Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress

Journal of Proteome Research

Volumn 14, Issue 9, 2015, Pages 3982-3995

  Chen, Liyan ^a,b   Li, Jing ^a,c,d   Guo, Tiannan ^e   Ghosh, Sujoy ^f   Koh, Siew Kwan ^a   Tian, Dechao ^a,b   Zhang, Liang ^a,b   Jia, Deyong ^a   Beuerman, Roger W ^a,c,f   Aebersold, Ruedi ^e,g   Chan, Eric Chun Yong ^b   Zhou, Lei ^a,c,f  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e ETH ZURICH   (Switzerland)

^f DUKE NUS MEDICAL SCHOOL   (Singapore)

^g UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

dry eye; hyperosmolarity; iTRAQ; metabolomics; metabonomics; osmoprotectants; osmostic stress; proteomics; SWATH

Indexed keywords

ADENOSYLHOMOCYSTEINASE; APOPTOSIS INDUCING FACTOR; BETA TUBULIN; CARBONYL REDUCTASE; CYTOKERATIN 8; CYTOSOLIC PHOSPHOLIPASE A2; G PROTEIN ALPHA INHIBITING ACTIVITY POLYPEPTIDE 2; G PROTEIN ALPHA INHIBITING ACTIVITY POLYPEPTIDE 3; GLYCEROPHOSPHORYLCHOLINE; GROUP IV CYTOSOLIC PHOSPHOLIPASE A2; INTERCELLULAR ADHESION MOLECULE 1; IP3 RECEPTOR; KERATIN; KERATIN 6A; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA; N ACETYLGLUCOSAMINE; POLY(RC) BINDING PROTEIN 1; PROSTAGLANDIN; PROSTAGLANDIN 2; PROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 1; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; PROTECTIVE AGENT; PROTEOME;

ARTICLE; CELL SURFACE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; DRY EYE; EPITHELIUM CELL; GLYCOSYLATION; HUMAN; HUMAN CELL; HYPEROSMOTIC STRESS; IMMORTALIZED CELL LINE; METABOLOMICS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEOMICS; CELL LINE; CONJUNCTIVA; CYTOLOGY; DRUG EFFECTS; ISOTOPE LABELING; METABOLOME; OSMOTIC PRESSURE; PHYSIOLOGY;

CELL LINE; CONJUNCTIVA; DRY EYE SYNDROMES; EPITHELIAL CELLS; HUMANS; ISOTOPE LABELING; METABOLOME; METABOLOMICS; OSMOTIC PRESSURE; PROTECTIVE AGENTS; PROTEOME; PROTEOMICS;

EID: 84941075562     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.5b00443     Document Type: Article

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