Compression Effects on the Phase Behaviour of Miconazole-Poly (1-Vinylpyrrolidone-Co-Vinyl Acetate) Solid Dispersions - Role of Pressure, Dwell Time, and Preparation Method

Journal of Pharmaceutical Sciences

Volumn 104, Issue 10, 2015, Pages 3366-3376

  Singh, Abhishek ^a   De Bisschop, Cathérine ^a   Schut, Henk ^b   Van Humbeeck, Jan ^c   Van Den Mooter, Guy ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

calorimetry (DSC); compression; extrusion; glass transition; mixing; solid dispersions; spectroscopy; spray drying; tableting; X ray diffractometry

Indexed keywords

MICONAZOLE; POLY(1 VINYLPYRROLIDONE CO VINYL ACETATE); POLYMER; UNCLASSIFIED DRUG; EXCIPIENT; POLY(VINYLPYRROLIDONE-CO-VINYL-ACETATE); POWDER; PYRROLIDINE DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; COMPRESSION; DISPERSION; GLASS TRANSITION TEMPERATURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE SEPARATION; SPRAY DRYING; TABLET; TEMPERATURE; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION; CHEMISTRY; DESICCATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; POWDER; PRESSURE; PROCEDURES; THERMODYNAMICS; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; DESICCATION; DRUG COMPOUNDING; EXCIPIENTS; MICONAZOLE; POWDERS; PRESSURE; PYRROLIDINES; THERMODYNAMICS; VINYL COMPOUNDS; X-RAY DIFFRACTION;

EID: 84941183977     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24540     Document Type: Article

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