Assessment and rehabilitation of neglect using virtual reality: A systematic review

Frontiers in Behavioral Neuroscience

Volumn 9, Issue AUGUST, 2015, Pages

  Pedroli, Elisa ^a   Serino, Silvia ^a   Cipresso, Pietro ^a   Pallavicini, Federica ^a   Riva, Giuseppe ^a,b  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

Author keywords

Assessment; PRISMA; Rehabilitation; USN; Virtual reality

Indexed keywords

ARTICLE; AVOIDANCE BEHAVIOR; CEREBROVASCULAR ACCIDENT; CLINICAL PRACTICE; DISEASE PREDISPOSITION; HUMAN; LOCOMOTION; NEGLECT; NEUROPSYCHOLOGY; PATIENT ASSESSMENT; PATIENT SAFETY; REACTION TIME; REHABILITATION RESEARCH; RIGHT HEMISPHERE; SYMPTOMATOLOGY; SYSTEMATIC REVIEW; VIRTUAL REALITY;

EID: 84941035852     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2015.00226     Document Type: Article

References (112)

1. Agrell, B. M., Dehlin, O. I., and Dahlgren, C. J. (1997). Neglect in elderly stroke patients: a comparison of five tests. Psychiatry Clin. Neurosci. 51, 295–300. doi: 10.1111/j.1440-1819.1997.tb03201.x
2. Albert, M. L. (1973). A simple test of visual neglect. Neurology 23, 658–664. doi: 10.1212/WNL.23.6.658
3. Appelros, P., Karlsson, G. M., Seiger, A., and Nydevik, I. (2002). Neglect and anosognosia after first-ever stroke: incidence and relationship to disability. J. Rehabil. Med. 34, 215–220. doi: 10.1080/165019702760279206
4. Aravind, G., Darekar, A., Fung, J., and Lamontagne, A. (2015). Virtual reality-based navigation task to reveal obstacle avoidance performance in individuals with visuospatial neglect. IEEE Trans. Neural Syst. Rehabil. Eng. 23, 179–188. doi: 10.1109/TNSRE.2014.2369812
5. Aravind, G., and Lamontagne, A. (2014). Perceptual and locomotor factors affect obstacle avoidance in persons with visuospatial neglect. J. Neuroeng. Rehabil. 11:38. doi: 10.1186/1743-0003-11-38
6. Army Individual Test Battery. (1944). Manual of Directions and Scoring. Washington, DC: War Department, Adjutant General’s Office.
7. Azouvi, P., Bartolomeo, P., Beis, J. M., Perennou, D., Pradat-Diehl, P., and Rousseaux, M. (2006). A battery of tests for the quantitative assessment of unilateral neglect. Restor. Neurol. Neurosci. 24, 273–285.
8. Azouvi, P., Olivier, S., de Montety, G., Samuel, C., Louis-Dreyfus, A., and Tesio, L. (2003). Behavioral assessment of unilateral neglect: study of the psychometric properties of the Catherine Bergego Scale. Arch. Phys. Med. Rehabil. 84, 51–57. doi: 10.1053/apmr.2003.50062
9. Bartolomeo, P., and Chokron, S. (2002). Orienting of attention in left unilateral neglect. Neurosci. Biobehav. Rev. 26, 217–234. doi: 10.1016/S01497634(01)00065-3
10. Bohil, C. J., Alicea, B., and Biocca, F. A. (2011). Virtual reality in neuroscience research and therapy. Nat. Rev. Neurosci. 12, 752–762. doi: 10.1038/nrn3122
11. Bonato, M. (2012). Neglect and extinction depend greatly on task demands: a review. Front. Hum. Neurosci. 6:195. doi: 10.3389/fnhum.2012.00195
12. Bonato, M., and Deouell, L. Y. (2013). Hemispatial neglect: computer-based testing allows more sensitive quantification of attentional disorders and recovery and might lead to better evaluation of rehabilitation. Front. Hum. Neurosci. 7:162. doi: 10.3389/fnhum.2013.00162
13. Bonato, M., Priftis, K., Marenzi, R., Umiltà, C., and Zorzi, M. (2012). Deficits of contralesional awareness: a case study on what paper-and-pencil tests neglect. Neuropsychology 26, 20. doi: 10.1037/a0025306
14. Bouchard, S., Bernier, F., Boivin, É., Dumoulin, S., Laforest, M., Guitard, T., et al. (2013). Empathy toward virtual humans depicting a known or unknown person expressing pain. Cyberpsychol. Behav. Soc. Netw. 16, 61–71. doi: 10.1089/cyber.2012.1571
15. Bowen, A., Hazelton, C., Pollock, A., and Lincoln, N. B. (2013). Cognitive rehabilitation for spatial neglect following stroke. Cochrane Database Syst. Rev. 7:CD0035860 doi: 10.1002/14651858.CD003 586.pub3
16. Bowen, A., McKenna, K., and Tallis, R. C. (1999). Reasons for variability in the reported rate of occurrence of unilateral spatial neglect after stroke. Stroke 30, 1196–1202. doi: 10.1161/01.STR.30.6.1196
17. Brochard, S., Robertson, J., Médée, B., and Rémy-Néris, O. (2010). What’s new in new technologies for upper extremity rehabilitation? Curr. Opin. Neurol. 23, 683–687. doi: 10.1097/WCO.0b013e32833f61ce
18. Brooks, B. M., and Rose, F. D. (2003). The use of virtual reality in memory rehabilitation: Current findings and future directions. NeuroRehabilitation 18, 147–157.
19. Butter, C. M., Kirsch, N. L., and Reeves, G. (1990). The effect of lateralized dynamic stimuli on unilateral spatial neglect following right hemisphere lesions. Restor. Neurol. Neurosci. 2, 39–46.
20. Buxbaum, L. J., Dawson, A. M., and Linsley, D. (2012). Reliability and validity of the Virtual Reality Lateralized Attention Test in assessing hemispatial neglect in right-hemisphere stroke. Neuropsychology 26, 430. doi: 10.1037/ a0028674
21. Buxbaum, L. J., Ferraro, M. K., Veramonti, T., Farne, A., Whyte, J., Ladavas, E., et al. (2004). Hemispatial neglect: subtypes, neuroanatomy, and disability. Neurology 62, 749–756. doi: 10.1212/01.WNL.0000113730.73031.F4
22. Buxbaum, L. J., Palermo, M. A., Mastrogiovanni, D., Read, M. S., RosenbergPitonyak, E., Rizzo, A. A., et al. (2008). Assessment of spatial attention and neglect with a virtual wheelchair navigation task. J. Clin. Exp. Neuropsychol. 30, 650–660. doi: 10.1080/13803390701625821
23. Cocchini, G., Beschin, N., and Jehkonen, M. (2001). The fluff test: a simple task to assess body representation neglect. Neuropsychol. Rehabil. 11, 17–31. doi: 10.1080/09602010042000132
24. Colarusso, R. P., and Hammill, D. D. (1972). Motor-free Visual Perception Test. Novato, CA: Academic Therapy Pub.
25. Corbetta, M., and Shulman, G. L. (2011). Spatial neglect and attention networks. Annu. Rev. Neurosci. 34, 569. doi: 10.1146/annurev-neuro-061010-113731
26. Corbetta, M., Kincade, M. J., Lewis, C., Snyder, A. Z., and Sapir, A. (2005). Neural basis and recovery of spatial attention deficits in spatial neglect. Nat. Neurosci. 8, 1603–1610. doi: 10.1038/nn1574
27. Dalmaijer, E. S., Van der Stigchel, S., Nijboer, T. C., Cornelissen, T. H., and Husain, M. (2014). CancellationTools: All-in-one software for administration and analysis of cancellation tasks. Behav. Res. Methods. doi: 10.3758/s13428014-0522-7. [Epub ahead of print].
28. DERENZI, E., and VIGNOLO, L. A. (1962). The tokentest: a sensitive test to detect receptive disturbances in aphasics. Brain 85, 665. doi: 10.1093/brain/85.4.665
29. Deouell, L. Y., Sacher, Y., and Soroker, N. (2005). Assessment of spatial attention after brain damage with a dynamic reaction time test. J. Int. Neuropsychol. Soc. 11, 697–707. doi: 10.1017/s1355617705050824
30. Di Carlo, A. (2009). Human and economic burden of stroke. Age Ageing 38, 4–5. doi: 10.1093/ageing/afn282
31. Diller, L., and Weinberg, J. (1976). Hemi-inattention in rehabilitation: the evolution of a rational remediation program. Adv. Neurol. 18, 63–82.
32. Dvorkin, A. Y., Rymer, W. Z., Settle, K., and Patton, J. L. (2007). “Perceptual assessment of spatial neglect within a virtual environment,” in Paper Presented at the Virtual Rehabilitation (Venice)
33. Eslinger, P. J., Flaherty-Craig, C. V., and Benton, A. L. (2004). Developmental outcomes after early prefrontal cortex damage. Brain Cogn. 55, 84–103. doi: 10.1016/S0278-2626(03)00281-1
34. Eslinger, P. J., Grattan, L. M., Damasio, H., and Damasio, A. R. (1992). Developmental consequences of childhood frontal lobe damage. Arch. Neurol. 49, 764–769. doi: 10.1001/archneur.1992.00530310112021
35. Folstein, M. F., Robins, L. N., and Helzer, J. E. (1983). The Minimental state examination. Arch. Gen. Psychiatry 40, 812. doi: 10.1001/archpsyc.1983.01790060110016
36. Fordell, H., Bodin, K., Bucht, G., and Malm, J. (2011). A virtual reality test battery for assessment and screening of spatial neglect. Acta Neurol. Scand. 123, 167–174. doi: 10.1111/j.1600-0404.2010.01390.x
37. Gauthier, L., Dehaut, F., and Joanette, Y. (1989). The bells test: a quantitative and qualitative test for visual neglect. Int. J. Clin. Neuropsychol. 11, 49–54.
38. Geeraerts, S., Lafosse, C., Vandenbussche, E., and Verfaillie, K. (2005). A psychophysical study of visual extinction: ipsilesional distractor interference with contralesional orientation thresholds in visual hemineglect patients. Neuropsychologia 43, 530–541. doi: 10.1016/j.neuropsychologia.2004.07.012
39. Gontkovsky, S. T., McDonald, N. B., Clark, P. G., and Ruwe, W. D. (2002). Current directions in computer-assisted cognitive rehabilitation. NeuroRehabilitation 17, 195–199.
40. Hackett, M. L., Yapa, C., Parag, V., and Anderson, C. S. (2005). Frequency of depression after stroke a systematic review of observational studies. Stroke 36, 1330–1340. doi: 10.1161/01.STR.0000165928.19135.35
41. Halligan, P. W., Fink, G. R., Marshall, J. C., and Vallar, G. (2003). Spatial cognition: evidence fromvisual neglect. Trends Cogn. Sci. 7, 125–133. doi: 10.1016/S13646613(03)00032-9
42. Halligan, P. W., Marshall, J. C., and Wade, D. T. (1989). Visuospatial neglect: underlying factors and test sensitivity. Lancet 334, 908–911. doi: 10.1016/S0140-6736(89)91561-4
43. Heilman, K. M., Watson, R. T., and Valenstein, E. (1985). Neglect and Related Disorders. NewYork, NY: Oxford University Press.
44. Hendricks, H. T., van Limbeek, J., Geurts, A. C., and Zwarts, M. J. (2002). Motor recovery after stroke: a systematic review of the literature. Arch. Phys. Med. Rehabil. 83, 1629–1637. doi: 10.1053/apmr.2002.35473
45. Jacquin-Courtois, S., O’Shea, J., Luauté, J., Pisella, L., Revol, P., Mizuno, K., et al. (2013). Rehabilitation of spatial neglect by prism adaptation: a peculiar expansion of sensorimotor after-effects to spatial cognition. Neurosci. Biobehav. Rev. 37, 594–609. doi: 10.1016/j.neubiorev.2013.02.007
46. Jehkonen, M., Laihosalo, M., and Kettunen, J. (2006). Impact of neglect on functional outcome after stroke-a review of methodological issues and recent research findings. Restor. Neurol. Neurosci. 24, 209–215.
47. Jung, H. Y., Park, B. K., Shin, H. S., Kang, Y. K., Pyun, S. B., Paik, N. J., et al. (2007). Development of the Koreanversionof ModifiedBarthel Index (K-MBI): multi-center study for subjects with stroke. J. Korean Acad. Rehabil. Med. 31, 283–297.
48. Kerkhoff, G., and Schenk, T. (2012). Rehabilitation of neglect: an update. Neuropsychologia 50, 1072–1079. doi: 10.1016/j.neuropsychologia.2012.01.024
49. Kim, D. Y., Ku, J., Chang, W. H., Park, T. H., Lim, J. Y., Han, K., et al. (2010). Assessment of post-stroke extrapersonal neglect using a three-dimensional immersive virtual street crossing program. Acta Neurol. Scand. 121, 171–177. doi: 10.1111/j.1600-0404.2009.01194.x
50. Kim, Y. M., Chun, M. H., Yun, G. J., Song, Y. J., and Young, H. E. (2011). The effect of virtual reality training on unilateral spatial neglect in stroke patients. Ann. Rehabil. Med. 35, 309–315. doi: 10.5535/arm.2011.35.3.309
51. Làdavas, E., Shallice, T., and Zanella, M. T. (1997). Preserved semantic access in neglect dyslexia. Neuropsychologia 35, 257–270. doi: 10.1016/S00283932(96)00066-8
52. Langhorne, P., Coupar, F., and Pollock, A. (2009). Motor recovery after stroke: a systematic review. Lancet Neurol. 8, 741–754. doi: 10.1016/S14744422(09)70150-4
53. Leigh, S., Danckert, J., and Eliasmith, C. (2015). Modelling the differential effects of prisms on perception and action in neglect. Exp. Brain Res. 233, 751–766. doi: 10.1007/s00221-014-4150-3
54. Levick, W. R. (2010). Observer rating of memory in children: a review. Brain Impair. 11, 144–151. doi: 10.1375/brim.11.2.144
55. Lindell, A. B., Jalas, M. J., Tenovuo, O., Brunila, T., Voeten, M. J., and Hämäläinen, H. (2007). Clinical assessment of hemispatial neglect: evaluation of different measures and dimensions. Clin. Neuropsychol. 21, 479–497. doi: 10.1080/13854040600630061
56. Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., et al. (2009). Heart disease and stroke statistics– 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119, 21–181. doi: 10.1161/CIRCULATIONAHA.108.191261
57. Mainetti, R., Sedda, A., Ronchetti, M., Bottini, G., and Borghese, N. A. (2013). Duckneglect: video-games based neglect rehabilitation. Technol. Health Care 21, 97–111. doi: 10.3233/THC-120712
58. Mattingley, J. B., Bradshaw, J. L., and Bradshaw, J. A. (1994). Horizontal visual motion modulates focal attention in left unilateral spatial neglect. J. Neurol. Neurosurg. Psychiatry 57, 1228–1235. doi: 10.1136/jnnp.57.10.1228
59. Mesa-Gresa, P., Lozano, J. A., Llórens, R., Alcañiz, M., Navarro, M. D., and Noé, E. (2011). “Clinical validation of a virtual environment test for safe street crossing in the assessment of acquired brain injury patients with and without neglect,” in Paper Presented at the Proceedings of the 13th IFIP TC 13 International Conference on Human-computer Interaction - Volume Part II (Lisbon).
60. Meyerbröker, K., Morina, N., Kerkhof, G., and Emmelkamp, P. M. (2010). Virtual reality exposure treatment of agoraphobia: a comparison of computer automatic virtual environment and head-mounted display. Stud. Health Technol. Inform. 167, 51–56. doi: 10.3233/978-1-60750-766-6-51
61. Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., and PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 6:e1000097. doi: 10.1371/journal.pmed.1000097
62. Mutai, H., Furukawa, T., Araki, K., Misawa, K., and Hanihara, T. (2012). Factors associated with functional recovery and home discharge in stroke patients admitted to a convalescent rehabilitation ward. Geriatr. Gerontol. Int. 12, 215–222. doi: 10.1111/j.1447-0594.2011.00747.x
63. Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., et al. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J. Am. Geriatr. Soc. 53, 695–699. doi: 10.1111/j.1532-5415.2005.53221.x
64. Navarro, M. D., Lloréns, R., Noé, E., Ferri, J., and Alcañiz, M. (2013). Validation of a low-cost virtual reality system for training street-crossing. A comparative study in healthy, neglected and non-neglected stroke individuals. Neuropsychol. Rehabil. 23, 597–618. doi: 10.1080/09602011.2013.806269
65. Newport, R., and Schenk, T. (2012). Prisms and neglect: what have we learned? Neuropsychologia 50, 1080–1091. doi: 10.1016/j.neuropsychologia.2012.01.023
66. Nijboer, T. C., Kollen, B. J., and Kwakkel, G. (2013a). Time course of visuospatial neglect early after stroke: a longitudinal cohort study. Cortex 49, 2021–2027. doi: 10.1016/j.cortex.2012.11.006
67. Nijboer, T. C. W., Kollen, B. J., and Kwakkel, G. (2014a). The impact of recovery of visuo-spatial neglect on motor recovery of the upper paretic limb after stroke. PLoS ONE 9:e100584. doi: 10.1371/journal.pone.0100584
68. Nijboer, T. C. W., Ten Brink, A. F., Kouwenhoven, M., and Visser-Meily, J. M. A. (2014b). Functional assessment of region-specific neglect: are there differential behavioural consequences of peripersonal versus extrapersonal neglect? Behav. Neurol. 2014:526407. doi: 10.1155/2014/526407
69. Nijboer, T. C., van de Port, I., Schepers, V., Post, M., and Visser-Meily, A. (2013b). Predicting functional outcome after stroke: the influence of neglect on basic activities in daily living. Front. Hum. Neurosci. 7:182. doi: 10.3389/fnhum.2013.00182
70. Paci, M., Matulli, G., Baccini, M., Rinaldi, L. A., and Baldassi, S. (2010). Reported quality of randomized controlled trials in neglect rehabilitation. Neurol. Sci. 31, 159–163. doi: 10.1007/s10072-009-0198-4
71. Peña-Casanova, J., Gramunt Fombuena, N., and Gich Fullà, J. (2006). Neurophychological Tests. Barcelona: Elsevier.
72. Pendlebury, S. T., Giles, M. F., and Rothwell, P. M. (2009). Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Management. Cambridge: Cambridge University Press.
73. Perez-Garcia, M., Godoy-Garcia, J. F., Vera-Guerrero, N., Laserna-Triguero, J. A., and Ouente, A. E. (1998). Neuropsychological evaluation of everyday memory. Neuropsychol. Rev. 8, 203–227. doi: 10.1023/A:1021622319851
74. Perez-Marcos, D., Solazzi, M., Steptoe, W., Oyekoya, O., Frisoli, A., Weyrich, T., et al. (2012). A fully-immersive set-up for remote interaction and neurorehabilitation based on virtual body ownership. Front. Neurol. 3:110. doi: 10.3389/fneur.2012.00110
75. Peskine, A., Rosso, C., Box, N., Galland, A., Caron, E., Rautureau, G., et al. (2011). Virtual reality assessment for visuospatial neglect: importance of a dynamic task. J. Neurol. Neurosurg. Psychiatr. 82, 1407–1409. doi: 10.1136/jnnp.2010.217513
76. Pflugshaupt, T., Bopp, S. A., Heinemann, D., Mosimann, U. P., von Wartburg, R., Nyffeler, T., et al. (2004). Residual oculomotor and exploratory deficits in patients with recovered hemineglect. Neuropsychologia 42, 1203–1211. doi: 10.1016/j.neuropsychologia.2004.02.002
77. Pierce, S. R., and Buxbaum, L. J. (2002). Treatments of unilateral neglect: a review. Arch. Phys. Med. Rehabil. 83, 256–268. doi: 10.1053/apmr.2002.27333
78. Pizzamiglio, L. (1990). La Rieducazione Dell’Eminattenzione Spaziale. Milano: Masson Ed.
79. Pohjasvaara, T., Leskelä, M., Vataja, R., Kalska, H., Ylikoski, R., Hietanen, M., et al. (2002). Post-stroke depression, executive dysfunction and functional outcome. Eur. J. Neurol. 9, 269–275. doi: 10.1046/j.1468-1331.2002.00396.x
80. Rabuffetti, M., Farina, E., Alberoni, M., Pellegatta, D., Appollonio, I., Affanni, P., et al. (2012). Spatio-temporal features of visual exploration in unilaterally brain-damaged subjects with or without neglect: results from a touchscreen test. PLoS ONE 7:e31511. doi: 10.1371/annotation/bf311a56-bc48-44b6-9b0f7ccc97fc290f
81. Rengachary, J., d’Avossa, G., Sapir, A., Shulman, G. L., and Corbetta, M. (2009). Is the posner reaction time test more accurate than clinical tests in detecting left neglect in acute and chronic stroke? Arch. Phys. Med. Rehabil. 90, 2081–2088. doi: 10.1016/j.apmr.2009.07.014
82. Riva, G. (2009). Virtual reality: an experiential tool for clinical psychology. Br. J. Guid. Couns. 37, 337–345. doi: 10.1080/03069880902957056
83. Riva, G., Castelnuovo, G., and Mantovani, F. (2006). Transformation of flow in rehabilitation: the role of advanced communication technologies. Behav. Res. Methods 38, 237–244. doi: 10.3758/BF03192775
84. Riva, G., Mantovani, F., and Gaggioli, A. (2004). Presence and rehabilitation: toward second-generation virtual reality applications in neuropsychology. J. Neuroeng. Rehabil. 1, 9. doi: 10.1186/1743-0003-1-9
85. Rizzo, A. A., Buckwalter, J. G., and van der Zaag, C. (2002). “Applications for neuropsychological assessment and rehabilitation,” in Handbook of Virtual Environments, ed K. Stanney (NewYork, NY: L. A. Earlbaum), 1027–1064.
86. Robertson, I. H., and Halligan, P. W. (1999). Spatial Neglect: A Clinical Handbook for Diagnosis and Treatment. Hove: Psychology Press.
87. Rossetti, Y., Rode, G., Pisella, L., Farné, A., Li, L., Boisson, D., et al. (1998). Prism adaptationto a rightward optical deviationrehabilitates left hemispatial neglect. Nature 395, 166–169. doi: 10.1038/25988
88. Schenkenberg, T., Bradford, D. C., and Ajax, E. T. (1980). Line bisection and unilateral visual neglect in patients with neurologic impairment. Neurology 30, 509–509. doi: 10.1212/WNL.30.5.509
89. Schultheis, M. T., and Rizzo, A. A. (2001). The application of virtual reality technology in rehabilitation. Rehabil. Psychol. 46, 296. doi: 10.1037/00905550.46.3.296
90. Sedda, A., Borghese, N. A., Ronchetti, M., Mainetti, R., Pasotti, F., Beretta, G., et al. (2013). Using virtual reality to rehabilitate neglect. Behav. Neurol. 26, 183–185. doi: 10.1155/2013/810279
91. Smania, N., Martini, M., Gambina, G., Tomelleri, G., Palamara, A., Natale, E., et al. (1998). The spatial distribution of visual attention in hemineglect and extinction patients. Brain 121, 1759–1770. doi: 10.1093/brain/121.9.1759
92. Smit, M., Van der Stigchel, S., Visser-Meily, J. M., Kouwenhoven, M., Eijsackers, A. L., and Nijboer, T. C. (2013). The feasibility of computerbased prism adaptation to ameliorate neglect in sub-acute stroke patients admitted to a rehabilitation center. Front. Hum. Neurosci. 7:353. doi: 10.3389/fnhum.2013.00353
93. Spinnler, H., and Tognoni, G. (1987). Standardizzazione e Taratura Italiana di Test Neuropsicologici. Milano: Masson Italia Periodici.
94. Sudlow, C. L. M., and Warlow, C. P. (1997). Comparable studies of the incidence of stroke and its pathological types - Results fromaminternational collaboration. Stroke 28, 491–499. doi: 10.1161/01.STR.28.3.491
95. Sugarman, H., Weisel-Eichler, A., Burstin, A., and Brown, R. (2011). “Use of novel virtual reality system for the assessment and treatment of unilateral spatial neglect: A feasibility study,” in Paper Presented 2011 International Conference on the Virtual Rehabilitation (ICVR) (Zurich). doi: 10.1109/ICVR.2011.5971859
96. Sundar, U., and Adwani, S. (2010). Post-stroke cognitive impairment at 3 months. Ann. Indian Acad. Neurol. 13, 42. doi: 10.4103/0972-2327.61276
97. Tanaka, T., Ifukube, T., Sugihara, S., and Izumi, T. (2010). A case study of new assessment and training of unilateral spatial neglect in stroke patients: effect of visual image transformation and visual stimulation by using a head mounted display system(HMD). J. Neuroeng. Rehabil. 7:20. doi: 10.1186/1743-0003-7-20
98. Tant, M. L. M., Kuks, J. M. B., Kooijman, A. C., Cornelissen, F. W., and Brouwer, W. H. (2002). Grey scales uncover similar attentional effects in homonymous hemianopia and visual neglect. Neuropsychologia 40, 1474–1481. doi: 10.1016/S0028-3932(01)00197-X
99. Tham, K. (1996). The baking tray task: a test of spatial neglect. Neuropsychol. Rehabil. 6, 19–26. doi: 10.1080/713755496
100. Tham, K., and Tegnér, R. (1996). The baking tray task: a test of spatial neglect. Neuropsychol. Rehabil. 6, 19–25. doi: 10.1080/713755496
101. Towle, D., and Lincoln, N. B. (1991). Development of a questionnaire for detecting everyday problems in stroke patients with unilateral neglect. Clin. Rehabil. 5, 135–140. doi: 10.1177/026921559100500208
102. Tsirlin, I., Dupierrix, E., Chokron, S., Coquillart, S., and Ohlmann, T. (2009). Uses of virtual reality for diagnosis, rehabilitation and study of unilateral spatial neglect: review and analysis. Cyberpsychol. Behav. 12, 175–181. doi: 10.1089/cpb.2008.0208
103. Vaes, N., Lafosse, C., Nys, G., Schevernels, H., Dereymaeker, L., Oostra, K., et al. (2015). Capturing peripersonal spatial neglect: An electronic method to quantify visuospatial processes. Behav. Res. Methods 47, 27–44. doi: 10.3758/s13428-014-0448-0
104. Vallar, G., and Perani, D. (1986). The anatomy of unilateral neglect after right-hemisphere stroke lesions. A clinical/CT-scan correlation study in man. Neuropsychologia 24, 609–622. doi: 10.1016/0028-3932(86) 90001-1
105. van Kessel, M. E., Geurts, A. C., Brouwer, W. H., and Fasotti, L. (2013). Visual scanning training for neglect after stroke with and without a computerized lane tracking dual task. Front. Hum. Neurosci. 7:358. doi: 10.3389/fnhum.2013.00358
106. Vriezen, E. R., Pigott, S. D., and Pelletier, P. M. (2001). Developmental implications of early frontal-lobe damage: a case study. Brain Cogn. 47, 222–225.
107. Wilson, B., Cockburn, J., and Halligan, P. (1987). Development of a behavioral test of visuospatial neglect. Arch. Phys. Med. Rehabil. 68, 98–102.
108. Witmer, B., and Singer, M. (1998). Measuring presence in virtual environments: a presence questionnaire. Presence 7, 225–240. doi: 10.1162/10547469 8565686
109. Wolfe, C. D. A. (2000). The impact of stroke. Br. Med. Bull. 56, 275–286. doi: 10.1258/0007142001903120
110. Yong Joo, L., Soon Yin, T., Xu, D., Thia, E., Pei Fen, C., Kuah, C. W., et al. (2010). A feasibility study using interactive commercial off-the-shelf computer gaming in upper limb rehabilitation in patients after stroke. J. Rehabil. Med. 42, 437–441. doi: 10.2340/16501977-0528
111. Zhang, Y., Chapman, A. M., Plested, M., Jackson, D., and Purroy, F. (2012). The incidence, prevalence, and mortality of stroke in France, Germany, Italy, Spain, the UK, and the US: a literature review. Stroke Res. Treat. 2012:436125. doi: 10.1155/2012/436125
112. Zoccolotti, P., Antonucci, G., and Judica, A. (1992). Psychometric characteristics of two semi-structured scales for the functional evaluation of hemi-inattention in extrapersonal and personal space. Neuropsychol. Rehabil. 2, 179–191. doi: 10.1080/09602019208401407