Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model

Diabetes

Volumn 64, Issue 6, 2015, Pages 2254-2264

  Vial, Guillaume ^a,b   Chauvin, Marie Agnès ^a   Bendridi, Nadia ^a   Durand, Annie ^a   Meugnier, Emmanuelle ^a   Madec, Anne Marie ^a   Bernoud Hubac, Nathalie ^a   De Barros, Jean Paul Pais ^c   Fontaine, Éric ^d,e,f   Acquaviva, Cécile ^g   Hallakou Bozec, Sophie ^h   Bolze, Sébastien ^h   Vidal, Hubert ^a,b,i   Rieusset, Jennifer ^a,b,i  

^a CarMeN   (France)

^b Center for European Nutrition and Health   (France)

^c HÔPITAL DU BOCAGE   (France)

^d Domaine Universitaire   (France)

^e UNIV GRENOBLE ALPES   (France)

^f GRENOBLE UNIVERSITY HOSPITAL   (France)

^g Centre de Biologie et Pathologie Est   (France)

^h Poxel SA   (France)

ⁱ CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; CHOLESTEROL; COENZYME A; DIACYLGLYCEROL; GLUCOSE; GLUTAMIC ACID; IMEGLIMIN; INSULIN; MALIC ACID; MITOCHONDRIAL DNA; OXIDOREDUCTASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; TRIACYLGLYCEROL; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIDIABETIC AGENT; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; EXPERIMENTAL DIABETES MELLITUS; FATTY ACID OXIDATION; FATTY LIVER; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RESPONSE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; LIPID LIVER LEVEL; LIPID OXIDATION; LIVER HISTOLOGY; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; SUGAR INTAKE; TRANSMISSION ELECTRON MICROSCOPY; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DRUG EFFECTS; INSULIN RESISTANCE; LIVER; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

ANIMALS; DIET, HIGH-FAT; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; TRIAZINES;

EID: 84941167763     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-1220     Document Type: Article

References (34)

1. Guariguata L, Nolan T, Beagley J, Linnenkamp U, Jacqmain O (Eds). IDF Diabetes Atlas. 6th ed. Brussels, International Diabetes Federation, 2013.
2. Reinehr T. Type 2 diabetes mellitus in children and adolescents. World J Diabetes 2013;4:270-281.
3. Fouqueray P, Pirags V, Diamant M, et al. The efficacy and safety of imeglimin as add-on therapy in patients with type 2 diabetes inadequately controlled with sitagliptin monotherapy. Diabetes Care 2014;37:1924-1930.
4. Fouqueray P, Pirags V, Inzucchi SE, et al. The efficacy and safety of imeglimin as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy. Diabetes Care 2013;36:565-568.
5. Pirags V, Lebovitz H, Fouqueray P. Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients. Diabetes Obes Metab 2012;14:852-858.
6. Fouqueray P, Leverve X, Fontaine E, et al. Imeglimin - A new oral antidiabetic that targets the three key defects of type 2 diabetes. J Diabetes Metab 2011;2:126.
7. Pacini G, Mari A, Brazzale A, Fouqueray F, Bolze S, Roden M. Imeglimin increases glucose-dependent insulin secretion and improves beta-cell function in patients with type 2 diabetes (120-OR). Diabetes 2014;63(Suppl. 1):A32.
8. Bonnard C, Durand A, Peyrol S, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 2008;118:789-800.
9. Vianey-Saban C, Guffon N, Delolne F, Guibaud P, Mathieu M, Divry P. Diagnosis of inborn errors of metabolism by acylcarnitine profiling in blood using tandem mass spectrometry. J Inherit Metab Dis 1997;20:411-414.
10. Klingenberg M, Slenczka W. Pyridine nucleotide in liver mitochondria. An analysis of their redox relationships. Biochem Z 1959;331:486-517 [in German].
11. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
12. Tubbs E, Theurey P, Vial G, et al. Mitochondria- Associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance. Diabetes 2014;63:3279-3294.
13. Vial G, Dubouchaud H, Couturier K, et al. Effects of a high-fat diet on energy metabolism and ROS production in rat liver. J Hepatol 2011;54:348-356.
14. Vial G, Dubouchaud H, Leverve XM. Liver mitochondria and insulin resistance. Acta Biochim Pol 2010;57:389-392.
15. Batandier C, Guigas B, Detaille D, et al. The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin. J Bioenerg Biomembr 2006;38:33-42.
16. Julienne CM, Tardieu M, Chevalier S, et al. Cardiolipin content is involved in liver mitochondrial energy wasting associated with cancer-induced cachexia without the involvement of adenine nucleotide translocase. Biochim Biophys Acta 2014;1842:726-733.
17. Ren M, Phoon CK, Schlame M. Metabolism and function of mitochondrial cardiolipin. Prog Lipid Res 2014;55:1-16.
18. Paradies G, Paradies V, De Benedictis V, Ruggiero FM, Petrosillo G. Functional role of cardiolipin in mitochondrial bioenergetics. Biochim Biophys Acta 2014;1837: 408-417.
19. Drahota Z, Palenickova E, Endlicher R, et al. Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties. Physiol Res 2014;63:1-11.
20. Lagace TA, Ridgway ND. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochim Biophys Acta 2013;1833:2499-2510.
21. Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res 2006;47:2726-2737.
22. Perry RJ, Kim T, Zhang XM, et al. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver- Targeted mitochondrial uncoupler. Cell Metab 2013;18:740-748.
23. Erion DM, Shulman GI. Diacylglycerol-mediated insulin resistance. Nat Med 2010;16:400-402.
24. Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 2014;510:84-91.
25. Kumashiro N, Erion DM, Zhang D, et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 2011;108:16381-16385.
26. Magkos F, Su X, Bradley D, et al. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology 2012;142:1444-1446.
27. Petersen KF, Shulman GI. Etiology of insulin resistance. Am J Med 2006; 119(Suppl. 1):S10-S16.
28. Imoto K, Kukidome D, Nishikawa T, et al. Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling. Diabetes 2006;55:1197-1204.
29. Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404:787-790.
30. Bobyleva V, Bellei M, Pazienza TL, Muscatello U. Effect of cardiolipin on functional properties of isolated rat liver mitochondria. Biochem Mol Biol Int 1997;41:469-480.
31. Lange C, Nett JH, Trumpower BL, Hunte C. Specific roles of proteinphospholipid interactions in the yeast cytochrome bc1 complex structure. EMBO J 2001;20:6591-6600.
32. Bazán S, Mileykovskaya E, Mallampalli VK, Heacock P, Sparagna GC, Dowhan W. Cardiolipin-dependent reconstitution of respiratory supercomplexes from purified Saccharomyces cerevisiae complexes III and IV. J Biol Chem 2013;288:401-411.
33. Mileykovskaya E, Dowhan W. Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes. Chem Phys Lipids 2014;179:42-48.
34. Genova ML, Lenaz G. Functional role of mitochondrial respiratory supercomplexes. Biochim Biophys Acta 2014;1837:427-443.