Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells

American Journal of Physiology - Renal Physiology

Volumn 278, Issue 2 47-2, 2000, Pages

  Michea, L ^a,e   Ferguson, D R ^a,d   Peters, E M ^a   Andrews, P M ^b   Kirby, M R ^c   Burg, M B ^a  

^a Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cell death; Cell proliferation; G2 arrest; Osmolality

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BROXURIDINE; CASPASE 3; DNA; SODIUM CHLORIDE; UREA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE PHASE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DIPLOIDY; FLOW CYTOMETRY; HYPEROSMOLALITY; KIDNEY COLLECTING TUBULE; KIDNEY MEDULLA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034055321     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.278.2.f209     Document Type: Article

References (43)

1. Baron, C., and C. Penit. Study of the thymocyte cell cycle by bivariate analysis of incorporated bromodeoxyuridine and DNA content. Eur. J. Immunol. 20: 1231-1236, 1990.
2. Begg, A. C., N. J. McNally, D. C. Shrieve, and H. Karcher. A method to measure the duration of DNA synthesis and the potential doubling time from a single sample. Cytometry 6: 620-626, 1985.
3. Bortner, C. D., and J. A. Cidlowski. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am. J. Physiol. Cell Physiol. 271: C950-C961, 1996.
4. Burg, M. B. Renal osmoregulatory transport of compatible organic osmolytes. Curr. Opin. Nephrol. Hypertens. 6: 430-433, 1997.
5. Cardone, M. H., G. S. Salvesen, C. Widmann, G. Johnson, and S. M. Frisch. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90: 315-323, 1997.
6. Chen, Y. R., X. Wang, D. Templeton, R. J. Davis, and T. H. Tan. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271: 31929-31936, 1996.
7. Cohen, D. M., and S. R. Gullans. Urea induces Egr-1 and c-fos expression in renal epithelial cells. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 264: F593-F600, 1993.
8. Cohen, D. M., and S. R. Gullans. Urea selectively induces DNA synthesis in renal epithelial cells. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 264: F601-F607, 1993.
9. Cohen, D. M., S. R. Gullans, and W. W. Chin. Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase. J. Clin. Invest. 97: 1884-1889, 1996.
10. Cohen, D. M., J. C. Wasserman, and S. R. Gullans. Immediate early gene and HSP70 expression in hyperosmotic stress in MDCK cells. Am. J. Physiol. Cell Physiol. 261: C594-C601, 1991.
11. Deak, J. C., J. V. Cross, M. Lewis, Y. Qian, L. A. Parrott, C. W. Distelhorst, and D. J. Templeton. Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc. Natl. Acad. Sci. USA 95: 5595-5600, 1998.
12. Denizot, F., and R. Lang. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 89: 271-277, 1986.
13. Evan, G., and T. Littlewood. A matter of life and cell death. Science 281: 1317-1322, 1998.
14. Fraker, P. J., L. E. King, D. Lill-Elghanian, and W. G. Telford. Quantification of apoptotic events in pure and heterogeneous populations of cells using the flow cytometer. Methods Cell Biol. 46: 57-76, 1995.
15. Garcia-Perez, A., and M. B. Burg. Renal medullary organic osmolytes. Physiol. Rev. 71: 1081-1115, 1991.
16. Green, D. R. Apoptotic pathways: the roads to ruin. Cell 94: 695-698, 1998.
17. Hollander, M. C., and A. J. J. Fornace. Cell cycle checkpoints and growth-arrest genes activated by genotoxic stress. In: DNA Repair Mechanisms: Impact on Human Diseases and Cancer, edited by J. H. Vos. Austin, TX: Landes, 1995, p. 219-237.
18. Jaattela, M., D. Wissing, K. Kokholm, T. Kallunki, and M. Egeblad. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 17: 6124-6134, 1998.
19. Kultz, D., and M. B. Burg. Intracellular signaling in response to osmotic stress. Contrib. Nephrol. 123: 94-109, 1998.
20. Kultz, D., S. Madhany, and M. B. Burg. Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2. J. Biol. Chem. 273: 13645-13651, 1998.
21. Matsuda, S., H. Kawasaki, T. Moriguchi, Y. Gotoh, and E. Nishida. Activation of protein kinase cascades by osmotic shock. J. Biol. Chem. 270: 12781-12786, 1995.
22. Meikrantz, W., and R. Schlegel. Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J. Biol. Chem. 271: 10205-10209, 1996.
23. Mosser, D. D., A. W. Caron, L. Bourget, C. Denis-Larose, and B. Massie. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol. Cell. Biol. 17: 5317-5327, 1997.
24. Neuhofer, W., E. Muller, A. Burger-Kentischer, M. L. Fraek, K. Thurau, and F. Beck. Pretreatment with hypertonic NaCl protects MDCK cells against high urea concentrations. Pflügers Arch. 435: 407-414, 1998.
25. Neuhofer, W., E. Muller, A. Burger-Kentischer, M. L. Fraek, K. Thurau, and F. Beck. Inhibition of NaCl-induced heat shock protein 72 expression renders MDCK cells susceptible to high urea concentrations. Pflügers Arch. 437: 611-616, 1999.
26. Nurse, P. Checkpoint pathways come of age. Cell 91: 865-867, 1997.
27. O'Connor, P. M. Mammalian G1 and G2 phase checkpoints. Cancer Surv. 29: 151-182, 1997.
28. Paulovich, A. G., D. P. Toczyski, and L. H. Hartwell. When checkpoints fail. Cell 88: 315-321, 1997.
29. Podgornik, R., H. H. Strey, D. C. Rau, and V. A. Parsegian. Watching molecules crowd: DNA double helices under osmotic stress. Biophys. Chem. 57: 111-121, 1995.
30. Rauchman, M. I., S. K. Nigam, E. Delpire, and S. R. Gullans. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 265: F416-F424, 1993.
31. Rauchman, M. I., J. Pullman, and S. R. Gullans. Induction of molecular chaperones by hyperosmotic stress in mouse inner medullary collecting duct cells. Am. J. Physiol. Renal Physiol. 273: F9-F17, 1997.
32. Santos, B. C., A. Chevaile, M. J. Hebert, J. Zagajeski, and S. R. Gullans. A combination of NaCl and urea enhances survival of IMCD cells to hyperosmolality. Am. J. Physiol. Renal Physiol. 274: F1167-F1173, 1998.
33. Sheikh-Hamad, D., A. Garcia-Perez, J. D. Ferraris, E. M. Peters, and M. B. Burg. Induction of gene expression by heat shock versus osmotic stress. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 267: F28-F34, 1994.
34. Sherwood, S. W., and R. T. Schimke. Cell cycle analysis of apoptosis using flow cytometry. Methods Cell Biol. 46: 77-97, 1995.
35. Takenaka, M., A. S. Preston, H. M. Kwon, and J. S. Handler. The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress. J. Biol. Chem. 269: 29379-29381, 1994.
36. Terada, Y., K. Tomita, M. K. Homma, H. Nonoguchi, T. Yang, T. Yamada, Y. Yuasa, E. G. Krebs, S. Sasaki, and F. Marumo. Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. J. Biol. Chem. 269: 31296-31301, 1994.
37. Uchida, S., N. Green, H. Coon, T. Triche, S. Mims, and M. Burg. High NaCl induces stable changes in phenotype and karyotype of renal cells in culture. Am. J. Physiol. Cell Physiol. 253: C230-C242, 1987.
38. Vanden Broeck, J., A. De Loof, and P. Callaerts. Electrical-ionic control of gene expression. Int. J. Biochem. 24: 1907-1916, 1992.
39. Weinert, T. DNA damage and checkpoint pathways: molecular anatomy and interactions with repair. Cell 94: 555-558, 1998.
40. Widmann, C., P. Gerwins, N. L. Johnson, M. B. Jarpe, and G. L. Johnson. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol. Cell. Biol. 18: 2416-2429, 1998.
41. 2-terminal kinase 2 sensitizes renal inner medullary collecting duct cells to hypertonicity-induced lethality independent of organic osmolyte transport. J. Biol. Chem. 273: 800-804, 1998.
42. Zhang, Z., X. Yang, and D. M. Cohen. Urea-associated stress and Gadd153/CHOP induction. Am. J. Physiol. Renal Physiol. 276: F786-F793, 1999.
43. Zhou, B. B., H. Li, J. Yuan, and M. W. Kirschner. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proc. Natl. Acad. Sci. USA 95: 6785-6790, 1998.