Cardiolipin content is involved in liver mitochondrial energy wasting associated with cancer-induced cachexia without the involvement of adenine nucleotide translocase

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 5, 2014, Pages 726-733

  Julienne, Cloé Mimsy ^a   Tardieu, Marine ^a,c   Chevalier, Stéphan ^a,b   Pinault, Michelle ^a,b   Bougnoux, Philippe ^a,b,c   Labarthe, François ^a,b,c   Couet, Charles ^a,b,c   Servais, Stéphane ^a,b,d   Dumas, Jean François ^a,b  

^a CHRU de Tours   (France)

^b UNIVERSITÉ DE TOURS   (France)

^c CHU BRETONNEAU   (France)

^d IUT   (France)

Author keywords

ANT; ATP synthesis; Cardiolipin; Oxidative phosphorylation; Peritoneal carcinosis; Undernutrition

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE TRIPHOSPHATE; CARDIOLIPIN; CYTOCHROME C OXIDASE; LIPOSOME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CACHEXIA; CARCINOMATOUS PERITONITIS; CONTROLLED STUDY; ENERGY; ISOLATED LIVER; LIVER MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; SYNTHESIS;

ANT; ATP SYNTHESIS; CARDIOLIPIN; OXIDATIVE PHOSPHORYLATION; PERITONEAL CARCINOSIS; UNDERNUTRITION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CACHEXIA; CARDIOLIPINS; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; MITOCHONDRIA, LIVER; MITOCHONDRIAL ADP, ATP TRANSLOCASES; NEOPLASMS, EXPERIMENTAL; PHOSPHORYLATION; RATS;

EID: 84896823942     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.02.003     Document Type: Article

References (29)

1. Nitenberg G., Raynard B. Nutritional support of the cancer patient: issues and dilemmas. Crit. Rev. Oncol. Hematol. 2000, 34:137-168.
2. Dewys W.D., Begg C., Lavin P.T., Band P.R., Bennett J.M., Bertino J.R., Cohen M.H., Douglass H.O., Engstrom P.F., Ezdinli E.Z., Horton J., Johnson G.J., Moertel C.G., Oken M.M., Perlia C., Rosenbaum C., Silverstein M.N., Skeel R.T., Sponzo R.W., Tormey D.C. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am. J. Med. 1980, 69:491-497.
3. Morley J.E., Thomas D.R., Wilson M.M. Cachexia: pathophysiology and clinical relevance. Am. J. Clin. Nutr. 2006, 83:735-743.
4. Fearon K., Arends J., Baracos V. Understanding the mechanisms and treatment options in cancer cachexia. Nat. Rev. Clin. Oncol. 2013, 10:90-99.
5. Rolfe D.F., Brown G.C. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol. Rev. 1997, 77:731-758.
6. Lieffers J.R., Mourtzakis M., Hall K.D., McCargar L.J., Prado C.M., Baracos V.E. A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. Am. J. Clin. Nutr. 2009, 89:1173-1179.
7. Tsuburaya A., Blumberg D., Burt M., Brennan M.F. Energy depletion in the liver and in isolated hepatocytes of tumor-bearing animals. J. Surg. Res. 1995, 59:421-427.
8. Hochwald S.N., Harrison L.E., Port J.L., Blumberg D., Brennan M.F., Burt M. Depletion of high energy phosphate compounds in the tumor-bearing state and reversal after tumor resection. Surgery 1996, 120:534-541.
9. Perumal S.S., Shanthi P., Sachdanandam P. Energy-modulating vitamins-a new combinatorial therapy prevents cancer cachexia in rat mammary carcinoma. Br. J. Nutr. 2005, 93:901-909.
10. Dumas J.F., Goupille C., Julienne C.M., Pinault M., Chevalier S., Bougnoux P., Servais S., Couet C. Efficiency of oxidative phosphorylation in liver mitochondria is decreased in a rat model of peritoneal carcinosis. J. Hepatol. 2011, 54:320-327.
11. Klingenberg M. Cardiolipin and mitochondrial carriers. Biochim. Biophys. Acta 2009, 1788:2048-2058.
12. Claypool S.M. Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function. Biochim. Biophys. Acta 2009, 1788:2059-2068.
13. Duszynski J., Bogucka K., Letko G., Kuster U., Kunz W., Wojtczak L. Relationship between the energy cost of ATP transport and ATP synthesis in mitochondria. Biochim. Biophys. Acta 1981, 637:217-223.
14. Brand M.D., Pakay J.L., Ocloo A., Kokoszka J., Wallace D.C., Brookes P.S., Cornwall E.J. The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem. Med. 2005, 392:353-362.
15. Shabalina I.G., Kramarova T.V., Nedergaard J., Cannon B. Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively. Biochem. Med. 2006, 399:405-414.
16. Arvier M., Lagoutte L., Johnson G., Dumas J.F., Sion B., Grizard G., Malthiery Y., Simard G., Ritz P. Adenine nucleotide translocator promotes oxidative phosphorylation and mild uncoupling in mitochondria after dexamethasone treatment. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E1320-E1324.
17. Dumas J.F., Goupille C., Pinault M., Fandeur L., Bougnoux P., Servais S., Couet C. n-3 PUFA-enriched diet delays the occurrence of cancer cachexia in rat with peritoneal carcinosis. Nutr. Cancer 2010, 62:343-350.
18. Zhou S., Starkov A., Froberg M.K., Leino R.L., Wallace K.B. Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin. Cancer Res. 2001, 61:771-777.
19. Roussel D., Dumas J.F., Augeraud A., Douay O., Foussard F., Malthiery Y., Simard G., Ritz P. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003, 541:75-79.
20. Petrosillo G., Portincasa P., Grattagliano I., Casanova G., Matera M., Ruggiero F.M., Ferri D., Paradies G. Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin. Biochim. Biophys. Acta 2007, 1767:1260-1267.
21. Piccotti L., Marchetti C., Migliorati G., Roberti R., Corazzi L. Exogenous phospholipids specifically affect transmembrane potential of brain mitochondria and cytochrome C release. J. Biol. Chem. 2002, 277:12075-12081.
22. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37:911-917.
23. + permeability by palmitate and anionic detergents. FEBS Lett. 1990, 272:187-189.
24. Chicco A.J., Sparagna G.C. Role of cardiolipin alterations in mitochondrial dysfunction and disease. Am. J. Physiol. Cell Physiol. 2007, 292:C33-C44.
25. Bobyleva V., Bellei M., Pazienza T.L., Muscatello U. Effect of cardiolipin on functional properties of isolated rat liver mitochondria. Biochem. Mol. Biol. Int. 1997, 41:469-480.
26. Fontaine E.M., Moussa M., Devin A., Garcia J., Ghisolfi J., Rigoulet M., Leverve X.M. Effect of polyunsaturated fatty acids deficiency on oxidative phosphorylation in rat liver mitochondria. Biochim. Biophys. Acta 1996, 1276:181-187.
27. Schlame M., Beyer K., Hayer-Hartl M., Klingenberg M. Molecular species of cardiolipin in relation to other mitochondrial phospholipids. Is there an acyl specificity of the interaction between cardiolipin and the ADP/ATP carrier?. Eur. J. Biochem. 1991, 199:459-466.
28. Petrosillo G., Casanova G., Matera M., Ruggiero F.M., Paradies G. Interaction of peroxidized cardiolipin with rat-heart mitochondrial membranes: induction of permeability transition and cytochrome c release. FEBS Lett. 2006, 580:6311-6316.
29. Liu S., Wu H.J., Zhang Z.Q., Chen Q., Liu B., Wu J.P., Zhu L. l-carnitine ameliorates cancer cachexia in mice by regulating the expression and activity of carnitine palmitoyl transferase. Cancer Biol. Ther. 2011, 12:125-130.