A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient

Food and Chemical Toxicology

Volumn 72, Issue , 2014, Pages 40-50

  Sullivan Jr , Dexter W ^a   Gad, Shayne C ^a   Julien, Marjorie ^b  

^a Gad Consulting Services   (United States)

^b GATTEFOSSÉ SAS   (France)

Author keywords

Cosmetic ingredient; Drug delivery; Excipient; Food additive; Oral formulation; Parenteral formulation

Indexed keywords

DIETHYLENE GLYCOL; DIETHYLENE GLYCOL MONOETHYL ETHER; ETHYLENE GLYCOL; EXCIPIENT; ETHYLENE GLYCOL DERIVATIVE;

ACUTE TOXICITY; BLOOD COMPATIBILITY; CARCINOGENICITY; CHEMICAL SAFETY; CHEMICAL STRUCTURE; CHRONIC TOXICITY; COMPUTER MODEL; DEVELOPMENTAL TOXICITY; DRUG IMPURITY; DRUG LEGISLATION; DRUG USE; ECONOMIC ASPECT; EXPOSURE; EYE IRRITATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY DISEASE; NONHUMAN; REPRODUCTIVE TOXICITY; REVIEW; SENSITIZATION; SKIN IRRITATION; TARGET ORGAN; TOXICITY TESTING; ANIMAL; ANIMAL MODEL; CARCINOGEN TESTING; CHEMISTRY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECTS; PRODUCT SAFETY; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM;

ANIMALS; CARCINOGENICITY TESTS; CONSUMER PRODUCT SAFETY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE GLYCOLS; EXCIPIENTS; HUMANS; MODELS, ANIMAL; SALMONELLA TYPHIMURIUM; TOXICITY TESTS, ACUTE; TOXICITY TESTS, CHRONIC; TOXICITY TESTS, SUBCHRONIC;

EID: 84904913462     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.06.028     Document Type: Review

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