Advances in measuring single-cell pharmacology in vivo

Drug Discovery Today

Volumn 20, Issue 9, 2015, Pages 1087-1092

  Vinegoni, Claudio ^a   Dubach, J Matthew ^a   Thurber, Greg M ^b   Miller, Miles A ^a   Mazitschek, Ralph ^a   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LEVEL; DRUG ACCUMULATION; DRUG BINDING; DRUG DEVELOPMENT; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MEASUREMENT; NONHUMAN; PHARMACODYNAMIC PARAMETERS; PHARMACOKINETICS; REVIEW; ANIMAL; BIOLOGICAL MODEL; DRUG DESIGN; HUMAN; PHARMACOLOGY; PROCEDURES; SINGLE CELL ANALYSIS;

ANIMALS; DRUG DESIGN; DRUG DISCOVERY; HUMANS; MODELS, BIOLOGICAL; PHARMACOKINETICS; PHARMACOLOGY; SINGLE-CELL ANALYSIS;

EID: 84941023743     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.05.011     Document Type: Review

References (31)

1. P.M. Paul, and et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discov. 9 2010 203 214
2. C.P. Paweletz, and et al. Identification of direct target engagement biomarkers for kinase-targeted therapeutics PLoS ONE 6 2011 e26459
3. I. Kola, and J. Landis Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3 2004 711 716
4. I. Collins, and P. Workman New approaches to molecular cancer therapeutics Nat. Chem. Biol. 2 2006 689 700
5. L. Troyer, and A.V. Krasnikov The effect of price regulation on innovation in the pharmaceutical industry J. Appl. Bus. Res. 18 2002 87
6. G.M. Simon, and et al. Determining target engagement in living systems Nat. Chem. Biol. 9 2013 200 205
7. M.E. Bunnage, and et al. Target validation using chemical probes Nat. Chem. Biol. 9 2013 195 199
8. M.J. Pittet, and R. Weissleder Intravital imaging Cell 147 2011 983 991
9. G.M. Thurber, and et al. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo Nat. Commun. 4 2013 1504
10. A.M. Laughney, and et al. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin Sci. Transl. Med. 6 2014 261ra152
11. G.M. Thurber Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors Mol. Cancer Ther. 13 2014 986 995
12. G.M. Thurber, and R. Weissleder A systems approach for tumor pharmacokinetics PLoS ONE 6 2011 e24696
13. M. Gerlinger, and et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing N. Engl. J. Med. 366 2012 883 892
14. S.L. Spencer, and et al. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis Nature 459 2009 428 432
15. D.B. Kirpotin, and et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models Cancer Res. 66 2006 6732 6740
16. P. Poulin, and F.P. Theil A priori prediction of tissue: plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery J. Pharm. Sci. 89 2000 16 35
17. T. Rodgers, and M. Rowland Mechanistic approaches to volume of distribution predictions: understanding the processes Pharm. Res. 24 2007 918 933
18. C.W. Cunningham, and et al. Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification Mol. Pharm. 7 2010 1301 1310
19. L.H. Jones, and et al. In-cell click labeling of small molecules to determine subcellular localization J. Chem. Biol. 4 2011 49 53
20. G.R. Rosania, and et al. Combinatorial approaches to organelle-targeted fluorescent library based on the styryl scaffold J. Am. Chem. Soc. 125 2003 1130 1131
21. X. Zhang, and et al. A cell-based molecular transport simulator for pharmacokinetic prediction and cheminformatic exploration Mol. Pharm. 3 2006 704 716
22. D.M. Molina, and et al. Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay Science 341 2013 84 87
23. M.M. Savitski, and et al. Tracking cancer drugs in living cells by thermal profiling of the proteome Science 346 2014 1255784
24. X.H. Liu, and et al. Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging Sci. Rep. 3 2013 2859
25. J.M. Dubach, and et al. In vivo imaging of specific drug-target binding at subcellular resolution Nat. Commun. 5 2014 3946
26. S. Brasselet Polarization-resolved nonlinear microscopy: application to structural molecular and biological imaging Adv. Opt. Photonics 3 2011 205 271
27. A. Bullen Microscopic imaging techniques for drug discovery Nat. Rev. Drug Discov. 1 2008 54 67
28. M.R. Juntilla, and et al. Influence of tumour micro-environment heterogeneity on therapeutic response Nature 501 2013 346 354
29. D. Bakstad, and et al. Quantitative measurement of single cell dynamics Curr. Opin. Biotechnol. 23 2012 103 109
30. S. Regot, and et al. High-sensitivity measurements of multiple kinase activities in live single cells Cell 157 2014 1724 1734
31. M.A. Miller, and et al. Platinum compounds for high resolution in vivo cancer imaging ChemMedChem 9 2014 1131 1135