메뉴 건너뛰기




Volumn 25, Issue 9, 2015, Pages 1470-1479

Novel dimensions of D3 receptor function: Focus on heterodimerisation, transactivation and allosteric modulation

Author keywords

Antiparkinson; Antipsychotic; Aripiprazole; G protein; Heteromerization; PHNO

Indexed keywords

ANTIPARKINSON AGENT; ARIPIPRAZOLE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR; G PROTEIN COUPLED RECEPTOR; HOMODIMER; LEVODOPA; MONOMER; NAXAGOLIDE; NEUROLEPTIC AGENT; PARTIAL AGONIST; DOPAMINE RECEPTOR STIMULATING AGENT;

EID: 84941314193     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2014.09.016     Document Type: Article
Times cited : (37)

References (53)
  • 1
    • 1542298866 scopus 로고    scopus 로고
    • The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of D2 receptors linked to the regulation of adenylyl cyclase activity and prolactin release
    • Aihara K., Shimada J., Miwa T., Tottori K., Burris K.D., Yocca F.D., Horie M., Kikuchi T. The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of D2 receptors linked to the regulation of adenylyl cyclase activity and prolactin release. Brain Res. 2004, 1003:9-17.
    • (2004) Brain Res. , vol.1003 , pp. 9-17
    • Aihara, K.1    Shimada, J.2    Miwa, T.3    Tottori, K.4    Burris, K.D.5    Yocca, F.D.6    Horie, M.7    Kikuchi, T.8
  • 2
    • 80055002811 scopus 로고    scopus 로고
    • Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease
    • Armentero M.T., Pinna A., Ferré S., Lanciego J.L., Müller C.E., Franco R. Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease. Pharmacol. Ther. 2011, 132:280-299.
    • (2011) Pharmacol. Ther. , vol.132 , pp. 280-299
    • Armentero, M.T.1    Pinna, A.2    Ferré, S.3    Lanciego, J.L.4    Müller, C.E.5    Franco, R.6
  • 3
    • 59949090278 scopus 로고    scopus 로고
    • Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization
    • Azdad K., Gall D., Woods A.S., Ledent C., Ferré S., Schiffmann S.N. Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization. Neuropsychopharmacology 2009, 34:972-986.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 972-986
    • Azdad, K.1    Gall, D.2    Woods, A.S.3    Ledent, C.4    Ferré, S.5    Schiffmann, S.N.6
  • 4
    • 0038392702 scopus 로고    scopus 로고
    • Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein
    • Banères J.L., Parello J. Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J. Mol. Biol. 2003, 329:815-829.
    • (2003) J. Mol. Biol. , vol.329 , pp. 815-829
    • Banères, J.L.1    Parello, J.2
  • 6
    • 0142149074 scopus 로고    scopus 로고
    • Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins
    • Carrillo J.J., Pediani J., Milligan G. Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. J. Biol. Chem. 2003, 278:42578-42587.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42578-42587
    • Carrillo, J.J.1    Pediani, J.2    Milligan, G.3
  • 7
  • 9
    • 30044442319 scopus 로고    scopus 로고
    • Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
    • Daniels D.J., Lenard N.R., Etienne C.L., Law P.Y., Roerig S.C., Portoghese P.S. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc. Natl. Acad. Sci. USA 2005, 102:19208-19213.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 19208-19213
    • Daniels, D.J.1    Lenard, N.R.2    Etienne, C.L.3    Law, P.Y.4    Roerig, S.C.5    Portoghese, P.S.6
  • 11
    • 78649286943 scopus 로고    scopus 로고
    • Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamineD(1)-D(3) receptor heteromer
    • Ferré S., LluiDs C., Lanciego J.L., Franco R. Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamineD(1)-D(3) receptor heteromer. CNS Neurol. Disord. Drug Targets 2010, 9:596-600.
    • (2010) CNS Neurol. Disord. Drug Targets , vol.9 , pp. 596-600
    • Ferré, S.1    Lluids, C.2    Lanciego, J.L.3    Franco, R.4
  • 13
    • 45649085857 scopus 로고    scopus 로고
    • Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization
    • Fiorentini C., Busi C., Gorruso E., Gotti C., Spano P., Missale C. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol. Pharmacol. 2008, 74:59-69.
    • (2008) Mol. Pharmacol. , vol.74 , pp. 59-69
    • Fiorentini, C.1    Busi, C.2    Gorruso, E.3    Gotti, C.4    Spano, P.5    Missale, C.6
  • 14
    • 7944228085 scopus 로고    scopus 로고
    • Dopamine receptor agonists in the therapy of Parkinson's disease
    • Foley P., Gerlach M., Double K.L., Riederer P. Dopamine receptor agonists in the therapy of Parkinson's disease. J. Neural Transm. 2004, 111:1375-1446.
    • (2004) J. Neural Transm. , vol.111 , pp. 1375-1446
    • Foley, P.1    Gerlach, M.2    Double, K.L.3    Riederer, P.4
  • 15
    • 0033953679 scopus 로고    scopus 로고
    • Effects of ropinirole on various parkinsonian models in mice, rats, and cynomolgus monkeys
    • Fukuzaki K., Kamenosono T., Nagata R. Effects of ropinirole on various parkinsonian models in mice, rats, and cynomolgus monkeys. Pharmacol. Biochem. Behav. 2000, 65:503-508.
    • (2000) Pharmacol. Biochem. Behav. , vol.65 , pp. 503-508
    • Fukuzaki, K.1    Kamenosono, T.2    Nagata, R.3
  • 16
    • 0035799569 scopus 로고    scopus 로고
    • BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
    • Guillin O., Diaz J., Carroll P., Griffon N., Schwartz J.C., Sokoloff P. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature 2001, 411:86-89.
    • (2001) Nature , vol.411 , pp. 86-89
    • Guillin, O.1    Diaz, J.2    Carroll, P.3    Griffon, N.4    Schwartz, J.C.5    Sokoloff, P.6
  • 17
    • 69249158290 scopus 로고    scopus 로고
    • Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation
    • Han Y., Moreira I.S., Urizar E., Weinstein H., Javitch J.A. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat. Chem. Biol. 2009, 5:688-695.
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 688-695
    • Han, Y.1    Moreira, I.S.2    Urizar, E.3    Weinstein, H.4    Javitch, J.A.5
  • 19
    • 33846900714 scopus 로고    scopus 로고
    • Dopamine D3 receptor agonists for protection and repair in Parkinson's disease
    • Joyce J.N., Millan M.J. Dopamine D3 receptor agonists for protection and repair in Parkinson's disease. Curr. Opin. Pharmacol. 2007, 7:100-105.
    • (2007) Curr. Opin. Pharmacol. , vol.7 , pp. 100-105
    • Joyce, J.N.1    Millan, M.J.2
  • 20
    • 84857759371 scopus 로고    scopus 로고
    • Selective agonists for dopamine/neurotensin receptor heterodimers
    • Koschatzky S., Gmeiner P. Selective agonists for dopamine/neurotensin receptor heterodimers. Chem. Med. Chem. 2012, 7:509-514.
    • (2012) Chem. Med. Chem. , vol.7 , pp. 509-514
    • Koschatzky, S.1    Gmeiner, P.2
  • 22
    • 0027467848 scopus 로고
    • Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors
    • Maggio R., Vogel Z., Wess J. Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proc. Natl. Acad. Sci. USA 1993, 90:3103-3107.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3103-3107
    • Maggio, R.1    Vogel, Z.2    Wess, J.3
  • 23
    • 0142241355 scopus 로고    scopus 로고
    • Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole
    • Maggio R., Scarselli M., Novi F., Millan M.J., Corsini G.U. Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. J. Neurochem. 2003, 87:631-641.
    • (2003) J. Neurochem. , vol.87 , pp. 631-641
    • Maggio, R.1    Scarselli, M.2    Novi, F.3    Millan, M.J.4    Corsini, G.U.5
  • 24
    • 36248986754 scopus 로고    scopus 로고
    • G protein-coupled receptor oligomerization provides the framework for signal discrimination
    • Maggio R., Innamorati G., Parenti M. G protein-coupled receptor oligomerization provides the framework for signal discrimination. J. Neurochem. 2007, 103:1741-1752.
    • (2007) J. Neurochem. , vol.103 , pp. 1741-1752
    • Maggio, R.1    Innamorati, G.2    Parenti, M.3
  • 25
    • 72649087941 scopus 로고    scopus 로고
    • Heterodimerization of dopamine receptors: new insights into functional and therapeutic significance
    • Maggio R., Aloisi G., Silvano E., Rossi M., Millan M.J. Heterodimerization of dopamine receptors: new insights into functional and therapeutic significance. Parkinsonism Relat. Disord. 2009, 15:S2-S7.
    • (2009) Parkinsonism Relat. Disord. , vol.15 , pp. S2-S7
    • Maggio, R.1    Aloisi, G.2    Silvano, E.3    Rossi, M.4    Millan, M.J.5
  • 26
    • 84941316870 scopus 로고    scopus 로고
    • The quaternary structure of dopamine D2 and D3 receptors: comparisons of the homo-oligomerisation of two closely related G protein-coupled receptors
    • (Aastract)
    • Marsango S., Caltabiano G., Pou C., Milligan G. The quaternary structure of dopamine D2 and D3 receptors: comparisons of the homo-oligomerisation of two closely related G protein-coupled receptors. Proc. Br. Pharmacol. Soc. 2014, 12(1):004. (Aastract).
    • (2014) Proc. Br. Pharmacol. Soc. , vol.12 , Issue.1 , pp. 004
    • Marsango, S.1    Caltabiano, G.2    Pou, C.3    Milligan, G.4
  • 27
    • 0029006499 scopus 로고
    • Pramipexole: a dopamine-receptor agonist for treatment of Parkinson's disease
    • Mierau J. Pramipexole: a dopamine-receptor agonist for treatment of Parkinson's disease. Clin. Neuropharmacol. 1995, 18:S195-S206.
    • (1995) Clin. Neuropharmacol. , vol.18 , pp. S195-S206
    • Mierau, J.1
  • 28
    • 0036827811 scopus 로고    scopus 로고
    • Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes
    • Millan M.J., Maiofiss L., Cussac D., Audinot V., Boutin J.-A., Newman-Tancredi A. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J. Pharmacol. Exp. Ther. 2002, 303:791-804.
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , pp. 791-804
    • Millan, M.J.1    Maiofiss, L.2    Cussac, D.3    Audinot, V.4    Boutin, J.-A.5    Newman-Tancredi, A.6
  • 30
    • 2442653993 scopus 로고    scopus 로고
    • S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole
    • Millan M.J., Brocco M., Papp M., Serres F., La Rochelle C.D., Sharp T., Peglion J.L., Dekeyne A. S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole. J. Pharmacol. Exp. Ther. 2004, 309:936-950.
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 936-950
    • Millan, M.J.1    Brocco, M.2    Papp, M.3    Serres, F.4    La Rochelle, C.D.5    Sharp, T.6    Peglion, J.L.7    Dekeyne, A.8
  • 31
    • 54449094499 scopus 로고    scopus 로고
    • Cognitive impairment in schizophrenia: a review of developmental and genetic models, and pro-cognitive profile of the optimised D(3) and D(2) antagonist, S33138
    • Millan M.J., Brocco M. Cognitive impairment in schizophrenia: a review of developmental and genetic models, and pro-cognitive profile of the optimised D(3) and D(2) antagonist, S33138. Therapie 2008, 63:187-229.
    • (2008) Therapie , vol.63 , pp. 187-229
    • Millan, M.J.1    Brocco, M.2
  • 32
    • 84899858579 scopus 로고    scopus 로고
    • Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment
    • Millan M.J., Fone K., Steckler T., Horan W.P. Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment. Eur. Neuropsychopharmacol. 2014, 24:645-692.
    • (2014) Eur. Neuropsychopharmacol. , vol.24 , pp. 645-692
    • Millan, M.J.1    Fone, K.2    Steckler, T.3    Horan, W.P.4
  • 33
    • 33749565739 scopus 로고    scopus 로고
    • Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo
    • Narendran R., Slifstein M., Guillin O., Hwang Y., Hwang D.R., Scher E., Reeder S., Rabiner E., Laruelle M. Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo. Synapse 2006, 60:485-495.
    • (2006) Synapse , vol.60 , pp. 485-495
    • Narendran, R.1    Slifstein, M.2    Guillin, O.3    Hwang, Y.4    Hwang, D.R.5    Scher, E.6    Reeder, S.7    Rabiner, E.8    Laruelle, M.9
  • 35
    • 0030613635 scopus 로고    scopus 로고
    • Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells
    • Nimchinsky E.A., Hof P.R., Janssen W.G., Morrison J.H., Schmauss C. Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells. J. Biol. Chem. 1997, 272:29229-29237.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29229-29237
    • Nimchinsky, E.A.1    Hof, P.R.2    Janssen, W.G.3    Morrison, J.H.4    Schmauss, C.5
  • 36
    • 34547451141 scopus 로고    scopus 로고
    • Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation
    • Novi F., Millan M.J., Corsini G.U., Maggio R. Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation. J. Neurochem. 2007, 102:1410-1424.
    • (2007) J. Neurochem. , vol.102 , pp. 1410-1424
    • Novi, F.1    Millan, M.J.2    Corsini, G.U.3    Maggio, R.4
  • 37
    • 84855787666 scopus 로고    scopus 로고
    • Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1-D2 heteromer formation
    • O'Dowd B.F., Ji X., Nguyen T., George S.R. Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1-D2 heteromer formation. Biochem. Biophys. Res. Commun. 2012, 417:23-28.
    • (2012) Biochem. Biophys. Res. Commun. , vol.417 , pp. 23-28
    • O'Dowd, B.F.1    Ji, X.2    Nguyen, T.3    George, S.R.4
  • 38
    • 84873729688 scopus 로고    scopus 로고
    • D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation
    • O'Dowd B.F., Nguyen T., Ji X., George S.R. D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation. Biochem. Biophys. Res. Commun. 2013, 431:586-589.
    • (2013) Biochem. Biophys. Res. Commun. , vol.431 , pp. 586-589
    • O'Dowd, B.F.1    Nguyen, T.2    Ji, X.3    George, S.R.4
  • 39
    • 84855340012 scopus 로고    scopus 로고
    • Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways
    • Papaleo F., Yang F., Garcia S., Chen J., Lu B., Crawley J.N., Weinberger D.R. Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways. Mol. Psychiatry 2012, 17:85-98.
    • (2012) Mol. Psychiatry , vol.17 , pp. 85-98
    • Papaleo, F.1    Yang, F.2    Garcia, S.3    Chen, J.4    Lu, B.5    Crawley, J.N.6    Weinberger, D.R.7
  • 41
    • 84881421201 scopus 로고    scopus 로고
    • A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex
    • Perreault M.L., Jones-Tabah J., O'Dowd B.F., George S.R. A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int. J. Neuropsychopharmacol. 2013, 25:1-7.
    • (2013) Int. J. Neuropsychopharmacol. , vol.25 , pp. 1-7
    • Perreault, M.L.1    Jones-Tabah, J.2    O'Dowd, B.F.3    George, S.R.4
  • 42
    • 84858607942 scopus 로고    scopus 로고
    • Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface
    • Pou C., Mannoury la Cour C., Stoddart L.A., Millan M.J., Milligan G. Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface. J. Biol. Chem. 2012, 287:8864-8878.
    • (2012) J. Biol. Chem. , vol.287 , pp. 8864-8878
    • Pou, C.1    Mannoury la Cour, C.2    Stoddart, L.A.3    Millan, M.J.4    Milligan, G.5
  • 44
    • 0029666441 scopus 로고    scopus 로고
    • Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells
    • Robinson S.W., Caron M.G. Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. J Neurochem 1996, 67:212-219.
    • (1996) J Neurochem , vol.67 , pp. 212-219
    • Robinson, S.W.1    Caron, M.G.2
  • 45
    • 0034596026 scopus 로고    scopus 로고
    • Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments
    • Scarselli M., Armogida M., Chiacchio S., DeMontis M.G., Colzi A., Corsini G.U., Maggio R. Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments. Eur. J. Pharmacol. 2000, 397:291-296.
    • (2000) Eur. J. Pharmacol. , vol.397 , pp. 291-296
    • Scarselli, M.1    Armogida, M.2    Chiacchio, S.3    DeMontis, M.G.4    Colzi, A.5    Corsini, G.U.6    Maggio, R.7
  • 47
    • 0142038894 scopus 로고    scopus 로고
    • Functional rescue of the inactive splice variant of the dopamine D3 receptor D3nf
    • Scarselli M., Novi F., Corsini G.U., Maggio R. Functional rescue of the inactive splice variant of the dopamine D3 receptor D3nf. Brain Res. 2003, 987:244-247.
    • (2003) Brain Res. , vol.987 , pp. 244-247
    • Scarselli, M.1    Novi, F.2    Corsini, G.U.3    Maggio, R.4
  • 48
    • 33745815313 scopus 로고    scopus 로고
    • Dopamine D2 and D3 receptors in human putamen, caudate nucleus and globus pallidus
    • Seeman P., Wilson A., Gmeiner P., Kapur S. Dopamine D2 and D3 receptors in human putamen, caudate nucleus and globus pallidus. Synapse 2006, 60:205-211.
    • (2006) Synapse , vol.60 , pp. 205-211
    • Seeman, P.1    Wilson, A.2    Gmeiner, P.3    Kapur, S.4
  • 51
    • 0038618835 scopus 로고    scopus 로고
    • Partial dopamine agonists and dopaminergic stabilizers, in the treatment of psychosis
    • Tamminga C.A., Carlsson A. Partial dopamine agonists and dopaminergic stabilizers, in the treatment of psychosis. Curr. Drug. Targets CNS Neurol. Disord. 2002, 1:141-147.
    • (2002) Curr. Drug. Targets CNS Neurol. Disord. , vol.1 , pp. 141-147
    • Tamminga, C.A.1    Carlsson, A.2
  • 52
    • 13444271067 scopus 로고    scopus 로고
    • Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes
    • Torvinen M., Marcellino D., Canals M., Agnati L.F., Lluis C., Franco R., Fuxe K. Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. Mol. Pharmacol. 2005, 67:400-407.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 400-407
    • Torvinen, M.1    Marcellino, D.2    Canals, M.3    Agnati, L.F.4    Lluis, C.5    Franco, R.6    Fuxe, K.7
  • 53


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.