The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors

Molecular Pharmacology

Volumn 78, Issue 5, 2010, Pages 925-934

  Silvano, Elena ^a   Millan, Mark J ^b   La Cour, Clotilde Mannoury ^b   Han, Yang ^c   Duan, Lihua ^c   Griffin, Suzy A ^d   Luedtke, Robert R ^d   Aloisi, Gabriella ^a   Rossi, Mario ^a   Zazzeroni, Francesca ^a   Javitch, Jonathan A ^c   Maggio, Roberto ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c New York Presbyterian Columbia University Medical Center   (United States)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H INDOLE 2 CARBOXYLIC ACID[4 [2 (CYANO 3,4 DIHYDRO 1H ISOQUINOLIN 2 YL)ETHYL]CYCLOHEXYL]AMIDE; AEQUORIN; BETA ARRESTIN 2; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; QUINPIROLE; RADIOLIGAND; SPIPERONE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; ENZYME PHOSPHORYLATION; IC 50; NONHUMAN; PRIORITY JOURNAL;

ALLOSTERIC REGULATION; ANIMALS; ARRESTINS; CELL LINE; CERCOPITHECUS AETHIOPS; CRICETINAE; CRICETULUS; DOPAMINE; HUMANS; INDOLES; ISOQUINOLINES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN TRANSPORT; QUINPIROLE; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; TETRAHYDROISOQUINOLINES;

EID: 77958134183     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.065755     Document Type: Article

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