메뉴 건너뛰기




Volumn 226, Issue 2, 2011, Pages 469-476

αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTYLSERINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; VITRONECTIN; VITRONECTIN RECEPTOR;

EID: 78649640382     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22356     Document Type: Article
Times cited : (108)

References (48)
  • 1
    • 0030979903 scopus 로고    scopus 로고
    • Aortic endothelial cells regulate proliferation of human monocytes in vitro via a mechanism synergistic with macrophage colony-stimulating factor. Convergence at the cyclin E/p27(Kip1) regulatory checkpoint
    • Antonov AS, Munn DH, Kolodgie FD, Virmani R, Gerrity RG. 1997. Aortic endothelial cells regulate proliferation of human monocytes in vitro via a mechanism synergistic with macrophage colony-stimulating factor. Convergence at the cyclin E/p27(Kip1) regulatory checkpoint. J Clin Invest 99: 2867-2876.
    • (1997) J Clin Invest , vol.99 , pp. 2867-2876
    • Antonov, A.S.1    Munn, D.H.2    Kolodgie, F.D.3    Virmani, R.4    Gerrity, R.G.5
  • 2
    • 3042690158 scopus 로고    scopus 로고
    • Regulation of macrophage foam cell formation by alphaVbeta3 integrin: Potential role in human atherosclerosis
    • Antonov AS, Kolodgie FD, Munn DH, Gerrity RG. 2004. Regulation of macrophage foam cell formation by alphaVbeta3 integrin: Potential role in human atherosclerosis. Am J Pathol 165: 247-258.
    • (2004) Am J Pathol , vol.165 , pp. 247-258
    • Antonov, A.S.1    Kolodgie, F.D.2    Munn, D.H.3    Gerrity, R.G.4
  • 3
    • 0034254811 scopus 로고    scopus 로고
    • The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells
    • Ardeshna KM, Pizzey AR, Devereux S, Khwaja A. 2000. The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96: 1039-1046.
    • (2000) Blood , vol.96 , pp. 1039-1046
    • Ardeshna, K.M.1    Pizzey, A.R.2    Devereux, S.3    Khwaja, A.4
  • 6
    • 0025702766 scopus 로고
    • Atherosclerosis. Scavenging for receptors
    • Brown MS, Goldstein JL. 1990. Atherosclerosis. Scavenging for receptors. Nature 343: 508-509.
    • (1990) Nature , vol.343 , pp. 508-509
    • Brown, M.S.1    Goldstein, J.L.2
  • 7
    • 0032576475 scopus 로고    scopus 로고
    • Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin
    • Byzova TV, Plow EF. 1998. Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin. J Cell Biol 143: 2081-2092.
    • (1998) J Cell Biol , vol.143 , pp. 2081-2092
    • Byzova, T.V.1    Plow, E.F.2
  • 9
    • 33748616254 scopus 로고    scopus 로고
    • Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    • Cai W, Chen X. 2006. Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents Med Chem 6: 407-428.
    • (2006) Anticancer Agents Med Chem , vol.6 , pp. 407-428
    • Cai, W.1    Chen, X.2
  • 10
    • 64249172774 scopus 로고    scopus 로고
    • MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells
    • Chetty C, Lakka SS, Bhoopathi P, Rao JS. 2009. MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Int J Cancer 124: 2468-2477.
    • (2009) Int J Cancer , vol.124 , pp. 2468-2477
    • Chetty, C.1    Lakka, S.S.2    Bhoopathi, P.3    Rao, J.S.4
  • 11
    • 0034128090 scopus 로고    scopus 로고
    • The role of nuclear factor-kappa B in pulmonary diseases
    • Christman JW, Sadikot RT, Blackwell TS. 2000. The role of nuclear factor-kappa B in pulmonary diseases. Chest 117: 1482-1487.
    • (2000) Chest , vol.117 , pp. 1482-1487
    • Christman, J.W.1    Sadikot, R.T.2    Blackwell, T.S.3
  • 12
    • 0033121275 scopus 로고    scopus 로고
    • The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
    • Eliceiri BP, Cheresh DA. 1999. The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development. J Clin Invest 103: 1227-1230.
    • (1999) J Clin Invest , vol.103 , pp. 1227-1230
    • Eliceiri, B.P.1    Cheresh, D.A.2
  • 13
    • 0022972464 scopus 로고
    • A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
    • Espevik T, Nissen-Meyer J. 1986. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods 95: 99-105.
    • (1986) J Immunol Methods , vol.95 , pp. 99-105
    • Espevik, T.1    Nissen-Meyer, J.2
  • 15
    • 33747086130 scopus 로고    scopus 로고
    • Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells
    • Galliher AJ, Schiemann WP. 2006. Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Breast Cancer Res 8: R42.
    • (2006) Breast Cancer Res , vol.8
    • Galliher, A.J.1    Schiemann, W.P.2
  • 16
    • 0019491124 scopus 로고
    • The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions
    • Gerrity RG. 1981. The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol 103: 181-190.
    • (1981) Am J Pathol , vol.103 , pp. 181-190
    • Gerrity, R.G.1
  • 17
    • 0034232080 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha blockade: A new era for effective management of rheumatoid arthritis
    • Hamilton K, Clair EW. 2000. Tumour necrosis factor-alpha blockade: A new era for effective management of rheumatoid arthritis. Expert Opin Pharmacother 1: 1041-1052.
    • (2000) Expert Opin Pharmacother , vol.1 , pp. 1041-1052
    • Hamilton, K.1    Clair, E.W.2
  • 18
    • 0000685254 scopus 로고    scopus 로고
    • Regulated expression of CD36 during monocyte-to-macrophage differentiation: Potential role of CD36 in foam cell formation
    • Huh HY, Pearce SF, Yesner LM, Schindler JL, Silverstein RL. 1996. Regulated expression of CD36 during monocyte-to-macrophage differentiation: Potential role of CD36 in foam cell formation. Blood 87: 2020-2028.
    • (1996) Blood , vol.87 , pp. 2020-2028
    • Huh, H.Y.1    Pearce, S.F.2    Yesner, L.M.3    Schindler, J.L.4    Silverstein, R.L.5
  • 19
    • 34047258169 scopus 로고    scopus 로고
    • Cellular mechanisms in sepsis
    • Jean-Baptiste E. 2007. Cellular mechanisms in sepsis. J Intensive Care Med 22: 63-72.
    • (2007) J Intensive Care Med , vol.22 , pp. 63-72
    • Jean-Baptiste, E.1
  • 22
    • 38449099025 scopus 로고    scopus 로고
    • Src tyrosine kinases mediate activations of NF-kappaB and integrin signal during lipopolysaccharide-induced acute lung injury
    • Lee HS, Moon C, Lee HW, Park EM, Cho MS, Kang JL. 2007. Src tyrosine kinases mediate activations of NF-kappaB and integrin signal during lipopolysaccharide-induced acute lung injury. J Immunol 179: 7001-7011.
    • (2007) J Immunol , vol.179 , pp. 7001-7011
    • Lee, H.S.1    Moon, C.2    Lee, H.W.3    Park, E.M.4    Cho, M.S.5    Kang, J.L.6
  • 23
    • 27944487579 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages
    • Leu TH, Charoenfuprasert S, Yen CK, Fan CW, Maa MC. 2006. Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages. Mol Immunol 43: 308-316.
    • (2006) Mol Immunol , vol.43 , pp. 308-316
    • Leu, T.H.1    Charoenfuprasert, S.2    Yen, C.K.3    Fan, C.W.4    Maa, M.C.5
  • 24
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. 2002. Inflammation in atherosclerosis. Nature 420: 868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 25
    • 33645116785 scopus 로고    scopus 로고
    • NF-kappa B activation as a pathological mechanism of septic shock and inflammation
    • Liu SF, Malik AB. 2006. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol 290: L622-L645.
    • (2006) Am J Physiol , vol.290
    • Liu, S.F.1    Malik, A.B.2
  • 26
    • 67349132318 scopus 로고    scopus 로고
    • Regulators of endothelial and epithelial barrier integrity and function in acute lung injury
    • Lucas R, Verin AD, Black SM, Catravas JD. 2009. Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem Pharmacol 77: 1763-1772.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1763-1772
    • Lucas, R.1    Verin, A.D.2    Black, S.M.3    Catravas, J.D.4
  • 27
    • 34548680519 scopus 로고    scopus 로고
    • Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling
    • McCabe NP, De S, Vasanji A, Brainard J, Byzova TV. 2007. Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling. Oncogene 26: 6238-6243.
    • (2007) Oncogene , vol.26 , pp. 6238-6243
    • McCabe, N.P.1    De, S.2    Vasanji, A.3    Brainard, J.4    Byzova, T.V.5
  • 28
    • 0034283972 scopus 로고    scopus 로고
    • Identification and in vivo efficacy of small-molecule antagonists of integrin alphavbeta3 (the vitronectin receptor)
    • Miller WH, Keenan RM, Willette RN, Lark MW. 2000. Identification and in vivo efficacy of small-molecule antagonists of integrin alphavbeta3 (the vitronectin receptor). Drug Discov Today 5: 397-408.
    • (2000) Drug Discov Today , vol.5 , pp. 397-408
    • Miller, W.H.1    Keenan, R.M.2    Willette, R.N.3    Lark, M.W.4
  • 29
    • 65649103043 scopus 로고    scopus 로고
    • Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways
    • Moon C, Han JR, Park HJ, Hah JS, Kang JL. 2009. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res 10: 18.
    • (2009) Respir Res , vol.10 , pp. 18
    • Moon, C.1    Han, J.R.2    Park, H.J.3    Hah, J.S.4    Kang, J.L.5
  • 30
    • 0030056027 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages
    • Ohlsson BG, Englund MC, Karlsson AL, Knutsen E, Erixon C, Skribeck H, Liu Y, Bondjers G, Wiklund O. 1996. Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages. J Clin Invest 98: 78-89.
    • (1996) J Clin Invest , vol.98 , pp. 78-89
    • Ohlsson, B.G.1    Englund, M.C.2    Karlsson, A.L.3    Knutsen, E.4    Erixon, C.5    Skribeck, H.6    Liu, Y.7    Bondjers, G.8    Wiklund, O.9
  • 31
    • 0027920980 scopus 로고
    • Pathogenetic mechanisms of septic shock
    • Parrillo JE. 1993. Pathogenetic mechanisms of septic shock. N Engl J Med 328: 1471-1477.
    • (1993) N Engl J Med , vol.328 , pp. 1471-1477
    • Parrillo, J.E.1
  • 32
    • 0024419385 scopus 로고
    • The association of circulating endotoxin with the development of the adult respiratory distress syndrome
    • Parsons PE, Worthen GS, Moore EE, Tate RM, Henson PM. 1989. The association of circulating endotoxin with the development of the adult respiratory distress syndrome. Am Rev Respir Dis 140: 294-301.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 294-301
    • Parsons, P.E.1    Worthen, G.S.2    Moore, E.E.3    Tate, R.M.4    Henson, P.M.5
  • 33
    • 77950340431 scopus 로고    scopus 로고
    • Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke
    • Rajendrasozhan S, Hwang JW, Yao H, Kishore N, Rahman I. 2010. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther 23: 172-181.
    • (2010) Pulm Pharmacol Ther , vol.23 , pp. 172-181
    • Rajendrasozhan, S.1    Hwang, J.W.2    Yao, H.3    Kishore, N.4    Rahman, I.5
  • 34
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R. 1993. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362: 801-809.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 35
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-An inflammatory disease
    • Ross R. 1999. Atherosclerosis-An inflammatory disease. N Engl J Med 340: 115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 37
    • 36348980445 scopus 로고    scopus 로고
    • Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression
    • Schneider JG, Zhu Y, Coleman T, Semenkovich CF. 2007. Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression. Arterioscler Thromb Vasc Biol 27: 2699-2706.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2699-2706
    • Schneider, J.G.1    Zhu, Y.2    Coleman, T.3    Semenkovich, C.F.4
  • 39
    • 0031758996 scopus 로고    scopus 로고
    • The nuclear factor-kappa B/inhibitor of kappa B autoregulatory system and atherosclerosis
    • Thurberg BL, Collins T. 1998. The nuclear factor-kappa B/inhibitor of kappa B autoregulatory system and atherosclerosis. Curr Opin Lipidol 9: 387-396.
    • (1998) Curr Opin Lipidol , vol.9 , pp. 387-396
    • Thurberg, B.L.1    Collins, T.2
  • 40
    • 0036667386 scopus 로고    scopus 로고
    • Inhibitors of integrins
    • Tucker GC. 2002. Inhibitors of integrins. Curr Opin Pharmacol 2: 394-402.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 394-402
    • Tucker, G.C.1
  • 43
    • 0035674403 scopus 로고    scopus 로고
    • Quantitative analysis of immune-mediated stimulation of tumor necrosis factor-alpha in macrophages measured at the level of mRNA and protein synthesis
    • Weghofer M, Karlic H, Haslberger A. 2001. Quantitative analysis of immune-mediated stimulation of tumor necrosis factor-alpha in macrophages measured at the level of mRNA and protein synthesis. Ann Hematol 80: 733-736.
    • (2001) Ann Hematol , vol.80 , pp. 733-736
    • Weghofer, M.1    Karlic, H.2    Haslberger, A.3
  • 46
    • 39749170615 scopus 로고    scopus 로고
    • TGF-beta1 increases motility and alphavbeta3 integrin up-regulation via PI3K, Akt and NF-kappaB-dependent pathway in human chondrosarcoma cells
    • Yeh YY, Chiao CC, Kuo WY, Hsiao YC, Chen YJ, Wei YY, Lai TH, Fong YC, Tang CH. 2008. TGF-beta1 increases motility and alphavbeta3 integrin up-regulation via PI3K, Akt and NF-kappaB-dependent pathway in human chondrosarcoma cells. Biochem Pharmacol 75: 1292-1301.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1292-1301
    • Yeh, Y.Y.1    Chiao, C.C.2    Kuo, W.Y.3    Hsiao, Y.C.4    Chen, Y.J.5    Wei, Y.Y.6    Lai, T.H.7    Fong, Y.C.8    Tang, C.H.9
  • 48
    • 68149150584 scopus 로고    scopus 로고
    • Resveratrol improves endothelial function: Role of TNF{alpha} and vascular oxidative stress
    • Zhang H, Zhang J, Ungvari Z, Zhang C. 2009b. Resveratrol improves endothelial function: Role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol 29: 1164-1171.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1164-1171
    • Zhang, H.1    Zhang, J.2    Ungvari, Z.3    Zhang, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.