메뉴 건너뛰기




Volumn 2015, Issue 101, 2015, Pages

Derivation of adult human fibroblasts and their direct conversion into expandable neural progenitor cells

Author keywords

Direct conversion; Disease modeling; Glial differentiation; Issue 101; Lineage reprogramming; Neural cell replacement; Neural stem cells; Neuronal differentiation; Neuroscience; Stem cell biology; Stem cell therapy; Transdifferentiation; Transgene free reprogrammed cells

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX;

EID: 84941243529     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/52831     Document Type: Article
Times cited : (35)

References (45)
  • 1
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 126 (4), 663-676, doi: 10.1016/j.cell.2006.07.024, (2006).
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 2
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 131 (5), 861-872, doi: 10.1016/j.cell.2007.11.019, (2007).
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1
  • 3
    • 77954932494 scopus 로고    scopus 로고
    • Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats
    • Cai, J., Yang, M., Poremsky, E., Kidd, S., Schneider, J.S., Iacovitti, L. Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev. 19 (7), 1017-1023, doi: 10.1089/scd.2009.0319, (2010).
    • (2010) Stem Cells Dev , vol.19 , Issue.7 , pp. 1017-1023
    • Cai, J.1    Yang, M.2    Poremsky, E.3    Kidd, S.4    Schneider, J.S.5    Iacovitti, L.6
  • 4
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
    • Kriks, S., et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature. 480 (7378), 547-551, doi: 10.1038/nature10648, (2011).
    • (2011) Nature , vol.480 , Issue.7378 , pp. 547-551
    • Kriks, S.1
  • 5
    • 79957913513 scopus 로고    scopus 로고
    • Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease
    • Rhee, Y.H., et al. Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest. 121 (6), 2326-2335, doi: 10.1172/JCI45794, (2011).
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2326-2335
    • Rhee, Y.H.1
  • 6
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita, K., Ichisaka, T., Yamanaka, S. Generation of germline-competent induced pluripotent stem cells. Nature. 448 (7151), 313-317, doi:10.1038/nature05934, (2007).
    • (2007) Nature , vol.448 , Issue.7151 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 7
    • 61349100729 scopus 로고    scopus 로고
    • Parkinson’s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    • Soldner, F., et al. Parkinson’s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 136 (5), 964-977, doi: 10.1016/j.cell.2009.02.013, (2009).
    • (2009) Cell , vol.136 , Issue.5 , pp. 964-977
    • Soldner, F.1
  • 8
    • 65249149666 scopus 로고    scopus 로고
    • Induced pluripotent stem cell generation using a single lentiviral stem cell cassette
    • Sommer, C.A., Stadtfeld, M., Murphy, G.J., Hochedlinger, K., Kotton, D.N., Mostoslavsky, G. Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells. 27 (3), 543-549, doi: 10.1634/stemcells.2008-1075, (2009).
    • (2009) Stem Cells , vol.27 , Issue.3 , pp. 543-549
    • Sommer, C.A.1    Stadtfeld, M.2    Murphy, G.J.3    Hochedlinger, K.4    Kotton, D.N.5    Mostoslavsky, G.6
  • 9
    • 72849137462 scopus 로고    scopus 로고
    • Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells
    • Zhou, W., Freed, C.R. Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells. 27, 2667-2674, doi: 10.1002/stem.201, (2009).
    • (2009) Stem Cells , vol.27 , pp. 2667-2674
    • Zhou, W.1    Freed, C.R.2
  • 10
    • 70450265981 scopus 로고    scopus 로고
    • Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
    • Fusaki, N., Ban, H., Nishiyama, A., Saeki, K., & Hasegawa, M. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci. 85, 348-362, doi: 10.2183/pjab.85.348, (2009).
    • (2009) Proc Jpn Acad Ser B Phys Biol Sci , vol.85 , pp. 348-362
    • Fusaki, N.1    Ban, H.2    Nishiyama, A.3    Saeki, K.4    Hasegawa, M.5
  • 11
    • 79953316849 scopus 로고    scopus 로고
    • Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system
    • Montserrat, N., et al. Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system. J Biol Chem. 286 (14), 12417-28, doi: 10.1074/jbc.M110.168013, (2011).
    • (2011) J Biol Chem , vol.286 , Issue.14 , pp. 12417-12428
    • Montserrat, N.1
  • 12
    • 84867019287 scopus 로고    scopus 로고
    • Feeder-free derivation of human induced pluripotent stem cells with messenger RNA
    • Warren, L., Nu, Y., Wang, J., Guo, X. Feeder-free derivation of human induced pluripotent stem cells with messenger RNA. Sci Rep. 2: 657, doi: 10.1038/srep00657, (2012).
    • (2012) Sci Rep , vol.2 , Issue.657
    • Warren, L.1    Nu, Y.2    Wang, J.3    Guo, X.4
  • 13
    • 49149127200 scopus 로고    scopus 로고
    • Generation of transducible factors Oct4 and Sox2
    • Bosnali, M., Edenhofer, F. Generation of transducible factors Oct4 and Sox2. Biol Chem. 389 (7), 851-861, doi: 10.1515/BC.2008.106, (2008).
    • (2008) Biol Chem , vol.389 , Issue.7 , pp. 851-861
    • Bosnali, M.1    Edenhofer, F.2
  • 14
    • 66049135249 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells using recombinant proteins
    • Zhou, H., et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell. 4 (5), 381-384, doi: 10.1016/j.stem.2009.04.005, (2009).
    • (2009) Cell Stem Cell , vol.4 , Issue.5 , pp. 381-384
    • Zhou, H.1
  • 15
    • 84880935695 scopus 로고    scopus 로고
    • Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinicalgrade state
    • Awe, J.P., et al. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinicalgrade state. Stem Cell Res Ther. 4 (4), 87, doi: 10.1186/scrt246, (2013).
    • (2013) Stem Cell Res Ther , vol.4 , Issue.4 , pp. 87
    • Awe, J.P.1
  • 16
    • 84900812586 scopus 로고    scopus 로고
    • Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells
    • Kadari, A., et al. Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells. Stem Cell Res Ther. 5 (2), 47, doi: 10.1186/scrt435, (2014).
    • (2014) Stem Cell Res Ther , vol.5 , Issue.2 , pp. 47
    • Kadari, A.1
  • 17
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen, T., Ostermeier, A., Pang, Z.P., Kokubu, Y., Südhof, T.C., Wernig, M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 463 (7284), 1035-1041, doi: 10.1038/nature08797, (2010).
    • (2010) Nature , vol.463 , Issue.7284 , pp. 1035-1041
    • Vierbuchen, T.1    Ostermeier, A.2    Pang, Z.P.3    Kokubu, Y.4    Südhof, T.C.5    Wernig, M.6
  • 18
    • 80051674431 scopus 로고    scopus 로고
    • Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
    • Caiazzo, M., et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature. 476 (7359), 224-227, doi: 10.1038/nature10284, (2011).
    • (2011) Nature , vol.476 , Issue.7359 , pp. 224-227
    • Caiazzo, M.1
  • 19
    • 79960854285 scopus 로고    scopus 로고
    • Induction of human neuronal cells by defined transcription factors
    • Pang, Z.P., et al. Induction of human neuronal cells by defined transcription factors. Nature. 476 (7359), 220-223, doi: 10.1038/nature10202, (2011).
    • (2011) Nature , vol.476 , Issue.7359 , pp. 220-223
    • Pang, Z.P.1
  • 20
    • 84861990748 scopus 로고    scopus 로고
    • Small molecules enable highly efficient neuronal conversion of human fibroblasts
    • Ladewig, J., et al. Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods. 9 (6), 575-578, doi:10.1038/nmeth.1972, (2012).
    • (2012) Nat Methods , vol.9 , Issue.6 , pp. 575-578
    • Ladewig, J.1
  • 21
    • 84862777308 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into neural stem cells by defined factors
    • Han, D.W., et al. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell. 10 (4), 465-472, doi: 10.1016/j.stem.2012.02.021, (2012).
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 465-472
    • Han, D.W.1
  • 22
    • 84859555919 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts into stably expandable neural stem cells
    • Thier, M., et al. Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell. 10 (4), 473-479, doi: 10.1016/j.stem.2012.03.003, (2012).
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 473-479
    • Thier, M.1
  • 23
    • 84878536910 scopus 로고    scopus 로고
    • Generation of integration-free and region-specific neural progenitors from primate fibroblasts
    • Lu, J., et al. Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep. 3 (5), 1580-1591, doi:10.1016/j.celrep.2013.04.004, (2013).
    • (2013) Cell Rep , vol.3 , Issue.5 , pp. 1580-1591
    • Lu, J.1
  • 24
    • 84857136772 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
    • Lujan, E., Chanda, S., Ahlenius, H., Südhof, T.C., Werning, M. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci USA. 109(7), 2527-32, doi: 10.1073/pnas.1121003109, (2012).
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.7 , pp. 2527-2532
    • Lujan, E.1    Chanda, S.2    Ahlenius, H.3    Südhof, T.C.4    Werning, M.5
  • 25
    • 84862971294 scopus 로고    scopus 로고
    • Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors
    • Tian, C., et al. Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors. Curr Mol Med. 12 (2), 126-137, doi: 10.2174/156652412798889018, (2012).
    • (2012) Curr Mol Med , vol.12 , Issue.2 , pp. 126-137
    • Tian, C.1
  • 26
    • 84891739297 scopus 로고    scopus 로고
    • Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells
    • Zhu, S., et al. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res. 24 (1), 126-129, doi: 10.1038/cr.2013.156, (2014).
    • (2014) Cell Res , vol.24 , Issue.1 , pp. 126-129
    • Zhu, S.1
  • 27
    • 84914101821 scopus 로고    scopus 로고
    • Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain
    • Hemmer, K., et al. Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain. Stem Cell Reports. 3 (3), 423-431, doi: 10.1016/j.stemcr.2014.06.017, (2014).
    • (2014) Stem Cell Reports , vol.3 , Issue.3 , pp. 423-431
    • Hemmer, K.1
  • 28
    • 24944484633 scopus 로고    scopus 로고
    • Niche-independent symmetrical self-renewal of a mammalian tissue stem cell
    • Conti, L., et al. Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol. 3 (9), e283, doi: 10.137/journal.pbio.0030283, (2005).
    • (2005) Plos Biol , vol.3 , Issue.9
    • Conti, L.1
  • 29
    • 38349062515 scopus 로고    scopus 로고
    • Human ES cell-derived rosettes reveal a functional distinct early neural stem cell stage
    • Elkabetz, Y., Panagiotakos, G., Al Shamy, G., Socci, N.D., Tabar, V., Studer, L. Human ES cell-derived rosettes reveal a functional distinct early neural stem cell stage. Genes Dev. 22 (2), 152-165, doi: 10.1101/gad.1616208, (2008).
    • (2008) Genes Dev , vol.22 , Issue.2 , pp. 152-165
    • Elkabetz, Y.1    Panagiotakos, G.2    Al Shamy, G.3    Socci, N.D.4    Tabar, V.5    Studer, L.6
  • 30
    • 62549127853 scopus 로고    scopus 로고
    • Rosette-type self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
    • Koch, P., Opitz, T., Steinbeck, J.A., Ladewig, J., Brüstle, O. A rosette-type self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci USA. 106 (9), 3225-3230, doi: 10.1073/pnas.0808387106, (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.9 , pp. 3225-3230
    • Koch, P.1    Opitz, T.2    Steinbeck, J.A.3    Ladewig, J.4    Brüstle, O.A.5
  • 31
    • 79957777958 scopus 로고    scopus 로고
    • Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
    • Li, W., et al. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci USA. 108 (20), 8299-8304, doi: 10.1073/pnas.1014041108, (2011).
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.20 , pp. 8299-8304
    • Li, W.1
  • 32
    • 84875284468 scopus 로고    scopus 로고
    • Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling
    • Reinhardt, P., et al. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS One. 8 (3), c59252, doi: 10.1371/journal.pone.0059252, (2013).
    • (2013) Plos One , vol.8 , Issue.3
    • Reinhardt, P.1
  • 33
    • 84863625049 scopus 로고    scopus 로고
    • Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor
    • Ring, K.L., et al. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell. 11 (1), 100-109, doi: 10.1016/j.stem.2012.05.018, (2012).
    • (2012) Cell Stem Cell , vol.11 , Issue.1 , pp. 100-109
    • Ring, K.L.1
  • 34
    • 84894413040 scopus 로고    scopus 로고
    • Direct conversion of human fibroblasts into neuronal restricted progenitors
    • Zou, Q., et al. Direct conversion of human fibroblasts into neuronal restricted progenitors. J Biol Chem. 289 (8), 5250-5260, doi: 10.1074/jbc.M113.516112, (2014).
    • (2014) J Biol Chem , vol.289 , Issue.8 , pp. 5250-5260
    • Zou, Q.1
  • 35
    • 52149111208 scopus 로고    scopus 로고
    • Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursor in an animal model of multiple sclerosis
    • Aharonowiz, M., Einstein, O., Fainstein, N., Lassmann, H., Reubinoff, B., Ben-Hur, T. Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursor in an animal model of multiple sclerosis. PLoS One. 3 (9), e3145, doi: 10.1371/journal.pone.0003145,(2008).
    • (2008) Plos One , vol.3 , Issue.9
    • Aharonowiz, M.1    Einstein, O.2    Fainstein, N.3    Lassmann, H.4    Reubinoff, B.5    Ben-Hur, T.6
  • 36
    • 84870371604 scopus 로고    scopus 로고
    • Immunomodulation by transplanted human embryonic stem cell-derived oligodendroglial progenitors in experimental autoimmune encephalomyelitis
    • Kim, H., et al. Immunomodulation by transplanted human embryonic stem cell-derived oligodendroglial progenitors in experimental autoimmune encephalomyelitis. Stem Cells. 30 (12), 2810-2829, doi: 10.1002/stem.1218, (2012).
    • (2012) Stem Cells , vol.30 , Issue.12 , pp. 2810-2829
    • Kim, H.1
  • 37
    • 0029965344 scopus 로고    scopus 로고
    • Transplantation of human fetal tissue from spontaneous abortions to a rodent model of Parkinson’s disease
    • Kondoh, T., Pundt, L. L., Blount, J. P., Conrad, J. A., & Low, W. C. Transplantation of human fetal tissue from spontaneous abortions to a rodent model of Parkinson’s disease. Cell Transplant. 5 (1), 69-75, doi: 10.1016/0963-6897(95)02015-2, (1996).
    • (1996) Cell Transplant , vol.5 , Issue.1 , pp. 69-75
    • Kondoh, T.1    Pundt, L.L.2    Blount, J.P.3    Conrad, J.A.4    Low, W.C.5
  • 38
    • 85047689727 scopus 로고    scopus 로고
    • Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model
    • Takagi, Y., et al. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest. 115 (1), 102-109, doi: 10.1172/JCI21137, (2005).
    • (2005) J Clin Invest , vol.115 , Issue.1 , pp. 102-109
    • Takagi, Y.1
  • 39
    • 84858264889 scopus 로고    scopus 로고
    • Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson’s disease
    • Kikuchi, T., et al. Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson’s disease. J Parkinson’s Dis. 1 (4), 395-412, doi: 10.3233/JPD-2011-11070, (2011).
    • (2011) J Parkinson’s Dis , Issue.4 , pp. 395-412
    • Kikuchi, T.1
  • 40
    • 84863094725 scopus 로고    scopus 로고
    • Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions
    • Kirkeby, A., et al. Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep. 1 (6), 703-714, doi: 10.1016/j.celrep.2012.04.009, (2012).
    • (2012) Cell Rep , Issue.6 , pp. 703-714
    • Kirkeby, A.1
  • 41
    • 3042769428 scopus 로고    scopus 로고
    • Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
    • Dezawa, M., et al. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest. 113, 1701-1710, doi: 10.1172/JCI20935, (2004).
    • (2004) J Clin Invest , vol.113 , pp. 1701-1710
    • Dezawa, M.1
  • 42
    • 33847275635 scopus 로고    scopus 로고
    • Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo
    • Izrael, M., et al. Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci. 34 (3), 310-323, doi: 10.1016/j.mcn.2006.11.008, (2007).
    • (2007) Mol Cell Neurosci , vol.34 , Issue.3 , pp. 310-323
    • Izrael, M.1
  • 43
    • 84923821722 scopus 로고    scopus 로고
    • Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells
    • Cassady, J.P. et al. Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells. Stem Cell Rep. 3 (6), 948-956, doi: 10.1016/j.stemcr.2014.10.001, (2014).
    • (2014) Stem Cell Rep , vol.3 , Issue.6 , pp. 948-956
    • Cassady, J.P.1
  • 44
    • 84923828573 scopus 로고    scopus 로고
    • Fast and efficient neural conversion of human hematopoietic cells
    • Castano, J. et al. Fast and efficient neural conversion of human hematopoietic cells. Stem Cell Rep. 3 (6), 1118-1131, doi: 10.1016/j.stemcr.2014.10.008, (2014).
    • (2014) Stem Cell Rep , vol.3 , Issue.6 , pp. 1118-1131
    • Castano, J.1
  • 45
    • 84908029917 scopus 로고    scopus 로고
    • Chemical conversion of human fibroblasts into functional Schwann cells
    • Thoma, E.C. et al. Chemical conversion of human fibroblasts into functional Schwann cells. Stem Cell Rep. 3 (4), 539-547, doi: 10.1016/j.stemcr.2014.07.014, (2014).
    • (2014) Stem Cell Rep , vol.3 , Issue.4 , pp. 539-547
    • Thoma, E.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.