Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice

Molecular Pharmaceutics

Volumn 12, Issue 9, 2015, Pages 3175-3183

  Sakai Kato, Kumiko ^a   Nanjo, Kunie ^a   Kusuhara, Hiroyuki ^b   Nishiyama, Nobuhiro ^e   Kataoka, Kazunori ^c,d   Kawanishi, Toru ^a   Okuda, Haruhiro ^a   Goda, Yukihiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Graduate School of Pharmaceutical Sciences   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

ABCB1; block copolymer micelles; clearance; systemic exposure

Indexed keywords

CD68 ANTIGEN; DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN 1; POLYMER; ABC TRANSPORTER; ANTINEOPLASTIC ANTIBIOTIC; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; P-GLYCOPROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BRAIN; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FECES LEVEL; FEMALE; HEART; IN VIVO STUDY; KIDNEY; LIVER; LUNG; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SPLEEN; URINE LEVEL; ANIMAL; CHEMISTRY; KNOCKOUT MOUSE; MOUSE; PHYSIOLOGY; TISSUE DISTRIBUTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ATP-BINDING CASSETTE TRANSPORTERS; DOXORUBICIN; FEMALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEINS; POLYMERS; TISSUE DISTRIBUTION;

EID: 84941061319     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00234     Document Type: Article

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