On prilling of hydrophilic microgels in lipid dispersions using mono-N-carboxymethyl chitosan for oral biologicals delivery

Journal of Pharmaceutical Sciences

Volumn 103, Issue 11, 2014, Pages 3675-3687

  De Kruif, Jan Kendall ^a,b   Fasler Kan, Elizaveta ^b   Varum, Felipe ^c   Bravo, Roberto ^c   Kuentz, Martin ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^c Tillotts Pharma UK Ltd   (Switzerland)

Author keywords

Chitosan; Hydrogel; Lipid based dispersion; Macromolecular drug delivery; Microencapsulation; Oral drug delivery; Prilling; Vibrating nozzle

Indexed keywords

BIOLOGICAL PRODUCT; BOVINE SERUM ALBUMIN; CALCIUM CHLORIDE; CHITOSAN; GELATIN; GELLING AGENT; LIPID; MONOMETHYLCARBOXYMETHYL CHITOSAN; UNCLASSIFIED DRUG; DRUG CARRIER; GEL; MICROCAPSULE; N-(CARBOXYMETHYL)CHITOSAN;

ARTICLE; BIOCHEMICAL COMPOSITION; CROSS LINKING; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; HYDROPHILICITY; ORAL DRUG ADMINISTRATION; PROTEIN DENATURATION; CHEMICAL PHENOMENA; CHEMISTRY; CIRCULAR DICHROISM; DRUG STABILITY; GEL; HARDNESS; KINETICS; MEDICINAL CHEMISTRY; MICROCAPSULE; PHARMACEUTICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCEDURES; PROTEIN STABILITY; SOLUBILITY; SPECTROFLUOROMETRY;

ADMINISTRATION, ORAL; BIOLOGICAL PRODUCTS; CAPSULES; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CIRCULAR DICHROISM; DRUG CARRIERS; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GELS; HARDNESS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LIPIDS; PROTEIN DENATURATION; PROTEIN STABILITY; SERUM ALBUMIN, BOVINE; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; TECHNOLOGY, PHARMACEUTICAL;

EID: 84915758377     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24172     Document Type: Article

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