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Volumn 64, Issue 9, 2015, Pages 1349-1350

Statins, Rho GTPases and KLF2: New mechanistic insight into liver fibrosis and portal hypertension

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KRUPPEL LIKE FACTOR 2; NITRIC OXIDE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; KRUPPEL LIKE FACTOR;

EID: 84941265711     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-308800     Document Type: Note
Times cited : (35)

References (16)
  • 1
    • 84919632658 scopus 로고    scopus 로고
    • The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease
    • Pastori D, Polimeni L, Baratta F, et al. The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease. Dig Liver Dis 2015;47:4-11.
    • (2015) Dig Liver Dis , vol.47 , pp. 4-11
    • Pastori, D.1    Polimeni, L.2    Baratta, F.3
  • 2
    • 49649106710 scopus 로고    scopus 로고
    • Statins in liver disease: A molehill an iceberg or neither?
    • Argo CK, Loria P, Caldwell SH, et al. Statins in liver disease: a molehill, an iceberg, or neither? Hepatology 2008;48:662-9.
    • (2008) Hepatology , vol.48 , pp. 662-669
    • Argo, C.K.1    Loria, P.2    Caldwell, S.H.3
  • 3
    • 62649086172 scopus 로고    scopus 로고
    • The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis
    • Blum A, Shamburek R. The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Atherosclerosis 2009;203: 325-30.
    • (2009) Atherosclerosis , vol.203 , pp. 325-330
    • Blum, A.1    Shamburek, R.2
  • 4
    • 84941281919 scopus 로고    scopus 로고
    • KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: Behind the molecular mechanisms of statins
    • Marrone G, Maeso-Diaz R, Garcia-Cardena G, et al. KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins. Gut 2015;64:1434-43.
    • (2015) Gut , vol.64 , pp. 1434-1443
    • Marrone, G.1    Maeso-Diaz, R.2    Garcia-Cardena, G.3
  • 5
    • 84918578495 scopus 로고    scopus 로고
    • Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C.
    • Simon TG, King LY, Zheng H, et al. Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C. J Hepatol 2015;62:18-23.
    • (2015) J Hepatol , vol.62 , pp. 18-23
    • Simon, T.G.1    King, L.Y.2    Zheng, H.3
  • 6
    • 1542317594 scopus 로고    scopus 로고
    • Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis
    • Zafra C, Abraldes JG, Turnes J, et al. Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis. Gastroenterology 2004;126:749-55.
    • (2004) Gastroenterology , vol.126 , pp. 749-755
    • Zafra, C.1    Abraldes, J.G.2    Turnes, J.3
  • 7
    • 65349094504 scopus 로고    scopus 로고
    • Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: A randomized controlled trial
    • Abraldes JG, Albillos A, Banares R, et al. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology 2009;136:1651-8.
    • (2009) Gastroenterology , vol.136 , pp. 1651-1658
    • Abraldes, J.G.1    Albillos, A.2    Banares, R.3
  • 8
    • 34547469050 scopus 로고    scopus 로고
    • Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    • Trebicka J, Hennenberg M, Laleman W, et al. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology 2007;46:242-53.
    • (2007) Hepatology , vol.46 , pp. 242-253
    • Trebicka, J.1    Hennenberg, M.2    Laleman, W.3
  • 9
    • 34247568377 scopus 로고    scopus 로고
    • Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats
    • Abraldes JG, Rodriguez-Vilarrupla A, Graupera M, et al. Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats. J Hepatol 2007;46:1040-6.
    • (2007) J Hepatol , vol.46 , pp. 1040-1046
    • Abraldes, J.G.1    Rodriguez-Vilarrupla, A.2    Graupera, M.3
  • 10
    • 79952538496 scopus 로고    scopus 로고
    • Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver
    • Gracia-Sancho J, Russo L, Garcia-Caldero H, et al. Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver. Gut 2011;60:517-24.
    • (2011) Gut , vol.60 , pp. 517-524
    • Gracia-Sancho, J.1    Russo, L.2    Garcia-Caldero, H.3
  • 11
    • 77956268976 scopus 로고    scopus 로고
    • Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells
    • Trebicka J, Hennenberg M, Odenthal M, et al. Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol 2010;53: 702-12.
    • (2010) J Hepatol , vol.53 , pp. 702-712
    • Trebicka, J.1    Hennenberg, M.2    Odenthal, M.3
  • 12
    • 84866858655 scopus 로고    scopus 로고
    • Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats
    • Klein S, Klosel J, Schierwagen R, et al. Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats. Lab Invest 2012;92:1440-50.
    • (2012) Lab Invest , vol.92 , pp. 1440-1450
    • Klein, S.1    Klosel, J.2    Schierwagen, R.3
  • 13
    • 84871211218 scopus 로고    scopus 로고
    • The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins
    • Marrone G, Russo L, Rosado E, et al. The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins. J Hepatol 2013;58:98-103.
    • (2013) J Hepatol , vol.58 , pp. 98-103
    • Marrone, G.1    Russo, L.2    Rosado, E.3
  • 14
    • 59449095024 scopus 로고    scopus 로고
    • Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver
    • Moreno M, Ramalho LN, Sancho-Bru P, et al. Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver. Am J Physiol Gastrointest Liver Physiol 2009;296:G147-56.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G147-G156
    • Moreno, M.1    Ramalho, L.N.2    Sancho-Bru, P.3
  • 15
    • 84869222173 scopus 로고    scopus 로고
    • HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects
    • Klein S, Van Beuge MM, Granzow M, et al. HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects. J Hepatol 2012;57:1220-7.
    • (2012) J Hepatol , vol.57 , pp. 1220-1227
    • Klein, S.1    Van Beuge, M.M.2    Granzow, M.3
  • 16
    • 84903187308 scopus 로고    scopus 로고
    • Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis
    • Granzow M, Schierwagen R, Klein S, et al. Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology 2014;60:334-48.
    • (2014) Hepatology , vol.60 , pp. 334-348
    • Granzow, M.1    Schierwagen, R.2    Klein, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.