Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 34, 2012, Pages 8427-8434

  Hung, Chao Ming ^a   Su, Yun Hsuan ^b   Lin, Hui Yi ^c   Lin, Jia Ni ^b   Liu, Liang Chih ^d   Ho, Chi Tang ^e   Way, Tzong Der ^b,f  

^a I SHOU UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e RUTGERS UNIVERSITY   (United States)

^f NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

AMPK; curcuminoids; demethoxycurcumin; EGFR; HSP70

Indexed keywords

AMPK; CURCUMINOIDS; DEMETHOXYCURCUMIN; EGFR; HSP70;

AMINO ACIDS; CELL PROLIFERATION; CELLS; CHEMICAL ACTIVATION; CYTOTOXICITY; DISEASES; PHOSPHORYLATION;

DERIVATIVES;

5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CBL PROTEIN; CBL PROTEIN, HUMAN; CURCUMIN; DEMETHOXYCURCUMIN; DRUG DERIVATIVE; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; FASN PROTEIN, HUMAN; FATTY ACID SYNTHASE; HEAT SHOCK PROTEIN 70; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; RIBONUCLEOTIDE;

ARTICLE; CELL PROLIFERATION; CHEMISTRY; CURCUMA; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROSTATE TUMOR; TUMOR CELL LINE;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMA; CURCUMIN; DOWN-REGULATION; FATTY ACID SYNTHASE, TYPE I; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RIBONUCLEOTIDES;

CURCUMA LONGA;

EID: 84865659467     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf302754w     Document Type: Article

References (36)

1. Siegel, R.; Ward, E.; Brawley, O.; Jemal, A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J. Clin. 2011, 61, 212-236
2. Clemens, M. J. Targets and mechanisms for the regulation of translation in malignant transformation Oncogene 2004, 23, 3180-3188
3. Voeller, D.; Rahman, L.; Zajac-Kaye, M. Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells Cell Cycle 2004, 3, 1005-1007
4. Migita, T.; Narita, T.; Nomura, K.; Miyagi, E.; Inazuka, F.; Matsuura, M.; Ushijima, M.; Mashima, T.; Seimiya, H.; Satoh, Y.; Okumura, S.; Nakagawa, K.; Ishikawa, Y. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer Cancer Res. 2008, 68, 8547-8554
5. Sivaprasad, U.; Abbas, T.; Dutta, A. Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells Mol. Cancer Ther. 2006, 5, 2310-2316
6. Flavin, R.; Zadra, G.; Loda, M. Metabolic alterations and targeted therapies in prostate cancer J. Pathol. 2011, 223, 283-294
7. Matsui, H.; Suzuki, K.; Ohtake, N.; Nakata, S.; Takeuchi, T.; Yamanaka, H.; Inoue, I. Genome-wide linkage analysis of familial prostate cancer in the Japanese population J. Hum. Genet. 2004, 49, 9-15
8. Ralhan, R.; Kaur, J. Differential expression Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix Clin. Cancer Res. 1995, 1, 1217-1222
9. Ciocca, D. R.; Calderwood, S. K. Heat shock proteins in cancer: Diagnostic, prognostic, predictive and treatment implications Cell Stress Chaperones 2005, 10, 86-103
10. Wang, R. E. Targeting heat shock proteins 70/90 and proteasome for cancer therapy Curr. Med. Chem. 2011, 18, 4250-4264
11. Wei, Y. Q.; Zhao, X.; Kariya, Y.; Teshigawara, K.; Uchida, A. Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells Cancer Immunol. Immunother. 1995, 40, 73-78
12. Kaur, J.; Ralhan, R. Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells Int. J. Cancer 2000, 85, 1-5
13. Nylandsted, J.; Wick, W.; Hirt, U. A.; Brand, K.; Rohde, M.; Leist, M.; Weller, M.; Jäättelä, M. Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion Cancer Res. 2002, 62, 7139-7142
14. Traish, A. M.; Morgentaler, A. Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growth Br. J. Cancer 2009, 101, 1949-1956
15. Bedford, L.; Lowe, J.; Dick, L. R.; Mayer, R. J.; Brownell, J. E. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets Nat. Rev. Drug Discov. 2011, 10, 29-46
16. Waterman, H.; Levkowitz, G.; Alroy, I.; Yarden, Y. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor J. Biol. Chem. 1999, 274, 22151-22154
17. Huang, F.; Kirkpatrick, D.; Jiang, X.; Gygi, S.; Sorkin, A. Differential regulation of EGFR internalization and degradation by multiubiquitination within the kinase domain Mol. Cell 2006, 21, 737-748
18. Wright, L. E.; Frye, J. B.; Timmermann, B. N.; Funk, J. L. Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition J. Agric. Food Chem. 2010, 58, 9498-9504
19. Gota, V. S.; Maru, G. B.; Soni, T. G.; Gandhi, T. R.; Kochar, N.; Agarwal, M. G. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers J. Agric. Food Chem. 2010, 58, 2095-2099
20. Huang, T. Y.; Tsai, T. H.; Hsu, C. W.; Hsu, Y. C. Curcuminoids suppress the growth and induce apoptosis through caspase-3-dependent pathways in glioblastoma multiforme (GBM) 8401 cells J. Agric. Food Chem. 2010, 58, 10639-10645
21. Lin, Y. T.; Wang, L. F.; Hsu, Y. C. Curcuminoids suppress the growth of pharynx and nasopharyngeal carcinoma cells through induced apoptosis J. Agric. Food Chem. 2009, 57, 3765-3770
22. Liao, K. K.; Wu, M. J.; Chen, P. Y.; Huang, S. W.; Chiu, S. J.; Ho, C. T.; Yen, J. H. Curcuminoids promote neurite outgrowth in PC12 cells through MAPK/ERK- and PKC-dependent pathways J. Agric. Food Chem. 2012, 60, 433-443
23. Shishu; Kaur, I. P. Antimutagenicity of curcumin and related compounds against genotoxic heterocyclic amines from cooked food: the structural requirement Food Chem. 2008, 111, 573-579
24. Dao, T. T.; Nguyen, P. H.; Won, H. K.; Kim, E. H.; Park, J.; Won, B. Y.; Oh, W. K. Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases Food Chem. 2012, 134, 21-28
25. Lin, H. Y.; Hou, S. C.; Chen, S. C.; Kao, M. C.; Yu, C. C.; Funayama, S.; Ho, C. T.; Way, T. D. (-)-Epigallocatechin gallate induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling in head and neck squamous cell carcinoma cells J. Agric. Food Chem. 2012, 60, 2480-2489
26. Jung, J. H.; Lee, J. O.; Kim, J. H.; Lee, S. K.; You, G. Y.; Park, S. H.; Park, J. M.; Kim, E. K.; Suh, P. G.; An, J. K.; Kim, H. S. Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation J. Cell. Physiol. 2010, 223, 408-414
27. Teiten, M. H.; Gaascht, F.; Cronauer, M.; Henry, E.; Dicato, M.; Diederich, M. Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway Int. J. Oncol. 2011, 38, 603-611
28. Deeb, D.; Xu, Y. X.; Jiang, H.; Gao, X.; Janakiraman, N.; Chapman, R. A.; Gautam, S. C. Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells Mol. Cancer Ther. 2003, 2, 95-103
29. Ireson, C.; Orr, S.; Jones, D. J.; Verschoyle, R.; Lim, C. K.; Luo, J. L.; Howells, L.; Plummer, S.; Jukes, R.; Williams, M.; Steward, W. P.; Gescher, A. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production Cancer Res. 2001, 61, 1058-1064
30. Han, G.; Cui, J. J.; Bi, R.; Zhao, L. L.; Zhang, W. G. Study on stability of curcumine, demethoxycurcumin and bisdemethoxycurcumin Zhongguo Zhong Yao Za Zhi 2008, 33, 2611-2614 (in Chinese)
31. Simon, A.; Allais, D. P.; Duroux, J. L.; Basly, J. P.; Durand-Fontanier, S.; Delage, C. Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure-activity relationships Cancer Lett. 1998, 129, 111-116
32. Luthra, P. M.; Kumar, R.; Prakash, A. Demethoxycurcumin induces Bcl-2 mediated G2/M arrest and apoptosis in human glioma U87 cells Biochem. Biophys. Res. Commun. 2009, 384, 420-425
33. Pan, W.; Yang, H.; Cao, C.; Song, X.; Wallin, B.; Kivlin, R.; Lu, S.; Hu, G.; Di, W.; Wan, Y. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells Oncol. Rep. 2008, 20, 1553-1559
34. Rossi, S.; Graner, E.; Febbo, P.; Weinstein, L.; Bhattacharya, N.; Onody, T.; Bubley, G.; Balk, S.; Loda, M. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer Mol. Cancer Res. 2003, 1, 707-715
35. Yang, J. M.; Hung, C. M.; Fu, C. N.; Lee, J. C.; Huang, C. H.; Yang, M. H.; Lin, C. L.; Kao, J. Y.; Way, T. D. Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation J. Agric. Food Chem. 2010, 58, 10020-10026
36. Lin, J. N.; Lin, V. C.; Rau, K. M.; Shieh, P. C.; Kuo, D. H.; Shieh, J. C.; Chen, W. J.; Tsai, S. C.; Way, T. D. Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation J. Agric. Food Chem. 2010, 58, 1584-1592