A Systematic Study on Manufacturing of Prilled Microgels into Lipids for Oral Protein Delivery

Journal of Pharmaceutical Sciences

Volumn 104, Issue 10, 2015, Pages 3351-3365

  De Kruif, Jan Kendall ^a,b   Varum, Felipe ^c   Bravo, Roberto ^c   Kuentz, Martin ^a  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c Tillotts Pharma UK Ltd   (Switzerland)

Author keywords

capsule compatibility; encapsulation; excipient compatibility; hydrogels; lipids; microgels; partial least squares; phase diagram; prilling; protein delivery

Indexed keywords

BOVINE SERUM ALBUMIN; CHITOSAN; EXCIPIENT; LIPID; MICROGEL; POLYMER; PROTEIN; UNCLASSIFIED DRUG; GEL;

ARTICLE; CAPILLARY ELECTROPHORESIS; CAPSULE FILLING; CIRCULAR DICHROISM; CROSS LINKING; DISPERSION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; EXCIPIENT COMPATIBILITY; MACROMOLECULE; MICROTECHNOLOGY; MISCIBILITY; MOLECULAR WEIGHT; PARTICLE SIZE; PHASE SEPARATION; PROTEIN AGGREGATION; PROTEIN CONTENT; PROTEIN DENATURATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SOLUBILITY; SOLUBILIZATION; TURBIDITY; CHEMISTRY; DRUG INDUSTRY; DRUG STABILITY; GEL; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PROCEDURES;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG INDUSTRY; DRUG STABILITY; EXCIPIENTS; GELS; LIPIDS; PROTEINS; SERUM ALBUMIN, BOVINE;

EID: 84941180902     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24526     Document Type: Article

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