2010). Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 115, e10-e19.
10. Kim, W. K., Sun, Y., Do, H., Autissier, P., Halpern, E. F., Piatak, M. Jr., et al. (2010). Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage. J. Leukoc. Biol. 87, 557-567.
11. Kittner, J. M., Jacobs, R., Pawlak, C. R., Heijnen, C. J., Schedlowski, M., and Schmidt, R. E. (2002). Adrenaline-induced immunological changes are altered in patients with rheumatoid arthritis. Rheumatology 41, 1031-1039.
12. Korkosz, M., Bukowska-Strakova, K., Sadis, S., Grodzicki, T., and Siedlar, M. (2012). Monoclonal antibodies against macrophage colony-stimulating factor diminish the number of circulating intermediate and nonclassical (CD14++ CD16+/CD14+CD16++) monocytes in rheumatoid arthritis patient. Blood 119, 5329-5330.
13. Kowal, K., Moniuszko, M., Dabrowska, M., and Bodzenta-Lukaszyk, A. (2012). Allergen challenge differentially affects the number of circulating monocyte subsets. Scand. J. Immunol. 75, 531-539.
14. Kwissa, M., Nakaya, H. I., Oluoch, H., and Pulendran, B. (2012). Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. Blood 119, 2044-2055.
15. Moniuszko, M., Bodzenta-Lukaszyk, A., Kowal, K., Lenczewska, D., and Dabrowska, M. (2009). Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients. Clin. Immunol. 130, 338-346.
16. Murdoch, C., Tazzyman, S., Webster, S., and Lewis, C. E. (2007). Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J. Immunol. 178, 7405-7411.
17. Passlick, B., Flieger, D., and Ziegler-Heitbrock, H. W. (1989). Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 74, 2527-2534.
18. Randolph, G. J., Sanchez-Schmitz, G., Liebman, R. M., and Schakel, K. (2002). The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting. J. Exp. Med. 196, 517-527.
19. Rogacev, K. S., Cremers, B., Zawada, A. M., Seiler, S., Binder, N., Ege, P., et al. (2012). CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography. J. Am. Coll. Cardiol. 60, 1512-1520.
20. Saleh, M. N., Goldman, S. J., Lobuglio, A. F., Beall, A. C., Sabio, H., McCord, M. C., et al. (1995). CD16+ monocytes in patients with cancer: spontaneous elevation and pharmacologic induction by recombinant human macrophage colony-stimulating factor. Blood 85, 2910-2917.
21. Schauer, D., Starlinger, P., Reiter, C., Jahn, N., Zajc, P., Buchberger, E., et al. (2012). Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer. PLoS ONE 7:e44450. doi:10.1371/journal.pone.0044450
22. Shantsila, E., Wrigley, B., Tapp, L., Apostolakis, S., Montoro-Garcia, S., Drayson, M. T., et al. (2011). Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology. J. Thromb. Haemost. 9, 1056-1066.
23. Skrzeczynska-Moncznik, J., Bzowska, M., Loseke, S., Grage-Griebenow, E., Zembala, M., and Pryjma, J. (2008). Peripheral blood CD14high CD16+ monocytes are main producers of IL-10. Scand. J. Immunol. 67, 152-159.
24. Steppich, B., Dayyani, F., Gruber, R., Lorenz, R., Mack, M., and Ziegler-Heitbrock, H. W. (2000). Selective mobilization of CD14(+)CD16(+) monocytes by exercise. Am. J. Physiol. Cell Physiol. 279, C578-C586.
25. Sulicka, J., Surdacki, A., Mikolajczyk, T., Strach, M., Gryglewska, B., Cwiklinska, M., et al. (2013). Elevated markers of inflammation and endothelial activation and increased counts of intermediate monocytes in adult survivors of childhood acute lymphoblastic leukemia. Immunobiology doi:10.1016/j.imbio.2012.09.003
26. Sunderkötter, C., Nikolic, T., Dillon, M. J., van Rooijen, N., Stehling, M., Drevets, D. A., et al. (2004). Subpopulations of mouse blood monocytes differ in maturation stage and inflammation response. J. Immunol. 172, 4410-4417.
27. Tapp, L. D., Shantsila, E., Wrigley, B. J., Pamukcu, B., and Lip, G. Y. H. (2012). The CD14++ CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction. J. Thromb. Haemost. 10, 1-11.
28. Urra, X., Villamor, N., Amaro, S., Gomez-Choco, M., Obach, V., Oleaga, L., et al. (2009). Monocyte subtypes predict clinical course and prognosis in human stroke. J. Cereb. Blood Flow Metab. 29, 994-1002.
29. Weiner, L. M., Li, W., Holmes, M., Catalano, R. B., Dovnarsky, M., Padavic, K., et al. (1994). Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects. Cancer Res. 54, 4084-4090.
30. Wong, K. L., Tai, J. J., Wong, W. C., Han, H., Sem, X., Yeap, W. H., et al. (2011). Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood 118, e16-e31.
31. Wong, K. L., Yeap, W. H., Tai, J. J., Ong, S. M., Dang, T. M., and Wong, S. C. (2012). The three human monocyte subsets: implications for health and disease. Immunol. Res. 53, 41-57.
32. Zawada, A. M., Rogacev, K. S., Rotter, B., Winter, P., Marell, R. R., Fliser, D., et al. (2011). SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 118, e50-e61.