D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation

Biochemical and Biophysical Research Communications

Volumn 431, Issue 3, 2013, Pages 586-589

  O'Dowd, Brian F ^a,b   Nguyen, Tuan ^a,b   Ji, Xiaodong ^b   George, Susan R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

D5 and D2 dopamine receptor; G protein coupled receptors; Heteromer; Interacting amino acids.; Nuclear localization; Protein structure

Indexed keywords

ARGININE; CYTOPLASM PROTEIN; DOPAMINE 2 RECEPTOR; DOPAMINE 5 RECEPTOR; GLUTAMIC ACID; DRD5 PROTEIN, HUMAN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; CYTOPLASM; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION;

AMINO ACID SEQUENCE; CELL LINE; CYTOPLASM; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D5;

EID: 84873729688     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.139     Document Type: Article

References (11)

1. George S.R., O'Dowd B.F., Lee S.P. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat. Rev. Drug Discovery 2002, 1:808-820.
2. Milligan G. G-protein-coupled receptor heterodimeraztion: contribution to pharmacology and function. Br. J. Pharmacol. 2009, 158:5-14.
3. Ciruela F., Vallano A., Arnau J.M., Sánchez S., Borroto-Escuela D.O., Agnati L.F., Fuxe K., Fernández-Dueñas V. G protein-coupled receptor oligomerization for what?. J. Recept. Signal Transductuction Res. 2010, 30:322-330.
4. Hasbi A., Fan T., Alijaniaram M., Nguyen T., Perreault M.L., O'Dowd B.F., George S.R. Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth. Proc. Natl. Acad. Sci. USA 2009, 106:21377-21382.
5. Perreault M.L., Hasbi A., Alijaniaram M., Fan T., Varghese G., Fletcher P.J., Seeman P., O'Dowd P.B.F., George S.R. The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia. J. Biol. Chem. 2010, 285:36625-36634.
6. O'Dowd B.F., Ji X., Alijaniaram M., Nguyen T., George S.R. Separation and reformation of cell surface dopamine receptor oligomers visualized in cells. Eur. J. Pharmacol. 2011, 658:74-83.
7. O'Dowd B.F., Ji X., Alijaniaram M., Rajaram R.D., Kong M.M., Rashid A., Nguyen T., George S.R. Dopamine receptor oligomerization visualized in living cells. J. Biol. Chem. 2005, 280:37225-37235.
8. O'Dowd B.F., Ji X., Nguyen T., George S.R. Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1-D2 heteromer formation. Biochem Biophys. Res. Commun. 2012, 417:23-28.
9. O'Dowd B.F., Ji X., O'Dowd P.B., Nguyen T., George S.R. Disruption of the mu-delta opioid receptor heteromer. Biochem. Biophys. Res. Commun. 2012, 422:556-560.
10. So C.H., Verma V., Alijaniaram M., Cheng R., Rashid A.J., O'Dowd B.F., George S.R. Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers. Mol. Pharmacol. 2009, 75:843-854.
11. O'Dowd B.F., Alijaniaram M., Ji X., Nguyen T., Eglen R.M., George S.R. Using ligand-induced conformational change to screen for compounds targeting G-protein-coupled receptors. J. Biomol. Screen. 2007, 12:175-185.