Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells

Cellular and Molecular Life Sciences

Volumn 67, Issue 22, 2010, Pages 3893-3903

  Shen, Xinchun ^a   Xi, Gang ^a   Radhakrishnan, Yashwanth ^a   Clemmons, David R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Cell proliferation; Grb2; IGF I; MAP kinase; Pyk2; Shc; SHPS 1

Indexed keywords

FOCAL ADHESION KINASE 2; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN SHC; PROTEIN TYROSINE PHOSPHATASE SHP; SOMATOMEDIN C; TYROSINE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE SILENCING; MITOGENESIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIGENS, DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FOCAL ADHESION KINASE 2; GENE KNOCKDOWN TECHNIQUES; GRB2 ADAPTOR PROTEIN; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; SIGNAL TRANSDUCTION; SWINE;

EID: 78149465199     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0411-x     Document Type: Article

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