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Volumn 185, Issue 9, 2015, Pages 2575-2589

αvβ3 Integrins Mediate Flow-Induced NF-κB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAVBETA1 INTEGRIN; ALPHAVBETA5 INTEGRIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; P21 ACTIVATED KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VITRONECTIN RECEPTOR;

EID: 84941127520     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2015.05.013     Document Type: Article
Times cited : (72)

References (50)
  • 1
    • 58049213928 scopus 로고    scopus 로고
    • Mechanotransduction in vascular physiology and atherogenesis
    • C. Hahn, and M.A. Schwartz Mechanotransduction in vascular physiology and atherogenesis Nat Rev Mol Cell Biol 10 2009 53 62
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 53-62
    • Hahn, C.1    Schwartz, M.A.2
  • 2
    • 84914162544 scopus 로고    scopus 로고
    • Shear stress-initiated signaling and its regulation of endothelial function
    • J. Zhou, Y.S. Li, and S. Chien Shear stress-initiated signaling and its regulation of endothelial function Arterioscler Thromb Vasc Biol 34 2014 2191 2198
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 2191-2198
    • Zhou, J.1    Li, Y.S.2    Chien, S.3
  • 3
    • 77952468065 scopus 로고    scopus 로고
    • Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells
    • S.D. Funk, A. Yurdagul Jr., J.M. Green, K.A. Jhaveri, M.A. Schwartz, and A.W. Orr Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells Circ Res 106 2010 1394 1403
    • (2010) Circ Res , vol.106 , pp. 1394-1403
    • Funk, S.D.1    Yurdagul, A.2    Green, J.M.3    Jhaveri, K.A.4    Schwartz, M.A.5    Orr, A.W.6
  • 4
    • 17644383381 scopus 로고    scopus 로고
    • The subendothelial extracellular matrix modulates NF-kappaB activation by flow: A potential role in atherosclerosis
    • A.W. Orr, J.M. Sanders, M. Bevard, E. Coleman, I.J. Sarembock, and M.A. Schwartz The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosis J Cell Biol 169 2005 191 202
    • (2005) J Cell Biol , vol.169 , pp. 191-202
    • Orr, A.W.1    Sanders, J.M.2    Bevard, M.3    Coleman, E.4    Sarembock, I.J.5    Schwartz, M.A.6
  • 5
    • 84873388580 scopus 로고    scopus 로고
    • Altered nitric oxide production mediates matrix-specific PAK2 and NF-kappaB activation by flow
    • A. Yurdagul Jr., J. Chen, S.D. Funk, P. Albert, C.G. Kevil, and A.W. Orr Altered nitric oxide production mediates matrix-specific PAK2 and NF-kappaB activation by flow Mol Biol Cell 24 2013 398 408
    • (2013) Mol Biol Cell , vol.24 , pp. 398-408
    • Yurdagul, A.1    Chen, J.2    Funk, S.D.3    Albert, P.4    Kevil, C.G.5    Orr, A.W.6
  • 6
    • 77953809406 scopus 로고    scopus 로고
    • Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation
    • R.E. Feaver, B.D. Gelfand, C. Wang, M.A. Schwartz, and B.R. Blackman Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation Circ Res 106 2010 1703 1711
    • (2010) Circ Res , vol.106 , pp. 1703-1711
    • Feaver, R.E.1    Gelfand, B.D.2    Wang, C.3    Schwartz, M.A.4    Blackman, B.R.5
  • 7
    • 84903154402 scopus 로고    scopus 로고
    • Alpha5beta1 integrin signaling mediates oxidized low-density lipoprotein-induced inflammation and early atherosclerosis
    • A. Yurdagul Jr., J. Green, P. Albert, M.C. McInnis, A.P. Mazar, and A.W. Orr alpha5beta1 integrin signaling mediates oxidized low-density lipoprotein-induced inflammation and early atherosclerosis Arterioscler Thromb Vasc Biol 34 2014 1362 1373
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1362-1373
    • Yurdagul, A.1    Green, J.2    Albert, P.3    McInnis, M.C.4    Mazar, A.P.5    Orr, A.W.6
  • 8
    • 53249142641 scopus 로고    scopus 로고
    • P21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow
    • A.W. Orr, C. Hahn, B.R. Blackman, and M.A. Schwartz p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow Circ Res 103 2008 671 679
    • (2008) Circ Res , vol.103 , pp. 671-679
    • Orr, A.W.1    Hahn, C.2    Blackman, B.R.3    Schwartz, M.A.4
  • 11
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • R.O. Hynes Integrins: bidirectional, allosteric signaling machines Cell 110 2002 673 687
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 12
    • 33750520931 scopus 로고    scopus 로고
    • Matrix-specific suppression of integrin activation in shear stress signaling
    • A.W. Orr, M.H. Ginsberg, S.J. Shattil, H. Deckmyn, and M.A. Schwartz Matrix-specific suppression of integrin activation in shear stress signaling Mol Biol Cell 17 2006 4686 4697
    • (2006) Mol Biol Cell , vol.17 , pp. 4686-4697
    • Orr, A.W.1    Ginsberg, M.H.2    Shattil, S.J.3    Deckmyn, H.4    Schwartz, M.A.5
  • 13
    • 0037121966 scopus 로고    scopus 로고
    • Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression
    • E. Tzima, M.A. Del Pozo, W.B. Kiosses, S.A. Mohamed, S. Li, S. Chien, and M.A. Schwartz Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression EMBO J 21 2002 6791 6800
    • (2002) EMBO J , vol.21 , pp. 6791-6800
    • Tzima, E.1    Del Pozo, M.A.2    Kiosses, W.B.3    Mohamed, S.A.4    Li, S.5    Chien, S.6    Schwartz, M.A.7
  • 14
    • 0028829070 scopus 로고
    • Alpha-v beta-3 integrin expression in normal and atherosclerotic artery
    • M. Hoshiga, C.E. Alpers, L.L. Smith, C.M. Giachelli, and S.M. Schwartz Alpha-v beta-3 integrin expression in normal and atherosclerotic artery Circ Res 77 1995 1129 1135
    • (1995) Circ Res , vol.77 , pp. 1129-1135
    • Hoshiga, M.1    Alpers, C.E.2    Smith, L.L.3    Giachelli, C.M.4    Schwartz, S.M.5
  • 16
    • 15644372038 scopus 로고    scopus 로고
    • National Academies Press Washington, DC
    • Committee for the Update of the Guide for the Care and Use of Laboratory Animals; National Research Council Guide for the Care and Use of Laboratory Animals: Eighth Edition 2011 National Academies Press Washington, DC
    • (2011) Guide for the Care and Use of Laboratory Animals: Eighth Edition
  • 18
    • 33845357881 scopus 로고    scopus 로고
    • VE-cadherin-CreERT2 transgenic mouse: A model for inducible recombination in the endothelium
    • A. Monvoisin, J.A. Alva, J.J. Hofmann, A.C. Zovein, T.F. Lane, and M.L. Iruela-Arispe VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium Dev Dyn 235 2006 3413 3422
    • (2006) Dev Dyn , vol.235 , pp. 3413-3422
    • Monvoisin, A.1    Alva, J.A.2    Hofmann, J.J.3    Zovein, A.C.4    Lane, T.F.5    Iruela-Arispe, M.L.6
  • 19
    • 80055108172 scopus 로고    scopus 로고
    • Isolation and culture of pulmonary endothelial cells from neonatal mice
    • M. Sobczak, J. Dargatz, and M. Chrzanowska-Wodnicka Isolation and culture of pulmonary endothelial cells from neonatal mice J Vis Exp 46 2010 2316
    • (2010) J Vis Exp , Issue.46 , pp. 2316
    • Sobczak, M.1    Dargatz, J.2    Chrzanowska-Wodnicka, M.3
  • 20
    • 70349626069 scopus 로고    scopus 로고
    • Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis
    • D. Nam, C.W. Ni, A. Rezvan, J. Suo, K. Budzyn, A. Llanos, D. Harrison, D. Giddens, and H. Jo Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis Am J Physiol Heart Circ Physiol 297 2009 H1535 H1543
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , pp. H1535-H1543
    • Nam, D.1    Ni, C.W.2    Rezvan, A.3    Suo, J.4    Budzyn, K.5    Llanos, A.6    Harrison, D.7    Giddens, D.8    Jo, H.9
  • 21
    • 0031858633 scopus 로고    scopus 로고
    • Integrin-mediated signaling events in human endothelial cells
    • S.M. Short, G.A. Talbott, and R.L. Juliano Integrin-mediated signaling events in human endothelial cells Mol Biol Cell 9 1998 1969 1980
    • (1998) Mol Biol Cell , vol.9 , pp. 1969-1980
    • Short, S.M.1    Talbott, G.A.2    Juliano, R.L.3
  • 24
    • 70350159878 scopus 로고    scopus 로고
    • Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis
    • A.W. Orr, N.E. Hastings, B.R. Blackman, and B.R. Wamhoff Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis J Vasc Res 47 2010 168 180
    • (2010) J Vasc Res , vol.47 , pp. 168-180
    • Orr, A.W.1    Hastings, N.E.2    Blackman, B.R.3    Wamhoff, B.R.4
  • 25
    • 0027944516 scopus 로고
    • Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation
    • H. Matsuno, J.M. Stassen, J. Vermylen, and H. Deckmyn Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation Circulation 90 1994 2203 2206
    • (1994) Circulation , vol.90 , pp. 2203-2206
    • Matsuno, H.1    Stassen, J.M.2    Vermylen, J.3    Deckmyn, H.4
  • 26
    • 77953812743 scopus 로고    scopus 로고
    • Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling
    • M. Panchatcharam, S. Miriyala, F. Yang, M. Leitges, M. Chrzanowska-Wodnicka, L.A. Quilliam, P. Anaya, A.J. Morris, and S.S. Smyth Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling Int J Biochem Cell Biol 42 2010 965 974
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 965-974
    • Panchatcharam, M.1    Miriyala, S.2    Yang, F.3    Leitges, M.4    Chrzanowska-Wodnicka, M.5    Quilliam, L.A.6    Anaya, P.7    Morris, A.J.8    Smyth, S.S.9
  • 30
    • 0035801529 scopus 로고    scopus 로고
    • Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment
    • E. Tzima, M.A. del Pozo, S.J. Shattil, S. Chien, and M.A. Schwartz Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment EMBO J 20 2001 4639 4647
    • (2001) EMBO J , vol.20 , pp. 4639-4647
    • Tzima, E.1    Del Pozo, M.A.2    Shattil, S.J.3    Chien, S.4    Schwartz, M.A.5
  • 31
    • 0032515036 scopus 로고    scopus 로고
    • Fluid shear stress activation of IkappaB kinase is integrin-dependent
    • I.S. Bhullar, Y.S. Li, H. Miao, E. Zandi, M. Kim, J.Y. Shyy, and S. Chien Fluid shear stress activation of IkappaB kinase is integrin-dependent J Biol Chem 273 1998 30544 30549
    • (1998) J Biol Chem , vol.273 , pp. 30544-30549
    • Bhullar, I.S.1    Li, Y.S.2    Miao, H.3    Zandi, E.4    Kim, M.5    Shyy, J.Y.6    Chien, S.7
  • 34
    • 67449164310 scopus 로고    scopus 로고
    • MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling
    • M.M. Aziz, S. Ishihara, Y. Mishima, N. Oshima, I. Moriyama, T. Yuki, Y. Kadowaki, M.A. Rumi, Y. Amano, and Y. Kinoshita MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling J Immunol 182 2009 7222 7232
    • (2009) J Immunol , vol.182 , pp. 7222-7232
    • Aziz, M.M.1    Ishihara, S.2    Mishima, Y.3    Oshima, N.4    Moriyama, I.5    Yuki, T.6    Kadowaki, Y.7    Rumi, M.A.8    Amano, Y.9    Kinoshita, Y.10
  • 35
    • 0028928138 scopus 로고
    • Vascular proliferation and angiogenic factors in psoriasis
    • J.D. Creamer, and J.N. Barker Vascular proliferation and angiogenic factors in psoriasis Clin Exp Dermatol 20 1995 6 9
    • (1995) Clin Exp Dermatol , vol.20 , pp. 6-9
    • Creamer, J.D.1    Barker, J.N.2
  • 36
    • 0032893957 scopus 로고    scopus 로고
    • Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist
    • C.M. Storgard, D.G. Stupack, A. Jonczyk, S.L. Goodman, R.I. Fox, and D.A. Cheresh Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist J Clin Invest 103 1999 47 54
    • (1999) J Clin Invest , vol.103 , pp. 47-54
    • Storgard, C.M.1    Stupack, D.G.2    Jonczyk, A.3    Goodman, S.L.4    Fox, R.I.5    Cheresh, D.A.6
  • 37
    • 0033528660 scopus 로고    scopus 로고
    • Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
    • K.S. Moulton, E. Heller, M.A. Konerding, E. Flynn, W. Palinski, and J. Folkman Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice Circulation 99 1999 1726 1732
    • (1999) Circulation , vol.99 , pp. 1726-1732
    • Moulton, K.S.1    Heller, E.2    Konerding, M.A.3    Flynn, E.4    Palinski, W.5    Folkman, J.6
  • 38
    • 34247608221 scopus 로고    scopus 로고
    • Signaling for integrin alpha5/beta1 expression in Helicobacter pylori-infected gastric epithelial AGS cells
    • S.O. Cho, K.H. Kim, J.H. Yoon, and H. Kim Signaling for integrin alpha5/beta1 expression in Helicobacter pylori-infected gastric epithelial AGS cells Ann N Y Acad Sci 1090 2006 298 304
    • (2006) Ann N y Acad Sci , vol.1090 , pp. 298-304
    • Cho, S.O.1    Kim, K.H.2    Yoon, J.H.3    Kim, H.4
  • 39
    • 28344432003 scopus 로고    scopus 로고
    • Angiotensin II stimulates endothelial integrin beta3 expression via nuclear factor-kappaB activation
    • S. Li, X. Wang, J. Qiu, Q. Si, H. Wang, H. Guo, R. Sun, and Q. Wu Angiotensin II stimulates endothelial integrin beta3 expression via nuclear factor-kappaB activation Exp Aging Res 32 2006 47 60
    • (2006) Exp Aging Res , vol.32 , pp. 47-60
    • Li, S.1    Wang, X.2    Qiu, J.3    Si, Q.4    Wang, H.5    Guo, H.6    Sun, R.7    Wu, Q.8
  • 40
    • 3042690158 scopus 로고    scopus 로고
    • Regulation of macrophage foam cell formation by alphaVbeta3 integrin: Potential role in human atherosclerosis
    • A.S. Antonov, F.D. Kolodgie, D.H. Munn, and R.G. Gerrity Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis Am J Pathol 165 2004 247 258
    • (2004) Am J Pathol , vol.165 , pp. 247-258
    • Antonov, A.S.1    Kolodgie, F.D.2    Munn, D.H.3    Gerrity, R.G.4
  • 41
  • 42
    • 78649640382 scopus 로고    scopus 로고
    • AlphaVbeta3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-kappaB activation
    • A.S. Antonov, G.N. Antonova, D.H. Munn, N. Mivechi, R. Lucas, J.D. Catravas, and A.D. Verin alphaVbeta3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-kappaB activation J Cell Physiol 226 2011 469 476
    • (2011) J Cell Physiol , vol.226 , pp. 469-476
    • Antonov, A.S.1    Antonova, G.N.2    Munn, D.H.3    Mivechi, N.4    Lucas, R.5    Catravas, J.D.6    Verin, A.D.7
  • 44
    • 36348980445 scopus 로고    scopus 로고
    • Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression
    • J.G. Schneider, Y. Zhu, T. Coleman, and C.F. Semenkovich Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression Arterioscler Thromb Vasc Biol 27 2007 2699 2706
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2699-2706
    • Schneider, J.G.1    Zhu, Y.2    Coleman, T.3    Semenkovich, C.F.4
  • 45
    • 84863145011 scopus 로고    scopus 로고
    • Role of integrin-beta3 protein in macrophage polarization and regeneration of injured muscle
    • L. Zhang, Y. Dong, J. Cheng, and J. Du Role of integrin-beta3 protein in macrophage polarization and regeneration of injured muscle J Biol Chem 287 2012 6177 6186
    • (2012) J Biol Chem , vol.287 , pp. 6177-6186
    • Zhang, L.1    Dong, Y.2    Cheng, J.3    Du, J.4
  • 46
    • 85047676421 scopus 로고
    • Stimulation of migration of human aortic smooth muscle cells by vitronectin: Implications for atherosclerosis
    • S.L. Brown, C.H. Lundgren, T. Nordt, and S. Fujii Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis Cardiovasc Res 28 1994 1815 1820
    • (1994) Cardiovasc Res , vol.28 , pp. 1815-1820
    • Brown, S.L.1    Lundgren, C.H.2    Nordt, T.3    Fujii, S.4
  • 47
    • 0034981380 scopus 로고    scopus 로고
    • Hypoxia stimulates osteopontin expression and proliferation of cultured vascular smooth muscle cells: Potentiation by high glucose
    • C.P. Sodhi, S.A. Phadke, D. Batlle, and A. Sahai Hypoxia stimulates osteopontin expression and proliferation of cultured vascular smooth muscle cells: potentiation by high glucose Diabetes 50 2001 1482 1490
    • (2001) Diabetes , vol.50 , pp. 1482-1490
    • Sodhi, C.P.1    Phadke, S.A.2    Batlle, D.3    Sahai, A.4
  • 48
    • 36349020945 scopus 로고    scopus 로고
    • Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1
    • J. Cheng, J. Zhang, A. Merched, L. Zhang, P. Zhang, L. Truong, A.M. Boriek, and J. Du Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1 J Biol Chem 282 2007 34268 34275
    • (2007) J Biol Chem , vol.282 , pp. 34268-34275
    • Cheng, J.1    Zhang, J.2    Merched, A.3    Zhang, L.4    Zhang, P.5    Truong, L.6    Boriek, A.M.7    Du, J.8
  • 49
    • 66349137052 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the thrombotic complications of atherosclerosis
    • P. Libby Molecular and cellular mechanisms of the thrombotic complications of atherosclerosis J Lipid Res 50 Suppl 2009 S352 S357
    • (2009) J Lipid Res , Issue.50 , pp. S352-S357
    • Libby, P.1


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